Effects of COVID-19 Lockdown on Physical Activity and Health-Related Quality of Life in Older Adults Who Regularly Exercise

The aim of the study was to analyze the effect of social distancing on physical activity (PA) and Health-Related Quality of Life (HRQoL) in active Spanish older adults according to their physical functionality. The study included 58 older adults aged 76.24 ± 6.00 years who were enrolled in a supervised physical exercise program before the COVID-19 outbreak. Anthropometric, physical function, physical activity and HRQoL were measured at baseline (October 2019). After the two-month lockdown due to the COVID-19, questionnaires were collected again during de-escalation (May 2020). Participants were divided into high- (n = 29) and low-functionality (n = 29) groups. Total PA, walking and cleaning significantly decreased (p < 0.001) whilst exercising or dancing increased (p < 0.001). General health, social and emotional role functioning dimensions and overall mental component scores worsened (p < 0.01–p < 0.05). Low-functionality participants had significantly lower physical functioning scores at baseline (p < 0.01) and lower bodily pain scores at de-escalation (p < 0.01). Emotional role functioning dimension and overall mental component significantly decreased only in low-functionality participants (p < 0.05). Although PA levels decreased significantly, older adults continued being active regardless of their functionality. While mental HRQoL in participants with higher physical functionality remained unchanged, participants with lower functional capacity had a higher risk of mental health concerns. Therefore, attention should focus on strategies to mitigate the negative effects of distancing measures on older people’s mental health, especially in those with lower functionality.This work was supported by the Basque Government (IT1288-19)

La imagen y la narrativa como herramientas para el abordaje psicosocial en escenarios de violencia. Departamentos de Bolívar y Cesar

En el siguiente escrito se evidencia el último trabajo propuesto del diplomado de Profundización en Acompañamiento Psicosocial en Escenario de Violencia, en el cual se deja en evidencia los flagelos que ha sufrido nuestro país (Colombia) al transcurrir el tiempo, donde se refleja las diferentes violencias vividas en diferentes escenarios, y las secuelas que hasta el día de hoy siguen afectando su desarrollo individual, familiar y comunitario dentro de la sociedad. En el transcurrir de este escrito podemos examinar testimonios de víctimas y casos de comunidades que reflejan el sufrimiento, la injusticia, el abandono del estado, el desarraigo que han tenido que vivir en carne propia debido a un confrontamiento absurdo de diferentes actores armados como la guerrilla y paramilitares, además de la violación de los derechos humanos por parte de las fuerzas armadas. Las experiencias de estos individuos han sido desgarradoras, esto ha causado que ellos se desplacen desde sus lugares de orígenes hacia otras comunidades en la búsqueda de tener una vida mejor, tratando de alejarse de todo aquello que conlleva la guerra. Por otro lado a partir del abordaje de los casos propuestos en los relatos de víctimas del conflicto armado en diferentes escenarios, se llega a un consenso de elegir colaborativamente el caso de Alfredo Campo llevando así un análisis detallado del mismo, lo cual nos permitió conocer las afecciones que sufren las víctimas del conflicto armado a manos de grupos al margen de la ley, las voces que transmiten las mismas, esto nos permite el abordaje psicosocial a través de estrategias a favor de las víctimas. Por último y no menos importante se realizaron estrategias psicosociales frente al caso Peñas Coloradas, por lo tanto se realizaron análisis de los emergentes psicosociales que están presentes en las víctimas; todo esto se llevó a cabo a través de la solución de preguntas orientadoras, que sirvieron para la contextualización de la situación presentada en esta población en específico, lo cual generó una serie de consideraciones sobre el abordaje y estrategias de acompañamiento psicosocial, los cuales permiten la potencialización de las posiciones resilientes y metamórfico de la población.The following writing shows the latest work proposed by the Diploma in Deepening in Psychosocial Accompaniment in the Scene of Violence, in which the scourges that our country (Colombia) has suffered over time are revealed, where the different types of violence are reflected lived in different settings, and the consequences that to this day continue to affect their individual, family and community development within society. In the course of this writing we can examine testimonies of victims and cases of communities that reflect the suffering, injustice, the abandonment of the state, the uprooting that they have had to live in their own flesh due to an absurd confrontation of different armed actors such as the guerrillas and paramilitaries, in addition to the violation of human rights by the armed forces. The experiences of these individuals have been heartbreaking, this has caused them to move from their places of origin to other communities in search of a better life, trying to get away from everything that war entails. On the other hand, from the approach of the cases proposed in the stories of victims of the armed conflict in different settings, a consensus is reached to collaboratively choose the case of Alfredo Campo, thus leading to a detailed analysis of it, which we will get to know the affections suffered by the victims of the armed conflict at the hands of groups outside the law, the voices that transmit them, this allows us to approach psychosocially through strategies in favor of the victims. Last but not least, psychosocial strategies were carried out in the case of the Peñas Coloradas case, therefore analyzes were carried out of the psychosocial emergencies that are present in the victims; All this was carried out through the solution of guiding questions, which served to contextualize the situation presented in this specific population, which generated a series of considerations on the approach and strategies of psychosocial support, which allow the potentialization of the resilient and metamorphic positions of the population

Riociguat treatment in patients with chronic thromboembolic pulmonary hypertension: Final safety data from the EXPERT registry

Objective: The soluble guanylate cyclase stimulator riociguat is approved for the treatment of adult patients with pulmonary arterial hypertension (PAH) and inoperable or persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH) following Phase

Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders.

Multiplex families with a high prevalence of a psychiatric disorder are often examined to identify rare genetic variants with large effect sizes. In the present study, we analysed whether the risk for bipolar disorder (BD) in BD multiplex families is influenced by common genetic variants. Furthermore, we investigated whether this risk is conferred mainly by BD-specific risk variants or by variants also associated with the susceptibility to schizophrenia or major depression. In total, 395 individuals from 33 Andalusian BD multiplex families (166 BD, 78 major depressive disorder, 151 unaffected) as well as 438 subjects from an independent, BD case/control cohort (161 unrelated BD, 277 unrelated controls) were analysed. Polygenic risk scores (PRS) for BD, schizophrenia (SCZ), and major depression were calculated and compared between the cohorts. Both the familial BD cases and unaffected family members had higher PRS for all three psychiatric disorders than the independent controls, with BD and SCZ being significant after correction for multiple testing, suggesting a high baseline risk for several psychiatric disorders in the families. Moreover, familial BD cases showed significantly higher BD PRS than unaffected family members and unrelated BD cases. A plausible hypothesis is that, in multiplex families with a general increase in risk for psychiatric disease, BD development is attributable to a high burden of common variants that confer a specific risk for BD. The present analyses demonstrated that common genetic risk variants for psychiatric disorders are likely to contribute to the high incidence of affective psychiatric disorders in the multiplex families. However, the PRS explained only part of the observed phenotypic variance, and rare variants might have also contributed to disease development

Hábitos de vida de los estudiantes de enfermería

"Cuidar" nuestro cuerpo es saludable, pero últimamente se está convirtiendo en peligroso, sobre todo enla adolescencia. El objetivo de este estudio es conocer los hábitos de alimentación y de actividad física en un grupo de alumnos/as de enfermerías; ya que en una de las funciones de estos profesionales es enseñar hábitos de vida saludables.Gure gorputza "zaintzea" osasungarria da, baina azkenaldian arriskutsua gertatzen ari da, batez ere nerabezaroan. Erizaintzako ikasle talde batek elikadura eta ariketa fisikoaren alorrean dituzten ohiturak ezagutzea da azterlan honen helburua, zeren bizi aztura osasungarriak irakasteabaita profesional horien zereginetako bat."Prendre soin" de notre corps est sain, mais dernièrement cela devient dangereux, surtout pendant l'adolescence. Le but de cette étude est de connaître les habitudes alimentation et l'activité physique dans un groupe d'élèves infirmiers/ères, étant donné que l'une des fonctions de cesprofessionnels est d'enseigner des habitudes de vie saines."Looking after" our body is a healthy practice, but lately it is also becoming a hazardous practice, especially during the adolescence. The objective of this study is to know the nutrition and physical activity habits of a group of nursing students, since one of the functions of such professionals is to teach healthy habits of living

Ingesta de energía y macronutrientes en jóvenes deportistas de diferentes edades

El propósito fue evaluar los hábitos nutricionales de jugadores de fútbol adolescentes. Nuestros resultados muestran ingestas de energía significativamente superiores en los grupos más jóvenes. Las distribuciones de la ingesta de macronutrientes no se ajustan a las recomendaciones, con bajo aporte de carbohidratos. Los hábitos nutricionales empeoran al avanzar en edad, sería recomendable promocionar la educación nutricional durante la formación de los futbolistas.Futbol jokalari nerabeen nutrizio ohiturak ebaluatzea da lan honen asmoa. Gure emaitzek erakusten dutenez, energia ingesta askoz handiagoak gertatzen dira talde gazteenetan. Makroelikagaien ingestaren banaketak ez datoz bat gomendioekin, karbohidratoen ekarpena txikia dela. Nutrizio ohiturek okerrera egiten dute adinean aurrera joan ahala. Futbol jokalarien prestakuntzan gomendagarria litzateke nutrizio heziketa bultzatzea.L'objectif a été d'évaluer les habitudes nutritionnelles de joueurs de football adolescents. Nos résultats montrent des ingestions d'énergie significativement supérieures dans les groupes plus jeunes. Les distributions de l'ingestion de macronutriments ne s'ajustent pas aux recommandations, avec un apport en hydrates de carbone bas. Les habitudes nutritionnelles empirent au fur et à mesure que l'on avance en âge. Il conviendrait de promouvoir l'éducation nutritionnelle durant la formation des footballeurs.The purpose of this work was to evaluate the nutritional habits of teenage soccer players. Our results show energy ingests that are significantly higher in the younger groups. The distributions of the ingest of macronutrients do not match recommendations, and have a low carbohydrate content. Such nutritional habits get worse with age, and it would be recommended all to promote nutritional education during the training of soccer players

Guía clínica para uso del misoprostol en ginecología y obstetricia

La presente guía de uso del misoprostol en ginecología y obstetricia, intenta contribuir a la reducción de la morbimortalidad materna, proporcionar lineamientos técnicos para uso del misoprostol en los establecimientos de salud, en base a la evidencia científica. Y contribuir a mejorar la accesibilidad para la atención de las hemorragias obstétricas, mediante el uso del misoprostol.CLACAI. Consejo Latinoamericano contra el aborto inseguro. Perú. Sub región de salud Luciano Castillo Colonna

The First Genomewide Interaction and Locus-Heterogeneity Linkage Scan in Bipolar Affective Disorder: Strong Evidence of Epistatic Effects between Loci on Chromosomes 2q and 6q

We present the first genomewide interaction and locus-heterogeneity linkage scan in bipolar affective disorder (BPAD), using a large linkage data set (52 families of European descent; 448 participants and 259 affected individuals). Our results provide the strongest interaction evidence between BPAD genes on chromosomes 2q22-q24 and 6q23-q24, which was observed symmetrically in both directions (nonparametric LOD [NPL] scores of 7.55 on 2q and 7.63 on 6q; P<.0001 and P=.0001, respectively, after a genomewide permutation procedure). The second-best BPAD interaction evidence was observed between chromosomes 2q22-q24 and 15q26. Here, we also observed a symmetrical interaction (NPL scores of 6.26 on 2q and 4.59 on 15q; P=.0057 and .0022, respectively). We covered the implicated regions by genotyping additional marker sets and performed a detailed interaction linkage analysis, which narrowed the susceptibility intervals. Although the heterogeneity analysis produced less impressive results (highest NPL score of 3.32) and a less consistent picture, we achieved evidence of locus heterogeneity at chromosomes 2q, 6p, 11p, 13q, and 22q, which was supported by adjacent markers within each region and by previously reported BPAD linkage findings. Our results provide systematic insights in the framework of BPAD epistasis and locus heterogeneity, which should facilitate gene identification by the use of more-comprehensive cloning strategies

Clinical and genetic differences between bipolar disorder type 1 and 2 in multiplex families

The two major subtypes of bipolar disorder (BD), BD-I and BD-II, are distinguished based on the presence of manic or hypomanic episodes. Historically, BD-II was perceived as a less severe form of BD-I. Recent research has challenged this concept of a severity continuum. Studies in large samples of unrelated patients have described clinical and genetic differences between the subtypes. Besides an increased schizophrenia polygenic risk load in BD-I, these studies also observed an increased depression risk load in BD-II patients. The present study assessed whether such clinical and genetic differences are also found in BD patients from multiplex families, which exhibit reduced genetic and environmental heterogeneity. Comparing 252 BD-I and 75 BD-II patients from the Andalusian Bipolar Family (ABiF) study, the clinical course, symptoms during depressive and manic episodes, and psychiatric comorbidities were analyzed. Furthermore, polygenic risk scores (PRS) for BD, schizophrenia, and depression were assessed. BD-I patients not only suffered from more severe symptoms during manic episodes but also more frequently showed incapacity during depressive episodes. A higher BD PRS was significantly associated with suicidal ideation. Moreover, BD-I cases exhibited lower depression PRS. In line with a severity continuum from BD-II to BD-I, our results link BD-I to a more pronounced clinical presentation in both mania and depression and indicate that the polygenic risk load of BD predisposes to more severe disorder characteristics. Nevertheless, our results suggest that the genetic risk burden for depression also shapes disorder presentation and increases the likelihood of BD-II subtype development