A Review of the Pathophysiology and Novel Treatments for Erectile Dysfunction

Erectile dysfunction (ED) affects up to 50% of men between the ages of 40 and 70. Treatment with PDE-5 inhibitors is effective in the majority of men with ED. However, PDE-5 inhibitors are not effective when levels of nitric oxide (NO), the principle mediator of erection, are low. The pharmacologic actions of three new potential treatments for ED are discussed in this paper: (1) sGC stimulators/activators, (2) Rho-kinase inhibitors, and (3) sodium nitrite

The identification of the optical companion to the binary millisecond pulsar J0610-2100 in the Galactic field

We have used deep V and R images acquired at the ESO Very Large Telescope to identify the optical companion to the binary pulsar PSR J0610-2100, one of the black-widow millisecond pulsars recently detected by the Fermi Gamma-ray Telescope in the Galactic plane. We found a faint star (V~26.7) nearly coincident (\delta r ~0".28) with the pulsar nominal position. This star is visible only in half of the available images, while it disappears in the deepest ones (those acquired under the best seeing conditions), thus indicating that it is variable. Although our observations do not sample the entire orbital period (P=0.28 d) of the pulsar, we found that the optical modulation of the variable star nicely correlates with the pulsar orbital period and describes a well defined peak (R~25.6) at \Phi=0.75, suggesting a modulation due to the pulsar heating. We tentatively conclude that the companion to PSR J0610-2100 is a heavily ablated very low mass star (~ 0.02Msun) that completely filled its Roche Lobe.Comment: 17 pages, 5 figures - Accepted for pubblication in Ap

The Hubble Legacy Archive NICMOS Grism Data

The Hubble Legacy Archive (HLA) aims to create calibrated science data from the Hubble Space Telescope archive and make them accessible via user-friendly and Virtual Observatory (VO) compatible interfaces. It is a collaboration between the Space Telescope Science Institute (STScI), the Canadian Astronomy Data Centre (CADC) and the Space Telescope - European Coordinating Facility (ST-ECF). Data produced by the Hubble Space Telescope (HST) instruments with slitless spectroscopy modes are among the most difficult to extract and exploit. As part of the HLA project, the ST-ECF aims to provide calibrated spectra for objects observed with these HST slitless modes. In this paper, we present the HLA NICMOS G141 grism spectra. We describe in detail the calibration, data reduction and spectrum extraction methods used to produce the extracted spectra. The quality of the extracted spectra and associated direct images is demonstrated through comparison with near-IR imaging catalogues and existing near-IR spectroscopy. The output data products and their associated metadata are publicly available through a web form at http://hla.stecf.org and via VO interfaces. In total, 2470 spectra of 1923 unique targets are included in the current release.Comment: 18 pages, 21 figures, accepted for publication in Astronomy & Astrophysic

The 3D Structure of N132D in the LMC: A Late-Stage Young Supernova Remnant

We have used the Wide Field Spectrograph (WiFeS) on the 2.3m telescope at Siding Spring Observatory to map the [O III] 5007{\AA} dynamics of the young oxygen-rich supernova remnant N132D in the Large Magellanic Cloud. From the resultant data cube, we have been able to reconstruct the full 3D structure of the system of [O III] filaments. The majority of the ejecta form a ring of ~12pc in diameter inclined at an angle of 25 degrees to the line of sight. We conclude that SNR N132D is approaching the end of the reverse shock phase before entering the fully thermalized Sedov phase of evolution. We speculate that the ring of oxygen-rich material comes from ejecta in the equatorial plane of a bipolar explosion, and that the overall shape of the SNR is strongly influenced by the pre-supernova mass loss from the progenitor star. We find tantalizing evidence of a polar jet associated with a very fast oxygen-rich knot, and clear evidence that the central star has interacted with one or more dense clouds in the surrounding ISM.Comment: Accepted for Publication in Astrophysics & Space Science, 18pp, 8 figure

Constraining the optical emission from the double pulsar system J0737-3039

We present the first optical observations of the unique system J0737-3039 (composed of two pulsars, hereafter PSR-A and PSR-B). Ultra-deep optical observations, performed with the High Resolution Camera of the Advanced Camera for Surveys on board the Hubble Space Telescope could not detect any optical emission from the system down to m_F435W=27.0 and m_F606W=28.3. The estimated optical flux limits are used to constrain the three-component (two thermal and one non-thermal) model recently proposed to reproduce the XMM-Newton X-ray spectrum. They suggest the presence of a break at low energies in the non-thermal power law component of PSR-A and are compatible with the expected black-body emission from the PSR-B surface. The corresponding efficiency of the optical emission from PSR-A's magnetosphere would be comparable to that of other Myr-old pulsars, thus suggesting that this parameter may not dramatically evolve over a time-scale of a few Myr.Comment: 16 pages, 3 figures, ApJ accepte

Deep optical observations of the interaction of the SS 433 microquasar jet with the W 50 radio continuum shell

Four mosaics of deep, continuum-subtracted, CCD images have been obtained over the extensive galactic radio continuum shell, W 50, which surrounds the remarkable stellar system SS 433. Two of these mosaics in the Halpha+[N II] and [O III] 5007 A emission lines respectively cover a field of ~2.3 x 2.5 degr^2 which contains all of W 50 but at a low angular resolution of 5 arcsec. The third and fourth mosaics cover the eastern (in [O III] 5007 A) and western (in Halpha+[N II]) filamentary nebulosity respectively but at an angular resolution of 1 arcsec. These observations are supplemented by new low dispersion spectra and longslit, spatially resolved echelle spectra. The [O III] 5007 A images show for the first time the distribution of this emission in both the eastern and western filaments while new Halpha+[N II] emission features are also found in both of these regions. Approaching flows of faintly emitting material from the bright eastern filaments of up 100 km/s in radial velocity are detected. The present observations also suggest that the heliocentric systemic radial velocity of the whole system is 56+-2 km/s. Furthermore, very deep imagery and high resolution spectroscopy of a small part of the northern radio ridge of W 50 has revealed for the first time the very faint optical nebulosity associated with this edge. It is suggested that patchy foreground dust along the ~5 kpc sightline is inhibiting the detection of all of the optical nebulosity associated with W 50. The interaction of the microquasar jets of SS 433 with the W 50 shell is discussed.Comment: 19 pages, 13 figures, 2 tables. Accepted for pubication in MNRA

The thick disk rotation-metallicity correlation as a fossil of an "inverse chemical gradient" in the early Galaxy

The thick disk rotation--metallicity correlation, \partial V_\phi/\partial[Fe/H] =40\div 50 km s^{-1}dex^{-1} represents an important signature of the formation processes of the galactic disk. We use nondissipative numerical simulations to follow the evolution of a Milky Way (MW)-like disk to verify if secular dynamical processes can account for this correlation in the old thick disk stellar population. We followed the evolution of an ancient disk population represented by 10 million particles whose chemical abundances were assigned by assuming a cosmologically plausible radial metallicity gradient with lower metallicity in the inner regions, as expected for the 10-Gyr-old MW. Essentially, inner disk stars move towards the outer regions and populate layers located at higher |z|. A rotation--metallicity correlation appears, which well resembles the behaviour observed in our Galaxy at a galactocentric distance between 8 kpc and 10 kpc. In particular,we measure a correlation of \partial V_\phi/\partial[Fe/H]\simeq 60 km s^{-1}dex^{-1} for particles at 1.5 kpc < |z| < 2.0 kpc that persists up to 6 Gyr. Our pure N-body models can account for the V_\phi vs. [Fe/H] correlation observed in the thick disk of our Galaxy, suggesting that processes internal to the disk such as heating and radial migration play a role in the formation of this old stellar component. In this scenario, the positive rotation-metallicity correlation of the old thick disk population would represent the relic signature of an ancient "inverse" chemical (radial) gradient in the inner Galaxy, which resulted from accretion of primordial gas.Comment: Accepted for publication on Astronomy and Astrophysic

Optically bright Active Galactic Nuclei in the ROSAT-Faint Source Catalogue

To build a large, optically bright, X-ray selected AGN sample we have correlated the ROSAT-FSC catalogue of X-ray sources with the USNO catalogue limited to objects brighter than O=16.5 and then with the APS database. Each of the 3,212 coincidences was classified using the slitless Hamburg spectra. 493 objects were found to be extended and 2,719 starlike. Using both the extended objects and the galaxies known from published catalogues we built up a sample of 185 galaxies with O_APS < 17.0 mag, which are high-probability counterparts of RASS-FSC X-ray sources. 130 galaxies have a redshift from the literature and for another 34 we obtained new spectra. The fraction of Seyfert galaxies in this sample is 20 %. To select a corresponding sample of 144 high-probability counterparts among the starlike sources we searched for very blue objects in an APS-based color-magnitude diagram. Forty-one were already known AGN and for another 91 objects we obtained new spectra, yielding 42 new AGN, increasing their number in the sample to 83. This confirms that surveys of bright QSOs are still significantly incomplete. On the other hand we find that, at a flux limit of 0.02 count /-1 and at this magnitude, only 40 % of all QSOs are detected by ROSAT.Comment: 17 pages, 16 figures, accepted by A&

An extension of the SHARC survey

We report on our search for distant clusters of galaxies based on optical and X-ray follow up observations of X-ray candidates from the SHARC survey. Based on the assumption that the absence of bright optical or radio counterparts to possibly extended X-ray sources could be distant clusters. We have obtained deep optical images and redshifts for several of these objects and analyzed archive XMM-Newton or Chandra data where applicable. In our list of candidate clusters, two are probably galaxy structures at redshifts of z$\sim$0.51 and 0.28. Seven other structures are possibly galaxy clusters between z$\sim$0.3 and 1. Three sources are identified with QSOs and are thus likely to be X-ray point sources, and six more also probably fall in this category. One X-ray source is spurious or variable. For 17 other sources, the data are too sparse at this time to put forward any hypothesis on their nature. We also serendipitously detected a cluster at z=0.53 and another galaxy concentration which is probably a structure with a redshift in the [0.15-0.6] range. We discuss these results within the context of future space missions to demonstrate the necessity of a wide field of view telescope optimized for the 0.5-2 keV range.Comment: Accepted in A&

The Large Quasar Reference Frame (LQRF) - an optical representation of the ICRS

The large number and all-sky distribution of quasars from different surveys, along with their presence in large, deep astrometric catalogs,enables the building of an optical materialization of the ICRS following its defining principles. Namely: that it is kinematically non-rotating with respect to the ensemble of distant extragalactic objects; aligned with the mean equator and dynamical equinox of J2000; and realized by a list of adopted coordinates of extragalatic sources. Starting from the updated and presumably complete LQAC list of QSOs, the initial optical positions of those quasars are found in the USNO B1.0 and GSC2.3 catalogs, and from the SDSS DR5. The initial positions are next placed onto UCAC2-based reference frames, following by an alignment with the ICRF, to which were added the most precise sources from the VLBA calibrator list and the VLA calibrator list - when reliable optical counterparts exist. Finally, the LQRF axes are inspected through spherical harmonics, contemplating to define right ascension, declination and magnitude terms. The LQRF contains J2000 referred equatorial coordinates for 100,165 quasars, well represented across the sky, from -83.5 to +88.5 degrees in declination, and with 10 arcmin being the average distance between adjacent elements. The global alignment with the ICRF is 1.5 mas, and the individual position accuracies are represented by a Poisson distribution that peaks at 139 mas in right ascension and 130 mas in declination. It is complemented by redshift and photometry information from the LQAC. The LQRF is designed to be an astrometric frame, but it is also the basis for the GAIA mission initial quasars' list, and can be used as a test bench for quasars' space distribution and luminosity function studies.Comment: 23 pages, 23 figures, 6 tables Accepted for publication by Astronomy & Astrophysics, on 25 May 200