Los fundamentos lingüísticos de la etnohistoria andina y comentarios en torno al anónimo de Charcas de 1604.

Sin resume

Implementación de estrategias y tácticas para mejorar los niveles de rentabilidad en comercial Gavilánez.

"El presente proyecto está dirigido a todos los locales que comercializan productos de consumo masivo dentro de la ciudad de Milagro y que no realizan innovaciones dentro de sus negocios tal vez sea por falta de conocimiento o por no realizar inversiones. Estos locales desconocen las oportunidades que están dejando pasar y en esta investigación se generan ideas que se podrán poner en práctica, para lograr un avance para los mismos, ya que no solo se beneficiarán ellos si no también los clientes ya que la atención hacia ellos mejorará. Cada estrategia planteada en la investigación para ser aplicada a nuestro local de estudio pronostica un éxito definitivo en la ejecución del trabajo propuesto, es por ese motivo que invitamos a los lectores a que conozcan más sobre técnicas y estrategias de marketing así como también la poca inversión que se debe realizar para que estas den resultado en corto tiempo. La aplicación de estrategias en nuestro local de estudio se da por el nivel bajo de ventas que ha venido presentando durante los últimos años, con el único objetivo de que aumente su rentabilidad y que brinde un mayor servicio a sus clientes para que haya total satisfacción y en un futuro logre su objetivo empresarial expandirse a nuevas localidades.

Planeamiento estratégico para la región Arequipa

El presente trabajo desarrolla el plan estratégico de la región Arequipa, región con alto potencial por desarrollar, representado principalmente por sus recursos turísticos y ubicación estratégica, aspectos que mediante un adecuado plan de desarrollo en infraestructura podrían generar un mayor dinamismo económico. La metodología utilizada para la formulación de este plan estratégico consideró el Modelo Secuencial del Proceso Estratégico desarrollado por el profesor Fernando D`Alessio. Para ello se verificó información bibliográfica disponible a partir de la cual se pudo conocer la situación actual de la región de Arequipa, de forma posterior, se efectuó un análisis externo e interno, con el propósito de establecer objetivos de corto y largo plazo los cuales se llevarán a cabo mediante la formulación, implementación y evaluación de estrategias, con el fin de alcanzar la visión planteada, para que en el 2028 Arequipa sea una de las primeras regiones en el Perú en el ranking de productividad medido por el PBI que represente un modelo en Latinoamérica, ofreciendo dinamismo agropecuario, textil y turístico, generando empleo digno y permitiendo incrementar los pilares de competitividad, economía, gobierno e infraestructura. El cumplimiento de los objetivos planteados a corto y largo plazo permitirá alcanzar el logro de la visión mediante la aplicación del presente plan estratégico, la región de Arequipa se consolidará como un modelo referencial para la economía nacional y mundial, y servirá como referencia para el accionar de medidas y políticas y alcanzar mayor bienestar de la población.This work develops the strategic plan of the region of Arequipa, a region with a high potential to develop, mainly represented by the strategical location and tourism factors, which could be better exploited through an effective infrastructure could generate greater economic dynamism. The methodology used to formulate this strategic plan has been based on the Sequential Model of the Strategic Process developed by Professor Fernando D´Alessio. To this end, bibliographic information based on reliable sources was reviewed, from which the current situation of the region could be known. After that, an external and internal analysis was carried out to establish short and long term objectives which will be carried out carried out through the formulation, implementation and evaluation of strategies, in order to achieve the desired vision, that by 2028 region of Arequipa can be considered as one of most important cities and as a reference for Latin America, which will allow promoting the most important economic activities such as tourism, gastronomy, between others. The achievement of the vision will depend on the fulfillment of the short and longterm objectives, through the application of this strategic plan, the region de Arequipa will be consolidated as a fundamental actor of the national and global economy, and will serve as a reference for the action of measures and policies and achieve greater welfare of the population.Tesi

Estructura de capital y gobierno corporativo de clubes de alto rendimiento de fútbol.

Estudio realizado para conocer la estructura de capital que presentan los equipos de fútbol de alto rendimiento en el Ecuador del periodo comprendido entre los años 2016 y 2018. El enfoque principal del estudio es la estructura de capital del club empleando el Costo Promedio Ponderado, además de indagar acerca del gobierno corporativo de la industria, a fin de conocer si tienen un procedimiento ordenado al momento de la toma de decisiones. El proyecto, de acuerdo a la teoría de la jerarquía, presenta la estructura de capital óptima del club analizado; además se observa que tres clubes estudiados muestran un comportamiento financiero similar

A cross-sectional study to assess the level of satisfaction with virtual education in Peruvian medical students

"Objectives: Education has totally changed in the context of the pandemic. Therefore, the objective of the present study was to evaluate the factors associated with the level of satisfaction with virtual education in Peruvian medical students during COVID-19. Methods: Analytical and cross-sectional study, based on an online survey of students nationwide. We use previously validated instruments to measure the level of satisfaction and stress (EPP-10-c) of students with virtual education. For the associated factors, adjusted prevalence ratios (PR) were estimated using Poisson regression. Results: Of the 1,878 students surveyed, the median age was 21 years, 57.8% (1,086) were women, 34.8% (654) had a high level of satisfaction with virtual education and 10.7% (202) presented high levels of stress. The factors associated with a low level of satisfaction were attending the fifth year of study, the partial and non-virtual adaptation of the university to virtual education, and a high level of stress. On the other hand, the factors associated with a high level of satisfaction were the education platform used and the study method used. Conclusion: Seven out of 10 students presented a low level of satisfaction with virtual education, 1 out of 10 presented a high level of stress. The factors associated with the low level of satisfaction were attending the fifth year of study, the non-virtual and partial adaptation of the university to virtual education, and the high level of stress.

Morphological Study and Dielectric Behavior of Nonisothermally Crystallized Poly(ethylene naphthalate) Nanocomposites as a Function of Graphene Content

Morphological evolution and dielectric properties of poly(ethylene naphthalate)- (PEN-) graphene nanocomposites nonisothermally crystallized have been investigated. PEN-graphene nanocomposites containing 0.01, 0.025, 0.05, 0.075, and 0.1 wt% of graphene were prepared by melt blending in a mini twin screw extruder. The results showed that graphene exhibited a superior influence on morphological and conformational structure of PEN during nonisothermal crystallization at low graphene contents. Crystallization temperature (Tc) was found to be increased up to 18°C supporting the high nucleating activity of graphene layers. Wide angle X-ray diffraction (WAXD) and Fourier Transform Infrared Spectroscopy (FTIR) indicated that graphene modifies the conformation of PEN chains promoting crystallinity and favoring the evolution from α to β crystalline form with homogeneous lamellar thickness. It may be attributed to the structural similarity between naphthalene rings and graphene structure and to π-π interactions during nucleation. Dielectric behavior was found to be a function of graphene content where the nanocomposites changed from dielectric to low conducting material when passing from 0.075 to 0.1 wt% of graphene content. This phenomenon permits having a wide range of properties to fit a wide variety of applications required to store electrical energy of low voltage

Anti‑inflammatory drugs and uterine cervical cancer cells: Antineoplastic effect of meclofenamic acid

Uterine cervical cancer (UCC) is one of the main causes of cancer-associated mortality in women. Inflammation has been identified as an important component of this neoplasia; in this context, anti-inflammatory drugs represent possible prophylactic and/or therapeutic alternatives that require further investigation. Anti-inflammatory drugs are common and each one may exhibit a different antineoplastic effect. As a result, the present study investigated different anti-inflammatory models of UCC in vitro and in vivo. Celecoxib, sulindac, nimesulide, dexamethasone, meclofenamic acid, flufenamic acid and mefenamic acid were tested in UCC HeLa, VIPA, INBL and SiHa cell lines. The cytotoxicity of the drugs was evaluated in vitro. Celecoxib, sulindac, nimesulide, mefenamic acid and flufenamic acid presented with slight to moderate toxicity (10–40% of cell death corresponding to 100 µM) in certain cell lines, while meclofenamic acid exhibited significant cytotoxicity in all essayed cell lines (50–90% of cell death corresponding to 100 µM). The meclofenamic acid was tested in murine models (immunodeficient and immunocompetent) of UCC, which manifested a significant reduction in tumor growth and increased mouse survival. It was demonstrated that of the evaluated anti-inflammatory drugs, meclofenamic acid was the most cytotoxic, with a significant antitumor effect in murine models. Subsequent studies are necessary to evaluate the clinical utility of this drug

Role of poly(ADP-ribose) polymerases in the regulation of inflammatory processes

AbstractPARP enzymes influence the immune system at several key points and thus modulate inflammatory diseases. PARP enzymes affect immune cell maturation and differentiation and regulate the expression of inflammatory mediators such as cytokines, chemokines, inducible nitric oxide synthase and adhesion molecules. Moreover, PARP enzymes are key regulators of cell death during inflammation-related oxidative and nitrosative stress. Here we provide an overview of the different inflammatory diseases regulated by PARP enzymes