Studies supporting an upper-atmosphere chemical release program. Part I - Experimental studies on chemiluminescence. Part II - A model of releases leading to upper-atmospheric chemi-ion formation Final report, May 1965 - May 1966

Chemiluminescence of chemical compounds released in upper atmosphere and model of releases leading to upper atmospheric chemi-ionizatio

Melanoma, the role of basic Fibroblast Growth Factor in the aggressive behaviour and chemotherapy response

Boven, E. [Promotor]Duyndam, M.C.A. [Copromotor

Possible coupling between climatically induced lake level change, volcanic eruptions and seismotectonic activation in the Rukwa-Rungwe-Nyasa rift, SW Tanzania

The Rukwa rift basin is presently a closed hydrogeological depression containing a shallow lake (max 20 me deep) with its surface at an altitude around 810 m above sea level. Lacustrine terraces and paleo-shorelines are known up to 980 m above sea level, an altitude at which it reach the overflow sill towards Lake Tanganyika. Both Lakes Tanganyika and Nyasa (Malawi) are presently overflowing, but as their lake level fluctuates, they have been disconnected from their outlet in the recent past. High resolution seismic profiling in both Lakes Rukwa and Malawi has show the presence of active fault systems underneath the lake floor. Some of these fault systems appear to have had a cyclic activity, with alternating periods of high tectonic activity/sedimentation and periods of tectonic quiescence. The accommodation zone between Lake Rukwa and Nyasa is occupied by the Rungwe volcanic Province, with the Ngozi, Rungwe and Kiejo volcanoes presenting signs of recent volcanic activity. The Rungwe Province is cross-cut by several directions of faults, which clearly control the location of the volcanic vents.In our work, we reviewed the available data on recent (Late Pleistocene – Holocene) volcanic eruptions, in the Rungwe area itself, in the drill cores from the surrounding lakes and from aerial observations up to 300 km away from the Rungwe Province. We performed morphotectonic and paleoseismic investigations of the Kanda fault, a major normal fault between lakes Rukwa and Tanganyika. We investigated lacustrine deposits of the Rukwa basin corresponding to the two last cycles of high lake level. The chronological framework was established using 30 new radiocarbon dating and the most prominent volcanic tephra layers were used as a reference in the correlations. The results are still preliminary, but a good correlation already appear between climatically induced lake level change (in Lake Rukwa), seismo-tectonic activation of the regional fault network (underneath Lake Rukwa and the Kanda fault between Lakes Rukwa and Tanganyika) and the timing of the recent strong volcanic eruptions in the Rungwe Volcanic Province since the last 40.000 years. This relation is explained taking into account that Lake Rukwa is very sensitive to climate change as it occupies a flat depression and its overflow outlet is 180 m above its present-day level. Its lake level rises rapidly when the climate becomes more humid as it was the case during the Last Glacial Maximum and during the Younger Dryas event. Increase in lake level means increasing of the load in the basin and perturbation of the ambient tectonic stresses. In most of the Rukwa rift, the tectonic stress is of extensional (normal faulting) regime, with the maximum principal stress axis (sigma 1) subvertical. In these conditions, increasing the vertical load will increase the shear stress on the existing normal faults, triggering (seismogenic) normal faulting deformation. As the architecture of the active volcanoes in the Rungwe Province is tectonically controlled, activation of the faults, together with a greater pressure of water in the tectonic discontinuities are likely to trigger large volcanic eruptions, strongly explosive

Neutron-based analyses of three Bronze Age metal objects: a closer look at the Buggenum, Jutphaas and Escharen artefacts

Three important Bronze Age copper-alloy artefacts from the permanent exhibition of the National Museum of Antiquity in Leiden (NL) have been studied by neutron-based methods. These artefacts are known as the Buggenum sword, the Jutphaas dirk, and the Escharen double axe. All three objects have been studied with neutron resonance capture analysis (NRCA), a non-destructive method to determine the bulk elemental compositions. The Buggenum sword is also studied with time-of-flight neutron diffraction (TOF-ND) giving additional information about crystalline properties and internal material structures, and neutron tomography (NT), showing details of the construction of this sword and voids inside the material. The composition of the Jutphaas dirk is compared with the compositions of two other dirks belonging to the group of six Plougrescant-Ommerschans (PO) ceremonial dirks. The Escharen double axe, identified as being of the Zabitz type, variant Westeregeln, is a rare object in the Low Countries. It is compared to finds from Central Europe. The results for all three objects are discussed with regards to their archaeological contexts and their relation to other finds

Lessons from Love-Locks: The archaeology of a contemporary assemblage

This document is the Accepted Manuscript version. The final, definitive version of this paper has been published in Journal of Material Culture, November 2017, published by SAGE Publishing, All rights reserved.Loss of context is a challenge, if not the bane, of the ritual archaeologist’s craft. Those who research ritual frequently encounter difficulties in the interpretation of its often tantalisingly incomplete material record. Careful analysis of material remains may afford us glimpses into past ritual activity, but our often vast chronological separation from the ritual practitioners themselves prevent us from seeing the whole picture. The archaeologist engaging with structured deposits, for instance, is often forced to study ritual assemblages post-accumulation. Many nuances of its formation, therefore, may be lost in interpretation. This paper considers what insights an archaeologist could gain into the place, people, pace, and purpose of deposition by recording an accumulation of structured deposits during its formation, rather than after. To answer this, the paper will focus on a contemporary depositional practice: the love-lock. This custom involves the inscribing of names/initials onto a padlock, its attachment to a bridge or other public structure, and the deposition of the corresponding key into the water below; a ritual often enacted by a couple as a statement of their romantic commitment. Drawing on empirical data from a three-year diachronic site-specific investigation into a love-lock bridge in Manchester, UK, the author demonstrates the value of contemporary archaeology in engaging with the often enigmatic material culture of ritual accumulations.Peer reviewe

Surface-wave imaging of the weakly-extended Malawi Rift from ambient-noise and teleseismic Rayleigh waves from onshore and lake-bottom seismometers

Located at the southernmost sector of the Western Branch of the East African Rift System, the Malawi Rift exemplifies an active, magma-poor, weakly extended continental rift. To investigate the controls on rifting, we image crustal and uppermost mantle structure beneath the region using ambient-noise and teleseismic Rayleigh-wave phase velocities between 9 and 100 s period. Our study includes six lake-bottom seismometers located in Lake Malawi (Nyasa), the first time seismometers have been deployed in any of the African rift lakes. Noise-levels in the lake are lower than that of shallow oceanic environments and allow successful application of compliance corrections and instrument orientation determination. Resulting phase-velocity maps reveal slow velocities primarily confined to Lake Malawi at short periods (T 25 s) a prominent low-velocity anomaly exists beneath the Rungwe Volcanic Province at the northern terminus of the rift basin. Estimates of phase-velocity sensitivity indicates these low velocities occur within the lithospheric mantle and potentially uppermost asthenosphere, suggesting that mantle processes may control the association of volcanic centers and the localization of magmatism. Beneath the main portion of the Malawi Rift, a modest reduction in velocity is also observed at periods sensitive to the crust and upper mantle, but these velocities are much higher than those observed beneath Rungwe

Fluidal pyroclasts reveal the intensity of peralkaline rhyolite pumice cone eruptions

This work is a contribution to the Natural Environment Research Council (NERC) funded RiftVolc project (NE/L013932/1, Rift volcanism: past, present and future) through which several of the authors are supported. In addition, Clarke was funded by a NERC doctoral training partnership grant (NE/L002558/1).Peralkaline rhyolites are medium to low viscosity, volatile-rich magmas typically associated with rift zones and extensional settings. The dynamics of peralkaline rhyolite eruptions remain elusive with no direct observations recorded, significantly hindering the assessment of hazard and risk. Here we describe uniquely-preserved, fluidal-shaped pyroclasts found within pumice cone deposits at Aluto, a peralkaline rhyolite caldera in the Main Ethiopian Rift. We use a combination of field-observations, geochemistry, X-ray computed microtomography (XCT) and thermal-modelling to investigate how these pyroclasts are formed. We find that they deform during flight and, depending on size, quench prior to deposition or continue to inflate then quench in-situ. These findings reveal important characteristics of the eruptions that gave rise to them: that despite the relatively low viscosity of these magmas, and similarities to basaltic scoria-cone deposits, moderate to intense, unstable, eruption columns are developed; meaning that such eruptions can generate extensive tephra-fall and pyroclastic density currents.Publisher PDFPeer reviewe

Event trees and epistemic uncertainty in long‐term volcanic hazard assessment of Rift Volcanoes: the example of Aluto (Central Ethiopia)

Aluto is a peralkaline rhyolitic caldera located in a highly populated area in central Ethiopia. Its postcaldera eruptive activity has mainly consisted of self‐similar, pumice‐cone‐building eruptions of varying size and vent location. These eruptions are explosive, generating hazardous phenomena that could impact proximal to distal areas from the vent. Volcanic hazard assessments in Ethiopia and the East African Rift are still limited in number. In this study, we develop an event tree model for Aluto volcano. The event tree is doubly useful: It facilitates the design of a conceptual model for the volcano and provides a framework to quantify volcanic hazard. We combine volcanological data from past and recent research at Aluto, and from a tool to objectively derive analog volcanoes (VOLCANS), to parameterize the event tree, including estimates of the substantial epistemic uncertainty. Results indicate that the probability of a silicic eruption in the next 50 years is highly uncertain, ranging from 2% to 35%. This epistemic uncertainty has a critical influence on event‐tree estimates for other volcanic events, like the probability of occurrence of pyroclastic density currents (PDCs) in the next 50 years. The 90% credible interval for the latter is 5–16%, considering only the epistemic uncertainty in conditional eruption size and PDC occurrence, but 2–23% when adding the epistemic uncertainty in the probability of eruption in 50 years. Despite some anticipated challenges, we envisage that our event tree could be translated to other rift volcanoes, making it an important tool to quantify volcanic hazard in Ethiopia and elsewhere

Endothelial-Derived Extracellular Vesicles Induce Cerebrovascular Dysfunction in Inflammation

Blood–brain barrier (BBB) dysfunction is a key hallmark in the pathology of many neuroinflammatory disorders. Extracellular vesicles (EVs) are lipid membrane-enclosed carriers of molecular cargo that are involved in cell-to-cell communication. Circulating endothelial EVs are increased in the plasma of patients with neurological disorders, and immune cell-derived EVs are known to modulate cerebrovascular functions. However, little is known about whether brain endothelial cell (BEC)-derived EVs themselves contribute to BBB dysfunction. Human cerebral microvascular cells (hCMEC/D3) were treated with TNFα and IFNy, and the EVs were isolated and characterised. The effect of EVs on BBB transendothelial resistance (TEER) and leukocyte adhesion in hCMEC/D3 cells was measured by electric substrate cell-substrate impedance sensing and the flow-based T-cell adhesion assay. EV-induced molecular changes in recipient hCMEC/D3 cells were analysed by RT-qPCR and Western blotting. A stimulation of naïve hCMEC/D3 cells with small EVs (sEVs) reduced the TEER and increased the shear-resistant T-cell adhesion. The levels of microRNA-155, VCAM1 and ICAM1 were increased in sEV-treated hCMEC/D3 cells. Blocking the expression of VCAM1, but not of ICAM1, prevented sEV-mediated T-cell adhesion to brain endothelia. These results suggest that sEVs derived from inflamed BECs promote cerebrovascular dysfunction. These findings may provide new insights into the mechanisms involving neuroinflammatory disorders