The Galactic Population of Low- and Intermediate-Mass X-ray Binaries

(abridged) We present the first study that combines binary population synthesis in the Galactic disk and detailed evolutionary calculations of low- and intermediate-mass X-ray binaries (L/IMXBs). We show that the formation probability of IMXBs with initial donor masses of 1.5--4 Msun is typically >~5 times higher than that of standard LMXBs, and suggest that the majority of the observed systems may have descended from IMXBs. Distributions at the current epoch of the orbital periods, donor masses, and mass accretion rates have been computed, as have orbital-period distributions of BMPs. Several significant discrepancies between the theoretical and observed distributions are discussed. The orbital-period distribution of observed BMPs strongly favors cases where the envelope of the neutron-star progenitor is more easily ejected during the common-envelope phase. However, this leads to a >~100-fold overproduction of the theoretical number of luminous X-ray sources relative to the total observed number of LMXBs. X-ray irradiation of the donor star may result in a dramatic reduction in the X-ray active lifetime of L/IMXBs, thus possibly resolving the overproduction problem, as well as the long-standing BMP/LMXB birthrate problem.Comment: 12 pages, emulateapj, submitted to Ap

The variable mass loss of the AGB star WX Psc as traced by the CO J=1-0 through 7-6 lines and the dust emission

Low and intermediate mass stars lose a significant fraction of their mass through a dust-driven wind during the Asymptotic Giant Branch (AGB) phase. Recent studies show that winds from late-type stars are far from being smooth. Mass-loss variations occur on different time scales, from years to tens of thousands of years. The variations appear to be particularly prominent towards the end of the AGB evolution. The occurrence, amplitude and time scale of these variations are still not well understood. The goal of our study is to gain insight into the structure of the circumstellar envelope (CSE) of WX Psc and map the possible variability of the late-AGB mass-loss phenomenon. We have performed an in-depth analysis of the extreme infrared AGB star WX Psc by modeling (1) the CO J=1-0 through 7-6 rotational line profiles and the full spectral energy distribution (SED) ranging from 0.7 to 1300 micron. We hence are able to trace a geometrically extended region of the CSE. Both mass-loss diagnostics bear evidence of the occurrence of mass-loss modulations during the last ~2000 yr. In particular, WX Psc went through a high mass-loss phase (Mdot~5e-5 Msun/yr) some 800 yr ago. This phase lasted about 600 yr and was followed by a long period of low mass loss (Mdot~5e-8 Msun/yr). The present day mass-loss rate is estimated to be ~6e-6 Msun/yr. The AGB star WX Psc has undergone strong mass-loss rate variability on a time scale of several hundred years during the last few thousand years. These variations are traced in the strength and profile of the CO rotational lines and in the SED. We have consistently simulated the behaviour of both tracers using radiative transfer codes that allow for non-constant mass-loss rates.Comment: 12 pages, accepted for publication in A&

An evolutionary study of the pulsating subdwarf B eclipsing binary PG1336-018 (NY Vir)

The formation of subdwarf B (sdB) stars is not well understood within the current framework of stellar single and binary evolution. In this study, we focus on the formation and evolution of the pulsating sdB star in the very short-period eclipsing binary PG1336-018. We aim at refining the formation scenario of this unique system, so that it can be confronted with observations. We probe the stellar structure of the progenitors of sdB stars in short-period binaries using detailed stellar evolution calculations. Applying this to PG1336-018 we reconstruct the common-envelope phase during which the sdB star was formed. The results are interpreted in terms of the standard common-envelope formalism (the alpha-formalism) based on the energy equation, and an alternative description (the gamma-formalism) using the angular momentum equation. We find that if the common-envelope evolution is described by the alpha-formalism, the sdB progenitor most likely experienced a helium flash. We then expect the sdB mass to be between 0.39 and 0.48 Msun, and the sdB progenitor initial mass to be below ~2 Msun. However, the results for the gamma-formalism are less restrictive, and a broader sdB mass range (0.3 - 0.8 Msun) is possible in this case. Future seismic mass determination will give strong constraints on the formation of PG1336-018 and, in particular, on the CE phase.Comment: 9 pages, 7 figures, 2 tables, accepted for publication in A&

Mitral regurgitation due to caseous calcification of the mitral annulus: two case reports

Caseous calcification is a rare variant of mitral annular calcification, occurring in about 0.06% of echocardiographic studies performed. It is usually a benign lesion, but it should be differentiated by abscess and tumors. Echocardiography is the most sensitive method to identify caseous calcification which appears typically as a round, calcified mass with an echo-lucent, liquid-like inner part

Low-Mass Binary Induced Outflows from Asymptotic Giant Branch Stars

A significant fraction of planetary nebulae (PNe) and proto-planetary nebulae (PPNe) exhibit aspherical, axisymmetric structures, many of which are highly collimated. The origin of these structures is not entirely understood, however recent evidence suggests that many observed PNe harbor binary systems, which may play a role in their shaping. In an effort to understand how binaries may produce such asymmetries, we study the effect of low-mass (< 0.3 M_sun) companions (planets, brown dwarfs and low-mass main sequence stars) embedded into the envelope of a 3.0 M_sun star during three epochs of its evolution (Red Giant Branch, Asymptotic Giant Branch (AGB), interpulse AGB). We find that common envelope evolution can lead to three qualitatively different consequences: (i) direct ejection of envelope material resulting in a predominately equatorial outflow, (ii) spin-up of the envelope resulting in the possibility of powering an explosive dynamo driven jet and (iii) tidal shredding of the companion into a disc which facilitates a disc driven jet. We study how these features depend on the secondary's mass and discuss observational consequences.Comment: 24 pages, 6 figures, submitted to MNRA

Annotation analysis for testing drug safety signals using unstructured clinical notes

BackgroundThe electronic surveillance for adverse drug events is largely based upon the analysis of coded data from reporting systems. Yet, the vast majority of electronic health data lies embedded within the free text of clinical notes and is not gathered into centralized repositories. With the increasing access to large volumes of electronic medical data-in particular the clinical notes-it may be possible to computationally encode and to test drug safety signals in an active manner.ResultsWe describe the application of simple annotation tools on clinical text and the mining of the resulting annotations to compute the risk of getting a myocardial infarction for patients with rheumatoid arthritis that take Vioxx. Our analysis clearly reveals elevated risks for myocardial infarction in rheumatoid arthritis patients taking Vioxx (odds ratio 2.06) before 2005.ConclusionsOur results show that it is possible to apply annotation analysis methods for testing hypotheses about drug safety using electronic medical records

Rings and Halos in the Mid-Infrared: The Planetary Nebulae NGC 7354 and NGC 3242

We present images of the planetary nebulae (PNe) NGC 7354 and NGC 3242 in four mid-infrared (MIR) photometric bands centred at 3.6, 4.5, 5.8 and 8.0 microns; the results of observations undertaken using the Spitzer Space Telescope (SST). The resulting images show the presence of a halo and rings in NGC 3242, as previously observed through narrow band imaging at visual wavelengths, as well as evidence for a comparable halo and ring system in NGC 7354. This is the first time that a halo and rings have been observed in the latter source. We have analysed the formation of halos as a result of radiatively accelerated mass loss in the AGB progenitors. Although the models assume that dust formation occurs in C-rich environments, we note that qualitatively similar results would be expected for O-rich progenitors as well. The model fall-offs in halo density are found to result in gradients in halo surface brightness which are similar to those observed in the visible and MIR.Comment: 19 pages, 12 figures, Accepted for publication in MNRAS. 56 pages in arXi

Computation of protein geometry and its applications: Packing and function prediction

This chapter discusses geometric models of biomolecules and geometric constructs, including the union of ball model, the weigthed Voronoi diagram, the weighted Delaunay triangulation, and the alpha shapes. These geometric constructs enable fast and analytical computaton of shapes of biomoleculres (including features such as voids and pockets) and metric properties (such as area and volume). The algorithms of Delaunay triangulation, computation of voids and pockets, as well volume/area computation are also described. In addition, applications in packing analysis of protein structures and protein function prediction are also discussed.Comment: 32 pages, 9 figure

Jejunal gene expression patterns correlate with severity of systemic infection in chicken

<p>Abstract</p> <p>Background</p> <p>Not much is known about the effect of <it>Salmonella enteritidis</it> on changes in the developmental processes occurring in the intestine of young chicken. Therefore we investigated the correlation of intestinal gene expression patterns with the severity of systemic Salmonella infections.</p> <p>Methods</p> <p>The number of Salmonella colony forming units (CFUs) in the liver of infected chicken were plotted against the average intestinal expression profiles of previously identified gene expression clusters. The functional properties of all the genes taken together present in 3 clusters exhibiting positive correlation at early time-points were compared with the functional properties of the genes displaying antagonistic correlations in 1 cluster. The top 5 ranking functional groups were analysed in further detail.</p> <p>Results</p> <p>Three clusters showed gene expression profiles which were positively correlated with the severity of systemic disease as measured by the number of Salmonella colony forming units in the liver. In these clusters, genes involved in morphological processes were predominantly present. One cluster had a profile that was negatively correlated with the severity of systemic disease, as measured by numbers of CFUs in the liver. The genes in the latter cluster were mostly involved in cell turn-over and metabolism.</p> <p>Conclusions</p> <p>In the developing jejunum of young chicken, both stimulatory and inhibitory gene expression mechanisms are correlated with the severity of systemic Salmonella infections.</p