Controlling the dynamics of an open many-body quantum system with localized dissipation

We experimentally investigate the action of a localized dissipative potential on a macroscopic matter wave, which we implement by shining an electron beam on an atomic Bose-Einstein condensate (BEC). We measure the losses induced by the dissipative potential as a function of the dissipation strength observing a paradoxical behavior when the strength of the dissipation exceeds a critical limit: for an increase of the dissipation rate the number of atoms lost from the BEC becomes lower. We repeat the experiment for different parameters of the electron beam and we compare our results with a simple theoretical model, finding excellent agreement. By monitoring the dynamics induced by the dissipative defect we identify the mechanisms which are responsible for the observed paradoxical behavior. We finally demonstrate the link between our dissipative dynamics and the measurement of the density distribution of the BEC allowing for a generalized definition of the Zeno effect. Due to the high degree of control on every parameter, our system is a promising candidate for the engineering of fully governable open quantum systems

Evaluation of Cirrus Parameterizations for Radiative Flux Computations in Climate Models Using TOVS-ScaRaB Satellite Observations

Combined simultaneous satellite observations are used to evaluate the performance of parameterizations of the microphysical and optical properties of cirrus clouds used for radiative flux computations in climate models. Atmospheric and cirrus properties retrieved from Television and Infrared Observation Satellite (TIROS-N) Operational Vertical Sounder (TOVS) observations are given as input to the radiative transfer model developed for the Met Office climate model to simulate radiative fluxes at the top of the atmosphere (TOA). Simulated cirrus shortwave (SW) albedos are then compared to those retrieved from collocated Scanner for Radiation Budget (ScaRaB) observations. For the retrieval, special care has been given to angular direction models. Three parameterizations of cirrus ice crystal optical properties are represented in the Met Office radiative transfer model. These parameterizations are based on different physical approximations and different hypotheses on crystal habit. One parameterization assumes pristine ice crystals and two ice crystal aggregates. By relating the cirrus ice water path (IWP) retrieved from the effective infrared emissivity to the cirrus SW albedo, differences between the parameterizations are amplified. This study shows that pristine crystals seem to be plausible only for cirrus with IWP less than 30 g m−2. For larger IWP, ice crystal aggregates lead to cirrus SW albedos in better agreement with the observations. The data also indicate that climate models should allow the cirrus effective ice crystal diameter (De) to increase with IWP, especially in the range up to 30 g m−2. For cirrus with IWP less than 20 g m−2, this would lead to SW albedos that are about 0.02 higher than the ones of a constant De of 55 μm

The ESA climate change initiative: Satellite data records for essential climate variables

The ESA’s Climate Change Initiative is reprocessing and reassessing over 40 years of multi-sensor satellite records to generate consistent, traceable, long-term datasets of “essential climate variables” for the climate modeling and research communities

The shape of two-dimensional liquid bridges

We have studied a single vertical, two-dimensional liquid bridge spanning the gap between two flat, horizontal solid substrates of given wettabilities. For this simple geometry, the Young-Laplace equation can be solved (quasi-)analytically to yield the equilibrium bridge shape under gravity. We establish the range of gap widths (as described by a Bond number ${\rm Bo}$) for which the liquid bridge can exist, for given contact angles at the top and bottom substrates ($\theta_c^t$ and $\theta_c^b$, respectively). In particular, we find that the absolute maximum span of a liquid bridge is four capillary lengths, for $\theta_c^b=180^\circ$ and $\theta_c^t=0^\circ$; whereas for $\theta_c^b=0^\circ$ and $\theta_c^t=180^\circ$ no bridge can form, for any substrate separation. We also obtain the minimum value of the cross-sectional area of such a liquid bridge, as well as the conditions for the existence and positions of any necks or bulges and inflection points on its surface. This generalises our earlier work in which the gap was assumed to be spanned by a liquid film of zero thickness connecting two menisci at the bottom and top substrates

Co-infection and ICU-acquired infection in COIVD-19 ICU patients: a secondary analysis of the UNITE-COVID data set

Background: The COVID-19 pandemic presented major challenges for critical care facilities worldwide. Infections which develop alongside or subsequent to viral pneumonitis are a challenge under sporadic and pandemic conditions; however, data have suggested that patterns of these differ between COVID-19 and other viral pneumonitides. This secondary analysis aimed to explore patterns of co-infection and intensive care unit-acquired infections (ICU-AI) and the relationship to use of corticosteroids in a large, international cohort of critically ill COVID-19 patients.Methods: This is a multicenter, international, observational study, including adult patients with PCR-confirmed COVID-19 diagnosis admitted to ICUs at the peak of wave one of COVID-19 (February 15th to May 15th, 2020). Data collected included investigator-assessed co-infection at ICU admission, infection acquired in ICU, infection with multi-drug resistant organisms (MDRO) and antibiotic use. Frequencies were compared by Pearson's Chi-squared and continuous variables by Mann-Whitney U test. Propensity score matching for variables associated with ICU-acquired infection was undertaken using R library MatchIT using the "full" matching method.Results: Data were available from 4994 patients. Bacterial co-infection at admission was detected in 716 patients (14%), whilst 85% of patients received antibiotics at that stage. ICU-AI developed in 2715 (54%). The most common ICU-AI was bacterial pneumonia (44% of infections), whilst 9% of patients developed fungal pneumonia; 25% of infections involved MDRO. Patients developing infections in ICU had greater antimicrobial exposure than those without such infections. Incident density (ICU-AI per 1000 ICU days) was in considerable excess of reports from pre-pandemic surveillance. Corticosteroid use was heterogenous between ICUs. In univariate analysis, 58% of patients receiving corticosteroids and 43% of those not receiving steroids developed ICU-AI. Adjusting for potential confounders in the propensity-matched cohort, 71% of patients receiving corticosteroids developed ICU-AI vs 52% of those not receiving corticosteroids. Duration of corticosteroid therapy was also associated with development of ICU-AI and infection with an MDRO.Conclusions: In patients with severe COVID-19 in the first wave, co-infection at admission to ICU was relatively rare but antibiotic use was in substantial excess to that indication. ICU-AI were common and were significantly associated with use of corticosteroids

Clinical and organizational factors associated with mortality during the peak of first COVID-19 wave: the global UNITE-COVID study

Purpose: To accommodate the unprecedented number of critically ill patients with pneumonia caused by coronavirus disease 2019 (COVID-19) expansion of the capacity of intensive care unit (ICU) to clinical areas not previously used for critical care was necessary. We describe the global burden of COVID-19 admissions and the clinical and organizational characteristics associated with outcomes in critically ill COVID-19 patients. Methods: Multicenter, international, point prevalence study, including adult patients with SARS-CoV-2 infection confirmed by polymerase chain reaction (PCR) and a diagnosis of COVID-19 admitted to ICU between February 15th and May 15th, 2020. Results: 4994 patients from 280 ICUs in 46 countries were included. Included ICUs increased their total capacity from 4931 to 7630 beds, deploying personnel from other areas. Overall, 1986 (39.8%) patients were admitted to surge capacity beds. Invasive ventilation at admission was present in 2325 (46.5%) patients and was required during ICU stay in 85.8% of patients. 60-day mortality was 33.9% (IQR across units: 20%–50%) and ICU mortality 32.7%. Older age, invasive mechanical ventilation, and acute kidney injury (AKI) were associated with increased mortality. These associations were also confirmed specifically in mechanically ventilated patients. Admission to surge capacity beds was not associated with mortality, even after controlling for other factors. Conclusions: ICUs responded to the increase in COVID-19 patients by increasing bed availability and staff, admitting up to 40% of patients in surge capacity beds. Although mortality in this population was high, admission to a surge capacity bed was not associated with increased mortality. Older age, invasive mechanical ventilation, and AKI were identified as the strongest predictors of mortality

A unified model for BAM function that takes into account type Vc secretion and species differences in BAM composition

Transmembrane proteins in the outer membrane of Gram-negative bacteria are almost exclusively β-barrels. They are inserted into the outer membrane by a conserved and essential protein complex called the BAM (for β-barrel assembly machinery). In this commentary, we summarize current research into the mechanism of this protein complex and how it relates to type V secretion. Type V secretion systems are autotransporters that all contain a β-barrel transmembrane domain inserted by BAM. In type Vc systems, this domain is a homotrimer. We argue that none of the current models are sufficient to explain BAM function particularly regarding type Vc secretion. We also find that current models based on the well-studied model system Escherichia coli mostly ignore the pronounced differences in BAM composition between different bacterial species. We propose a more holistic view on how all OMPs, including autotransporters, are incorporated into the lipid bilayer