Entwicklung von Phytophthora-resistentem Zuchtmaterial für den ökologischen Landbau

Die Ansprüche des ökologischen Landbaus an Kartoffelsorten unterscheiden sich zum Teil erheblich von denen des konventionellen Anbaus. Dies ist bedingt durch den alternativen Pflanzenschutz mit mechanischer Unkrautbekämpfung sowie durch eine in der Regel geringere Stickstoffversorgung der Pflanzen. Darum benötigt der ökologische Landbau spezielle Sorten, die neben den vom Verbraucher gewünschten Qualitätsmerkmalen auch eine hohe Widerstandsfähigkeit gegenüber Krankheiten und Schädlingen besitzen, durch schnelle Jugendentwicklung das Unkrautwachstum unterdrücken und eine hohe Nährstoffeffizienz aufweisen. Um neue Zuchtstämme zu schaffen, in denen die im Biolandbau gewünschten Eigenschaften kombiniert vorliegen, etablierte das seit 2012 im „Bundesprogramm Ökologischer Landbau und andere Formen nachhaltiger Landwirtschaft“ geförderte Projekt „Entwicklung von Phytophthora-resistentem Zuchtmaterial für den ökologischen Landbau“ ein Zuchtprogramm speziell für den ökologischen Kartoffelanbau. Für die Züchtung auf geringe Anfälligkeit gegenüber der Kraut- und Knollenfäule, die durch den Oomyceten Phytophthora infestans hervorgerufen wird, wurde auf resistente Kartoffelklone aus der Vorzüchtung des Julius-Kühn Institutes zurückgegriffen. Die untersuchten Zuchtstämme und Vergleichssorten wurden parallel in einem Beobachtungsanbau hinsichtlich weiterer agronomischer und qualitativer Eigenschaften wie Ertragsleistung, Wuchsform, Stärkegehalt, Speise- und Veredelungseignung und Abreifeverhalten untersucht. Weitere Resistenzen sowie gewünschte Qualitätsmerkmale wurden aus modernen Hochleistungssorten deutscher Züchtungsunternehmen und historischen Sorten der IPK Genbank während des Projektverlaufs ins Zuchtmaterial eingebracht. Neben der Evaluierung der Prüfglieder hinsichtlich der Resistenzeigenschaften wurden zur Erweiterung des Basiszuchtmaterials zahlreiche Kreuzungen durchgeführt. Hierbei wurden die Kreuzungseltern gezielt aus den im Projekt geprüften Sorten und Zuchtstämmen ausgewählt. Für die Bewertung und die Selektion der Klone wurde ein partizipativer Züchtungsansatz gewählt und dafür drei ökologisch wirtschaftende, landwirtschaftliche Betriebe ins Projekt eingebunden. Die Betriebsleiter wurden intensiv geschult und führten die Bewertung der Klone und die Selektion der Knollen in enger Zusammenarbeit mit den wissenschaftlichen Mitarbeitern der Institute durch. Ein solches Modell ist bislang in der der deutschen Kartoffelzüchtung einzigartig. Wissenschaftlich begleitet wurden die Züchtungsarbeiten durch eine phänotypische und genotypische Charakterisierung des Ausgangsmaterials und der Zuchtklone. Ziel hierbei war es, Grundlagen für eine molekulare Selektion KF-resistenter Nachkommen zu schaffen. Hierzu wurden an einem Prüfgliedsortiment Assoziationsstudien mit DArT- und SNP-Markern durchgeführt und ausgewertet. Im Projekt wurden am IPK erstmalig zwei Sortimente umfassend genetisch mittels zwei verschiedener Markersysteme zu charakterisiert. Mit den erzielten Ergebnisse konnten Duplikatgruppen innerhalb der Genbankakzessionen aufgedeckt sowie Unstimmigkeiten erkannt und bereinigt werden. Damit wurde das Genbankmanagement verbessert und nutzerorientiert gestaltet. Somit hat das Projekt eine nachhaltigere und intensivere Nutzung pflanzengenetischer Ressourcen ermöglicht. Dadurch ist es Züchtern wie auch Forschungsinstitutionen zukünftig möglich, zielgerichteter auf genetische Ressourcen der Kartoffel zuzugreifen und diese in die eigenen Zuchtprogramme und Forschungsprojekte einzubringen

Positivity of relative canonical bundles and applications

Given a family $f:\mathcal X \to S$ of canonically polarized manifolds, the unique K\"ahler-Einstein metrics on the fibers induce a hermitian metric on the relative canonical bundle $\mathcal K_{\mathcal X/S}$. We use a global elliptic equation to show that this metric is strictly positive on $\mathcal X$, unless the family is infinitesimally trivial. For degenerating families we show that the curvature form on the total space can be extended as a (semi-)positive closed current. By fiber integration it follows that the generalized Weil-Petersson form on the base possesses an extension as a positive current. We prove an extension theorem for hermitian line bundles, whose curvature forms have this property. This theorem can be applied to a determinant line bundle associated to the relative canonical bundle on the total space. As an application the quasi-projectivity of the moduli space $\mathcal M_{\text{can}}$ of canonically polarized varieties follows. The direct images $R^{n-p}f_*\Omega^p_{\mathcal X/S}(\mathcal K_{\mathcal X/S}^{\otimes m})$, $m > 0$, carry natural hermitian metrics. We prove an explicit formula for the curvature tensor of these direct images. We apply it to the morphisms $S^p \mathcal T_S \to R^pf_*\Lambda^p\mathcal T_{\mathcal X/S}$ that are induced by the Kodaira-Spencer map and obtain a differential geometric proof for hyperbolicity properties of $\mathcal M_{\text{can}}$.Comment: Supercedes arXiv:0808.3259v4 and arXiv:1002.4858v2. To appear in Invent. mat

Beiträge zur Geschichte des Landkreises Regensburg 30

Marginalien von 14 Autoren; darin: Hecht, Otto: Die Altstraße Regensburg-Landshut (auf dem Gebiet des Landkreises ) (S.2); Hecht, Otto: Die erste urkundliche Erwähnung des Bäumel-Hofes in Obertraubling (S. 5); Böck, Emmi / Herzog, Hans / Doerfler, Heinrich: Drei Sagen bzw. Sagengestalten aus dem Regensburger Süden (S. 6); Motyka, Gustl: Mittelalterliches Geleit von Hemau nach Regensburg (S. 9); Strehler, Heinz: Haus Nr. 21 in Matting - eines der ältesten Häuser Bayerns (S. 10); Zink, Wendelin: Die Wasserburg Haidau vor 200 Jahren (S. 11); Färber, Konrad M.: Ein Augenblick europäischer Geschichte (S. 12); Fendl, Josef: Fünf Säcke Brot für Tegernheim (S. 14); Bäumel, Xaver: Ein Lehrer der "schlechtesten Schule im ganzen Königreich" (S. 18); Rösch, Georg: 600 Jahre Hofgeschichte Kleinkiefenholz (S. 22); Deininger, Leonhard: Mit 3,3 Millionen nachts unterwegs (S. 24); Zausinger, Ludwig: Ein Nachtrag zum Heimatbuch "Thalmassing" (S. 26); Forster, Fritz: Beim Korea-Wirt (S. 28); Fendl, Josef: Neutraubling - Choppertown (S. 20

The effects of stereo disparity on the behavioural and electrophysiological correlates of audio-visual motion in depth.

Motion is represented by low-level signals, such as size-expansion in vision or loudness changes in the auditory modality. The visual and auditory signals from the same object or event may be integrated and facilitate detection. We explored behavioural and electrophysiological correlates of congruent and incongruent audio-visual depth motion in conditions where auditory level changes, visual expansion, and visual disparity cues were manipulated. In Experiment 1 participants discriminated auditory motion direction whilst viewing looming or receding, 2D or 3D, visual stimuli. Responses were faster and more accurate for congruent than for incongruent audio-visual cues, and the congruency effect (i.e., difference between incongruent and congruent conditions) was larger for visual 3D cues compared to 2D cues. In Experiment 2, event-related potentials (ERPs) were collected during presentation of the 2D and 3D, looming and receding, audio-visual stimuli, while participants detected an infrequent deviant sound. Our main finding was that audio-visual congruity was affected by retinal disparity at an early processing stage (135 – 160 ms) over occipito-parietal scalp. Topographic analyses suggested that similar brain networks were activated for the 2D and 3D congruity effects, but that cortical responses were stronger in the 3D condition. Differences between congruent and incongruent conditions were observed between 140 – 200 ms, 220 – 280 ms, and 350 – 500 ms after stimulus onset

Creativity and commerce: Michael Klinger and new film history

The crisis in film studies and history concerning their legitimacy and objectives has provoked a reinvigoration of scholarly energy in historical enquiry. 'New film history' attempts to address the concerns of historians and film scholars by working self-reflexively with an expanded range of sources and a wider conception of 'film' as a dynamic set of processes rather than a series of texts. The practice of new film history is here exemplified through a detailed case study of the independent British producer Michael Klinger (active 1961-87) with a specific focus on his unsuccessful attempt to produce a war film, Green Beach, based on a memoir of the Dieppe raid (August 1942). This case study demonstrates the importance of analysing the producer's role in understanding the complexities of film-making, the continual struggle to balance the competing demands of creativity and commerce. In addition, its subject matter - an undercover raid and a Jewish hero - disturbed the dominant myths concerning the Second World War, creating what turned out to be intractable ideological as well as financial problems. The paper concludes that the concerns of film historians need to engage with broader cultural and social histories. © 2010 Taylor & Francis

Latent class analysis reveals clinically relevant atopy phenotypes in 2 birth cohorts

Background: Phenotypes of childhood-onset asthma are characterized by distinct trajectories and functional features. For atopy, definition of phenotypes during childhood is less clear. Objective: We sought to define phenotypes of atopic sensitization over the first 6 years of life using a latent class analysis (LCA) integrating 3 dimensions of atopy: allergen specificity, time course, and levels of specific IgE (sIgE). Methods: Phenotypes were defined by means of LCA in 680 children of the Multizentrische Allergiestudie (MAS) and 766 children of the Protection against allergy: Study in Rural Environments (PASTURE) birth cohorts and compared with classical nondisjunctive definitions of seasonal, perennial, and food sensitization with respect to atopic diseases and lung function. Cytokine levels were measured in the PASTURE cohort. Results: The LCA classified predominantly by type and multiplicity of sensitization (food vs inhalant), allergen combinations, and sIgE levels. Latent classes were related to atopic disease manifestations with higher sensitivity and specificity than the classical definitions. LCA detected consistently in both cohorts a distinct group of children with severe atopy characterized by high seasonal sIgE levels and a strong propensity for asthma; hay fever; eczema; and impaired lung function, also in children without an established asthma diagnosis. Severe atopy was associated with an increased IL-5/IFN-gamma ratio. A path analysis among sensitized children revealed that among all features of severe atopy, only excessive sIgE production early in life affected asthma risk. Conclusions: LCA revealed a set of benign, symptomatic, and severe atopy phenotypes. The severe phenotype emerged as a latent condition with signs of a dysbalanced immune response. It determined high asthma risk through excessive sIgE production and directly affected impaired lung function.Peer reviewe

Meta Modeling for Business Process Improvement

Conducting business process improvement (BPI) initiatives is a topic of high priority for today’s companies. However, performing BPI projects has become challenging. This is due to rapidly changing customer requirements and an increase of inter-organizational business processes, which need to be considered from an end-to-end perspective. In addition, traditional BPI approaches are more and more perceived as overly complex and too resource-consuming in practice. Against this background, the paper proposes a BPI roadmap, which is an approach for systematically performing BPI projects and serves practitioners’ needs for manageable BPI methods. Based on this BPI roadmap, a domain-specific conceptual modeling method (DSMM) has been developed. The DSMM supports the efficient documentation and communication of the results that emerge during the application of the roadmap. Thus, conceptual modeling acts as a means for purposefully codifying the outcomes of a BPI project. Furthermore, a corresponding software prototype has been implemented using a meta modeling platform to assess the technical feasibility of the approach. Finally, the usability of the prototype has been empirically evaluated

Earth Virtualization Engines (EVE)

To manage Earth in the Anthropocene, new tools, new institutions, and new forms of international cooperation will be required. Earth Virtualization Engines is proposed as an international federation of centers of excellence to empower all people to respond to the immense and urgent challenges posed by climate change

A História da Alimentação: balizas historiográficas

Os M. pretenderam traçar um quadro da História da Alimentação, não como um novo ramo epistemológico da disciplina, mas como um campo em desenvolvimento de práticas e atividades especializadas, incluindo pesquisa, formação, publicações, associações, encontros acadêmicos, etc. Um breve relato das condições em que tal campo se assentou faz-se preceder de um panorama dos estudos de alimentação e temas correia tos, em geral, segundo cinco abardagens Ia biológica, a econômica, a social, a cultural e a filosófica!, assim como da identificação das contribuições mais relevantes da Antropologia, Arqueologia, Sociologia e Geografia. A fim de comentar a multiforme e volumosa bibliografia histórica, foi ela organizada segundo critérios morfológicos. A seguir, alguns tópicos importantes mereceram tratamento à parte: a fome, o alimento e o domínio religioso, as descobertas européias e a difusão mundial de alimentos, gosto e gastronomia. O artigo se encerra com um rápido balanço crítico da historiografia brasileira sobre o tema

Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation