Autoprésentation de l’autrice et performeuse

Die Autor*in und Performer*in Aude Fondard stellt sich vor.The author and performer Aude Fondard presents her œuvre.La autora y la artista Aude Fondard presenta su obra.L’autrice et performeuse Aude Fondard présente son œuvre

Au-delà: Un poème en mouvement

Dokumentation der Performance und Video-EssayDocumentation and video essayDocumentación y videoensayoDocumentation et essai vidé

Synthesis and characterization of La2NiO4+δ coatings deposited by reactive magnetron sputtering using plasma emission monitoring

This work focuses on the structural and electrical characterization of La–Ni–O coatings deposited by reactive magnetron sputtering using Plasma Emission Monitoring (PEM) which allows high deposition rate. The optimal regulation setpoint for lanthanumdeposition is determined and then the current dissipated on the nickel target is adjusted to obtain the convenient La/Ni ratio to achieve the K2NiF4 structure. After an appropriate annealing treatment, all coatings exhibit crystalline structures that depend on the La/Ni ratio. Some cracks appear on samples deposited on alumina substrates depending to the argon flow rate and influence their electrical behavior

Synthesis of Half Fuel Cell Ni-YSZ / YSZ on Porous Metallic Support by Dry Surface Deposition Processes

A new cell design with metallic porous support was selected in order to face with the reduction of IT-SOFC's operation temperature. Nevertheless, the excessive roughness of the porous metallic interconnect induce additional problems when a thin electrolyte layer is required. In this work, an anode material (NiO-TSZ) by Atmospheric Plasma Spraying was deposited on metallic supports (ITM) produced by PLANSEE able to cover the roughness of the support. Then, a second thin and dense electrolyte layer (YSZ) by reactive magnetron sputtering was produced on the anode material. In this study, for both processing routes, the optimal process parameters regarding the structural, morphological and electrical characterizations were investigated

Les langages de la danse

Les éditions Contredanse, créées en 1990, répondent-elles au constat d’un manque dans le monde de la danse ? Florence Corin : L’association Contredanse a vu le jour à l’initiative de Patricia Kuypers, qui souhaitait élargir le paysage de la danse à Bruxelles, notamment en invitant des chorégraphes et des artistes qui n’y avaient jamais enseigné, en faisant découvrir des pratiques qu’on connaissait peu en Belgique, en mettant en place une bibliothèque de référence et en créant un médium qui fa..

Ln 2 NiO 4+δ (Ln = La, Pr, Nd) coatings deposited by reactive magnetron sputtering as cathode material for intermediate temperature solid oxide fuel cell

This work focuses on the comparison of Ln-Ni-O coatings (Ln = La, Nd, Pr) deposited by reactive magnetron sputtering using Plasma Emission Monitoring (PEM) which allows high deposition rate. Each layer is deposited by different steps. The optimal regulation setpoint for oxide rare-earth deposition is determined and then the current dissipated on the nickel target is adjusted to obtain the convenient Ln/Ni ratio and to achieve the K2NiF4 structure. After an appropriate annealing treatment, all coatings exhibit crystalline structures, which depend on the Ln/Ni ratio. Due to the instability of Pr2NiO4 structure at intermediate temperatures, the crystallization step of praseodymium nickelate is performed at higher temperature than the other materials. This further thermal treatment implies a more porous structure. Each coating exhibits interesting properties. Electrical and electrochemical characterizations performed on these deposits prove better properties of the praseodymium nickelate coating

Inhibition of MAPK-Erk pathway in vivo attenuates aortic valve disease processes in Emilin1-deficient mouse model

Aortic valve disease (AVD) is a common condition with a progressive natural history, and presently, there are no pharmacologic treatment strategies. Elastic fiber fragmentation (EFF) is a hallmark of AVD, and increasing evidence implicates developmental elastic fiber assembly defects. Emilin1 is a glycoprotein necessary for elastic fiber assembly that is present in both developing and mature human and mouse aortic valves. The Emilin1‐deficient mouse (Emilin1 (−/−)) is a model of latent AVD, characterized by activated TGFβ/MEK/p‐Erk signaling and upregulated elastase activity. Emilin1 (−/−) aortic valves demonstrate early EFF and aberrant angiogenesis followed by late neovascularization and fibrosis. The objective of this study was to test the effectiveness of three different targeted therapies. Aged (12–14 months) Emilin1 (−/−) mice were treated with refametinib (RDEA‐119, MEK1/2 inhibitor), doxycycline (elastase inhibitor), or G6‐31 (anti‐VEGF‐A mouse antibody) for 4 weeks. Refametinib‐ and doxycycline‐treated Emilin1 (−/−) mice markedly reduced MEK/p‐Erk activation in valve tissue. Furthermore, both refametinib and doxycycline attenuated elastolytic cathepsin K, L, MMP‐2, and MMP‐9 activation, and abrogated macrophage and neutrophil infiltration in Emilin1 (−/−) aortic valves. RNAseq analysis was performed in aortic valve tissue from adult (4 months) and aged (14 months) Emilin1 (−/−) and age‐matched wild‐type control mice, and demonstrated upregulation of genes associated with MAPK/MEK/p‐Erk signaling and elastases at the adult stage and inflammatory pathways at the aged stage controlling for age. These results suggest that Erk1/2 signaling is an important modulator of early elastase activation, and pharmacological inhibition using refametinib may be a promising treatment to halt AVD progressio

Early detection and prediction of cardiotoxicity after radiation therapy for breast cancer: the BACCARAT prospective cohort study

International audienceBackground Radiotherapy (RT) for breast cancer presents a benefit in terms of reducing local recurrence and deaths resulting from breast cancer but it can lead to secondary effects due to the presence of neighboring cardiac normal tissues within the irradiation field. Breast RT has been shown to be associated with long-term increased risk of heart failure, coronary artery disease, myocardial infarction and finally cardiovascular death more than 10 years after RT. However, there is still a lack of knowledge for early cardiotoxicity induced by breast RT that can appear long before the onset of clinically significant cardiac events. Based on a 2-year follow-up prospective cohort of patients treated with breast RT, the BACCARAT (BreAst Cancer and CArdiotoxicity Induced by RAdioTherapy) study aims to enhance knowledge on detection and prediction of early subclinical cardiac dysfunction and lesions induced by breast RT and on biological mechanisms potentially involved, based on functional and anatomical cardiac imaging combined with simultaneous assessment of multiple circulating biomarkers and accurate heart dosimetry. Methods/Design BACCARAT study consists in a monocentric prospective cohort study that will finally include 120 women treated with adjuvant 3D CRT for breast cancer, and followed for 2 years after RT. Women aged 50 to 70 years, treated for breast cancer and for whom adjuvant 3D CRT is indicated, without chemotherapy are eligible for the study. Baseline (before RT) and follow-up data include measurements of functional myocardial dysfunction including strain and strain rate based on 2D-speckle tracking echocardiography, anatomical coronary lesions including description of plaques in segments of coronary arteries based on Coronary computed tomography angiography, and a wide panel of circulating biomarkers. The absorbed dose is evaluated for the whole heart and its substructures, in particular the coronary arteries. Analysis on occurrence and evolution of subclinical cardiac lesions and biomarkers will be performed and completed with dose-response relationship. Multivariate model of normal tissue complication probability (NTCP) will also be proposed. Discussion Tools and results developed in the BACCARAT study should allow improving prediction and prevention of potential lesions to cardiac normal tissues surrounding tumors and ultimately enhance patients' care and quality of life. Trial registration ClinicalTrials.gov NCT02605512. © 2016 Jacob et al

Elaboration et test d’une pile à combustible IT-SOFC à support métallique poreux par l’intermédiaire de techniques de dépôt en voie sèche : projection thermique et pulvérisation cathodique magnétron

Energy production by a clean and environmental processes is a real challenge. Fuel cell technology is good candidate to answer this objective. The major problem of the Solid Oxide Fuel Cell is their high operating temperature (around 1000°C) for a massive industrialisation. Decreasing these temperature at 700°C allows a reduction of cost manufacturing and increase the lifetime, in this case the new challenge is to avoid the performances losses.During this phD work, dry surface treatment processes are employed for produce the fuel cell core. The thickness reduction of each part limit the performances decreasing generate by the modification of the temperature. The materials used is a Ni-Yttria stabilised zirconia cermet (Ni-YSZ) for the anode, YSZ with or without gadolinnia doped ceria (GDC) for electrolyte and rare earth nickelate for the cathode component. All material are a usual employed in the SOFC technology. All coating are synthesized and characterised separately. After a third generation of fuel cell is realized on ITM porous metal support produced by PLANSEE. The anode has been deposit by atmospheric plasma spray, the electrolyte and cathode have been synthesised by reactive magnetron sputtering.L’un des enjeux relatif au déploiement des piles à combustible à oxyde solide comme système de production d’une énergie propre relève de la température de fonctionnement qui est actuellement autour de 1000°C. Abaisser cette température tout en préservant les performances afin de réduire les coûts de fabrication et d’augmenter la durée de vie des systèmes a été l’objectif dece travail de doctorat.Un coeur de pile à combustible (anode-électrolyte-cathode) élaboré avec des procédés physiques de dépôts (projection par plasma atmosphérique et pulvérisation cathodique magnétron) a été développé et optimisé sur un support métallique poreux. Les matériaux étudiés ont été un cermet en Nickel-Zircone stabilisée à l’Ytttrium (Ni-YSZ) pour l’anode, un électrolyte en YSZ avec ou sans couche de cérine gadoliniée (GDC) et les nickelates de terres rares comme cathode. La maitrise des procédés de revêtements a permis de réduire les épaisseurs de chaque couche et d’assurer la cohésion de l’ensemble des 3 couches avec des caractéristiques cristallographiques, microstructurales et de porosité adaptées. . Les performances électrochimiques ont été étudiées pour chaque élément du coeur de pile puis pour l’ensemble du système élaboré sur métal poreux. Même si les performances atteintes ne sont pas encore suffisantes, les procédés de revêtements optimisés pour recouvrir un support métallique poreux ont confirmé leur potentiel