CCL5 Neutralization Restricts Cancer Growth and Potentiates the Targeting of PDGFRβ in Colorectal Carcinoma

Increased CCL5 levels are markers of an unfavourable outcome in patients with melanoma, breast, cervical, prostate, gastric or pancreatic cancer. Here, we have assessed the role played by CCL5/CCR5 interactions in the development of colon cancer. To do so, we have examined a number of human colorectal carcinoma clinical specimens and found CCL5 and its receptors over-expressed within primary as well as liver and pulmonary metastases of patients compared to healthy tissues. In vitro, CCL5 increased the growth and migratory responses of colon cancer cells from both human and mouse origins. In addition, systemic treatment of mice with CCL5-directed antibodies reduced the extent of development of subcutaneous colon tumors, of liver metastases and of peritoneal carcinosis. Consistently, we found increased numbers of CD45-immunoreactive cells within the stroma of the remaining lesions as well as at the interface with the healthy tissue. In contrast, selective targeting of CCR5 through administration of TAK-779, a CCR5 antagonist, only partially compromised colon cancer progression. Furthermore, CCL5 neutralization rendered the tumors more sensitive to a PDGFRβ-directed strategy in mice, this combination regimen offering the greatest protection against liver metastases and suppressing macroscopic peritoneal carcinosis. Collectively, our data demonstrate the involvement of CCL5 in the pathogenesis of colorectal carcinoma and point to its potential value as a therapeutic target

Comparaison des propriétés catalytiques de quelques oxydes sulfatés

Les oxydes sulfatés constituent une famille de catalyseurs solides susceptibles de remplacer les acides liquides dans les réactions d'isomérisation ou d'alkylation aliphatique. Dans ce travail, quatre oxydes sulfatés ont été préparés. Nous nous sommes attachés, d'une part, à déterminer les conditions d'activation permettant de générer une acidité forte et d’autre part, à comparer ces solides entre eux dans les réactions d'isomérisation du n-butane et de déshydratation du propanol-2-ol. Une interprétation basée sur la valeur de la charge portée par les cations est proposée

CO and C-2 excited states relaxation in CO2 plasmas derived from a Collisional-Radiative model

WOS:000337223400059International audienceIn order to explain the behavior of the main excited electronic states of CO and C-2 molecules formed in CO2 entry or ground test facilities plasmas, a time-dependent Collisional-Radiative (CR) model is elaborated. This CR model is then included in the general balance equation of the species to give an insight on the influence of the transport and elementary processes. The related flows are generally observed under relatively low temperature owing to the numerous internal degrees of freedom to be excited, leading to a rather weak ionization degree. The electron-induced processes are even so taken into account: their influence is studied and commented. The conditions to reach non-equilibrium steady states and the related characteristic time scales are discussed as well

Sulfate species in MgO-supported LaMn0.5Mg0.5O3 perovskites: an insigh into the chemistry of MgO

The structure, thermal stability, and reducibility in H2 of sulfate species formed in MgO-promoted perovskites, LaMn0.5Mg0.5O3·17 MgO, have been studied by infrared spectroscopy, temperature-programmed desorption, and temperature-programmed reduction−mass spectrometry. Sulfation at 1073 K generates on the MgO phase both bulk and subsurface sulfates, whereas the latter species are the major product of sulfation at room temperature. In contrast with high-surface MgO samples (where sulfate species of covalent nature are found), the surface species closely resemble those in the bulk. Bulk sulfates are more resistant to thermal treatments than surface sulfates. A transformation of bulk sulfates at higher temperature into sulfides is suggested by IR spectroscopy and proved by chemical analysis. SO2, SO, and H2S are the products of sulfate reduction

Progress report on measurement of the polarization in K+nK^{+}n charge exchange

The experiment is being performed at the CERN PS, and measures polarisation in $K^{+}n$ charge exchange at 6 GeV/c for -0.15>t>-1.5 (GeV/c)/sup 2/. Data-taking began in spring 1976. (3 refs)