62 research outputs found
Dabigatran and rivaroxaban, new oral anticoagulants. New approaches in Dentistry
Treatment in patients with atrial fibrillation or venous thromboembolism in recent decades has been based almost
exclusively on the use of vitamin K antagonists. These drugs have a narrow therapeutic index, so it is precise to
repeated adjustments of doses that require analytical monitoring. For many years it has advocated the need to have
more convenient new antithrombotic drugs. So is developing a new generation of antithrombotic not related to
coumarin. In 2008 and 2009, two of these new anticoagulants have been registered and approved in Europe and Ca-
nada-these are dabigatran etexilate (Pradaxa ®) and rivaroxaban (Xarelto ®). Anticoagulant dabigatran is the first
direct thrombin inhibitor, orally available. Specifically and reversibly inhibits thrombin, so the duration of action
is predictable. The anticoagulant effect correlates well with plasma drug concentrations, which implies an effective
anticoagulation with low bleeding risk without major problems of interactions with other drugs. Rivaroxaban is first
oral anticoagulant inhibitor of factor Xa (FXa). It produces a predictable and reversible inhibition of FXa activity
with ability to inhibit clot-bound FXa. The predictable pharmacokinetics and pharmacodynamics characteristics
of dabigatran and rivaroxaban may facilitate dental management of patients who until now have been in treatment
with traditional anticoagulants, given that it doesn’t require routine laboratory monitoring in the vast majority of
patients treated. They also present a profile of drug interactions very favourable
Evaluación y mejora de la herramienta on-line DESweb para la enseñanza de bases de datos (2)
El objetivo es la herramienta DESweb de apoyo a la docencia virtual y presencial para la enseñanza de bases de datos relacionales (SQL) y deductivas (Datalog). Esta solicitud es continuación de un proyecto de la convocatoria anterior
Novel utility-scale photovoltaic plant electroluminescence maintenance technique by means of bidirectional power inverter controller
Producción CientíficaNowadays, photovoltaic (PV) silicon plants dominate the growth in renewable energies generation. Utility-scale photovoltaic plants (USPVPs) have increased exponentially in size and power in the last decade and, therefore, it is crucial to develop optimum maintenance techniques. One of the most promising maintenance techniques is the study of electroluminescence (EL) images as a complement of infrared thermography (IRT) analysis. However, its high cost has prevented its use regularly up to date. This paper proposes a maintenance methodology to perform on-site EL inspections as efficiently as possible. First, current USPVP characteristics and the requirements to apply EL on them are studied. Next, an increase over the automation level by means of adding automatic elements in the current PV plant design is studied. The new elements and their configuration are explained, and a control strategy for applying this technique on large photovoltaic plants is developed. With the aim of getting on-site EL images on a real plant, a PV inverter has been developed to validate the proposed methodology on a small-scale solar plant. Both the electrical parameters measured during the tests and the images taken have been analysed. Finally, the implementation cost of the solution has been calculated and optimised. The results conclude the technical viability to perform on-site EL inspections on PV plants without the need to measure and analyse the panel defects out of the PV installation.Ministerio de Industria, Economía y Competitividad (grant number RTC-2017-6712-3)Junta de Castilla y León (grant VA283P18
Effects of Extracurricular Sports in Prepubertal and Pubertal Girls.
The aim of this study was to analyse the effects of the type of extracurricular sport on the body composition, respiratory parameters, and physical condition in prepubertal and pubertal girls. Four hundred and eighty-five female athletes (aged 8–14) from different sports participated in this study. They were gathered into four groups according to the sport typology and maturity level: ‘prepubertal girls who practise collective sports’ (PRE-CS), ‘prepubertal girls who practise individual sports’ (PRE-IS), ‘pubertal girls who practise collective sports’ (PUB-CS), and ‘pubertal girls who practise individual sports’ (PUB-IS). The cardiorespiratory fitness (the 20 m shuttle run test, 20 mSRT), anthropometry, respiratory capacity (forced spirometry), handgrip, CMJ test, and stabilometry were collected. Prepubertal girls showed a lower muscle mass (kg) and fat mass (kg) than pubertal girls regardless of the extracurricular sports typology. PRE-CS and PRE-IS also showed a lower respiratory fitness and physical fitness than pubertal girls (p 0.05) in any of the body composition, respiratory fitness, and physical fitness variables when comparing between collective sports and individual sports. The results show that extracurricular participation in these types sports by prepubertal girls can influence their body composition, respiratory fitness, and physical condition.post-print300 K
Six Collective Challenges for Sustainability of Almería Greenhouse Horticulture
Globally, current food consumption and trade are placing unprecedented demand on agricultural systems and increasing pressure on natural resources, requiring tradeoffs between food security and environmental impacts especially given the tension between market-driven agriculture and agro-ecological goals. In order to illustrate the wicked social, economic and environmental challenges and processes to find transformative solutions, we focus on the largest concentration of greenhouses in the world located in the semi-arid coastal plain of South-east Spain. Almería family farming, predominantly cooperative, greenhouse intensive production, commenced after the 1960s and has resulted in very significant social and economic benefits for the region, while also having important negative environmental and biodiversity impacts, as well as creating new social challenges. The system currently finds itself in a crisis of diminishing economic benefits and increasing environmental and social dilemmas. Here, we present the outcomes of multi-actor, transdisciplinary research to review and provide collective insights for solutions-oriented research on the sustainability of Almeria’s agricultural sector. The multi-actor, transdisciplinary process implemented collectively, and supported by scientific literature, identified six fundamental challenges to transitioning to an agricultural model that aims to ameliorate risks and avoid a systemic collapse, whilst balancing a concern for profitability with sustainability: (1) Governance based on a culture of shared responsibility for sustainability, (2) Sustainable and efficient use of water, (3) Biodiversity conservation, (4) Implementing a circular economy plan, (5) Technology and knowledge transfer, and (6) Image and identity. We conclude that the multi-actor transdisciplinary approach successfully facilitated the creation of a culture of shared responsibility among public, private, academic, and civil society actors. Notwithstanding plural values, challenges and solutions identified by consensus point to a nascent acknowledgement of the strategic necessity to locate agricultural economic activity within social and environmental spheres.This paper demonstrates the need to establish transdisciplinary multi-actor work-schemes to continue collaboration and research for the transition to an agro-ecological model as a means to remain competitive and to create value
Metabolomic profile of cancer stem cell-derived exosomes from patients with malignant melanoma
Malignant melanoma (MM) is the most aggressive and life-threatening
form of skin cancer. It is characterized by an extraordinary metastasis
capacity and chemotherapy resistance, mainly due to melanoma cancer
stem cells (CSCs). To date, there are no suitable clinical diagnostic, prognostic
or predictive biomarkers for this neoplasia. Therefore, there is an
urgent need for new MM biomarkers that enable early diagnosis and effective
disease monitoring. Exosomes represent a novel source of biomarkers
since they can be easily isolated from different body fluids. In this work, a
primary patient-derived MM cell line enriched in CSCs was characterized
by assessing the expression of specific markers and their stem-like properties.
Exosomes derived from CSCs and serums from patients with MM
were characterized, and their metabolomic profile was analysed by highresolution
mass spectrometry (HRMS) following an untargeted approach
and applying univariate and multivariate statistical analyses. The aim of
this study was to search potential biomarkers for the diagnosis of this disease.
Our results showed significant metabolomic differences in exosomes
derived from MM CSCs compared with those from differentiated tumour
cells and also in serum-derived exosomes from patients with MM compared
to those from healthy controls. Interestingly, we identified similarities between structural lipids differentially expressed in CSC-derived exosomes
and those derived from patients with MM such as the glycerophosphocholine
PC 16:0/0:0. To our knowledge, this is the first metabolomic-based
study aimed at characterizing exosomes derived from melanoma CSCs and
patients’ serum in order to identify potential biomarkers for MM diagnosis.
We conclude that metabolomic characterization of CSC-derived exosomes
sets an open door to the discovery of clinically useful biomarkers in
this neoplasia.MICIU
FPU15/03682
FPU15/02350Ministerio de Ciencia, Innovación y Universidades (MICIU)
MAT2015-62644.C2.2.R
RTI2018-101309-BC2Instituto de Salud Carlos III
PIE16-00045Junta de Andalucía
SOMM17/6109/UGR (UCE-PP2017-3)European Union (EU)
SOMM17/6109/UGR (UCE-PP2017-3)Chair 'Doctors Galera-Requena in cancer stem cell research'
CMC-CTS963Fundación MEDIN
La inmigración en la UE. Situación y perspectivas para Euskadi
Jornada: La inmigración en la UE. Situación y perspectivas para Euskadi
4 y 5 de noviembre de 200
Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2
The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality
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