153 research outputs found
L'Homme face à son environnement : une histoire génétique et épigénétique du génome humain
Human populations have faced a large number of environmental challenges during their evolutionary history and present today a wide range of habitats and mode of subsistence. However, the extent of genetic adaptation and epigenetic responses to such environmental variation remains controversial. We first explored the power of several statistics to detect hard selective sweeps in the context of whole-genome sequencing data, and evaluated their robustness to demography and other selection modes. Using data from the 1,000 Genomes Project and Complete Genomics, we showed that hard sweeps targeting low-frequency standing variation have played a moderate, albeit significant, role in recent human evolution. The signals of selection detected were moreover enriched in functional variants detected by genome-wide association studies. We then evaluated the relative impacts of genetic and environmental factors on human epigenomic diversity. To do so, we generated genome-wide genetic and DNA methylation profiles for Central African populations differing in their current habitat or in their historical lifestyle and genetic background. We found that both factors have similar critical impacts on the shaping of the global methylome, but the biological functions affected and the mechanisms underlying DNA methylation variation strongly differ. More generally, methylation variation shows strong associations with nearby genetic variants that, moreover, are enriched in signals of natural selection. Together, this work provides new insight into the contribution of genetic adaptation and epigenetic responses to the adaptation of humans to environmental changes over different time scales.Les populations humaines ont été confrontées à de nombreux changements environnementaux au cours de leur histoire et présentent aujourd’hui une grande diversité d’habitats et de modes de subsistance. Cependant, l’ampleur de l’adaptation génétique et des réponses épigénétiques à ces changements est débattue. Nous avons d’abord étudié la puissance de diverses statistiques pour détecter les balayages sélectifs dans le contexte des données de séquençage à haut débit, et évalué leur robustesse à différents facteurs confondants. En utilisant des jeux de données de séquençage, nous montrons que les balayages sélectifs ont eu un impact modéré mais non négligeable dans l’évolution récente du génome humain. Les régions sous sélection sont enrichies en mutations associées à des variations phénotypiques. Nous avons ensuite évalué l’impact respectif des facteurs génétiques et environnementaux sur la diversité épigénétique humaine. Pour cela, nous avons obtenu les génotypes et les profiles de méthylation de l’ADN de populations d’Afrique Centrale présentant des différences récentes d’habitat ou historiques de modes de vie et de profil génétique. Nous montrons que les deux facteurs ont un effet similaire sur le méthylome mais diffèrent par les fonctions biologiques affectées et les mécanismes expliquant les variations observées. Plus généralement, les variations de méthylation sont fortement associées à des mutations génétiques qui sont enrichies en signaux de sélection positive. En conclusion, ce travail apporte un aperçu de la contribution des mutations génétiques et des réponses épigénétiques à l’adaptation humaine aux changements environnementaux sur plusieurs échelles de temps
Los juegos verbales y su incidencia en el desarrollo del lenguaje oral, en los niños y niñas de 1º año de educación básica de la Academia Aeronáutica Mayor Pedro Traversari, de la ciudad de Quito, en el año lectivo 2010-2011.
Los juegos verbales permiten desarrollar la función lúdica y creativa del lenguaje oral, como también la conciencia lingüística, sus características progresivas en los diferentes niveles de edad y a su entorno social. Los niños que crecen rodeados y estimulados lingüísticamente por sus hermanos, o a quienes sus padres les han hablado aun antes de que puedan comprender el sentido de las palabras, aprenden fácilmente a hablar. Mediante rondas, cantos, adivinanzas y trabalenguas se estimula la capacidad intelectual de los niños y fortalecen el vínculo afectivo con sus padres. De esa forma la familia cumple una función importante en la aparición y en el ritmo del desarrollo del lenguaje oral del niño. Si éste se siente emocionalmente seguro y lingüísticamente estimulado, se desarrollará normal y óptimamente su expresión verbal.The games allow the development of verbal fun and creative role of oral language, as well as linguistic awareness, progressive features at different levels of age and social environment. Children who grow up surrounded and linguistically challenged by his brothers, or whose parents have talked about even before they can understand the meaning of words, learn to speak easily. By rounds, songs, riddles and tongue twisters stimulates the intellectual capacity of children and strengthen the bond with their parents. That way the family plays an important role in the onset and pace of oral language development of children. If he feels emotionally safe and linguistically stimulated, normal and optimally develop their verbal expression
The epigenomic landscape of African rainforest hunter-gatherers and farmers
International audienceThe genetic history of African populations is increasingly well documented, yet their patterns of epigenomic variation remain uncharacterized. Moreover, the relative impacts of DNA sequence variation and temporal changes in lifestyle and habitat on the human epigenome remain unknown. Here we generate genome-wide genotype and DNA methylation profiles for 362 rainforest hunter-gatherers and sedentary farmers. We find that the current habitat and historical lifestyle of a population have similarly critical impacts on the methylome, but the biological functions affected strongly differ. Specifically, methylation variation associated with recent changes in habitat mostly concerns immune and cellular functions, whereas that associated with historical lifestyle affects developmental processes. Furthermore, methylation variation—particularly that correlated with historical lifestyle—shows strong associations with nearby genetic variants that, moreover, are enriched in signals of natural selection. Our work provides new insight into the genetic and environmental factors affecting the epigenomic landscape of human populations over time
Ergänzungen zur iberischen Pseudoscorpioniden-Fauna
Die systematischen Aufsammlungen, die Prof. Dr. H. Franz in
den letzten Jahren in weiten Teilen der iberischen Halbinsel durchführte,
schliessen weitgehend die Lücken, die bisher noch zwischen
den explorierten Gebieten klafften. Sie ergänzen und berichtigen daher
unsere bisherigen, von mir letztmals 1955 (Eos, XXXI, pp. 87-122)
zusammengefassten Kenntnisse in taxonomischer und faunistischer
Hinsicht und runden das Faunenbild auch tiergeographisch zu erfreulicher
Vollständigkeit ab. Die Ausbeuten enthielten wiederum 8 neue
Arten beziehungsweise Unterarten. Drei weitere Arten waren für
Spanien neu. In den cantabrischen Gebirgen tritt nunmehr die Gattung
Microcreagris als charakteristisches Faunenelement noch stärker hervor.—
Im folgenden werden die seither gemachten Funde angeführt.Peer reviewe
The single-cell eQTLGen consortium
In recent years, functional genomics approaches combining genetic information with bulk RNA-sequencing data have identified the downstream expression effects of disease-associated genetic risk factors through so-called expression quantitative trait locus (eQTL) analysis. Single-cell RNA-sequencing creates enormous opportunities for mapping eQTLs across different cell types and in dynamic processes, many of which are obscured when using bulk methods. Rapid increase in throughput and reduction in cost per cell now allow this technology to be applied to large-scale population genetics studies. To fully leverage these emerging data resources, we have founded the single-cell eQTLGen consortium (sc-eQTLGen), aimed at pinpointing the cellular contexts in which disease-causing genetic variants affect gene expression. Here, we outline the goals, approach and potential utility of the sc-eQTLGen consortium. We also provide a set of study design considerations for future single-cell eQTL studies.</p
Genome-wide scans identify known and novel regions associated with prolificacy and reproduction traits in a sub-Saharan African indigenous sheep (Ovis aries)
Maximizing the number of offspring born per female is a key functionality trait in commercial- and/or subsistence-oriented livestock enterprises. Although the number of offspring born is closely associated with female fertility and reproductive success, the genetic control of these traits remains poorly understood in sub-Saharan Africa livestock. Using selection signature analysis performed on Ovine HD BeadChip data from the prolific Bonga sheep in Ethiopia, 41 candidate regions under selection were identified. The analysis revealed one strong selection signature on a candidate region on chromosome X spanning BMP15, suggesting this to be the primary candidate prolificacy gene in the breed. The analysis also identified several candidate regions spanning genes not reported before in prolific sheep but underlying fertility and reproduction in other species. The genes associated with female reproduction traits included SPOCK1 (age at first oestrus), GPR173 (mediator of ovarian cyclicity), HB-EGF (signalling early pregnancy success) and SMARCAL1 and HMGN3a (regulate gene expression during embryogenesis). The genes involved in male reproduction were FOXJ1 (sperm function and successful fertilization) and NME5 (spermatogenesis). We also observed genes such as PKD2L2, MAGED1 and KDM3B, which have been associated with diverse fertility traits in both sexes of other species. The results confirm the complexity of the genetic mechanisms underlying reproduction while suggesting that prolificacy in the Bonga sheep, and possibly African indigenous sheep is partly under the control of BMP15 while other genes that enhance male and female fertility are essential for reproductive fitness
Uncovering the multifaceted roles played by neutrophils in allogeneic hematopoietic stem cell transplantation
Allogeneic hematopoietic stem cell transplantation (alloHSCT) is a life-saving procedure used for the treatment of selected hematological malignancies, inborn errors of metabolism, and bone marrow failures. The role of neutrophils in alloHSCT has been traditionally evaluated only in the context of their ability to act as a first line of defense against infection. However, recent evidence has highlighted neutrophils as key effectors of innate and adaptive immune responses through a wide array of newly discovered functions. Accordingly, neutrophils are emerging as highly versatile cells that are able to acquire different, often opposite, functional capacities depending on the microenvironment and their differentiation status. Herein, we review the current knowledge on the multiple functions that neutrophils exhibit through the different stages of alloHSCT, from the hematopoietic stem cell (HSC) mobilization in the donor to the immunological reconstitution that occurs in the recipient following HSC infusion. We also discuss the influence exerted on neutrophils by the immunosuppressive drugs delivered in the course of alloHSCT as part of graft-versus-host disease (GVHD) prophylaxis. Finally, the potential involvement of neutrophils in alloHSCT-related complications, such as transplant-associated thrombotic microangiopathy (TA-TMA), acute and chronic GVHD, and cytomegalovirus (CMV) reactivation, is also discussed. Based on the data reviewed herein, the role played by neutrophils in alloHSCT is far greater than a simple antimicrobial role. However, much remains to be investigated in terms of the potential functions that neutrophils might exert during a highly complex procedure such as alloHSCT
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