Using coloured filters to reduce the symptoms of visual stress in children with reading delay

Background: Meares Irlen Syndrome (MIS), otherwise known as “visual stress”, is one condition that can cause difficulties with reading. Aim: This study aimed to compare the effect of two coloured-filter systems on the symptoms of visual stress in children with reading delay. Methods: The study design was a pre-test, post-test, randomized head-to-head comparison of two filter systems on the symptoms of visual stress in school children. A total of 68 UK mainstream schoolchildren with significant impairment in reading ability completed the study. Results: The filter systems appeared to have a large effect on the reported symptoms between pre and post three-month time points (d = 2.5, r = 0.78). Both filter types appeared to have large effects (Harris d = 1.79, r = 0.69 and DRT d = 3.22, r = 0.85). Importantly, 35% of participants’ reported that their symptoms had resolved completely; 72% of the 68 children appeared to gain improvements in three or more visual stress symptoms. Conclusion and significance: The reduction in symptoms, which appeared to be brought about by the use of coloured filters, eased the visual discomfort experienced by these children when reading. This type of intervention therefore has the potential to facilitate occupational engagement

Changes in the red giant and dusty environment of the recurrent nova RS Ophiuchi following the 2006 eruption

We present near-infrared spectroscopy of the recurrent nova RS Ophiuchi (RS Oph) obtained on several occasions after its latest outburst in 2006 February. The 1–5 μm spectra are dominated by the red giant, but the H i, He i and coronal lines present during the eruption are present in all our observations. From the fits of the computed infrared spectral energy distributions to the observed fluxes, we find Teff= 4200 ± 200 K for the red giant. The first overtone CO bands at 2.3 μm, formed in the atmosphere of the red giant, are variable. The spectra clearly exhibit an infrared excess due to dust emission longward of 5 μm; we estimate an effective temperature for the emitting dust shell of 500 K, and find that the dust emission is also variable, being beyond the limit of detection in 2007. Most likely, the secondary star in RS Oph is intrinsically variable

The noise properties of stochastic processes and entropy production

Based on a Fokker-Planck description of external Ornstein-Uhlenbeck noise and cross-correlated noise processes driving a dynamical system we examine the interplay of the properties of noise processes and the dissipative characteristic of the dynamical system in the steady state entropy production and flux. Our analysis is illustrated with appropriate examples.Comment: RevTex, 1 figure, To appear in Phys. Rev.

The Spatial Distribution of Star Formation in the Solar Neighbourhood: Do all stars form in clusters?

We present a global study of low mass, young stellar object (YSO) surface densities in nearby (< 500 pc) star forming regions based on a comprehensive collection of Spitzer Space Telescope surveys. We show that the distribution of YSO surface densities in the solar neighbourhood is a smooth distribution, being adequately described by a lognormal function from a few to 10^3 YSOs per pc^2, with a peak at 22 stars/pc^2 and a dispersion of 0.85. We do not find evidence for multiple discrete modes of star-formation (e.g. clustered and distributed). Comparing the observed surface density distribution to previously reported surface density threshold definitions of clusters, we find that the fraction of stars in clusters is crucially dependent on the adopted definitions, ranging from 40 to 90%. However, we find that only a low fraction (< 26%) of stars are formed in dense environments where their formation/evolution (along with their circumstellar disks and/or planets) may be affected by the close proximity of their low-mass neighbours.Comment: 6 pages, 2 figures, MNRAS letters, accepte

Effects of multiple-bond ruptures on kinetic parameters extracted from force spectroscopy measurements: Revisiting biotin-streptavidin interactions

Force spectroscopy measurements of the rupture of the molecular bond between biotin and streptavidin often results in a wide distribution of rupture forces. We attribute the long tail of high rupture forces to the nearly simultaneous rupture of more than one molecular bond. To decrease the number of possible bonds, we employed hydrophilic polymeric tethers to attach biotin molecules to the atomic force microscope probe. It is shown that the measured distributions of rupture forces still contain high forces that cannot be described by the forced dissociation from a deep potential well. We employed a recently developed analytical model of simultaneous rupture of two bonds connected by polymer tethers with uneven length to fit the measured distributions. The resulting kinetic parameters agree with the energy landscape predicted by molecular dynamics simulations. It is demonstrated that when more than one molecular bond might rupture during the pulling measurements there is a noise-limited range of probe velocities where the kinetic parameters measured by force spectroscopy correspond to the true energy landscape. Outside this range of velocities, the kinetic parameters extracted by using the standard most probable force approach might be interpreted as artificial energy barriers that are not present in the actual energy landscape. Factors that affect the range of useful velocities are discussed

The outburst of an embedded low-mass YSO in L1641

Strong outbursts in very young and embedded protostars are rare and not yet fully understood. They are believed to originate from an increase of the mass accretion rate onto the source. We report the discovery of a strong outburst in a low-mass embedded young stellar object (YSO), namely 2MASS-J05424848-0816347 or [CTF93]216-2, as well as its photometric and spectroscopic follow-up. Using near- to mid-IR photometry and NIR low-resolution spectroscopy, we monitor the outburst, deriving its magnitude, duration, as well as the enhanced accretion luminosity and mass accretion rate. [CTF93]216-2 increased in brightness by ~4.6, 4.0, 3.8, and 1.9 mag in the J, H, Ks bands and at 24 um, respectively, corresponding to an L_bol increase of ~20 L_sun. Its early spectrum, probably taken soon after the outburst, displays a steep almost featureless continuum, with strong CO band heads and H_2O broad-band absorption features, and Br gamma line in emission. A later spectrum reveals more absorption features, allowing us to estimate T_eff~3200 K, M~0.25 M_sun, and mass accretion rate~1.2x10^{-6} M_sun yr^{-1}. This makes it one of the lowest mass YSOs with a strong outburst so far discovered.Comment: To be published in A&A letter; 5 pages, 4 figure

Dynamics of Highly Supercooled Liquids:Heterogeneity, Rheology, and Diffusion

Highly supercooled liquids with soft-core potentials are studied via molecular dynamics simulations in two and three dimensions in quiescent and sheared conditions.We may define bonds between neighboring particle pairs unambiguously owing to the sharpness of the first peak of the pair correlation functions. Upon structural rearrangements, they break collectively in the form of clusters whose sizes grow with lowering the temperature $T$. The bond life time $\tau_b$, which depends on $T$ and the shear rate \gdot, is on the order of the usual structural or $\alpha$ relaxation time $\tau_{\alpha}$ in weak shear \gdot \tau_{\alpha} \ll 1, while it decreases as 1/\gdot in strong shear \gdot\tau_{\alpha} \gg 1 due to shear-induced cage breakage. Accumulated broken bonds in a time interval ($\sim 0.05\tau_b$) closely resemble the critical fluctuations of Ising spin systems. For example, their structure factor is well fitted to the Ornstein-Zernike form, which yields the correlation length $\xi$ representing the maximum size of the clusters composed of broken bonds. We also find a dynamical scaling relation, $\tau_b \sim \xi^{z}$, valid for any $T$ and \gdot with $z=4$ in two dimensions and $z=2$ in three dimensions. The viscosity is of order $\tau_b$ for any $T$ and \gdot, so marked shear-thinning behavior emerges. The shear stress is close to a limiting stress in a wide shear region. We also examine motion of tagged particles in shear in three dimensions. The diffusion constant is found to be of order $\tau_b^{-\nu}$ with $\nu=0.75 \sim 0.8$ for any $T$ and \gdot, so it is much enhanced in strong shear compared with its value at zero shear. This indicates breakdown of the Einstein-Stokes relation in accord with experiments. Some possible experiments are also proposed.Comment: 20pages (including figures

Bio-informatics analysis of a gene co-expression module in adipose tissue containing the diet-responsive gene Nnat

Background: Obesity causes insulin resistance in target tissues - skeletal muscle, adipose tissue, liver and the brain. Insulin resistance predisposes to type-2 diabetes (T2D) and cardiovascular disease (CVD). Adipose tissue inflammation is an essential characteristic of obesity and insulin resistance. Neuronatin (Nnat) expression has been found to be altered in a number of conditions related to inflammatory or metabolic disturbance, but its physiological roles and regulatory mechanisms in adipose tissue, brain, pancreatic islets and other tissues are not understood. Results: We identified transcription factor binding sites (TFBS) conserved in the Nnat promoter, and transcription factors (TF) abundantly expressed in adipose tissue. These include transcription factors concerned with the control of: adipogenesis (Ppar gamma, Klf15, Irf1, Creb1, Egr2, Gata3); lipogenesis (Mlxipl, Srebp1c); inflammation (Jun, Stat3); insulin signalling and diabetes susceptibility (Foxo1, Tcf7l2). We also identified NeuroD1 the only documented TF that controls Nnat expression. We identified KEGG pathways significantly associated with Nnat expression, including positive correlations with inflammation and negative correlations with metabolic pathways (most prominently oxidative phosphorylation, glycolysis and gluconeogenesis, pyruvate metabolism) and protein turnover. 27 genes, including; Gstt1 and Sod3, concerned with oxidative stress; Sncg and Cxcl9 concerned with inflammation; Ebf1, Lgals12 and Fzd4 involved in adipogenesis; whose expression co-varies with Nnat were identified, and conserved transcription factor binding sites identified on their promoters. Functional networks relating to each of these genes were identified. Conclusions: Our analysis shows that Nnat is an acute diet-responsive gene in white adipose tissue and hypothalamus; it may play an important role in metabolism, adipogenesis, and resolution of oxidative stress and inflammation in response to dietary exces

Angular Momentum and the Formation of Stars and Black Holes

The formation of compact objects like stars and black holes is strongly constrained by the requirement that nearly all of the initial angular momentum of the diffuse material from which they form must be removed or redistributed during the formation process. The mechanisms that may be involved and their implications are discussed for (1) low-mass stars, most of which probably form in binary or multiple systems; (2) massive stars, which typically form in clusters; and (3) supermassive black holes that form in galactic nuclei. It is suggested that in all cases, gravitational interactions with other stars or mass concentrations in a forming system play an important role in redistributing angular momentum and thereby enabling the formation of a compact object. If this is true, the formation of stars and black holes must be a more complex, dynamic, and chaotic process than in standard models. The gravitational interactions that redistribute angular momentum tend to couple the mass of a forming object to the mass of the system, and this may have important implications for mass ratios in binaries, the upper stellar IMF in clusters, and the masses of supermassive black holes in galaxies.Comment: Accepted by Reports on Progress in Physic