Cianofitas de los sistemas fluvio-lagunares Pom-Atasta y Palizada del Este, adyacentes a la Laguna de Términos, Campeche, México

Las cianofitas son un grupo muy diverso de microorganismos procariontes fotosintetizadores, con una amplia distribución en diferentes ambientes tanto terrestres como acuáticos. Algunas especies pueden formar florecimientos algales nocivos o tóxicos. El objetivo de este estudio consistió en identificar la composición de las especies de cianofitas en los sistemas fluvio-lagunares Pom-Atasta (PA) y Palizada del Este (PE). Se recolectaron muestras de agua tanto en superficie como medio fondo para cada laguna, en febrero del 2011, en 10 sitios utilizando una botella van Dorn. Se identificaron 21 taxones, de las cuales siete especies forman florecimientos algales como: Pseudanabaena catenata, P. limnetica, Anabaenopsis circularis, A. elenkinii, Aphanizomenon cf. ovalisporum, Ap. schindleri y Dolichospermum circinalis. Además, se reportan dos nuevos registros correspondientes a Aphanizomenon cf. ovalisporum y Ap. schindleri

7th Drug hypersensitivity meeting: part two

No abstract availabl

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus

A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P=9.2 × 10-20), ER-negative BC (P=1.1 × 10-13), BRCA1-associated BC (P=7.7 × 10-16) and triple negative BC (P-diff=2 × 10-5). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (P=2 × 10-3) and ABHD8 (P<2 × 10-3). Chromosome conformation capture identifies interactions between four candidate SNPs and ABHD8, and luciferase assays indicate six risk alleles increased transactivation of the ADHD8 promoter. Targeted deletion of a region containing risk SNP rs56069439 in a putative enhancer induces ANKLE1 downregulation; and mRNA stability assays indicate functional effects for an ANKLE1 3′-UTR SNP. Altogether, these data suggest that multiple SNPs at 19p13 regulate ABHD8 and perhaps ANKLE1 expression, and indicate common mechanisms underlying breast and ovarian cancer risk

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

A global research priority agenda to advance public health responses to fatty liver disease

Background & aims An estimated 38% of adults worldwide have non-alcoholic fatty liver disease (NAFLD). From individual impacts to widespread public health and economic consequences, the implications of this disease are profound. This study aimed to develop an aligned, prioritised fatty liver disease research agenda for the global health community. Methods Nine co-chairs drafted initial research priorities, subsequently reviewed by 40 core authors and debated during a three-day in-person meeting. Following a Delphi methodology, over two rounds, a large panel (R1 n = 344, R2 n = 288) reviewed the priorities, via Qualtrics XM, indicating agreement using a four-point Likert-scale and providing written feedback. The core group revised the draft priorities between rounds. In R2, panellists also ranked the priorities within six domains: epidemiology, models of care, treatment and care, education and awareness, patient and community perspectives, and leadership and public health policy. Results The consensus-built fatty liver disease research agenda encompasses 28 priorities. The mean percentage of ‘agree’ responses increased from 78.3 in R1 to 81.1 in R2. Five priorities received unanimous combined agreement (‘agree’ + ‘somewhat agree’); the remaining 23 priorities had >90% combined agreement. While all but one of the priorities exhibited at least a super-majority of agreement (>66.7% ‘agree’), 13 priorities had 90% combined agreement. Conclusions Adopting this multidisciplinary consensus-built research priorities agenda can deliver a step-change in addressing fatty liver disease, mitigating against its individual and societal harms and proactively altering its natural history through prevention, identification, treatment, and care. This agenda should catalyse the global health community’s efforts to advance and accelerate responses to this widespread and fast-growing public health threat. Impact and implications An estimated 38% of adults and 13% of children and adolescents worldwide have fatty liver disease, making it the most prevalent liver disease in history. Despite substantial scientific progress in the past three decades, the burden continues to grow, with an urgent need to advance understanding of how to prevent, manage, and treat the disease. Through a global consensus process, a multidisciplinary group agreed on 28 research priorities covering a broad range of themes, from disease burden, treatment, and health system responses to awareness and policy. The findings have relevance for clinical and non-clinical researchers as well as funders working on fatty liver disease and non-communicable diseases more broadly, setting out a prioritised, ranked research agenda for turning the tide on this fast-growing public health threat

Phytoplankton of the Sontecomapan lagoon, Veracruz, Mexico

Phytoplankton plays a key role in aquatic ecosytems as an oxygen producer, a CO2 trap, a primary source of food in trophic chains and as an indicator of changes in the environment. However, despite this positive importance, it can also develop into harmful algal blooms. With the aim of increasing knowledge about this group of microorganisms in Mexican aquatic ecosystems, a list of the phytoplankton species of the Sontecomapan Lagoon was made indicating those that potentially can provoke red tides. Besides, the distribution and abundance of these species was studied in two seasons, the rainy one (June, 2015) and the dry one (February, 2016) on eight sampling stations. Phytoplankton samples were collected with a Van Dorn bottle to measure environmental factors (transparency, salinity, temperature, pH and dissolved oxygen). A list with 357 species with a clear dominance of diatoms (67.8%) and dinoflagellates (20.16%) was obtained from literature review and materials derived from this study. Among them, 19.88% can potentially from red tides, and some of them are toxic. From the sample collected, 102 species of phytoplankton were recorded; 42 of them during the rainy season, 65 during the dry one and 7 présents in both. Among these species, 17 can potentially form red tides and from these, only two can be toxic for humans : Dinophysis caudata and Lyngbya majuscula. The cluster analysis of the environmental factors showed the formation of four groups in the rainy season and three in the dry season, associated to teh salinity gradients

Cianofitas de los sistemas fluvio-lagunares Pom-Atasta y Palizada del Este, adyacentes a la Laguna de T\ue9rminos, Campeche, M\ue9xico

The cyanophyta are a diverse group prokaryotic photosynthetic microorganisms, distributed in different terrestrial and aquatic environments. Some species of cyanophyta, can form toxic or harmful algal bloom. The objective of this study was to identify the species composition of cyanophyta in fluvio-lagoon systems Pom-Atasta (PA) and East Palisade (PE). Water samples were collected in ten sampling sites in each lagoon, with a van Dorn bottle at the surface and in the middle of the water column, in February, 2011. Twenty one were identified, of which seven species are bloom-forming as: Pseudanabaena catenata, P. limnetica, Anabaenopsis circularis, A. elenkinii, Aphanizomenon cf. ovalisporum, Ap. schindleri and Dolichospermum circinalis. Also, two new records reported: Aphanizomenon cf. ovalisporum y A. schindleri.Las cianofitas son un grupo muy diverso de microorganismos procariontes fotosintetizadores, con una amplia distribución en diferentes ambientes tanto terrestres como acuáticos. Algunas especies pueden formar florecimientos algales nocivos o tóxicos. El objetivo de este estudio consistió en identificar la composición de las especies de cianofitas en los sistemas fluvio-lagunares Pom-Atasta (PA) y Palizada del Este (PE). Se recolectaron muestras de agua tanto en superficie como medio fondo para cada laguna, en febrero del 2011, en 10 sitios utilizando una botella van Dorn. Se identificaron 21 taxones, de las cuales siete especies forman florecimientos algales como: Pseudanabaena catenata, P. limnetica, Anabaenopsis circularis, A. elenkinii, Aphanizomenon cf. ovalisporum, Ap. schindleri y Dolichospermum circinalis. Además, se reportan dos nuevos registros correspondientes a Aphanizomenon cf. ovalisporum y A. schindleri

Ecology of the Sontecomapan lagoon, Veracruz

Nitrogen fixation and denitrification are processes poorly studied in Mexican coastal lagoons. In this study the N incorporation and loss rates of the bottom water and sediments were analyzed in six zones of Sontecomapan lagoon during "Nortes" and rainy seasons and their relation with the rivers outflows and the coastal marine waters entrance. The rate of N2 fixation was calculated through acetylene reduction and the denitrification through N2O production techniques. The N2 fixation was lower than the nitrogen loss as N2O production (denitrification). The greatest fixation rate was registered in the "Nortes" season ; being favorated by oxic conditions and high organic matter concentrations in the sediments. In the rainy season, the N2 fixation was lowered by 80% compared to the "Nortes" season. Denitrification was favored by low salinities in November and was 23% higher than in February, 2005. In the rainy season the nitrous oxide production was related to the high N-NO3 - concentrations and decreased by 18% when the salinity increased from 13 to 22 PSU

Bacterial community contribution to nitrogen fixation and nitrous oxides production in the Sontecomapan lagoon

Tropical coastal lagoon environments provide a number of ecosystem services, but are threatened by the pressure lmposed by human activities and climatic change; these systems are particularly vulnerable because of a high demographic growth. Therefore, the understanding of their ecological behavior and the characterization of lagoon health indicators have attained importance. Under thls perspective Mexican (UAM-Xl and French (UMRs MIO and MARBEC) researchers have collaborated from 2011 to 2014 as part of one action of the international exchange program ECOS/ANUIES, and chose the Sontecomapan lagoon (at the Mexican state of Veracruz) as a case study.This book provides information of the ecological behavior, water quality indicators, and details of microorganisms and plankton, which due to their short life cycles and their high reactivity to environmental conditions are good indicators of ecological changes. The equilibria of benthic and pelagic compartments and their interaction are other important elements in this shallow environment. The nature, magnitude and effects of human-related activities also have been considered in order to understand the possible evolution of the ecosystem's behavior to evaluate its capacity for resilience and gives some hints on rehabilitation actions