Wound Healing in Peripheral Arterial Disease: Current and Future Therapy

Wounds secondary to peripheral arterial disease (PAD) result in substantial morbidity and burden to the healthcare industry. To aid in the care of this patient population, knowledge of the disease process and current standards of therapy is paramount for healthcare providers.The future care of these patients and improvement from our existing standards hinges on the active translational research. To implement new technologies and advances in the treatment of PAD-induced wounds and ensure adequate utilization of our current therapies a PAD-wound team is necessary

The clinical effectiveness and cost-effectiveness of point-of-care tests (CoaguChek system, INRatio2 PT/INR monitor and ProTime Microcoagulation system) for the self-monitoring of the coagulation status of people receiving long-term vitamin K antagonist therapy, compared with standard UK practice : systematic review and economic evaluation

Funding The National Institute for Health Research Health Technology Assessment programme.Peer reviewedPublisher PD

Renal Function and Risk of Coronary Heart Disease in General Populations: New Prospective Study and Systematic Review

John Danesh and colleagues conclude there may be a moderate increase in risk of coronary heart disease associated with very low estimated glomerular filtration rate

Vitamin C for treating atrial fibrillation : [Protocol]

This document contains the Protocol for a Cochrane review. A review was prepared, but it was not published. We found strong evidence that vitamin C has prevented atrial fibrillation outside of the USA. The Cochrane review manuscript is available at: http://www.mv.helsinki.fi/home/hemila/H/HH_2015_CochAF_Protocol.pdf. The review was not rejected because of valid scientific reasons, see responses to reviewer comments at: http://www.mv.helsinki.fi/home/hemila/H/VitC_AF_1308_reviewer_comments.pdf. The Cochrane editors rejection statement is shown below. However, there is no description why the topic has low priority. Thus, was the low priority caused by effects seen only outside of the USA or because vitamin C is not interesting in the view of the Cochrane editors. A shortened version was published in BMC Cardiovascular Disorders: https://doi.org/10.1186/s12872-017-0478-5 ## Reason for withdrawal from publication: The CRG withdrew this protocol as the current author team is unable to progress to the final stage of the review. The editors consider this title as low priority for the current portfolio of the Heart Group and therefore this title is not open to a new author team. https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD011471.pub2/abstractPeer reviewe

Vitamin C for treating atrial fibrillation : [Withdrawal from publication]

The Cochrane editors statement is shown below.However, there is no description why the topic has low priority. We found strong evidence that in RCTs published so far, vitamin C has prevented atrial fibrillation outside of the USA. Thus, was the low priority caused by effects seen only outside of the USA or because vitamin C is not interesting in the view of the Cochrane editors. The manuscript for the Cochrane review is available at: http://www.mv.helsinki.fi/home/hemila/H/HH_2015_CochAF_Protocol.pdf. The review was not rejected because of valid scientific reasons, see responses to reviewer comments at: http://www.mv.helsinki.fi/home/hemila/H/VitC_AF_1308_reviewer_comments.pdf. A shortened version was published in BMC Cardiovascular Disorders: https://doi.org/10.1186/s12872-017-0478-5. ## Reason for withdrawal from publication: The CRG withdrew this protocol as the current author team is unable to progress to the final stage of the review. The editors consider this title as low priority for the current portfolio of the Heart Group and therefore this title is not open to a new author team.Peer reviewe

Teacher quality in the twenty first century: new lives, old truths

This chapter is based upon a keynote address to the first global teacher education summit, organised by Beijing Normal University in 2011, in which research across the world about influences which affect teachers' sense of professional identity, capacity for compassion, commitment, resilience and effectiveness long after they have graduated from their pre-service education and training programmes in universities and colleges were shared. The findings suggest that teaching pre-service students about how the conditions in which they work may enhance or diminish their capacity to teach to their best and how they might act to mediate these is a key part of the work of all teacher educators and an important focus for the work of educational researchers

Multiple Changes in Peptide and Lipid Expression Associated with Regeneration in the Nervous System of the Medicinal Leech

peer reviewe

Drug export and allosteric coupling in a multidrug transporter revealed by molecular simulations

Multidrug resistance is a serious problem in current chemotherapy. The efflux system largely responsible for resistance in Escherichia coli contains the drug transporter, AcrB. The structures of AcrB were solved in 2002 as the symmetric homo-trimer, and then in 2006 as the asymmetric homo-trimer. The latter suggested a functionally rotating mechanism. Here, by molecular simulations of the AcrB porter domain, we uncovered allosteric coupling and the drug export mechanism in the AcrB trimer. Allosteric coupling stabilized the asymmetric structure with one drug molecule bound, which validated the modelling. Drug dissociation caused a conformational change and stabilized the symmetric structure, providing a unified view of the structures reported in 2002 and 2006. A dynamic study suggested that, among the three potential driving processes, only protonation of the drug-bound protomer can drive the functional rotation and simultaneously export the drug