Fabrication and characterization of magnetic thin films and multilayers

135 p.Los objetivos principales de esta tesis han sido por un lado la fabricación de películas y multicapas magnéticas de alta calidad y con alta reproducibilidad a la nanoescala y, por otro lado, la comprensión y modelización de los fenómenos magnéticos a dicha escala. En la primera parte se han estudiado las propiedades magnéticas de películas epitaxiales de aleaciones de cobalto y cromo, y sus dependencias con la composición y temperatura. Dichas muestras presentan una composición que posee un perfil de profundidad similar al de una ¿bañera¿. El estudio muestra que las propiedades magnéticas varían en función de la profundidad, siguiendo el perfil de la composición de cromo. En la segunda parte, se ha estudiado el proceso de inversión de la magnetización en función de la temperatura y del ángulo de aplicación del campo magnético externo en muestras de cobalto y cobalto-rutenio. Detalladas simulaciones micromagnéticas han complementado los resultados experimentales y han permitido la identificación de tres fases magnéticas diferentes cuyo punto de coexistencia es tricrítico en su naturaleza. En la última parte, se ha demostrado la inversión de la magnetización de superficie por medio del campo magnético en capas finas de Cr2O3, descubriendo una dependencia gigante con la temperatura del campo coercitivo. Este efecto resultaría óptimo para la técnica de grabación magnética asistida por calor. Además, hemos investigado películas epitaxiales de Cr2-xAlxO3, observando que la temperatura crítica se puede modificar mediante la aleación de Al2O3 utilizando la magnetización de superficie como una sonda para estudiar la transición de fase antiferromagnética.CICnanoGun

Giant temperature dependence of the spin reversal field in magnetoelectric chromia

Magnetic field-induced reversal of surface spin polarization for the magnetoelectric antiferromagnet chromia is studied via magnetometry in (0001)-textured thin films of various thicknesses. Reversal solely by magnetic means has been experimentally evidenced in sufficiently thin films. It sets the field-response of chromia films apart from bulk behavior, where switching between time-reversed single domain states requires the simultaneous presence of electric and magnetic fields. In our detailed experiments, we furthermore observe a giant sensitivity of the coercive field on temperature, thus, indicating the potential of magnetoelectric antiferromagnets as promising candidates for energy assisted magnetic recording media

Magnetic field induced switching of the antiferromagnetic order parameter in thin films of magnetoelectric chromia

A Landau-theoretical approach is utilized to model the magnetic field induced reversal of the antiferromagnetic order parameter in thin films of magnetoelectric antiferromagnets. A key ingredient of this peculiar switching phenomenon is the presence of a robust spin polarized state at the surface of the antiferromagnetic films. Surface or boundary magnetization is symmetry allowed in magnetoelectric antiferromagnets and experimentally established for chromia thin films. It couples rigidly to the antiferromagnetic order parameter and its Zeeman energy creates a pathway to switch the antiferromagnet via magnetic field application. In the framework of a minimalist Landau free energy expansion, the temperature dependence of the switching field and the field dependence of the transition width are derived. Least-squares fits to magnetometry data of (0001) textured chromia thin films strongly support this model of the magnetic reversal mechanism

Boundary magnetization properties of epitaxial Cr2−xAlxO3 thin films

The magnetoelectric antiferromagnet α-Cr2O3 (chromia) is known to possess a roughness insensitive net equilibrium magnetization at the (0001) surface, called boundary magnetization (BM), which is coupled to the bulk antiferromagnetic order parameter. In order to verify whether this symmetry sensitive BM persists in alloys, we investigate the impact of diamagnetic dilution on chromia thin films alloyed with the isostructural α-Al2O3 (alumina). Single-crystalline Cr2−xAlxO3 thin films with (0001) surface orientation and varying stoichiometry have been grown by sputter codeposition in the concentration range between x = 0 and x = 0.6. For these samples, we find the corundum crystal structure, the antiferromagnetic ordering, and the boundary magnetization to be preserved. We also find that the critical temperature TN can be tuned by alloying with α-Al2O3, using the BM as a probe to study the magnetic phase transition. Furthermore, we were able to evaluate the critical exponent and the absolute BM values for different samples. Both properties corroborate that the observed magnetic signals originate from the BM rather than the bulk of the samples

The proteasome inhibitor bortezomib controls indoleamine 2,3-dioxygenase 1 breakdown and restores immune regulation in autoimmune diabetes

Bortezomib (BTZ) is a first-in-class proteasome inhibitor approved for the therapy of multiple myeloma that also displays unique regulatory activities on immune cells. The enzyme indoleamine 2,3-dioxygenase 1 (IDO1) is a tryptophan metabolizing enzyme exerting potent immunoregulatory effects when expressed in dendritic cells (DCs), the most potent antigen-presenting cells capable of promoting either immunity or tolerance. We previously demonstrated that, in inflammatory conditions, IDO1 is subjected to proteasomal degradation in DCs, turning these cells from immunoregulatory to immunostimulatory. In non-obese diabetic (NOD) mice, an experimental model of autoimmune diabetes, we also identified an IDO1 defect such that the DCs do not develop tolerance toward pancreatic islet autoantigens. We found that BTZ rescues IDO1 protein expression in vitro in a particular subset of DCs, i.e., plasmacytoid DCs (pDCs) from NOD mice. When administered in vivo to prediabetic mice, the drug prevented diabetes onset through IDO1- and pDC-dependent mechanisms. Although the drug showed no therapeutic activity when administered alone to overtly diabetic mice, its combination with otherwise suboptimal dosages of autoimmune-preventive anti-CD3 antibody resulted in disease reversal in 70% diabetic mice, a therapeutic effect similar to that afforded by full-dosage anti-CD3. Thus, our data indicate a potential for BTZ in the immunotherapy of autoimmune diabetes and further underline the importance of IDO1-mediated immune regulation in such disease

Giant temperature dependence of the spin reversal field in magnetoelectric chromia

Magnetic field-induced reversal of surface spin polarization for the magnetoelectric antiferromagnet chromia is studied via magnetometry in (0001)-textured thin films of various thicknesses. Reversal solely by magnetic means has been experimentally evidenced in sufficiently thin films. It sets the field-response of chromia films apart from bulk behavior, where switching between time-reversed single domain states requires the simultaneous presence of electric and magnetic fields. In our detailed experiments, we furthermore observe a giant sensitivity of the coercive field on temperature, thus, indicating the potential of magnetoelectric antiferromagnets as promising candidates for energy assisted magnetic recording media

Short-term effects of glucagon-like peptide 1 (GLP-1) receptor agonists on fat distribution in patients with type 2 diabetes mellitus: an ultrasonography study

AIMS:Glucagon-like peptide 1 receptor agonists (GLP-1 RA) induce weight loss and reduction in adipose tissue, but the effects of GLP-1 RA on the distribution of fat deposits have been poorly investigated. METHODS: In 25 patients with type 2 diabetes (16 females and 9 males, mean age 63.5 ± 8.8 years), treated with GLP-1 RA (exenatide, n. 12; liraglutide, n.13), both before and 3 months after starting treatment, an abdominal ultrasonographic scan, with Doppler of renal arteries, and echocardiography were performed. Subcutaneous fat width (peri-umbilical and sub-xiphoid), deep fat deposits (pre-aortic, peri-renal, and epicardial), and renal resistive index (RI) were evaluated. RESULTS: GLP-1 RA induced highly significant (p < 0.001) decrease in BMI and in fat thickness at all the assessed sites, without differences between exenatide and liraglutide treatment. A slight decrease in RI (p = 0.055) was also found. The percent changes of fat thickness was different between sites (p < 0.025), and the changes in subcutaneous deposits showed no significant correlation (p = 0.064) with those of deep fat deposits. CONCLUSIONS: A short course of treatment with GLP-1 RA, besides weight loss, induces a redistribution of adipose tissue deposits, possibly contributing to a better cardiovascular risk profile in patients with type 2 diabetes mellitus