Helium mixtures in nanotube bundles

An analogue to Raoult's law is determined for the case of a 3He-4He mixture adsorbed in the interstitial channels of a bundle of carbon nanotubes. Unlike the case of He mixtures in other environments, the ratio of the partial pressures of the coexisting vapor is found to be a simple function of the ratio of concentrations within the nanotube bundle.Comment: 3 pages, no figures, submitted to Phys. Rev. Let

The Random-bond Potts model in the large-q limit

We study the critical behavior of the q-state Potts model with random ferromagnetic couplings. Working with the cluster representation the partition sum of the model in the large-q limit is dominated by a single graph, the fractal properties of which are related to the critical singularities of the random Potts model. The optimization problem of finding the dominant graph, is studied on the square lattice by simulated annealing and by a combinatorial algorithm. Critical exponents of the magnetization and the correlation length are estimated and conformal predictions are compared with numerical results.Comment: 7 pages, 6 figure

Cosmological Parameters Degeneracies and Non-Gaussian Halo Bias

We study the impact of the cosmological parameters uncertainties on the measurements of primordial non-Gaussianity through the large-scale non-Gaussian halo bias effect. While this is not expected to be an issue for the standard LCDM model, it may not be the case for more general models that modify the large-scale shape of the power spectrum. We consider the so-called local non-Gaussianity model and forecasts from planned surveys, alone and combined with a Planck CMB prior. In particular, we consider EUCLID- and LSST-like surveys and forecast the correlations among $f_{\rm NL}$ and the running of the spectral index $\alpha_s$, the dark energy equation of state $w$, the effective sound speed of dark energy perturbations $c^2_s$, the total mass of massive neutrinos $M_\nu=\sum m_\nu$, and the number of extra relativistic degrees of freedom $N_\nu^{rel}$. Neglecting CMB information on $f_{\rm NL}$ and scales $k > 0.03 h$/Mpc, we find that, if $N_\nu^{\rm rel}$ is assumed to be known, the uncertainty on cosmological parameters increases the error on $f_{\rm NL}$ by 10 to 30% depending on the survey. Thus the $f_{\rm NL}$ constraint is remarkable robust to cosmological model uncertainties. On the other hand, if $N_\nu^{\rm rel}$ is simultaneously constrained from the data, the $f_{\rm NL}$ error increases by $\sim 80$. Finally, future surveys which provide a large sample of galaxies or galaxy clusters over a volume comparable to the Hubble volume can measure primordial non-Gaussianity of the local form with a marginalized 1--$\sigma$ error of the order $\Delta f_{\rm NL} \sim 2-5$, after combination with CMB priors for the remaining cosmological parameters. These results are competitive with CMB bispectrum constraints achievable with an ideal CMB experiment.Comment: 17 pages, 1 figure added, typos corrected, comments added, matches the published versio

HI Observations of Giant Low Surface Brightness Galaxies

We have used the Nancay Radio Telescope to obtain new global HI data for 16 giant low surface brightness (LSB) galaxies. Our targets have optical luminosities and disk scale lengths at the high end for spiral galaxies (L_B~10^10 Lsun and h_r>~6 kpc for H_0=75 km/s/Mpc), but they have diffuse stellar disks, with mean disk surface brightnesses ~1 magnitude or more fainter than normal giant spirals. Thirteen of the galaxies previously had been detected in HI by other workers, but the published HI observations were either confused, resolved by the telescope beam, of low signal-to-noise, or showed significant discrepancies between different authors. For the other 3 galaxies, no HI data were previously available. Several of the galaxies were resolved by the Nancay 3.6' E-W beam, so global parameters were derived from multiple-point mapping observations. Typical HI masses for our sample are ~10^10 Msun, with M_HI/L_B=0.3-1.7 (in solar units). All of the observed galaxies have published optical surface photometry, and we have compiled key optical measurements for these objects from the literature. We frequently find significant variations among physical parameters of giant LSB galaxies reported by various workers.Comment: accepted to Astronomy and Astrophysics Supplements; 14 pages; improved table formattin

WINGS: a WIde-field Nearby Galaxy-cluster Survey. I - Optical imaging

This is the first paper of a series that will present data and scientific results from the WINGS project, a wide-field, multiwavelength imaging and spectroscopic survey of galaxies in 77 nearby clusters. The sample was extracted from the ROSAT catalogs with constraints on the redshift (0.0420). The global goal of the WINGS project is the systematic study of the local cosmic variance of the cluster population and of the properties of cluster galaxies as a function of cluster properties and local environment. This data collection will allow to define a local 'Zero-Point' reference against which to gauge the cosmic evolution when compared to more distant clusters. The core of the project consists of wide-field optical imaging of the selected clusters in the B and V bands. We have also completed a multi-fiber, medium resolution spectroscopic survey for 51 of the clusters in the master sample. In addition, a NIR (JK) survey of ~50 clusters and an H_alpha + UV survey of some 10 clusters are presently ongoing, while a very-wide-field optical survey has also been programmed. In this paper we briefly outline the global objectives and the main characteristics of the WINGS project. Moreover, the observing strategy and the data reduction of the optical imaging survey (WINGS-OPT) are presented. We have achieved a photometric accuracy of ~0.025mag, reaching completeness to V~23.5. Field size and resolution (FWHM) span the absolute intervals (1.6-2.7)Mpc and (0.7-1.7)kpc, respectively, depending on the redshift and on the seeing. This allows the planned studies to get a valuable description of the local properties of clusters and galaxies in clusters.Comment: 24 pages, 15 figures, Accepted by Astronomy and Astrophysic

The ABCD of usability testing

We introduce a methodology for tracking and auditing feedback, errors and suggestions for software packages. This short paper describes how we innovate on the evaluation mechanism, introducing an (Antecedent, Barrier, Consequence and Development) ABCD form, embedded within an eParticipation platform to enable end users to easily report on any usability issues. This methodology will be utilised to improve the STEP cloud eParticipation platform (part of the current STEP Horizon2020 project http://step4youth.eu. The platform is currently being piloted in real life contexts, with the participation of public authorities that are integrating the eParticipation platform into their regular decision-making practices. The project is involving young people, through engagement and motivation strategies and giving them a voice in Environmental decision making at the local level. The pilot evaluation aims to demonstrate how open engagement needs to be embedded within public sector processes and the usability methodology reported here will help to identify the key barriers for wide scale deployment of the platform

Ecological Invasion, Roughened Fronts, and a Competitor's Extreme Advance: Integrating Stochastic Spatial-Growth Models

Both community ecology and conservation biology seek further understanding of factors governing the advance of an invasive species. We model biological invasion as an individual-based, stochastic process on a two-dimensional landscape. An ecologically superior invader and a resident species compete for space preemptively. Our general model includes the basic contact process and a variant of the Eden model as special cases. We employ the concept of a "roughened" front to quantify effects of discreteness and stochasticity on invasion; we emphasize the probability distribution of the front-runner's relative position. That is, we analyze the location of the most advanced invader as the extreme deviation about the front's mean position. We find that a class of models with different assumptions about neighborhood interactions exhibit universal characteristics. That is, key features of the invasion dynamics span a class of models, independently of locally detailed demographic rules. Our results integrate theories of invasive spatial growth and generate novel hypotheses linking habitat or landscape size (length of the invading front) to invasion velocity, and to the relative position of the most advanced invader.Comment: The original publication is available at www.springerlink.com/content/8528v8563r7u2742

A Functional Signature Ontology (FUSION) screen detects an AMPK inhibitor with selective toxicity toward human colon tumor cells

AMPK is a serine threonine kinase composed of a heterotrimer of a catalytic, kinase-containing α and regulatory β and γ subunits. Here we show that individual AMPK subunit expression and requirement for survival varies across colon cancer cell lines. While AMPKα1 expression is relatively consistent across colon cancer cell lines, AMPKα1 depletion does not induce cell death. Conversely, AMPKα2 is expressed at variable levels in colon cancer cells. In high expressing SW480 and moderate expressing HCT116 colon cancer cells, siRNA-mediated depletion induces cell death. These data suggest that AMPK kinase inhibition may be a useful component of future therapeutic strategies. We used Functional Signature Ontology (FUSION) to screen a natural product library to identify compounds that were inhibitors of AMPK to test its potential for detecting small molecules with preferential toxicity toward human colon tumor cells. FUSION identified 5′-hydroxy-staurosporine, which competitively inhibits AMPK. Human colon cancer cell lines are notably more sensitive to 5′-hydroxy-staurosporine than are non-transformed human colon epithelial cells. This study serves as proof-of-concept for unbiased FUSION-based detection of small molecule inhibitors of therapeutic targets and highlights its potential to identify novel compounds for cancer therapy development

Interpreting large-scale redshift-space distortion measurements

The simplest theory describing large-scale redshift-space distortions (RSD), based on linear theory and distant galaxies, depends on the growth of cosmological structure, suggesting that strong tests of General Relativity can be constructed from galaxy surveys. As data sets become larger and the expected constraints more precise, the extent to which the RSD follow the simple theory needs to be assessed in order that we do not introduce systematic errors into the tests by introducing inaccurate simplifying assumptions. We study the impact of the sample geometry, non-linear processes, and biases induced by our lack of understanding of the radial galaxy distribution on RSD measurements. Using LasDamas simulations of the Sloan Digital Sky Survey II (SDSS-II) Luminous Red Galaxy (LRG) data, these effects are shown to be important at the level of 20 per cent. Including them, we can accurately model the recovered clustering in these mock catalogues on scales 30 -- 200 Mpc/h. Applying this analysis to robustly measure parameters describing the growth history of the Universe from the SDSS-II data, gives $f(z=0.25)\sigma_8(z=0.25)=0.3512\pm0.0583$ and $f(z=0.37)\sigma_8(z=0.37)=0.4602\pm0.0378$ when no prior is imposed on the growth-rate, and the background geometry is assumed to follow a $\Lambda$CDM model with the WMAP + SNIa priors. The standard WMAP constrained $\Lambda$CDM model with General Relativity predicts $f(z=0.25)\sigma_8(z=0.25)=0.4260\pm0.0141$ and $f(z=0.37)\sigma_8(z=0.37)=0.4367\pm0.0136$, which is fully consistent with these measurements.Comment: 20 pages, 17 figures, 1 tabl

‘Working with the media taught us a lot’: Understanding The Guardian’s Katine initiative

One of the more important ventures in the world of media and development over the past decade has been The Guardian newspaper’s ‘Katine’ project in Uganda. The newspaper, with funding from its readers and Barclays Bank, put more than 2.5 million pounds into a Ugandan sub-county over the course of 4 years. The project was profiled on a dedicated Guardian microsite, with regular updates in the printed edition of the newspaper. In this article, I look at the relationship that developed between journalists and the non-governmental organisation and show that the experience was both disorienting and reorienting for the development project that was being implemented. The scrutiny of the project that appeared on the microsite disoriented the non-governmental organisation, making its work the subject of public criticism. The particular issues explored by journalists also reoriented what the non-governmental organisation did on the ground. I also point to the ways the relationship grew more settled as the project moved along, suggesting the amount of work that sometimes goes into what is often characterised as the relatively uncritical relationship between journalists and non-governmental organisations