70 research outputs found
Regulatory T Cells Restrain Interleukin-2- and Blimp-1-Dependent Acquisition of Cytotoxic Function by CD4⁺ T Cells
- Author
- Publication venue
- Publication date
- 14/01/2020
- Field of study
In addition to helper and regulatory potential, CD4+ T cells also acquire cytotoxic activity marked by granzyme B (GzmB) expression and the ability to promote rejection of established tumors. Here, we examined the molecular and cellular mechanisms underpinning the differentiation of cytotoxic CD4+ T cells following immunotherapy. CD4+ transfer into lymphodepleted animals or regulatory T (Treg) cell depletion promoted GzmB expression by tumor-infiltrating CD4+, and this was prevented by interleukin-2 (IL-2) neutralization. Transcriptional analysis revealed a polyfunctional helper and cytotoxic phenotype characterized by the expression of the transcription factors T-bet and Blimp-1. While T-bet ablation restricted interferon-γ (IFN-γ) production, loss of Blimp-1 prevented GzmB expression in response to IL-2, suggesting two independent programs required for polyfunctionality of tumor-reactive CD4+ T cells. Our findings underscore the role of Treg cells, IL-2, and Blimp-1 in controlling the differentiation of cytotoxic CD4+ T cells and offer a pathway to enhancement of anti-tumor activity through their manipulation
Dose-related effects of propericiazine in rats
- Author
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Laparoscopy in management of appendicitis in high-, middle-, and low-income countries: a multicenter, prospective, cohort study.
- Author
- Abantanga F
- Abbas M
- Abbo O
- Abd El Galeel A
- Abd El Hameed OS
- Abd El Hamid N
- Abd El Salam Y
- Abd El Slam M
- Abd El-Salam F
- Abd Elrasoul Y
- Abd-Elrasoul Y
- Abdallah E
- Abdel-Wahab NYE
- AbdelFattah I
- Abdelgelil A
- Abdelghany S
- Abdelkader M
- Abdelkareem A
- Abdelraheim M
- Abdelshafy M
- Abdulgawad M
- Abdullah AAN
- Abdullah NAN
- Abebe NS
- Abebe NS
- Aber A
- Abington E
- Aboarab A
- Aboraya M
- Aboraya M
- Abouelnasr A
- Abouzahra A
- Abozaid M
- Abozeid K
- Abozyed MAF
- Abudeeb H
- Abuseif M
- Acharya P
- Adams R
- Adebanjo A
- Adekoya A
- Adel A
- Adel A
- Ademuyiwa A
- Ademuyiwa AO
- Adeniran J
- Adeniyi A
- Adesanya O
- Adesina A
- Adesuyi A
- Adeyeye A
- Adham W
- Afandy A
- Afifi AM
- Afzal M
- Agalianos C
- Agarwal A
- Agius M
- Aguilar-Jimenez J
- Aguilera M
- Aguilera O
- Ahlqvist S
- Ahmed A
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- Ahmed H
- Ahmed SM
- Aigrain Y
- Ajao AE
- Akeel N
- Akhtar M
- Al Awwad S
- Al-Aarag AA-R
- Al-Azraqi IAA
- Al-Faifi JJ
- Al-Hameedi HII
- Al-Hasani RKMJ
- Al-Mallah A
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- Al-shammari A
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- Alkammash A
- Alkhabbaz D
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- Almallah A
- Almoflihi A
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- Alnuqaydan SA
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- Elkady F
- Elkelany A
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- Elkholy A
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
BACKGROUND: Appendicitis is the most common abdominal surgical emergency worldwide. Differences between high- and low-income settings in the availability of laparoscopic appendectomy, alternative management choices, and outcomes are poorly described. The aim was to identify variation in surgical management and outcomes of appendicitis within low-, middle-, and high-Human Development Index (HDI) countries worldwide. METHODS: This is a multicenter, international prospective cohort study. Consecutive sampling of patients undergoing emergency appendectomy over 6 months was conducted. Follow-up lasted 30 days. RESULTS: 4546 patients from 52 countries underwent appendectomy (2499 high-, 1540 middle-, and 507 low-HDI groups). Surgical site infection (SSI) rates were higher in low-HDI (OR 2.57, 95% CI 1.33-4.99, p = 0.005) but not middle-HDI countries (OR 1.38, 95% CI 0.76-2.52, p = 0.291), compared with high-HDI countries after adjustment. A laparoscopic approach was common in high-HDI countries (1693/2499, 67.7%), but infrequent in low-HDI (41/507, 8.1%) and middle-HDI (132/1540, 8.6%) groups. After accounting for case-mix, laparoscopy was still associated with fewer overall complications (OR 0.55, 95% CI 0.42-0.71, p < 0.001) and SSIs (OR 0.22, 95% CI 0.14-0.33, p < 0.001). In propensity-score matched groups within low-/middle-HDI countries, laparoscopy was still associated with fewer overall complications (OR 0.23 95% CI 0.11-0.44) and SSI (OR 0.21 95% CI 0.09-0.45). CONCLUSION: A laparoscopic approach is associated with better outcomes and availability appears to differ by country HDI. Despite the profound clinical, operational, and financial barriers to its widespread introduction, laparoscopy could significantly improve outcomes for patients in low-resource environments. TRIAL REGISTRATION: NCT02179112
Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy
- Author
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- Aaniana K
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- Abd-Elmawla M
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- Magdy M
- Magdy S
- Magee C
- Maghrabi A
- Maghrabi AA
- Magri D
- Mahanty S
- Maharaj G
- Mahdi A
- Mahdi S
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- Maher ME
- Mahmoud B
- Mahmoud H
- Mahmoud M
- Mahmoud MA
- Mahmoud MI
- Mahmoud S
- Mahmoud SME
- Mahmud K
- Maillot B
- Maimbo M
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- Maison K
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- Majbar A
- Majid AHHA
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- Major CP
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- Mak T
- Mak TWC
- Makama J
- Makinde M
- Makupe A
- Malaga B
- Malavenda M
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- Malik P
- Malik TAM
- Mamdouh E
- Mamdouh R
- Manatakis DK
- Manchego Bautista AC
- Manchego Bautista AC
- Manfreda S
- Mangan C
- Mangan C
- Mangiapane M
- Manipal CE
- Maniscalco A
- Mann T
- Mannu GS
- Mano MJB
- Manrique Sila G
- Manrique Sila GC
- Manriquez-Reyes M
- Manrrique Sila G
- Mansor EY
- Mansour B
- Mansour S
- Mansuri A
- Mao P
- Mapasse D
- Maple N
- Maraie N
- Marcelo Delgado J
- Marey A
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- Margaritis M
- Maria Garcia-Perez J
- Mariani A
- Marinkovic B
- Marinos C
- Marks E
- Marples L
- Marret J-B
- Marroquin Rodriguez DE
- Marshall DC
- Martian B-V
- Martin A
- Mas R
- Mason C
- Mat TNT
- Mata LPS
- Matheu A
- Mathew SW
- Matos-Puig R
- Mattar O
- Matter SM
- Mauro L
- Mayasari M
- Mazelyte R
- Mazrimas P
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- Mcaleer S
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- Melo Cardozo RA
- Melo R
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- Mendoza Arango MC
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- Mendoza I
- Menegussi J
- Mensah E
- Menshawy A
- Mentula P
- Meqbil J
- Mercado Rodriguez L-A
- Mericliler M
- Merlini D
- Merlini D
- Merlo MS
- Mesbah N
- Meshref A
- Messa Aguilar WL
- Messa Aguilar WL
- Metwally MM
- Migliore M
- Mihaljevic AL
- Mihaljevic AL
- Mihanovic J
- Mihanovic J
- Mijuskovic B
- Mikalauskas S
- Mikalauskas S
- Mikuckyte D
- Mikwar Z
- Milligan W
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- Minguez Garcia J
- Minguez G
- Minocha A
- Minocha A
- Miranda C
- Mircea H
- Mirghani D
- Mironescu A
- Mironescu A
- Mironescu AS
- Mironescu AS
- Mirza A
- Mirza S
- Mistry A
- Mitrasinovic S
- Mitroudi M
- Mitroudis N
- Mittal A
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- Miyarde Leon A
- Mizzi C
- Mizzi S
- Mlotshwa M
- Moaty M
- Mochet S
- Modolo MM
- Modolo MM
- Modolo MM
- Moe TT
- Mogan YP
- Moghazy ME
- Mohamed A
- Mohamed A
- Mohamed AM
- Mohamed AR
- Mohamed B
- Mohamed F
- Mohamed I
- Mohamed M
- Mohamed MA
- Mohamed MAEH
- Mohamed MM
- Mohamed O
- Mohamed SR
- Mohameden A
- Mohammad A
- Mohammad A
- Mohammed A
- Mohammed A
- Mohammed AR
- Mohammed H
- Mohammed MM
- Mohammed MMH
- Mohammed S
- Mohan H
- Mohan M
- Mohan M
- Mok YT
- Mokhtar A
- Molina G
- Monaghan E
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- Monrad-Hansen PW
- Monteleone M
- Monteleone M
- Montes I
- Montes I
- Montoya Botero JA
- Montrimaite M
- Montrimaite M
- Moodley Y
- Moore R
- Moore R
- Mora JJV
- Morales C
- Morandi E
- Moreira G
- Moreno SC
- Morgan C
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- Morshedy EM
- Morsi A
- Morsi M
- Morton D
- Morton D
- Morton R
- Mosad A
- Mosalum O
- Mostafa HA
- Mostafa M
- Mostafa M
- Mousa M
- Moussa O
- Moustafa A
- Mouttalib S
- Mowafy B
- Mphatsoe AM
- Mshelbwala P
- Msiska N
- Msosa V
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- Muddebihal U
- Mukin ADF
- Muktar U
- Mukuzunga C
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- Muller J
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- Munhoz MM
- Munipalle PC
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- Murutoglu B
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- Musowoya J
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- Musyoka CK
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- Mutabazi AZ
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- Mutlu D
- Mutlu V
- Muzio E
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- Mykoniatis I
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- Nadkarni S
- Naess PA
- Nagy GS
- Nahar SN
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- Najjar M
- Nanthakumaran S
- Napolitano L
- Napolitano L
- Naqvi SA
- Naqvi T
- Naranjo Aristizaibal FA
- Narayanan R
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- Narvestad JK
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- Nashat M
- Nasher O
- Nashidengo P
- Nasir A
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- Nasir WNWM
- Nasr A
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- Nassif D
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- Natalie H
- Nataraja R
- Natili A
- Navarro A
- Nawara C
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- Nayel AR
- Nazir M
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- Ndajiwo A
- Ndegwa W
- Ndlovu SR
- Ndwambi P
- Negida A
- Negoi I
- Nel D
- Nemeth K
- Neo YN
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- Neophytou C
- Nepogodiev D
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- Nepogodiev D
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- Nesaratnam A
- Nessa A
- Nestorovic M
- Nevieraite V
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- Ng ZH
- Ngayu N
- Ngwa TE
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- Nikoloudis N
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- Niranjan N
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- Niyirera E
- Njokanma I
- Nnajiuba H
- Nocito A
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- Nofal E
- Noor F
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- Noukpozounkou B
- Novak A
- Nowers J
- Nsengimana VJP
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- Ntirenganya F
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- Nurqistan HD
- Nwabuoku E
- Nwinee V
- Nwokoro C
- Nyberg J
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- O'Connor T
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- O'neill M
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- Palomino Castillo VD
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- Papaskarlatos I-A
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- Patoulias I
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- Pena L
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- Perez Velasquez CI
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- Pertersen Servin GR
- Pesenti G
- Petrikenas S
- Peycelon M
- Peycelon M
- Pezas T
- Pezas T
- Pezelj N
- Phillips N
- Picardo A
- Picciariello A
- Pimenta ML
- Pineno-Flores C
- Pinkney T
- Pinkney T
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- Pino W
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- Powell A
- Prabhudesai A
- Pranevicius R
- Prasad SS
- Preckailaite E
- Primavesi F
- Prins M
- Proctor VK
- Pronin S
- Prudhomme T
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- Punja V
- Purwaningsih NA
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- Qaissieh A
- Qawasmi I
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- Qureshi AU
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- Rajmohan S
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- Rakita I
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- Ramarez Cabrera CC
- Ramazzini P
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- Raza I
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- Razek T
- Razi SAU
- Razmdjou S
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- Razzaque J
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- Redota MAP
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- Salah OM
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- Samaraweera DI
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- Sandoval Barrantes AM
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- Schultz JK
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- Scott M
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- Semeda N
- Semiz A
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- Senanayake KJ
- Senanayake WSMKJ
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- Sgroi G
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- Shachykava T
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- Shaharuddin S
- Shahbaz AR
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- Shillito S
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- Snyder E
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- Sobnach S
- Sodde P
- Soeselo DA
- Sokratous A
- Solaini L
- Solar Garcia L
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- Soldevila-Verdeguer C
- Soley R
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- Soltani N
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- Soulou V
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- Srinivasan R
- Sriram A
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- Sruogiene EZ
- Staerkle RF
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- Steccanella F
- Stefanopoulos A
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- Summerour V
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- Sundstrom SM
- Suresh S
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- Sutanto EPR
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- Suyadi A
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- Syibrah KZ
- Sykes M
- Szczap A
- Szeto CCL
- Szeto KJ-Y
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- Tabiri S
- Tackie E
- Taddei A
- Tade A
- Tafazal H
- Taha EMS
- Tahboub H
- Taher AA
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- Taieb C
- Taiwo A
- Taiwo O
- Taiwo O
- Talaat M
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- Talukder S
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- Talving P
- Tammam A
- Tan C
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- Tan CY
- Tan JJ
- Tan JK
- Tan KSK
- Tan RCK
- Tan YK
- Tan YW
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- Tanase A
- Tang A
- Tang L
- Tani SI
- Tansoker I
- Tarek A
- Tarek A
- Tarek D
- Targa S
- Tariq S
- Tata MD
- Tatagiba LS
- Tawfik BA
- Tawfik G
- Tawfik G
- Taylor F
- Teasdale E
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- Teasdale E
- Teasdale E
- Tedeschi U
- Tedjaatmadja C
- Telfah MM
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- Temoche E
- Tennakoon A
- Teo SY
- Ter EZ
- Tessera G
- Teufelberger G
- Tew YY
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- Th'ng F
- Thabet W
- Thalgaspitiya SPB
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- Thanusan V
- Tharmalingam S
- Theodosopoulos T
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- Thompson B
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- Toto OF
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- Turner M
- Turpo Espinoza K
- Turpo Espinoza K
- Tutino R
- Tverskis Z
- Tyler R
- Tyler R
- Tze RGE
- Tze RGE
- Tzikos G
- Ubhi HK
- Ubiali P
- Ugalde P
- Ukwenya Y
- Ulusahin M
- Upadhyaya V
- Upchurch E
- Urbanavicius L
- Urbina Rojas NM
- Urbonas T
- Urbonas T
- Urniezius Z
- Urniezius Z
- Usaityte A
- Uscinas L
- Utter M
- Uzabumwana N
- Vaicius A
- Valcarcel-Saldana M
- Valente Laufer LA
- Valioulis I
- Van Der Naald N
- Van Duren B
- Van Niekerk M
- Van Straten S
- Varcada M
- Vargas M
- Varkalys K
- Vartanoglu T
- Vartic M
- Vartic M
- Vasquez G
- Vasquez I
- Veen T
- Velasquez R
- Vella-Baldacchino M
- Venclauskas L
- Vendramin E
- Venskutonis D
- Venskutonis D
- Venskutonis D
- Venskutonis D
- Venugopal C
- Verbeek A
- Vergara Celis JM
- Vergara Mejia AG
- Verjee A
- Vermaas M
- Veronese E
- Vianna JGP
- Vicario E
- Vicenta Collado M
- Vida LC
- Vida LC
- Vilcinskas M
- Villa R
- Villalobos S
- Vimalachandran D
- Vincent J
- Violi P
- Visinskas P
- Vivekanantham S
- Vlachogiorgos A
- Voulgaris E
- Wael N
- Wagener M
- Wakefield R
- Waledziak M
- Waleed H
- Walker M
- Walker N
- Walls L
- Walsh M
- Walsh U
- Waqar M
- Ward AE
- Ward S
- Warda M
- Warren O
- Warren O
- Warwick AM
- Waterman A
- Watson NF
- Watson NF
- Watts A
- Weber B
- Weber P
- Weber P
- Weinstein MS
- Weiser TG
- Werder G
- Wheeler J
- Whewell H
- Whitaker J
- White R
- White T
- Whitehurst K
- Wiborg J
- Widiastini TA
- Widmer LW
- Wijayarathna LS
- Wild JRL
- Williams E
- Williams G
- Williams O
- Williams O
- Williamson A
- Wilson A
- Wilson L
- Wilson M
- Wilson M
- Wilson MSJ
- Wilson MSJ
- Wimalge PMSN
- Winstanley J
- Witherspoon P
- Wogensen F
- Wogensen F
- Wogensen F
- Woin E
- Wold TB
- Wolf B
- Wolf B
- Wondimu S
- Wondoh P
- Wondoh P
- Wong CS
- Wong CY
- Wong F
- Wong HY
- Wood G
- Woodward H
- Worku M
- Worku M
- Worku T
- Wredberg C
- Wright N
- Wright NJ
- Xerri T
- Xerri T
- Yahaya MT
- Yakubu M
- Yallop L
- Yam SY
- Yang J
- Yap S
- Yaseen T
- Yaseen TM
- Yau JD
- Yavuz MA
- Ye J
- Yeang LJ
- Yee J
- Yeo LS
- Yeung ENW
- Yeung MHA
- Yifieyeh A
- Yildirim R
- Yip C
- Ymeri S
- Yoganathan P
- Yolcu S
- Yong CO
- Yong GL
- Younis A
- Youssef D
- Youssef H
- Youssef M
- Youssif JH
- Yuksek MA
- Yusufali T
- Zaa'treh R
- Zachariades D-C
- Zadoroznas A
- Zahran D
- Zakaria E
- Zakaria M
- Zakaria Y
- Zaki A
- Zakir M
- Zalabia MF
- Zamarin K
- Zammit S
- Zampitis N
- Zani A
- Zani A
- Zani A
- Zanini N
- Zanini N
- Zapata Ponze De Leon M
- Zapata Ponze De Leon M
- Zapata F
- Zarb C
- Zardab A
- Zegarra S
- Zeidan S
- Zelada Alvarez II
- Zerihun AB
- Zeta Solis LA
- Zhang Z
- Zheng F
- Zidan H
- Zidan H
- Zidan M
- Zielinski M
- Ziff O
- Zikry M
- Zil-E-Ali A
- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskiene R
- Zilinskiene R
- Zimmermann EF
- Ziubryte G
- Zohair A
- Zorrilla CD
- Zuber M
- Zuber M
- Zuk G
- Zulkifli A
- Zumbuhl L
- Publication venue
- Publication date
- 15/10/2018
- Field of study
Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe
An embryological perspective on the early arthropod fossil record
- Author
- A Abzhanov
- A Maas
- A Minelli
- A Minelli
- A Weisbrod
- AC Daley
- AD Chipman
- AD Chipman
- AD Peel
- AM Simonetta
- Ariel D. Chipman
- B Mittmann
- B Mittmann
- B Mittmann
- B Mittmann
- BJ Eriksson
- BJ Eriksson
- C Aria
- C Brena
- C Schomburg
- C Wolff
- CL Hughes
- D Pisani
- D Walossek
- DA Legg
- DA Legg
- DA Legg
- DE Briggs
- DR Angelini
- DR Angelini
- DR Angelini
- F Galis
- FA Franke
- G Budd
- G Fusco
- G Mayer
- G Scholtz
- G Tanaka
- GD Edgecombe
- GD Edgecombe
- GE Budd
- GE Budd
- GE Budd
- GE Budd
- GE Budd
- GE Budd
- I Hao
- J Ortega-Hernández
- J Ortega-Hernández
- J Vinther
- J Yang
- J Yang
- JA Lynch
- JC Regier
- JM Mallatt
- JN Liu
- JT Haug
- JT Haug
- JY Chen
- KM Swanson
- M Birkan
- M Gerberding
- M Milatovic
- M Stein
- MK Richardson
- N Posnien
- N Wakayama
- NC Hughes
- NC Hughes
- NM Prpic
- O Rota-Stabelli
- O Rota-Stabelli
- P Cong
- P Van Roy
- PP Sharma
- PP Sharma
- R Janssen
- R Janssen
- RA Jenner
- RA Jenner
- RL Hannibal
- S Kittelmann
- SJ Brown
- T Nakamura
- VS Hunnekuhl
- W Arthur
- X Hou
- X Ma
- X Ma
- XG Zhang
- XL Zhang
- Y Liu
- Y Liu
- Y Shinmyo
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Global Biodiversity and Phylogenetic Evaluation of Remipedia (Crustacea)
- Author
- A Carapelli
- A Fosshagen
- A García-Valdecasas
- A Rambaut
- Alexandra Bergmann
- Anna Stepanova
- B Ertas
- BE Felgenhauer
- CE Cook
- CE Resser
- CS Bate
- CS Rafinesque
- CW Hart
- D Hazerli
- D Jaume
- D Jaume
- D Lorentzen
- DEG Briggs
- DL Danielopol
- DV Lavrov
- EP Creaser
- F Alvarez
- F Kiefer
- F Silvestri
- FA Chace
- FR Schram
- FR Schram
- FR Schram
- FR Schram
- FR Schram
- FR Schram
- G Giribet
- G Moura
- GA Boxshall
- GA Boxshall
- H Akaike
- H Wilkens
- HK Brooks
- HL Sanders
- J Daenekas
- J Yager
- J Yager
- J Yager
- J Yager
- J Yager
- J Yager
- J Yager
- J Yager
- J Yager
- JAA Nylander
- JC Fabricius
- JC Regier
- JC Regier
- JC Regier
- Jes Rust
- JH Carpenter
- JH Stock
- JH Stock
- JH Stock
- JH Stock
- JH Stock
- JP Huelsenbeck
- JR Holsinger
- LS Kornicker
- LS Kornicker
- M Fanenbruck
- M Fanenbruck
- M Shimomura
- MA Wills
- Marco T. Neiber
- MH de Blainville
- MJ Emerson
- MJ Emerson
- MS Wilson
- MT Brünnich
- N Goldman
- O Folmer
- PA Latreille
- PA Latreille
- R Huys
- R Rouch
- RA Jenner
- RC Edgar
- S Black
- S Koenemann
- S Koenemann
- S Koenemann
- S Koenemann
- S Koenemann
- S Koenemann
- S Koenemann
- S Koenemann
- S Koenemann
- S Koenemann
- S Muse
- S Tavaré
- Stefan Koenemann
- T Scott
- T Spears
- Tamara R. Hartke
- Thomas M. Iliffe
- TM Iliffe
- TM Iliffe
- TM Iliffe
- TM Iliffe
- Torben Stemme
- U Wollermann
- W De Haan
- W Krijgsman
- WC Wheeler
- WF Humphreys
- WF Humphreys
- WF Humphreys
- WJ Dakin
- Y Kano
- YA Birshtein
- Z Yang
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2011
- Field of study
Remipedia is one of the most recently discovered classes of crustaceans, first described in 1981 from anchialine caves in the Bahamas Archipelago. The class is divided into the order Enantiopoda, represented by two fossil species, and Nectiopoda, which contains all known extant remipedes. Since their discovery, the number of nectiopodan species has increased to 24, half of which were described during the last decade. Nectiopoda exhibit a disjunct global distribution pattern, with the highest abundance and diversity in the Caribbean region, and isolated species in the Canary Islands and in Western Australia. Our review of Remipedia provides an overview of their ecological characteristics, including a detailed list of all anchialine marine caves, from which species have been recorded. We discuss alternative hypotheses of the phylogenetic position of Remipedia within Arthropoda, and present first results of an ongoing molecular-phylogenetic analysis that do not support the monophyly of several nectiopodan taxa. We believe that a taxonomic revision of Remipedia is absolutely essential, and that a comprehensive revision should include a reappraisal of the fossil record
Evaluation of appendicitis risk prediction models in adults with suspected appendicitis
- Author
- Abbas Sh
- Abbas Sh
- Abbassi Oa
- Abbott T
- Abdelgadir Am
- Abdelrahman A
- Abdelrahman M
- Abdelrahman M
- Abdelwahed A
- Abellan M
- Abellán Am
- Abellán Am
- Abulafi M
- Acharya A
- Acosta A
- Adam Me
- Adams Re
- Adegbola So
- Adegbola So
- Adimonye A
- Adnan M
- Afshar S
- Agresta F
- Agua Ia
- Aguayo Jl
- Agudo Ar
- Ahad A
- Ahel J
- Ahern Dp
- Ahmad A
- Ahmed B
- Ahmed G
- Ahmed Os
- Ahmed Os
- Ahmed S
- Ainsworth P
- Ais G
- Ais G
- Aisoni F
- Akbari K
- Akhtar K
- Akinsola O
- Akram F
- Al-Faham Z
- Al-Khafaji N
- Al-Khyatt W
- Al-Musawi S
- Al-Sarireh B
- Al-Sheikh M
- Alagna V
- Alani M
- Alberca-Paramo A
- Aldrey I
- Alexander R
- Alhammali T
- Alhammali T
- Ali M
- Aljorfi A
- Allen M
- Allington J
- Alonzo A
- Alshafei A
- Altomare Ma
- Alvarez Cm
- Alvarez E
- Alvarez-Gallego M
- Amaducci E
- Amarasinghe R
- Amayo A
- Ambrona-Zafra D
- Amin V
- Ammendola M
- Amtul N
- Amtul N
- Amuthalingam T
- Anandan L
- Anania G
- Anania M
- Anderson Dj
- Anderson O
- Andolfi E
- Andreani Sm
- Andreani Sm
- Andrews B
- Ang A
- Ang A
- Angelieri D
- Angelini M
- Angrisani M
- Anguita F
- Ansaloni L
- Ansari A
- Aravind B
- Archer Je
- Arcuri Ga
- Arcuri Ga
- Aremu Ma
- Arenal-Vera Jj
- Aresu S
- Aresu S
- Argenio G
- Argenti F
- Armellini A
- Arnau M
- Arredondo J
- Arroyo A
- Arshad F
- Arunachalam S
- Arunachalam S
- Arunachalam S
- Aruparayil N
- Asensio-Gomez L
- Ashmore Dl
- Ashmore Dl
- Ashour O
- Ashraf N
- Asmadi Aa
- Assaf N
- Assaf N
- Assaf N
- Athersmith Mj
- Atzeni J
- Avalapati H
- Avanzolini A
- Avanzolini A
- Awokoya Oo
- Ayllón-Gámez S
- Ayube-Brown J
- Azabdaftari A
- Azevedo J
- Azevedo Jm
- Baddams Ts
- Badenoch T
- Badii B
- Badran A
- Baeza-Murcia M
- Bagga R
- Baginski A
- Bailey Ja
- Bailey S
- Bailey S
- Bailon-Cuadrado M
- Baird C
- Bairos F
- Baker B
- Balai Ej
- Balasubramaniam A
- Balestra F
- Ball A
- Ball A
- Ball A.
- Ballabio M
- Ballester Mm
- Bandyopadhyay Sk
- Banks A
- Bansal H
- Baraghini M
- Barbosa L
- Barker T
- Barker T
- Barnieh W
- Baronio G
- Baronio G
- Barrie A
- Barter Ca
- Bartoli A
- Bascuas-Rodrigo B
- Baseggio M
- Bastianpillai J
- Bawa S
- Baz-Figueroa C
- Bazán-Hinojo Mc
- Bazán-Hinojo Mc
- Beasley Wd
- Bedoya S
- Beggs A
- Bell Cr
- Bell J
- Bellochi R
- Beltran-De-Heredia J
- Beltran-De-Heredia J
- Belvedere A
- Benevento A
- Bennett Jm
- Beral D
- Beral D
- Bernal-Sprekelsen Jc
- Berry B
- Berti S
- Bevan Ke
- Bevan V
- Beverstock A
- Bhanderi S
- Bhanderi S
- Bhanderi S
- Bhanderi S
- Bhanderi S.
- Bhangu A. Nepogodiev D
- Bhangu A
- Bhangu A
- Bhangu A
- Bhangu A
- Bhargava A
- Biancafarina A
- Biancafarina A
- Bianchi Cl
- Bianchi Cl
- Bianco A
- Bilku D
- Birindelli A
- Birindelli A
- Birindelli A
- Blackford Od
- Blackwell J
- Blake L
- Blanco F
- Blanco-Colino R
- Blanco-Colino R
- Blanco-Colino R
- Blanco-Colino R
- Blanco-Colino R.
- Blazeby Jm
- Blencowe N. S.
- Blencowe Ns
- Blencowe Ns
- Blencowe Ns
- Blencowe Ns
- Boddy Ap
- Boereboom C
- Bogdan M
- Bohra P
- Boland M
- Boland M
- Bolger Jc
- Bolger Jc
- Bolton W
- Bolzon S
- Bond S
- Bond-Smith G
- Bondurri A
- Bonfante P
- Bonomo M
- Borg Cm
- Borges Fc
- Borghi F
- Borghol K
- Boshier Pr
- Botelho P
- Bowen J
- Bowerman H
- Bowley D
- Bowman Cr
- Bowman Cr
- Boyd-Carson H
- Boza K
- Bradshaw Cj
- Branagan G
- Bravo-Gutiérrez Af
- Bravo-Gutiérrez Af
- Brennan S
- Brett M
- Brewer H
- Brewer Hk
- Brewer Hk
- Brews R
- Brien Jo
- Bronder C
- Brown A
- Brown Ag
- Brown Ce
- Brown Ce
- Brown Ce
- Brown M
- Brown M
- Brown Od
- Brown R
- Bruce Js
- Brunelli Db
- Bryan Es
- Buckley-Jones S
- Bukhari W
- Bull C
- Bullivant Jk
- Burke J
- Burns Km
- Burnside D
- Busuttil A
- Byrne Be
- Byrnes Ck
- Caballero A
- Caldeira Ab
- Caldwell M
- Callan R
- Calussi M
- Calvo H
- Calvo M
- Cameron Fc
- Campagnaro T
- Campagnaro T
- Campbell U
- Campbell Um
- Campbell W
- Cannata G
- Cannavò M
- Cantafio S
- Capelli P
- Carcoforo P
- Carden Ca
- Carder C
- Cardona R
- Cardoso D
- Carlucci M
- Carney K
- Caro A
- Carral-Freire M
- Carrano Fm
- Carrano Fm
- Cartwright H
- Carvalho Lc
- Carvalho N
- Casimiro C
- Castagnoli G
- Castagnoli G
- Caula C
- Caula C
- Cavallo D
- Cavero A
- Cay P
- Ceccarelli G
- Cerdán-Santacruz C
- Cerdán-Santacruz C
- Cerdán-Santacruz C
- Cerdán-Santacruz C
- Cervellera M
- Cesari Mc
- Chalk A
- Chambers B
- Chan D
- Chan T
- Chan Wh
- Chandler Sb
- Chandratreya N
- Chandratreya N
- Chapman J
- Chapman Sj
- Chapple Ks
- Charalabopoulos A
- Charalambous Mp
- Chasty B
- Chatzikonstantinou M
- Chatzikonstantinou M
- Chauhan P
- Chauhan P
- Chauhan P.
- Cheah Wl
- Chean Cs
- Chean Cs
- Checcacci P
- Cheng Sa
- Cheruvu M
- Chessa A
- Chessa A
- Chetta G
- Chetta N
- Chianese G
- Chillitupa Cz
- Chimetto A
- Chin My
- Chishti Ia
- Chitsabesan P
- Chng S
- Choi S
- Chok Sm
- Chok Sm
- Chong B
- Choolani-Bhojwani E
- Choong Jh
- Choong Jh
- Choong Jh
- Chowdhary M
- Chowdhury F
- Chowdhury F
- Choy Ch
- Choy Ch
- Chrastek D
- Christian L
- Christides A
- Christopoulos P
- Chudek D
- Chui K
- Cianchi F
- Cidoncha A
- Cillara N
- Cillara N
- Cillara N
- Cipparrone M
- Cirillo B
- Clark Gl
- Clark S
- Clement Kd
- Clement Kd
- Clements B
- Clements C
- Clements J
- Clements J.
- Clements Ja
- Clements Jd
- Clements Jm
- Clements Jm
- Clements Js
- Clerici F
- Clingan R
- Cloney L
- Clough E
- Coccolini F
- Coccolini F
- Cocorullo G
- Coe Po
- Cohen Ja
- Colangelo E
- Coletta D
- Coletta D
- Coletti M
- Collado-Roura F
- Collier-Wakefield O
- Colombo F
- Colombo F
- Colvin Da
- Colvin Da
- Compagnoni B
- Conci S
- Connelly Tm
- Connor Kl
- Connor Kl
- Connor Mj
- Connor Mj
- Conti D
- Contine Ac
- Contreras Rg
- Contreras-Saiz E
- Cook V
- Cooke F
- Coppola M
- Coratti F
- Corbellini C
- Cordoba E
- Cordoba E
- Cormenzana Ob
- Correia D
- Correia J
- Cortés Gv
- Cosci M
- Cossu F
- Costa Sd
- Costamagna D
- Cotton Ae
- Couch Dg
- Cousins L
- Couso Jr
- Cox M
- Coyle D
- Creasy W
- Cremades P
- Criado Adc
- Crone A
- Crozier J
- Cruccu A
- Cruickshank N
- Cuadrado Mm
- Cucinotta E
- Cuello-Guzmán E
- Cunha P
- Currow C
- Curti R
- Curtis Nj
- Curtis-Martínez C
- Cynthia G
- Cánovas-Moreno G
- D'Ambra L
- D'Amico Fe
- D'Amico Fe
- D'Amico Fe
- D'Auria M
- D'Auria M
- D'Souza N
- Daga O
- Dalmia S
- Dandy R
- Daniels I
- Danquah-Boateng D
- Dar Fa
- Dar Fa
- Dart K
- Das A
- Daureeawoo R
- Davidson Jr
- Davidson S
- Davies Pl
- Davis S
- De Andres U
- De Burgos Cb
- De Chaves-Rodríguez Pg
- De Freitas S
- De Luca E
- De Marchi F
- De Marco P
- De Nardi P
- De Nardi P
- De Nisco C
- De Padua C
- De Prizio M
- De-La-Herranz-Guerrero P
- De-Manzoni-Garberini A
- De-Manzoni-Garberini A
- De-Manzoni-Garberini A
- De-Marchi Ja
- De-Marchi Ja
- De-Soto-Cardenal B
- Dean Ea
- Dean S
- Del Basso C
- Del Pozo E
- Del-Valle-Ruiz Sr
- Delgado-Plasencia Lj
- Delimpalta C
- Delimpalta C
- Delogu D
- Denley S
- Dennison G
- Depalma N
- Deserra A
- Desiderio J
- Devezas V
- Devine Aa
- Dhar M
- Dharamavaram S
- Dhari Aa
- Dhesi S
- Di Cintio A
- Di Franco F
- Di Gioia P
- Di Saverio S
- Di Zitti L
- Diaz A
- Dickson Ea
- Divekar Ga
- Dixon F
- Dobbs S
- Dobson C
- Docherty Ja
- Doherty C
- Dominguez-Sanchez C
- Donaldson G
- Donaldson G
- Donohoe No
- Donohoe No
- Douka E
- Doulias T
- Dova L
- Downey M
- Doyle C
- Doyle C
- Drake T. M.
- Drake Tm
- Drye N
- Du Dt
- Dubois As
- Dubois As
- Dudek Jg
- Dujovne P
- Dujovne P
- Dunning Pg
- Duran-Muñoz-Cruzado Vm.
- Durbacz M
- Dyal A
- Dyson S
- Díaz-Vico T
- Eardley Nj
- Earnshaw L
- Easdon S
- Ebied H
- Echazarreta E
- Edwards Se
- Egan Rj
- Egan Rj
- Eguaras I
- Eiben I
- Eiben Ie
- Eiben P
- El-Masry S
- El-Tayar O
- El-Tayar O
- Elbetti C
- Elgaddal S
- Elia M
- Ellis B
- Elseedawy M
- Elshaer M
- Elshaer M
- Emslie Km
- Engall N
- Engall N
- Engall N
- English Wj
- Ercolani G
- Erdas E
- Erdas E
- Eretta Co
- Escoll-Rufino J
- Escuder J
- Esmail Hd
- Espin-Basany E
- Espin-Basany E
- Espina B
- Espinosa J
- Esteves Mb
- Ettles C
- Evans J
- Evans Jd
- Everden A
- Evoli Le
- Ezerska E
- Fadel M
- Fahmy Se
- Fahmy Se
- Fairfield Cj
- Falaschi F
- Falco N
- Fanibi Bf
- Fareleira A
- Farhan-Alanie M
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- Szucs A
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- Sánchez-Fuentes Mn
- Sánchez-Rubio M
- Tabain V
- Taglietti L
- Tague Le
- Tahir W
- Tailor K
- Tallon-Aguilar L
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- Tamayo-López Mj
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- Zelazek M
- Zerpa C
- Zhang Ay
- Zhou S
- Zorrilla L
- Zuin M
- Zurleni Tz
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2019
- Field of study
Background
Appendicitis is the most common general surgical emergency worldwide, but its diagnosis remains challenging. The aim of this study was to determine whether existing risk prediction models can reliably identify patients presenting to hospital in the UK with acute right iliac fossa (RIF) pain who are at low risk of appendicitis.
Methods
A systematic search was completed to identify all existing appendicitis risk prediction models. Models were validated using UK data from an international prospective cohort study that captured consecutive patients aged 16–45 years presenting to hospital with acute RIF in March to June 2017. The main outcome was best achievable model specificity (proportion of patients who did not have appendicitis correctly classified as low risk) whilst maintaining a failure rate below 5 per cent (proportion of patients identified as low risk who actually had appendicitis).
Results
Some 5345 patients across 154 UK hospitals were identified, of which two‐thirds (3613 of 5345, 67·6 per cent) were women. Women were more than twice as likely to undergo surgery with removal of a histologically normal appendix (272 of 964, 28·2 per cent) than men (120 of 993, 12·1 per cent) (relative risk 2·33, 95 per cent c.i. 1·92 to 2·84; P < 0·001). Of 15 validated risk prediction models, the Adult Appendicitis Score performed best (cut‐off score 8 or less, specificity 63·1 per cent, failure rate 3·7 per cent). The Appendicitis Inflammatory Response Score performed best for men (cut‐off score 2 or less, specificity 24·7 per cent, failure rate 2·4 per cent).
Conclusion
Women in the UK had a disproportionate risk of admission without surgical intervention and had high rates of normal appendicectomy. Risk prediction models to support shared decision‐making by identifying adults in the UK at low risk of appendicitis were identified
Global variation in anastomosis and end colostomy formation following left-sided colorectal resection
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- de Lima CVB
- De Luca E
- De Marco P
- De Sousa AV
- Deal R
- Dean R
- Deane C
- Debrah S
- Deckelbaum Dl
- Decker E
- Decoud Hp
- Dedekind B
- Dedey F
- Deichsel F
- Del Basso C
- Del Pilar Paucar A
- Delforge X
- Delgado Jm
- Delgado Msftl
- Dell A
- Dempster E
- Denewar A
- Depalma N
- Deputy M
- Der Y
- Dervenis C
- Despotidis V
- Desta S
- Deutschmann P
- Devadasar Gh
- Dharamshi Ha
- Dhillon D
- Di Franco F
- Di Martino N
- Di Saverio S
- Di Saverio S
- Diab A
- Diaconescu B
- Diaconescu Ib
- Dias S
- Diaz-Jover P
- Diaz-Zorrilla C
- Dick L
- Dickfos M
- Dickson L
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- Dimech T
- Din F
- Dindyal S
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- Dissanayake T
- Djivoh F
- Domini E
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- Donnelly P
- Donoghue D
- Dorani Rmnr
- Dorismé
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- Dossou F
- Doughan S
- Doughty J
- Dousset B
- Dragatas D
- Drake Tm
- Drake Tm
- Driscoll A
- Drungilas M
- Du Plessis D
- du Plooy F
- Du Toit F
- Duane T
- Dubois A
- Dueñ
- Duffy L
- Duhoranenayo D
- Duinhouwer L
- Dulskas A
- Durand Sya
- Dwydar A
- Ebdewi H
- Ebidy M
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- Ebrahim Os
- Eduard P
- Edwards J
- Edye M
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- Ekow M
- El Ashal G
- El Dahab AA
- El Deen KN
- El Galeel AA
- El Gendy NH
- El Gendy A
- El Halawany M
- El Hameed OSA
- El Hamid NA
- El Jamassi A
- El Kashash A
- El Kholy A
- El Magd AA
- El Mesery S
- El Salam YA
- El Sayed GS
- El Sayed IM
- El Shoura Y
- El Slam MA
- El-Badawy Ha
- El-Dien Ks
- El-Dien Ks
- El-Din Ra
- El-Din Sa
- El-Gizawy E
- El-Hamouly As
- El-Kashef H
- El-Latif Nka
- El-Ma&apos
- El-Rabaa S
- El-Sagheer N
- El-Salam Fa
- El-Sawy A
- El-Sehily A
- El-Shahat Ns
- El-Sheemy H
- El-Taher E
- Elabdin Hz
- Elashmawy M
- Elashry R
- Elazab A
- Elazayem Aa
- Elazoul M
- Elbanby E
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- Elbatahgy A
- Elbe P
- Elbermawy M
- Elbisomy Kh
- Eldafrawy M
- Eldamaty L
- Eldeeb Az
- Eldeen Ea
- Eldin Mab
- Elebute O
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- Elena G
- Elfarargy A
- Elfeki H
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- Elfiky M
- Elfil M
- Elfouly N
- Elfouly N
- Elfouly Y
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- Elgebaly A
- Elgendy Ah
- Elgendy Fi
- Elgheriany M
- Elhadad A
- Elhadary Nm
- Elhadry S
- Elhalawany E
- Elhamouly S
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- Elhendawy A
- Elhendawy Aoa
- Elhoseny G
- Elhusseiny Aae
- Elkadsh I
- Elkady F
- Elkelany A
- Elkelany A
- Elkelany A
- Elkelany A
- Elkhadrawi M
- Elkhalek Ea
- Elkholy A
- Elkholy Ss
- Elkolaly Ss
- Elkorashy Am
- Ellison Q
- Elmashala A
- Elmasry M
- Elmelegy R
- Elmihy S
- Elnagar A
- Elnajjar Ma
- Elnemr Ae
- Elrasoul Ya
- Elrazek Aa
- Elsabbagh N
- Elsameea Aa
- Elsawahly Dme
- Elsawy A
- Elsayed M
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- Elsayed N
- Elsayed Nar
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- Elsebaaye Ao
- Elsehimy M
- Elsemelawy R
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- Elshafay Ae
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- Elsharkawy Aa
- Elsheikh S
- Elsherbiney S
- Elsherbiny As
- Elsherif Fa
- Elshobary M
- Elsiddig M
- Elsobky S
- Elsorogy Deaa
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- Elwan A
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- Elwy E
- Elzahed N
- Elzayat I
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- Elzayyat I
- Elzowawi F
- Emadeldin D
- Emadeldin H
- Emara E
- Emile S
- Eng C
- English W
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- Escobar Eg.
- Espin-Basany E
- Espinoza F
- Espinoza Kt
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- Estee Mm
- Estupinian S
- Etchill E
- Etchill E
- Etienne S
- Etman M
- Etwire V
- Evajelista Cv
- Evans D
- Evans E
- Eysa A
- Eyssartier E
- Ezzat E
- Ezzat T
- Faboya O
- Faccincani R
- Fadel A
- Fahiem A
- Fahim M
- Fahy C
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- Falco N
- Falzon M
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- Farag S
- Farah A
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- Faraz A
- Fares M
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- Farhan-Alanie Mmh
- Farhangmehr N
- Farinella E
- Farmakis K
- Farooq T
- Farouk Sam
- Farquharson A
- Farrugia A
- Farrugia A
- Faruq A
- Fathy Am
- Fattah Aa
- Fatuga A
- Faturoti O
- Faturoti O
- Faure A
- Fautz T
- Favero A
- Fawzy A
- Feidantsis T
- Felipe Co
- Fergany A
- Fergusson Sj
- Fergusson Sj
- Fergusson Sj
- Fermani C
- Fermani Cg
- Ferná
- Fernandes C
- Fernandez-Bueno F
- Fernandez-Vega L
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- Ferrero E
- Fievet L
- Filatau A
- Findlay-Cooper K
- Firdouse M
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- Firdouse M
- Firwana A
- Fitsum A
- Fitzgerald Je
- Florez Ljg
- Foco M
- Fok Cyj
- Fontana T
- Foo Cc
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- Fouad A
- Fouad D
- Fouad D
- Fourcade L
- Fowler Aj
- Fozard T
- Fozard T
- Frade F
- Fraga Gp
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- Francois P
- Francois-Coridon H
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- Freitas Av
- Frey D
- Frisk B
- Fuentes-Rivera L
- Fujii F
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- Gaafar S
- Gaarder T
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- Gad Mo
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- Gadhvi V
- Gado A
- Gaiž
- Gaignard E
- Gaignard E
- Gala T
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- Galiqi G
- Galleano R
- Gallo G
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- Galvez Cp
- Gamal D
- Gamal E
- Gamal H
- Gamal S
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- Gamil D
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- Gani Ma
- Garaycochea O
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- Garland A
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- Gemeah M
- Gemenetzis G
- Gemenetzis G
- George R
- Germanos S
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- Gerosa A
- Gerosa A
- Geuoshy A
- Ghaben A
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- Ghanem A
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- Ghanem S
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- Ghannam M
- Gharib A
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- Ghazy Aa
- Gheith A
- Ghetia M
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- Giardino Fr
- Giavarini L
- Giglio Mc
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- Grizhja B
- Grobler Dc
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- Gudal A
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- Guevara R
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- Gui D
- Gulbinas A
- Gulcicek Ob
- Gulielmi A
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- Gunnarsson U
- Guo W
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- Gustafsson U
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- Habeebullah A
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- Haddad N
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- Hafez S
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- Hafiz S
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- Hagar A
- Haines M
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- Hajeh H
- Hakim H
- Halhouli O
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- Halicioglu I
- Hall E
- Hall N
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- Hamad Mgm
- Hamaguchi Jlh
- Hamarshi A
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- Hamdan A
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- Hany E
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- Harrison N
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- Harvey N
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- Hasan D
- Hasanah A
- Hasanain D
- Hascoet J
- Hashad E
- Hasheminia A
- Hashim A
- Hashish A
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- Haslegrave A
- Hasnan Mb
- Hassaan A
- Hassaan A
- Hassan A
- Hassan A
- Hassan A
- Hassan Ata
- Hassan I
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- Hassan Omm
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- Hassan Z
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- Hassanain M
- Hassanein Ab
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- Hemmila M
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- Herebat A
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- Hesham O
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- Horobjowsky A
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- Iannone I
- Ibraheem Aa
- Ibraheem Hi
- Ibrahem Aa
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- Ibrahim A
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- Ibrahim A
- Ibrahim Am
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- Ibrahim Em
- Ibrahim I
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- Ibrahim M
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- Ihediwa G
- Imoro O
- Ingabire Jca
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- Mclachlan G
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- Mclean K
- McMorran D
- Mcnish D
- Mcphee A
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- Mendoza I
- Menegussi J
- Mensah E
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- Mentula P
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- Mihaljevic Al
- Mihanovic J
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- Mijuskovic B
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- Mikuckyte D
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- Milligan W
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- Minguez G
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- Miranda C
- Mircea H
- Mirghani D
- Mironescu A
- Mironescu A
- Mironescu As
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- Mirza A
- Mirza S
- Mistry A
- Mitrasinovic S
- Mitroudi M
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- Mittal A
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- Mizzi C
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- Mlotshwa M
- Moaty M
- Mochet S
- Modolo Mm
- Modolo Mm
- Modolo Mm
- Moe Tt
- Mogan Yp
- Moghazy Me
- Mohamed A
- Mohamed A
- Mohamed Am
- Mohamed Ar
- Mohamed B
- Mohamed F
- Mohamed I
- Mohamed M
- Mohamed Ma
- Mohamed Maeh
- Mohamed Mm
- Mohamed O
- Mohamed Sr
- Mohameden A
- Mohammad A
- Mohammad A
- Mohammed A
- Mohammed A
- Mohammed Ae
- Mohammed Ar
- Mohammed H
- Mohammed Mm
- Mohammed Mmh
- Mohammed S
- Mohan H
- Mohan M
- Mohan M
- Mok Yt
- Mokhtar A
- Molina G
- Mollo Mc
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- Monrad-Hansen Pw
- Montejo Msg
- Monteleone M
- Monteleone M
- Montes I
- Montes I
- Montrimaite M
- Montrimaite M
- Moodley Y
- Moore R
- Moore R
- Mora Jjv
- Morais Pab
- Morales C
- Moran Aer
- Morandi E
- Moreira G
- Moreno Sc
- Morgan C
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- Morsi A
- Morsi M
- Morton D
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- Morton R
- Mosad A
- Mosalum O
- Mostafa Ha
- Mostafa M
- Mostafa M
- Mousa M
- Moussa O
- Moustafa A
- Mouttalib S
- Mowafy B
- Mphatsoe Am
- Mshelbwala P
- Msiska N
- Msosa V
- Msosa V
- Muddebihal U
- Mukin Adf
- Muktar U
- Mukuzunga C
- Muller C
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- Munera A
- Munhoz Mm
- Munipalle Pc
- Muntean L
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- Muralha N
- Murphy J
- Murray A
- Murutoglu B
- Musa Aek
- Musleh A
- Musowoya J
- Mussad A
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- Mustafa M
- Mustafa Ma
- Musyoka Ck
- Mutabazi Az
- Mutabazi Az
- Mutlu D
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- Muzio E
- Myers J
- Mykoniatis I
- Næ
- Nabawi A
- Nada F
- Nadeem N
- Nadkarni S
- Nagy Gs
- Nahar Sn
- Nair H
- Nanthakumaran S
- Napolitano L
- Napolitano L
- Naqvi Sa
- Naqvi T
- Naranjo Aristizã
- Narayanan R
- Narayanan R
- Narvestad Jk
- Nashaat A
- Nashat M
- Nasher O
- Nashidengo P
- Nasir A
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- Nassif D
- Nastri G
- Natalie H
- Nataraja R
- Natili A
- Navarro A
- Nawara C
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- Nayel Ar
- Nazir M
- Ndajiwo A
- Ndajiwo A
- Ndegwa W
- Ndlovu Sr
- Ndwambi P
- Ne&apos
- Negida A
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- Nel D
- Nemeth K
- Neo Yn
- Neo Yt
- Neophytou C
- Nepogodiev D
- Nepogodiev D
- Nepogodiev D
- Nepogodiev D
- Nesaratnam A
- Nessa A
- Nestorovic M
- Nevieraite V
- Newton T
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- Nikoloudis N
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- Njokanma I
- Nnajiuba H
- Nocito A
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- Nofal E
- Noor F
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- Notarnicola M
- Nouh T
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- Noukpozounkou B
- Novak A
- Nowers J
- Nsengimana Vjp
- Nsengiyumva C
- Ntirenganya F
- Nur&apos
- Nurqistan Hd
- Nwabuoku E
- Nwinee V
- Nwokoro C
- Nyberg J
- Nymo L
- O&apos
- O&apos
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- Obute Rd
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- Odeyemi B
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- Odutola O
- Ogunsua O
- Ogunyemi A
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- Ojeda Rrb
- Okenabirhie O
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- Olaolorun A
- Olivier J
- Olori S
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- Oludara M
- Olugbemi M
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- Omar Me
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- Oosterkamp A
- Opoku-Agyeman R
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- Ortega-Vazquez I
- Ortiz N
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- Osei-Nketiah S
- Oshati O
- Oshodi O
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- Othman M
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- Owusu F
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- Ozben V
- Ozkan Bb
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- Ozkan Bb
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- Pabla G
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- Padmore G
- Pagano G
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- Pagnozzi J
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- Palliyil Mm
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- Palma Af
- Paludi Ma
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- Panez Wr
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- Papaskarlatos Ia
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- Parreno-Sacdalan Md
- Parseliunas A
- Parthiban S
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- Pasquali S
- Pastora J
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- Pata F
- Pata F
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- Pata F
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- Patoulias I
- Paul M
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- Perino M
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- Perrotta G
- Pesenti G
- Petrikenas S
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- Pezas T
- Pezas T
- Pezelj N
- Phillips N
- Picardo A
- Picciariello A
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- Pineñ
- Pinkney T
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- Pino W
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- Poskus T
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- Pozo Dar
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- Pranevicius R
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- Preckailaite E
- Primavesi F
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- Pronin S
- Prudhomme T
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- Psarianos K
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- Puma Cmh
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- Quezada Jhj
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- Qureshi Au
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- Rahantasoa Fcfp
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- Raza A
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- Razek T
- Razmdjou S
- Razuri C
- Razzaque J
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- Redota Map
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- Renaux-Petel M
- Restrepo Im
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- Runigamugabo E
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- Saad Ha
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- Sabour Fa
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- Sahel S
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- Salama M
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- Salas Mdce
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- Senanayake Kj
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- Septiem Jg
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- Shahbaz Ar
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- Sokratous A
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- Sundstrom Sm
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- Tedeschi U
- Tedjaatmadja C
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- Ubiali P
- Ugalde P
- Ukwenya Y
- Uluş
- Ulusahin M
- Upadhyaya V
- Upchurch E
- Urbanavicius L
- Urbonas T
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- Urniež
- Urniezius Z
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- Valioulis I
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- Wolf B
- Wondimu S
- Wondoh P
- Wondoh P
- Wong Cs
- Wong Cy
- Wong F
- Wong Hy
- Wood G
- Woodward H
- Worku M
- Worku M
- Worku T
- Wredberg C
- Wright N
- Wright Nj
- Xerri T
- Xerri T
- Yahaya Mt
- Yakubu M
- Yallop L
- Yam Sy
- Yang J
- Yap S
- Yaseen T
- Yaseen Tm
- Yau Jd
- Yavuz Ma
- Ye J
- Yeang Lj
- Yee J
- Yeo Ls
- Yeung En
- Yeung Mha
- Yifieyeh A
- Yildirim R
- Yip C
- Yip Sbs
- Ymeri S
- Yoganathan P
- Yolcu S
- Yong Co
- Yong Gl
- Younis A
- Youssef D
- Youssef H
- Youssef M
- Youssif Jh
- Yuksek Ma
- Yusufali T
- Zaa&apos
- Zachariades Dc
- Zadoroznas A
- Zahran D
- Zakaria E
- Zakaria M
- Zakaria Y
- Zaki A
- Zakir M
- Zalabia Mf
- Zamarin K
- Zammit S
- Zampitis N
- Zani A
- Zani A
- Zani A
- Zanini N
- Zanini N
- Zapata F
- Zarb C
- Zardab A
- Zegarra S
- Zeidan S
- Zerihun Ab
- Zhang Z
- Zheng F
- Zidan H
- Zidan H
- Zidan M
- Zielinski M
- Ziff O
- Zikry M
- Zil-E-Ali A
- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskiene R
- Zimmermann Ef
- Zohair A
- Zorrilla Cd
- Zuber M
- Zuber M
- Zuk G
- Zulkifli A
- Zumbü
- Publication venue
- 'Wiley'
- Publication date
- 27/11/2018
- Field of study
Background
End colostomy rates following colorectal resection vary across institutions in high-income settings, being influenced by patient, disease, surgeon and system factors. This study aimed to assess global variation in end colostomy rates after left-sided colorectal resection.
Methods
This study comprised an analysis of GlobalSurg-1 and -2 international, prospective, observational cohort studies (2014, 2016), including consecutive adult patients undergoing elective or emergency left-sided colorectal resection within discrete 2-week windows. Countries were grouped into high-, middle- and low-income tertiles according to the United Nations Human Development Index (HDI). Factors associated with colostomy formation versus primary anastomosis were explored using a multilevel, multivariable logistic regression model.
Results
In total, 1635 patients from 242 hospitals in 57 countries undergoing left-sided colorectal resection were included: 113 (6·9 per cent) from low-HDI, 254 (15·5 per cent) from middle-HDI and 1268 (77·6 per cent) from high-HDI countries. There was a higher proportion of patients with perforated disease (57·5, 40·9 and 35·4 per cent; P < 0·001) and subsequent use of end colostomy (52·2, 24·8 and 18·9 per cent; P < 0·001) in low- compared with middle- and high-HDI settings. The association with colostomy use in low-HDI settings persisted (odds ratio (OR) 3·20, 95 per cent c.i. 1·35 to 7·57; P = 0·008) after risk adjustment for malignant disease (OR 2·34, 1·65 to 3·32; P < 0·001), emergency surgery (OR 4·08, 2·73 to 6·10; P < 0·001), time to operation at least 48 h (OR 1·99, 1·28 to 3·09; P = 0·002) and disease perforation (OR 4·00, 2·81 to 5·69; P < 0·001).
Conclusion
Global differences existed in the proportion of patients receiving end stomas after left-sided colorectal resection based on income, which went beyond case mix alone
THE USE OF NALOXONE DURING THE WITHDRAWAL SYNDROME FROM HEROIN
- Publication venue
- Publication date
- 01/01/1988
- Field of study
The angry elderly patient
- Author
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
- …