1,941 research outputs found
Inflection points and industry change: Was Andy Grove right after all?
We examine whether the âstrategic inflection pointsâ described by former Intel CEO Andy Grove correspond to mathematical inflection points in the product/technology life cycle. We find one sense in which they do and two senses in which they do not. This leads to a mapping of colloquial uses of inflection point, tipping point, volatility, chaos, and turbulence against the scientific definitions of these terms. The mapping should be of use to researchers and educators, and also suggests to managers that the possibility of foresight and control in technology-dependent industries is more sharply limited than generally believed. The paper highlights implications for organizational sustainability and offers possible coping mechanisms for managers and directions for educators and researchers
Towards photostatistics from photon-number discriminating detectors
We study the properties of a photodetector that has a number-resolving
capability. In the absence of dark counts, due to its finite quantum
efficiency, photodetection with such a detector can only eliminate the
possibility that the incident field corresponds to a number of photons less
than the detected photon number. We show that such a {\em non-photon}
number-discriminating detector, however, provides a useful tool in the
reconstruction of the photon number distribution of the incident field even in
the presence of dark counts.Comment: 7 pages, 4 figure
Hot Carrier Transport and Photocurrent Response in Graphene
Strong electron-electron interactions in graphene are expected to result in
multiple-excitation generation by the absorption of a single photon. We show
that the impact of carrier multiplication on photocurrent response is enhanced
by very inefficient electron cooling, resulting in an abundance of hot
carriers. The hot-carrier-mediated energy transport dominates the photoresponse
and manifests itself in quantum efficiencies that can exceed unity, as well as
in a characteristic dependence of the photocurrent on gate voltages. The
pattern of multiple photocurrent sign changes as a function of gate voltage
provides a fingerprint of hot-carrier-dominated transport and carrier
multiplication.Comment: 4 pgs, 2 fg
The X-ray spectra and spectral variability of intermediate type Seyfert galaxies: ASCA observations of NGC 4388 and ESO 103-G35
The X-ray spectra of two intermediate type Seyfert galaxies are investigated
using ASCA observations separated by more than a year. Both NGC 4388 and ESO
103-G35 exhibit strong, narrow Fe K alpha line emission and absorption by cold
neutral gas with a column density ~ 10^23 cm^-2, characteristic of the X-ray
spectra of type 2 Seyfert galaxies. The power law continuum flux has changed by
a factor of 2 over a time-scale of ~ 2 years for both objects, declining in the
case of NGC 4388 and rising in ESO 103-G35. No variation was observed in the
equivalent width of the Fe K alpha line in the spectra of NGC 4388, implying
that the line flux declined with the continuum. We find that the strength of
the line cannot be accounted for by fluorescence in line-of-sight material with
the measured column density unless a `leaky-absorber' model of the type favored
for IRAS 04575-7537 is employed. The equivalent width of the Fe K alpha
emission line is seen to decrease between the observations of ESO 103-G35 while
the continuum flux increased. The 1996 observation of ESO 103-G35 can also be
fitted with an absorption edge at 7.4 0.2 keV due to partially ionized
iron, and when an ionized absorber model is fitted to the data it is found that
the equivalent column of neutral hydrogen rises to 3.5 x 10^23 cm^-2. The Fe K
alpha line flux can be accounted by fluorescence in this material alone and
this model is also a good representation of the 1988 and 1991 Ginga
observations. There is then no requirement for a reflection component in the
ASCA spectra of ESO 103-G35 or NGC 4388.Comment: 45 pages, 5 tables, 11 figures. Accepted for publication in the
Astrophysical Journa
Ultrafast Relaxation Dynamics of Hot Optical Phonons in Graphene
Using ultrafast optical pump-probe spectroscopy, we study the relaxation
dynamics of hot optical phonons in few-layer and multi-layer graphene films
grown by epitaxy on silicon carbide substrates and by chemical vapor deposition
on nickel substrates. In the first few hundred femtoseconds after
photoexcitation, the hot carriers lose most of their energy to the generation
of hot optical phonons which then present the main bottleneck to subsequent
carrier cooling. Optical phonon cooling on short time scales is found to be
independent of the graphene growth technique, the number of layers, and the
type of the substrate. We find average phonon lifetimes in the 2.5-2.55 ps
range. We model the relaxation dynamics of the coupled carrier-phonon system
with rate equations and find a good agreement between the experimental data and
the theory. The extracted optical phonon lifetimes agree very well with the
theory based on anharmonic phonon interactions.Comment: 4 pages, 3 figure
Competing Ultrafast Energy Relaxation Pathways in Photoexcited Graphene
For most optoelectronic applications of graphene a thorough understanding of
the processes that govern energy relaxation of photoexcited carriers is
essential. The ultrafast energy relaxation in graphene occurs through two
competing pathways: carrier-carrier scattering -- creating an elevated carrier
temperature -- and optical phonon emission. At present, it is not clear what
determines the dominating relaxation pathway. Here we reach a unifying picture
of the ultrafast energy relaxation by investigating the terahertz
photoconductivity, while varying the Fermi energy, photon energy, and fluence
over a wide range. We find that sufficiently low fluence ( 4
J/cm) in conjunction with sufficiently high Fermi energy (
0.1 eV) gives rise to energy relaxation that is dominated by carrier-carrier
scattering, which leads to efficient carrier heating. Upon increasing the
fluence or decreasing the Fermi energy, the carrier heating efficiency
decreases, presumably due to energy relaxation that becomes increasingly
dominated by phonon emission. Carrier heating through carrier-carrier
scattering accounts for the negative photoconductivity for doped graphene
observed at terahertz frequencies. We present a simple model that reproduces
the data for a wide range of Fermi levels and excitation energies, and allows
us to qualitatively assess how the branching ratio between the two distinct
relaxation pathways depends on excitation fluence and Fermi energy.Comment: Nano Letters 201
WNT signaling regulates self-renewal and differentiation of prostate cancer cells with stem cell characteristics
Prostate cancer cells with stem cell characteristics were identified in human prostate cancer cell lines by their ability to form from single cells self-renewing prostaspheres in non-adherent cultures. Prostaspheres exhibited heterogeneous expression of proliferation, differentiation and stem cell-associated makers CD44, ABCG2 and CD133. Treatment with WNT inhibitors reduced both prostasphere size and self-renewal. In contrast, addition of Wnt3a caused increased prostasphere size and self-renewal, which was associated with a significant increase in nuclear Î-catenin, keratin 18, CD133 and CD44 expression. As a high proportion of LNCaP and C4-2B cancer cells express androgen receptor we determined the effect of the androgen receptor antagonist bicalutamide. Androgen receptor inhibition reduced prostasphere size and expression of PSA, but did not inhibit prostasphere formation. These effects are consistent with the androgen-independent self-renewal of cells with stem cell characteristics and the androgen-dependent proliferation of transit amplifying cells. As the canonical WNT signaling effector Î-catenin can also associate with the androgen receptor, we propose a model for tumour propagation involving a balance between WNT and androgen receptor activity. That would affect the self-renewal of a cancer cell with stem cell characteristics and drive transit amplifying cell proliferation and differentiation. In conclusion, we provide evidence that WNT activity regulates the self-renewal of prostate cancer cells with stem cell characteristics independently of androgen receptor activity. Inhibition of WNT signaling therefore has the potential to reduce the self-renewal of prostate cancer cells with stem cell characteristics and improve the therapeutic outcome.Peer reviewe
Satellite content and quenching of star formation in galaxy groups at z ~ 1.8
We study the properties of satellites in the environment of massive star-forming galaxies at z ~ 1.8 in the COSMOS field, using a sample of 215 galaxies on the main sequence of star formation with an average mass of ~1011Mâ. At z> 1.5, these galaxies typically trace halos of mass âł1013Mâ. We use optical-near-infrared photometry to estimate stellar masses and star formation rates (SFR) of centrals and satellites down to ~ 6 Ă 109Mâ. We stack data around 215 central galaxies to statistically detect their satellite halos, finding an average of ~3 galaxies in excess of the background density. We fit the radial profiles of satellites with simple ÎČ-models, and compare their integrated properties to model predictions. We find that the total stellar mass of satellites amounts to ~68% of the central galaxy, while spectral energy distribution modeling and far-infrared photometry consistently show their total SFR to be 25-35% of the central's rate. We also see significant variation in the specific SFR of satellites within the halo with, in particular, a sharp decrease at <100 kpc. After considering different potential explanations, we conclude that this is likely an environmental signature of the hot inner halo. This effect can be explained in the first order by a simple free-fall scenario, suggesting that these low-mass environments can shut down star formation in satellites on relatively short timescales of ~0.3 Gyr
Averaged Differential Expression for the Discovery of Biomarkers in the Blood of Patients with Prostate Cancer
<div><h3>Background</h3><p>The identification of a blood-based diagnostic marker is a goal in many areas of medicine, including the early diagnosis of prostate cancer. We describe the use of averaged differential display as an efficient mechanism for biomarker discovery in whole blood RNA. The process of averaging reduces the problem of clinical heterogeneity while simultaneously minimizing sample handling.</p> <h3>Methodology/Principal Findings</h3><p>RNA was isolated from the blood of prostate cancer patients and healthy controls. Samples were pooled and subjected to the averaged differential display process. Transcripts present at different levels between patients and controls were purified and sequenced for identification. Transcript levels in the blood of prostate cancer patients and controls were verified by quantitative RT-PCR. Means were compared using a t-test and a receiver-operating curve was generated. The Ring finger protein 19A (RNF19A) transcript was identified as having higher levels in prostate cancer patients compared to healthy men through the averaged differential display process. Quantitative RT-PCR analysis confirmed a more than 2-fold higher level of RNF19A mRNA levels in the blood of patients with prostate cancer than in healthy controls (pâ=â0.0066). The accuracy of distinguishing cancer patients from healthy men using RNF19A mRNA levels in blood as determined by the area under the receiving operator curve was 0.727.</p> <h3>Conclusions/Significance</h3><p>Averaged differential display offers a simplified approach for the comprehensive screening of body fluids, such as blood, to identify biomarkers in patients with prostate cancer. Furthermore, this proof-of-concept study warrants further analysis of RNF19A as a clinically relevant biomarker for prostate cancer detection.</p> </div
Antisocial behaviour and teacherâstudent relationship quality: The role of emotionârelated abilities and callousâunemotional traits
Background: Childhood antisocial behaviour has been associated with poorer teacher-student relationship (TSR) quality. It is also well-established that youth with antisocial behaviour have a range of emotion-related deficits, yet the impact of these studentsâ emotion-related abilities on the TSR is not understood. Furthermore, the addition of the Limited Prosocial Emotions specifier in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) indicates that understanding the role of callous-unemotional (CU) traits for youth with antisocial behaviour problems is of particular importance.
Aims: The aim of this study was to investigate the association between antisocial behaviour difficulties and the TSR by examining the influence of emotion-related abilities and CU traits.
Sample: Twelve teachers from 10 primary schools provided anonymised information on 108 children aged 6-11 years.
Results: Antisocial behaviour was associated with higher teacher-student conflict (but not closeness) as well as higher emotion lability/negativity and lower emotion understanding/empathy. Emotion lability/negativity was associated with higher teacher-student conflict (but not closeness), and emotion understanding/empathy was associated with lower teacher-student conflict and higher closeness. CU traits was associated with higher teacher-student conflict and lower teacher-student closeness (controlling for antisocial behaviour more broadly). We found no evidence of a moderating effect of CU traits or emotion-related abilities on the association between antisocial behaviour and TSR quality.
Conclusions: Interventions for behaviour difficulties should consider teacher-student relationships in the classroom. Strategies which aim to improve teacher-student closeness as well as reduce teacher-student conflict may be of particular value to students with high CU traits
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