Nasalization in Sharanahua

From the introduction: The nasalization of vowels in Sharanahua can be explained on the basis of consonants present in the underlying form of the morphemes, but the underlying consonants are not always nasal consonants. The explanation proposed here for oral consonants producing nasal vowels exploits the notion of sequential constraint rules ordered among or after other phonological rules

Connecting geodesics and security of configurations in compact locally symmetric spaces

A pair of points in a riemannian manifold makes a secure configuration if the totality of geodesics connecting them can be blocked by a finite set. The manifold is secure if every configuration is secure. We investigate the security of compact, locally symmetric spaces.Comment: 27 pages, 2 figure

Genetic determinants of telomere length from 109,122 ancestrally diverse whole-genome sequences in TOPMed

Genetic studies on telomere length are important for understanding age-related diseases. Prior GWAS for leukocyte TL have been limited to European and Asian populations. Here, we report the first sequencing-based association study for TL across ancestrally-diverse individuals (European, African, Asian and Hispanic/Latino) from the NHLBI Trans-Omics for Precision Medicine (TOPMed) program. We used whole genome sequencing (WGS) of whole blood for variant genotype calling and the bioinformatic estimation of telomere length in n=109,122 individuals. We identified 59 sentinel variants (p-value OBFC1indicated the independent signals colocalized with cell-type specific eQTLs for OBFC1 (STN1). Using a multi-variant gene-based approach, we identified two genes newly implicated in telomere length, DCLRE1B (SNM1B) and PARN. In PheWAS, we demonstrated our TL polygenic trait scores (PTS) were associated with increased risk of cancer-related phenotypes

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

Diccionario capanahua-castellano

Este volumen fue preparado para ayudar a los hablantes del capanahua a valorar mejor su lengua materna y su cultura, también para promover una mejor comprensión entre los pueblos capanahuas y los hispano-hablantes

Double Binding Communication: Emotionally Disruptive Effects on College Students

This study investigated the emotionally disruptive effects of double binding communication, as compared with overtly punitive, and warm, accepting interactions. Forty-two college undergraduates scoring above the mean on the Neuroticism Subscale of Eysenck's Personality Questionaire were each directed to play the part of a small child in a spontaneous role-played family interaction. A pre-post mood test (Multiple Adjective Affect Check List), sensitive to changes in depression, hostility, and anxiety was administered. It was found that subjects in the double-bind and punitive conditions evidenced significant mood disturbance while subjects in the control group did not (all ps < .05). Implications for Double Bind Theory were discussed

Communication and Conflict in Marital Dyads: A Personal Construct Approach

A typology of marital dyads derived from Kelly's (1955) Personal Construct Psychology was used to investigate the communicative behaviors of married companions. Four groups based on Kelly's Commonality (dyadic similarity) and Sociality (dyadic understanding) corollaries were contrasted: similar-understanding, dissimilar-understanding, similar-misunderstanding, and dissimilar-misunderstanding couples. It was expected that dyadic understanding would contribute more to self-disclosure, cooperative involvement, and marital satisfaction than dyadic similarity. Furthermore, it was anticipated that couples high in understanding and low in similarity would represent optimally functioning couples, as evidenced by disclosure, satisfaction, and involvement with each other. Sixty-three married couples who had known each other at least two years completed questionnaire items assessing demographic variables, marital satisfaction (Dyadic Adjustment Scale) and self-reported communication behaviors (Partner Communication Inventory, Dyadic Disclosure Inventory). Each spouse also completed an 8 X 8 Repertory Grid and predicted the mate's responses on the Rep Grid. Subjects then participated in three different audio-taped discussion tasks (an informal conversation, a consensus decision-making task, and a role-played conflict-resolution scene) which were rated for avoidant, competitive, and cooperative responses, as well as overall self-disclosure. Although understanding facilitated disclosure in conflict situations and similarity fostered marital satisfaction, communicative behaviors generally reflected the joint influence of both similarity and understanding. Dissimilar-understanding couples were intensely involved with each other and freely disclosed, but were not highly satisfied. Similar-understanding couples were the most content and had the greatest sense of validation as a couple. Similar-misunderstanding couples restricted their relationship by attempting to avoid expected confrontations. Dissimilar-misunderstanding couples viewed themselves in a socially desirable light, tried to maintain congenial, nonintimate interactions, and were moderately contented. Implications for therapeutic programs, for Kelly's theory, and for future research were discussed

Estudios Panos I

Esta colección de estudios panos intenta proveer datos empíricos a la categoría general de la gramática. Cada estudio se profundiza, en lo posible, en un aspecto diferente de la gramática