Diastereoselective and catalytic α-alkylation of chiral N-acyl thiazolidinethiones with stable carbocationic salts

Direct nickel-catalyzed alkylation of chiral N-acyl-4-isopropyl-1,3-thiazolidine-2-thiones using a commercially available nickel(II) complex, (Me3P)2NiCl2, has been developed for tropylium and trityl tetrafluoroborate salts. The reaction provides a single diastereomer of the corresponding adducts in good to high yields, which, in turn, can be easily converted into a wide array of enantiomerically pure compounds that are difficult to obtain by other asymmetric procedures

Etiology and susceptbility to antimicrobials of urinary tract infections in patients of Rehabilitation Unit of a regional hospital

Objetivos: Conocer los resultados del estudio microbiológico de las muestras de orina de pacientes de la Unidad de Rehabilitación de un hospital regional, incluyendo los datos locales de sensibilidad antibiótica. Material y métodos: Se analizó la base de datos del Laboratorio de Microbiología del Hospital Universitario Virgen de las Nieves con los estudios microbiológicos de las muestras de orinas realizados durante el año 2012. Se investigó la etiología y la sensibilidad a los antibióticos de los uropatógenos más frecuentes presentes en 143 muestras de orina obtenidas mediante sondaje o cateterismo. Los resultados del estudio de 9066 muestras de orina de micción media de sujetos estudiados en Atención Primaria fueron utilizados como grupo control. Resultados: El 50% de los pacientes neurológicos presentaron urocultivos positivos, frente al 23% de los controles. E. coli fue el microorganismo más frecuentemente aislado en el grupo de enfermos neurológicos, al igual que en los controles. En el estudio de resistencias E. coli presentó altas tasas de resistencia a ampicilina, cotrimoxazol, ciprofloxacino y amoxicilina con ácido clavulánico. Conclusiones: E. coli es el microorganismo más frecuentemente aislado en los dos grupos de pacientes estudiados. Las resistencias a los antibióticos de los microorganismos procedentes de los dos grupos tienen patrones diferentes, siendo globalmente menor a fosfomicina.Objectives: Knowing the results of microbiological tests of urine samples of patients from the Rehabilitation Unit of a regional hospital, including local data of antibiotic susceptibility. Material and methods: We analyzed the database of the Microbiology Laboratory of the Hospital Universitario Virgen de las Nieves with microbiological studies conducted urine samples during 2012. We investigated the etiology and antimicrobial susceptibility of uropathogens frequently present in 143 urine samples. The 9066 survey results voiding urine mean in Primary Care study subjects were used as controls. Results: The 50% of neurological patients had positive urine cultures, versus 23% of controls. E. coli was the most frequently isolated organism group neurological patients, as in the controls. Resistance studies in E. coli showed high rates of resistance to ampicillin, cotrimoxazole, ciprofloxacin and amoxicillin with clavulanic acid. Conclusions: E. coli is the most frequently isolated microorganism in both groups of patients studied. The antibiotic resistance of microorganisms from the two groups have different patterns, being globally less to fosfomycin

Pharmacological Alterations of Anxious Behaviour in Mice Depending on Both Strain and the Behavioural Situation

A previous study comparing non-emotive mice from the strain C57BL/6/ByJ with ABP/Le mice showed ABP/Le to be more anxious in an open-field situation. In the present study, several compounds affecting anxiety were assayed on ABP/Le and C57BL/6/ByJ mice using three behavioural models of anxiety: the elevated plus-maze, the light-dark discrimination test and the free exploratory paradigm. The compounds used were the full benzodiazepine receptor agonist, chlordiazepoxide, and the antagonist, flumazenil, the GABAA antagonist, bicuculline, the full 5-HT1A agonist 8-OH-DPAT, and the mixed 5-HT1A/5-HT1B agonist, RU 24969. Results showed the effect of the compounds to be dependent on both the strain and the behavioural task. Several compounds found to be anxiolytic in ABP/Le mice had an anxiogenic effect on C57BL/6/ByJ mice. More behavioural changes were observed for ABP/Le in the elevated plus-maze, but the clearest findings for C57BL/6/ByJ mice were observed in the light-dark discrimination apparatus. These data demonstrate that anxious behaviour is a complex phenomenon which cannot be described by a single behavioural task nor by the action of a single compound

The Strategies of the Spanish cotton textile companies before the Civil War: the road to longevity

This study, based on family business theories, offers an innovative vision of the Spanish cotton industry. It proves that Spanish cotton companies, just like their European counterparts, implemented a strategy that was consistent with their nature as family businesses and went beyond the economic-institutional frames within which they developed. The article identifies this strategy as `conservative, because its main objectives were longevity and family control and because it was based on a high percentage of own resources, low levels of indebtedness and organic growth, thus sacrificing profitability for the sake of security.Universidad Pablo de OlavidePostprin

Minerales 'exóticos' en cromititas ofiolíticas. Implicaciones para la geodinámica mantélica

Los depósitos ofiolíticos de cromita constituyen un rasgo característico de la secuencia mantélica de las ofiolitas (González-Jiménez et al., 2014 y referencias en éste). Los cuerpos de cromititas se encuentran en dunitas y harzburgitas distribuyéndose a lo largo de una zona de espesor variable, entre 1 y 2 km, debajo de los niveles de gabros bandeados de la corteza inferior oceánica. El origen de cuerpos monominerálicos de cromita en el manto, especialmente el mecanismo de concentración de cromita y el ambiente tectónico de formación, continúa siendo un tema sujeto a debate (e.g., Proenza et al., 1999; González-Jiménez et al., 2014). A tal efecto, se han propuesto hipótesis basadas en: i) cristalización cotéctica de cromita+olivino y su posterior separación mecánica; ii) procesos de mezcla o contaminación de magmas; iii) asimilación de piroxenitas y gabros; iv) aumento del grado de polimerización del fundido debido a la pérdida de agua; v) cambios en la fugacidad de oxígeno. Todas estas hipótesis asumen procesos a baja presión en el manto (<20 km profundidad)

The LifeCycle Project-EU Child Cohort Network : a federated analysis infrastructure and harmonized data of more than 250,000 children and parents

Early life is an important window of opportunity to improve health across the full lifecycle. An accumulating body of evidence suggests that exposure to adverse stressors during early life leads to developmental adaptations, which subsequently affect disease risk in later life. Also, geographical, socio-economic, and ethnic differences are related to health inequalities from early life onwards. To address these important public health challenges, many European pregnancy and childhood cohorts have been established over the last 30 years. The enormous wealth of data of these cohorts has led to important new biological insights and important impact for health from early life onwards. The impact of these cohorts and their data could be further increased by combining data from different cohorts. Combining data will lead to the possibility of identifying smaller effect estimates, and the opportunity to better identify risk groups and risk factors leading to disease across the lifecycle across countries. Also, it enables research on better causal understanding and modelling of life course health trajectories. The EU Child Cohort Network, established by the Horizon2020-funded LifeCycle Project, brings together nineteen pregnancy and childhood cohorts, together including more than 250,000 children and their parents. A large set of variables has been harmonised and standardized across these cohorts. The harmonized data are kept within each institution and can be accessed by external researchers through a shared federated data analysis platform using the R-based platform DataSHIELD, which takes relevant national and international data regulations into account. The EU Child Cohort Network has an open character. All protocols for data harmonization and setting up the data analysis platform are available online. The EU Child Cohort Network creates great opportunities for researchers to use data from different cohorts, during and beyond the LifeCycle Project duration. It also provides a novel model for collaborative research in large research infrastructures with individual-level data. The LifeCycle Project will translate results from research using the EU Child Cohort Network into recommendations for targeted prevention strategies to improve health trajectories for current and future generations by optimizing their earliest phases of life.Peer reviewe

Les col·leccions de mineralogia de la UB. Una eina d'aprenentatge i de participació dels estudiants

Les col·leccions de Mineralogia de la Universitat de Barcelona poden ser de litoteca (emprades en l'ensenyament presencial i no presencial) i sistemàtica (usades com a material de referència de recerca). Comprenen mostres de mà, làmines primes i probetes. Les col leccions de referència son controlades per estudiants, els quals comproven la identitat del mineral i en fan la catalogació. Així s'introdueix els estudiants en les tècniques de caracterització i en les tècniques de musealització

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

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