Survival and Nonescape Probabilities for Resonant and Nonresonant Decay

In this paper we study the time evolution of the decay process for a particle confined initially in a finite region of space, extending our analysis given recently (Phys. Rev. Lett. 74, 337 (1995)). For this purpose, we solve exactly the time-dependent Schroedinger equation for a finite-range potential. We calculate and compare two quantities: (i) the survival probability S(t), i.e., the probability that the particle is in the initial state after a time t; and (ii) the nonescape probability P(t), i.e., the probability that the particle remains confined inside the potential region after a time t. We analyze in detail the resonant and nonresonant decay. In the former case, after a very short time, S(t) and P(t) decay exponentially, but for very long times they decay as a power law, albeit with different exponents. For the nonresonant case we obtain that both quantities differ initially. However, independently of the resonant and nonresonant character of the initial state we always find a transition to the ground state of the system which indicates a process of ``loss of memory'' in the decay.Comment: 26 pages, RevTex file, figures available upon request from [email protected] (To be published in Annals of Physics

Halpha Kinematics of S4G Spiral Galaxies - III. Inner rotation curves

We present a detailed study of the shape of the innermost part of the rotation curves of a sample of 29 nearby spiral galaxies, based on high angular and spectral resolution kinematic Halpha Fabry-Perot observations. In particular, we quantify the steepness of the rotation curve by measuring its slope dRvc(0). We explore the relationship between the inner slope and several galaxy parameters, such as stellar mass, maximum rotational velocity, central surface brightness ({\mu}0), bar strength and bulge-to-total ratio. Even with our limited dynamical range, we find a trend for low-mass galaxies to exhibit shallower rotation curve inner slopes than high-mass galaxies, whereas steep inner slopes are found exclusively in high-mass galaxies. This trend may arise from the relationship between the total stellar mass and the mass of the bulge, which are correlated among them. We find a correlation between the inner slope of the rotation curve and the morphological T-type, complementary to the scaling relation between dRvc(0) and {\mu}0 previously reported in the literature. Although we find that the inner slope increases with the Fourier amplitude A2 and decreases with the bar torque Qb, this may arise from the presence of the bulge implicit in both A2 and Qb. As previously noted in the literature, the more compact the mass in the central parts of a galaxy (more concretely, the presence of a bulge), the steeper the inner slopes. We conclude that the baryonic matter dominates the dynamics in the central parts of our sample galaxies.Comment: 11 pages, 11 figures, accepted for publication in MNRA

Dynamic actin-mediated nano-scale clustering of CD44 regulates its meso-scale organization at the plasma membrane

Transmembrane adhesion receptors at the cell surface, such as CD44, are often equipped with modules to interact with the extracellular matrix (ECM) and the intracellular cytoskeletal machinery. CD44 has been recently shown to compartmentalize the membrane into domains by acting as membrane pickets, facilitating the function of signaling receptors. While spatial organization and diffusion studies of membrane proteins are usually conducted separately, here we combine observations of organization and diffusion by using high spatio-temporal resolution imaging on living cells to reveal a hierarchical organization of CD44. CD44 is present in a meso-scale meshwork pattern where it exhibits enhanced confinement and is enriched in nanoclusters of CD44 along its boundaries. This nanoclustering is orchestrated by the underlying cortical actin dynamics. Interaction with actin is mediated by specific segments of the intracellular domain. This influences the organization of the protein at the nano-scale, generating a selective requirement for formin over Arp2/3-based actin-nucleation machinery. The extracellular domain and its interaction with elements of ECM do not influence the meso-scale organization, but may serve to reposition the meshwork with respect to the ECM. Taken together, our results capture the hierarchical nature of CD44 organization at the cell surface, with active cytoskeleton-templated nanoclusters localized to a meso-scale meshwork pattern

Az előszerződés, mint a jövőbeli ismételt foglalkoztatás jogi keretbe foglalt ígérete

Abstract: In this paper a methodology is proposed to elaborate landslide activity maps through the use of PS (Persistent Scatterer) data. This is illustrated through the case study of Tramuntana Range in the island of Majorca (Spain), where ALOS (Advanced Land Observing Satellite) images have been processed through a Persistent Scatterer Interferometry (PSI) technique during the period of 2007–2010. The landslide activity map provides, for every monitored landslide, an assessment of the PS visibility according to the relief, land use, and satellite acquisition parameters. Landslide displacement measurements are projected along the steepest slope, in order to compare landslide velocities with different slope orientations. Additionally, a ground motion activity map is also generated, based on active PS clusters not included within any known landslide phenomenon, butRemote Sens. 2013, 5 6199 even moving, potentially referred to unmapped landslides or triggered by other kinds o

The Herschel Virgo Cluster Survey: IV. Resolved dust analysis of spiral galaxies

We present a resolved dust analysis of three of the largest angular size spiral galaxies, NGC 4501 and NGC 4567/8, in the Herschel Virgo Cluster Survey (HeViCS) Science Demonstration field. Herschel has unprecedented spatial resolution at far-infrared wavelengths and with the PACS and SPIRE instruments samples both sides of the peak in the far infrared spectral energy distribution (SED).We present maps of dust temperature, dust mass, and gas-to-dust ratio, produced by fitting modified black bodies to the SED for each pixel. We find that the distribution of dust temperature in both systems is in the range ~19 - 22 K and peaks away from the centres of the galaxies. The distribution of dust mass in both systems is symmetrical and exhibits a single peak coincident with the galaxy centres. This Letter provides a first insight into the future analysis possible with a large sample of resolved galaxies to be observed by Herschel.Comment: Letter accepted for publication in A&A (Herschel special issue

Arginine deprivation alters microglia polarity and synergises with radiation to eradicate non arginine auxotrophic glioblastoma tumors

New approaches for the management of glioblastoma (GBM) are an urgent and unmet clinical need. Here, we illustrate that the efficacy of radiotherapy for GBM is strikingly potentiated by concomitant therapy with the arginine depleting agent ADI-PEG20 in a non-arginine auxotrophic cellular background (Arginine Succinate Synthetase 1 positive). Moreover, this combination led to durable and complete radiological and pathological response with extended disease-free survival in an orthotopic immune competent model of GBM with no significant toxicity. ADI-PEG20 not only enhances the cellular sensitivity of Arginine succinate synthetase 1 positive GBM to ionising radiation by elevated production of nitric oxide (NO) and hence generation of cytotoxic peroxynitrites, but also promotes glioma-associated macrophages/microglia infiltration into tumors and turns their classical anti-inflammatory (pro-tumor) phenotype into a pro-inflammatory (anti-tumor) phenotype. Our results provide an effective, well-tolerated and simple strategy to improve GBM treatment which merits consideration for early evaluation in clinical trials

Changes in health behaviors, mental and physical health among older adults under severe lockdown restrictions during the covid-19 pandemic in spain

We used data from 3041 participants in four cohorts of community-dwelling individuals aged =65 years in Spain collected through a pre-pandemic face-to-face interview and a telephone interview conducted between weeks 7 to 15 after the beginning of the COVID-19 lockdown. On average, the confinement was not associated with a deterioration in lifestyle risk factors (smoking, alcohol intake, diet, or weight), except for a decreased physical activity and increased sedentary time, which reversed with the end of confinement. However, chronic pain worsened, and moderate declines in mental health, that did not seem to reverse after restrictions were lifted, were observed. Males, older adults with greater social isolation or greater feelings of loneliness, those with poorer housing conditions, as well as those with a higher prevalence of chronic morbidities were at increased risk of developing unhealthier lifestyles or mental health declines with confinement. On the other hand, previously having a greater adherence to the Mediterranean diet and doing more physical activity protected older adults from developing unhealthier lifestyles with confinement. If an-other lockdown were imposed during this or future pandemics, public health programs should spe-cially address the needs of older individuals with male sex, greater social isolation, sub-optimal housing conditions, and chronic morbidities because of their greater vulnerability to the enacted movement restrictions. © 2021 by the authors. Licensee MDPI, Basel, Switzerland

SIVA UAV: A Case Study for the EMC Analysis of Composite Air Vehicles

[EN] The increased use of carbon-fiber composites in unmanned aerial vehicles is a challenge for their EMC assessment by numerical solvers. For accurate and reliable simulations, numerical procedures should be tested not only for individual components, but also within the framework of complete systems. With this aim, this paper presents a benchmark test case based on experimental measurements coming from direct-current injection tests in the SIVA unmanned air vehicle, reproduced by a numerical finite-difference-time-domain solver that employs a new subgridding scheme to treat lossy composite thin panels. Validation was undertaken by applying the feature selective validation method, which quantifies the agreement between experimental and numerical data.This work was supported by the Projects TEC2013-48414C3-{ 1,2,3}-R, TEC2016-79214-C3-{1,2,3}-R, and TEC2015-68766-REDC (Spanish MINECO, EU FEDER), P12-TIC-1442 (J. de Andalucia, Spain), Alhambra-UGRFDTD (AIRBUS DS), and by the CSIRC alhambra.ugr.es supercomputing center.Cabello, MR.; Fernández, S.; Pous, M.; Pascual-Gil, E.; Angulo, LD.; López, P.; Riu, PJ.... (2017). SIVA UAV: A Case Study for the EMC Analysis of Composite Air Vehicles. IEEE Transactions on Electromagnetic Compatibility. 59(4):1103-1113. https://doi.org/10.1109/TEMC.2017.2648507S1103111359

Dust and Ionized Gas Association in E/S0 Galaxies with Dust Lanes: Clues to their Origin

We present results from an on-going programme to study the dust and ionized gas in E/S0 galaxies with dust lanes. Our data, together with results from previous studies of E/S0 galaxies, are used to demonstrate the tight relationship between these two components. This relationship is discussed in light of our current understanding of the nature and origin of the interstellar medium (ISM), and in particular in the context of the interplay between the different multi-temperature components. We show that focusing on dust obscured regions as tracers of the ISM, and on their properties, serves as independent evidence for the external origin of the dust and ionized gas.Comment: 11 pages, 5 figures, 3 tables. MNRAS in pres