Efficacy of comprehensive dental treatment for lichenoid reactions of the mucoparodontal complex: A single-center pilot cohort study

Background. Lichenoid reactions of the oral mucosa are currently recognized as a serious issue for dentists of various specialties, since their knowledge and competence in the diagnosis and pathogenetic treatment of lichenoid lesions of the oral cavity are yet to be improved. Following the data on high oncogenic potential in some forms of lichenoid reactions of oral cavity mucous membranes, the issue should be given serious considerations, and dentists should keep oncology-related suspicion when receiving these patients.Objective. To evaluate the efficacy of comprehensive dental treatment for lichenoid reactions of the mucoparodontal complex.Methods. A single-center pilot cohort study was conducted to evaluate the efficacy of the comprehensive treatment (combination of pharmacotherapy and physiotherapy) of patients with lichenoid reactions of the oral mucosa. The observation group consisted of 49 patients (15 males, 34 females) aged 58.92 ± 0.82 years with verified diagnoses of oral mucosa lichenoid reactions. The suggested treatment included pharmacotherapy (highly-potent topical steroids, calcineurin inhibitors) and physiotherapy in the form of low level laser therapy (635 nm, 10 W) provided via Matrix laser (Matrix, Russia). Treatment efficacy was assessed by the total scale of treatment efficacy, registering indicators of the area of focal lesions and the severity of pain syndrome, as well as by changes in dental quality of life indicators according to OHIP-49-RU (Oral Health Impact Profile) in the Russian version. Statistical processing of the data involved Student’s t-test and Wilcoxon t-test. Differences were considered significant at p ≤ 0.05. Data statistical analysis was performed using SPSS 13.0 (SPSS Inc., USA).Results. During the follow-up period, the indicators of the total scale of treatment efficacy decreased significantly (p < 0.001) in 100% of patients and amounted (as medians and quartiles): 6.0 (4.0–7.0) points before treatment and 1.0 (1.0–2.0) points after treatment to be objectified by a significant reduction in the area of focal lesions (by 63.2%, p < 0.001) and in pain syndrome (spontaneous pain from 2.0 (1.5–3.0) points before treatment to 0.0 (0.0–1.0) points after treatment; induced pain from 3.0 (2.0–3.0) points to 1.0 (0.0–1.0) points). Along with the clinical improvement, the scores in dental quality of life improved from 83.11 ± 2.58 to 39.94 ± 0.86 points, according to OHIP-49 RU (Oral Health Impact Profile).Conclusion. Early detection and differentiation of lichenoid reactions in oral mucous membranes ensure timely treatment using the developed protocol of comprehensive treatment (combination of pharmacotherapy and physiotherapy). The efficacy of the protocol was confirmed clinically and justified in relation to quality of life

Use of biologically inactive materials in surgical and orthopedic treatment of patients with jaws defects

The aim of the investigation is evaluation of clinical efficiency of the use of modern constractional materials in complex treatment of patients with defects of upper jaw and after osteoplastic operations on the lower jaw. The abstract contains survey of the main methods of jaw bones defect replacement with the use of different plastic materials including alio- and autotransplants, implants made from carbonic composition material "Uglekon^M". Possibilities of titanium alloy use in maxillofacial orthopedy are demonstrated. The results of surgical and orthopedic treatment of patients with jaw bones defects with the use of modern constractional materials are given.Цель работы: оценка клинической эффективности применения современных конструкционных материалов при комплексном лечении пациентов с дефектами верхней челюсти и после остеопластических операций на нижней челюсти. В данной статье представлен обзор основных методов замещения дефектов челюстных костей с использованием различных пластических материалов, в том числе: алло - и аутотрансплантатов, имплантатов, выполненных из углеродного композиционного материала «Углекон М». Показаны возможности применения сплавов титана в челюстно - лицевой ортопедии. Описаны результаты хирургического и ортопедического лечения больных с дефектами челюстных костей с использованием современных конструкционных материалов

The characteristic of reaction of biological tissues of animals to implantation of the samples from dioxide of zirconium received with use of various technological approaches

The aim of the study was to determine experimentally the reaction of biological tissues of animals and a comparison of data on the effect of four kinds of samples stabilized zirconia and various additives prepared using different technological approaches. Samples implanted into a muscle of a hip of an animal and in 10,20 and 40 days after operation investigated a condition of muscular tissue, salivary glands, a liver, a spleen, a kidney, a cerebral cortex and the regionarnykh of lymph nodes. Data of histologic supervision show that for practical use in medicine the most rational is use of dioxide of the zirconium stabilized by oxide of yttrium or dioxide of cerium. As changes in bodies of animals with the implanted samples of dioxide of the zirconium stabilized by oxide of aluminum remain twice more long and don't come to an end until the end of research terms.Целью исследования являлось определениев эксперименте реакции биологических тканей животных и проведение сравнения данных по влиянию четырех видов образцов диоксида циркония, стабилизированного различными добавками и полученного с помощью разных технологических подходов. Образцы имплантировали в мышцу бедра животного и через 10,20 и 40 суток после операции исследовали состояние мышечной ткани, слюнных желез, печени, селезенки, почки, коры головного мозга и регионарных лимфатических узлов. Данные гистологических наблюдений показывают, что для практического использования в медицине наиболее рациональным является применение диоксида циркония, стабилизированного оксидом иттрия или диоксидом церия. Так как изменения в органах животных с имплантированными образцами диоксида циркония, стабилизированного оксидом алюминия сохраняются в два раза дольше и не заканчиваются до конца сроков исследования

Possibilities of clinical use of designs based on zirconium dioxide, andevaluation of the main features of the new ceramic dental appointment

Every year, steadily increasing the quantity of patients, ortopedic treatment which is performed using structures made of zirconium dioxide. The interest of dentists to this method of replacing teeth and defects of dentition due to the fact that orthopedic constructions made of zirconium dioxide with the use of CAD I CAM technologies have high durability, aesthetics and precision. A method for the synthesis of nanocrystalline powder of Zr02, stabilizet with Y203, by co-deposition with the use of elements of the solgel technology for low temperature sintering. X-ray diffraction, thermal desorption of nitrogen, and electron microscopy study of powder characteristics, depending on synthesis conditions. Preclinical trials indicate the developed material meets the require ments of durability end aesthetics.С каждым годом, неуклонно увеличивается число пациентов, ортопедическое лечение которых проводится с использованием конструкций выполненных из диоксида циркония. Интерес стоматологов к данному методу замещения дефектов зубов и зубных рядов обусловлен тем, что ортопедические конструкции, изготовленные из диоксида циркония с применением CAD/CAM технологий обладают высокой прочностью, эстетичностью и прецензионностью. Разработана методика синтеза нанокристаллического порошка Zr02, стабилизированного Y203, методом совместного осаждения с применением элементов золь-гель технологии, для низкотемпературного спекания. Методами рентгеновской дифракции, тепловой десорбции азота и электронной микроскопии изучены характеристики порошка в зависимости от условий синтеза. Проведенные доклинические испытания свидетельствуют, что разработанный материал отвечает требованиям прочности и эстетичности

Morphological aspects of the issues in the treatment of chronic apical periodontitis

The purpose of the study - to evaluate the degree ot purification ot the deltoid branch of root canal during endodontic treatment of teeth. Morphological assessment of hard tissues of teeth 14 svezheudalennyh (incisors, premolars) in patients aged 24 - 56 years with a diagnosis - chronic apical periodontitis. Based on these data we recommend using the hydrodynamic method of irrigation of root canals 3% sodium hypochlorite solution using the apparatus «Rins Endo» in addition to the traditional endodontic treatment of patients with chronic apical periodontitis.Цель исследования - оценить степень очистки дельтовидных ответвлений корневого канала в процессе зндодонтического лечения зубов. Проведена морфологическая оценка состояния твердых тканей 14 удаленных зубов (резцы, премоляры) у пациентов в возрасте 24 - 56 лет с диагнозом - хронический апикальный периодонтит. На основании полученных данных рекомендуется использование гидродинамического метода ирригации корневых каналов зубов 3% раствором гипохлорита натрия с помощью аппарата «Rins Endo» дополнительно к традиционному эндодонтическому лечению пациентов с хроническими формами апикального периодонтита

Study of influence of intramuscular implantation of basalt threads on structure of different tissues in animal experiment

Rat experiments were carried out so as to study the influence ot intram uscular implantation of basalt threads on the structure of different tissues and to ground the expediency of their use in medicine. During the experiment, intramuscular implantation using glass samples and basalt threads was performed in the control and main groups. The number of animals in each group was 20. The follow -up period was 1 0 ,3 0 and 50 days. The following subjects were investigated: post-striated muscle in the site of im plantation, salivary glands, liver, pancreas, lungs, kidneys, adrenal glands, lymph nodes, spleen, red bone m arrow. The study of m icrospecim ens showed that basalt threads applied in animal experiment have no harmful effect on their body.С целью исследования влияния внутримы шечной имплантации базальтовых нитей на структуру различных тканей и обоснования целесообразности их использования в медицине, проведено экспериментальное исследование на крысах. В ходе эксперимента в контрольной и основной группе осуществлена внутримышечная имплантация образцами стекла и базальтовых нитей. Количество животных в каждой группе составило 20 особей. Сроки наблюдения -1 0 ,3 0 и 50 суток. Исследованы: поперечнополосатая мышца в месте имплантации, слюнные железы , печень, поджелудочная железа, легкие, почки, надпочечники, лимфатические узлы, селезенка, красный костный мозг. Изучение микропрепаратов показало, что применение базальтовых нитей в эксперименте на животных не наносит вреда их организму

A facility to Search for Hidden Particles (SHiP) at the CERN SPS

A new general purpose fixed target facility is proposed at the CERN SPS accelerator which is aimed at exploring the domain of hidden particles and make measurements with tau neutrinos. Hidden particles are predicted by a large number of models beyond the Standard Model. The high intensity of the SPS 400~GeV beam allows probing a wide variety of models containing light long-lived exotic particles with masses below ${\cal O}$(10)~GeV/c$^2$, including very weakly interacting low-energy SUSY states. The experimental programme of the proposed facility is capable of being extended in the future, e.g. to include direct searches for Dark Matter and Lepton Flavour Violation.Comment: Technical Proposa

Measurement of the mass and lifetime of the Ωb−\Omega_b^- baryon

A proton-proton collision data sample, corresponding to an integrated luminosity of 3 fb$^{-1}$ collected by LHCb at $\sqrt{s}=7$ and 8 TeV, is used to reconstruct $63\pm9$ $\Omega_b^-\to\Omega_c^0\pi^-$, $\Omega_c^0\to pK^-K^-\pi^+$ decays. Using the $\Xi_b^-\to\Xi_c^0\pi^-$, $\Xi_c^0\to pK^-K^-\pi^+$ decay mode for calibration, the lifetime ratio and absolute lifetime of the $\Omega_b^-$ baryon are measured to be \begin{align*} \frac{\tau_{\Omega_b^-}}{\tau_{\Xi_b^-}} &= 1.11\pm0.16\pm0.03, \\ \tau_{\Omega_b^-} &= 1.78\pm0.26\pm0.05\pm0.06~{\rm ps}, \end{align*} where the uncertainties are statistical, systematic and from the calibration mode (for $\tau_{\Omega_b^-}$ only). A measurement is also made of the mass difference, $m_{\Omega_b^-}-m_{\Xi_b^-}$, and the corresponding $\Omega_b^-$ mass, which yields \begin{align*} m_{\Omega_b^-}-m_{\Xi_b^-} &= 247.4\pm3.2\pm0.5~{\rm MeV}/c^2, \\ m_{\Omega_b^-} &= 6045.1\pm3.2\pm 0.5\pm0.6~{\rm MeV}/c^2. \end{align*} These results are consistent with previous measurements.Comment: 11 pages, 5 figures, All figures and tables, along with any supplementary material and additional information, are available at https://lhcbproject.web.cern.ch/lhcbproject/Publications/LHCbProjectPublic/LHCb-PAPER-2016-008.htm

Measurement of the Bs0→J/ψηB_{s}^{0} \rightarrow J/\psi \eta lifetime

Using a data set corresponding to an integrated luminosity of $3 fb^{-1}$, collected by the LHCb experiment in $pp$ collisions at centre-of-mass energies of 7 and 8 TeV, the effective lifetime in the $B^0_s \rightarrow J/\psi \eta$ decay mode, $\tau_{\textrm{eff}}$, is measured to be $\tau_{\textrm{eff}} = 1.479 \pm 0.034~\textrm{(stat)} \pm 0.011 ~\textrm{(syst)}$ ps. Assuming $CP$ conservation, $\tau_{\textrm{eff}}$ corresponds to the lifetime of the light $B_s^0$ mass eigenstate. This is the first measurement of the effective lifetime in this decay mode.Comment: All figures and tables, along with any supplementary material and additional information, are available at https://lhcbproject.web.cern.ch/lhcbproject/Publications/LHCbProjectPublic/LHCb-PAPER-2016-017.htm

Model-independent evidence for J/ψpJ/\psi p contributions to Λb0→J/ψpK−\Lambda_b^0\to J/\psi p K^- decays

The data sample of $\Lambda_b^0\to J/\psi p K^-$ decays acquired with the LHCb detector from 7 and 8~TeV $pp$ collisions, corresponding to an integrated luminosity of 3 fb$^{-1}$, is inspected for the presence of $J/\psi p$ or $J/\psi K^-$ contributions with minimal assumptions about $K^- p$ contributions. It is demonstrated at more than 9 standard deviations that $\Lambda_b^0\to J/\psi p K^-$ decays cannot be described with $K^- p$ contributions alone, and that $J/\psi p$ contributions play a dominant role in this incompatibility. These model-independent results support the previously obtained model-dependent evidence for $P_c^+\to J/\psi p$ charmonium-pentaquark states in the same data sample.Comment: 21 pages, 12 figures (including the supplemental section added at the end