Perfectionism and attitudes toward cognitive enhancers (“smart drugs”)

Perfectionism is a personality disposition characterized by exceedingly high standards of performance and pressure to be perfect which may incline students to take cognitive enhancers (“smart drugs”) to boost their academic performance. So far, however, no study has investigated the relationships of multidimensional perfectionism and attitudes toward cognitive enhancers. The present study investigated these relationships in 272 university students examining different dimensions of perfectionism. Results showed that socially prescribed perfectionism, perfectionist concerns and doubts, and perceived parental pressure to be perfect showed positive correlations with attitudes favoring the use of cognitive enhancers. In contrast, self-oriented perfectionism, perfectionist personal standards, and organization showed negative correlations. The findings suggest that perfectionism may play a role as both a risk factor for and a protective factor against using cognitive enhancers depending on what dimensions of perfectionism are regarded

The application of implementation science for pressure ulcer prevention best practices in an inpatient spinal cord injury rehabilitation program

To implement pressure ulcer (PU) prevention best practices in spinal cord injury (SCI) rehabilitation using implementation science frameworks

Targeted prevention of common mental health disorders in university students: randomised controlled trial of a transdiagnostic trait-focused web-based intervention

Background: A large proportion of university students show symptoms of common mental disorders, such as depression, anxiety, substance use disorders and eating disorders. Novel interventions are required that target underlying factors of multiple disorders.<p></p> Aims: To evaluate the efficacy of a transdiagnostic trait-focused web-based intervention aimed at reducing symptoms of common mental disorders in university students.<p></p> Method: Students were recruited online (n = 1047, age: M = 21.8, SD = 4.2) and categorised into being at high or low risk for mental disorders based on their personality traits. Participants were allocated to a cognitive-behavioural trait-focused (n = 519) or a control intervention (n = 528) using computerised simple randomisation. Both interventions were fully automated and delivered online (trial registration: ISRCTN14342225). Participants were blinded and outcomes were self-assessed at baseline, at 6 weeks and at 12 weeks after registration. Primary outcomes were current depression and anxiety, assessed on the Patient Health Questionnaire (PHQ9) and Generalised Anxiety Disorder Scale (GAD7). Secondary outcome measures focused on alcohol use, disordered eating, and other outcomes.<p></p> Results: Students at high risk were successfully identified using personality indicators and reported poorer mental health. A total of 520 students completed the 6-week follow-up and 401 students completed the 12-week follow-up. Attrition was high across intervention groups, but comparable to other web-based interventions. Mixed effects analyses revealed that at 12-week follow up the trait-focused intervention reduced depression scores by 3.58 (p<.001, 95%CI [5.19, 1.98]) and anxiety scores by 2.87 (p = .018, 95%CI [1.31, 4.43]) in students at high risk. In high-risk students, between group effect sizes were 0.58 (depression) and 0.42 (anxiety). In addition, self-esteem was improved. No changes were observed regarding the use of alcohol or disordered eating.<p></p> Conclusions This study suggests that a transdiagnostic web-based intervention for university students targeting underlying personality risk factors may be a promising way of preventing common mental disorders with a low-intensity intervention

Evidence for three factors of perfectionism: : Perfectionistic Strivings, Order, and Perfectionistic Concerns

The factor structure of perfectionism is inconsistent across models. Most models distinguish between adaptive and maladaptive aspects of perfectionism, but often do not include elements representing order. Order, however, is theoretically important and distinct from the broad adaptive perfectionism factor. Therefore, a three-factor model of perfectionism was tested in a sample of undergraduate students (N = 208) who completed the Almost Perfect Scale-Revised and the Frost Multidimensional Perfectionism Scale. According to the chi-squared difference test and CFI differences, model fit improved when repre- senting Order as a separate factor. In addition, Order and Perfectionistic Strivings factors showed signif- icantly different correlations with Conscientiousness and Neuroticism, academic performance expectation, and four achievement goal orientations, providing further evidence of their distinctiveness. Therefore, including Order as a separate factor represents a better model of perfectionism

Intravenous sodium nitrite in acute ST-elevation myocardial infarction: a randomized controlled trial (NIAMI).

AIM: Despite prompt revascularization of acute myocardial infarction (AMI), substantial myocardial injury may occur, in part a consequence of ischaemia reperfusion injury (IRI). There has been considerable interest in therapies that may reduce IRI. In experimental models of AMI, sodium nitrite substantially reduces IRI. In this double-blind randomized placebo controlled parallel-group trial, we investigated the effects of sodium nitrite administered immediately prior to reperfusion in patients with acute ST-elevation myocardial infarction (STEMI). METHODS AND RESULTS: A total of 229 patients presenting with acute STEMI were randomized to receive either an i.v. infusion of 70 μmol sodium nitrite (n = 118) or matching placebo (n = 111) over 5 min immediately before primary percutaneous intervention (PPCI). Patients underwent cardiac magnetic resonance imaging (CMR) at 6-8 days and at 6 months and serial blood sampling was performed over 72 h for the measurement of plasma creatine kinase (CK) and Troponin I. Myocardial infarct size (extent of late gadolinium enhancement at 6-8 days by CMR-the primary endpoint) did not differ between nitrite and placebo groups after adjustment for area at risk, diabetes status, and centre (effect size -0.7% 95% CI: -2.2%, +0.7%; P = 0.34). There were no significant differences in any of the secondary endpoints, including plasma troponin I and CK area under the curve, left ventricular volumes (LV), and ejection fraction (EF) measured at 6-8 days and at 6 months and final infarct size (FIS) measured at 6 months. CONCLUSIONS: Sodium nitrite administered intravenously immediately prior to reperfusion in patients with acute STEMI does not reduce infarct size

A systematic review on the impact of leg ulceration on patients' quality of life

<p>Abstract</p> <p>Background</p> <p>A systematic review was conducted to analyse journal articles that describe or measure the impact of leg ulceration on patients' quality of life (QoL) in order to improve the content of an educational programme that aims to enhance self-care agency in leg ulcer patients.</p> <p>Method</p> <p>Original articles published in English and German between 1990 and 2006 were included if the findings were analysed at the level of patients. Articles were excluded if (1) they investigated the impact of specific treatments or settings on QoL or (2) focused mainly on arterial ulcers or diabetic foot ulcers.</p> <p>Results</p> <p>Twenty-four original research articles met the inclusion criteria; 11 studies used a quantitative, 11 studies a qualitative, and 2 used a mixed method approach. The findings were collapsed into 5 core domains. Quantitative studies commonly investigated the parameters of pain, sleep, social isolation, and physical mobility. Patients had significantly more pain, more restrictions regarding social functioning, less vitality, and limitations with respect to emotional roles compared to the respective controls. Other problem areas identified were restrictions in work capacity, recreation, social interaction, psychological well-being, as well as problems caused by treatment regimes. Inconclusive results were obtained regarding pain intensity, physical restrictions, and gender effects.</p> <p>Limitations</p> <p>Numerous original studies neither undertook a differentiation of participants by ulcer aetiology nor did they analyse the results according to gender differences.</p> <p>Conclusion</p> <p>As leg ulceration has an impact on QoL, national guidelines on the treatment of leg ulceration need to more specifically address these far-ranging effects identified in this review.</p

Order and Chaos in some Trigonometric Series: Curious Adventures of a Statistical Mechanic

This paper tells the story how a MAPLE-assisted quest for an interesting undergraduate problem in trigonometric series led some "amateurs" to the discovery that the one-parameter family of deterministic trigonometric series \pzcS_p: t\mapsto \sum_{n\in\Nset}\sin(n^{-{p}}t), $p>1$, exhibits both order and apparent chaos, and how this has prompted some professionals to offer their expert insights. It is proved that \pzcS_p(t) = \alpha_p\rm{sign}(t)|t|^{1/{p}}+O(|t|^{1/{(p+1)}})\;\forall\;t\in\Rset, with explicitly computed constant $\alpha_p$. Experts' commentaries are reproduced stating the fluctuations of \pzcS_p(t) - \alpha_p{\rm{sign}}(t)|t|^{1/{p}} are presumably not Gaussian. Inspired by a central limit type theorem of Marc Kac, a well-motivated conjecture is formulated to the effect that the fluctuations of the $\lceil t^{1/(p+1)}\rceil$-th partial sum of \pzcS_p(t), when properly scaled, do converge in distribution to a standard Gaussian when $t\to\infty$, though --- provided that $p$ is chosen so that the frequencies \{n^{-p}\}_{n\in\Nset} are rationally linear independent; no conjecture has been forthcoming for rationally dependent \{n^{-p}\}_{n\in\Nset}. Moreover, following other experts' tip-offs, the interesting relationship of the asymptotics of \pzcS_p(t) to properties of the Riemann $\zeta$ function is exhibited using the Mellin transform.Comment: Based on the invited lecture with the same title delivered by the author on Dec.19, 2011 at the 106th Statistical Mechanics Meeting at Rutgers University in honor of Michael Fisher, Jerry Percus, and Ben Widom. (19 figures, colors online). Comments of three referees included. Conjecture 1 revised. Accepted for publication in J. Stat. Phy