The scientific impact of Francisco Rodríguez-Reinoso in carbon research and beyond

This review article is dedicated to the memory of Francisco (Paco) Rodríguez-Reinoso (Granada 1941 - Alicante 2020). Paco dedicated more than 56 years of his life to research on carbon materials, covering from their synthesis and characterization, to their evaluation using a range of processes such as gas adsorption/separation, heterogeneous catalysis, and drug delivery, among others. His extensive research was mainly performed in the Advanced Materials Laboratory (LMA) located at the University of Alicante, Spain. This research has been reflected in more than 400 research articles in high quality international journals. This review article summarizes some of Paco’s main achievements in carbon-related research emphasizing his main contributions and perspectives in the field

Long-Term Operational Data Analysis of an In-Service Wind Turbine DFIG

(c) 2019 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other users, including reprinting/ republishing this material for advertising or promotional purposes, creating new collective works for resale or redistribution to servers or lists, or reuse of any copyrighted components of this work in other works.[EN] While wind turbine (WT) power capacities continue to increase and new offshore developments are being deployed, operation and maintenance (O&M) costs continue to rise, becoming the center of attention in the wind energy sector. The electric generator is among the top three contributors to failure rates and downtime of WTs, where the doubly fed induction generator (DFIG) is the dominant technology among variable speed WTs. Thus, the early detection of generator faults, which can be achieved through predictive maintenance, is vital in order to reduce O&M costs. The goal of this paper is to analyze a long-term monitoring campaign of an in-service WT equipped with a DFIG. A novel method named the harmonic order tracking analysis is used with two main objectives: first, to facilitate the data interpretation for non-trained maintenance personnel, and second, to reduce the amount of data that must be stored and transferred for the diagnosis of the DFIG. This method is applied and validated for the first time on an operating WT.This work was supported in part by the Agreement signed between the UCLM and the Council of Albacete to promote research in the Campus of Albacete, and in part by the European Union Horizon 2020 Research and Innovation Programme through the Marie Sklodowska-Curie Grant (AWESOME Project) under Grant 642108. The authors would like to thank Ingeteam Power Technology S.A. UP Service, part of the AWESOME Project Consortium providing the wind turbine data.Artigao, E.; Sapena-Bano, A.; Honrubia-Escribano, A.; Martinez-Roman, J.; Puche-Panadero, R.; Gómez-Lázaro, E. (2019). Long-Term Operational Data Analysis of an In-Service Wind Turbine DFIG. IEEE Access. 7:17896-17906. https://doi.org/10.1109/ACCESS.2019.2895999S1789617906

Protocol: Value Stream Maping in Healthcare. A systematic literature review

[EN] Until 2016, very few works had investigated the use of the VSM. With this research, we will discover if the situation has changed in the last 3 years. In the lean manufacturing context, different techniques that help the continuous improvement process can be used (MarinGarcia & Bonavia, 2011; Marin-Garcia & Carneiro, 2010; Marin-Garcia et al., 2012; Scott, 2001). One is the Value Stream Map (VSM) (Coetzee et al., 2016; Marin-Garcia & Mateo Martínez, 2013; Vidal-Carreras et al., 2015). This publication is a protocol (MarinGarcia, 2015; Marin-Garcia, 2019) that aims to promote research transparency and replication. The concepts investigated in it are defined (VSM and health services sector), a research niche is justified, and the search and codification procedure of the systematic literature review is established. Although there are different versions of the VSM (DinisCarvalho et al., 2018; Hines & Rich, 1997; Shou et al., 2017), we will focus on that proposed by Rother and Shook (1998). The main peculiarity of the version by Rother and Shook (1998) is that it graphically shows the flow of information and the flow of materials in the same diagram (Lucherini & Rapaccini, 2017; Shou et al., 2017; Vidal-Carreras et al., 2015), which is necessary to complete a project, a product or a service (Bevilacqua et al., 2014; Lucherini & Rapaccini, 2017). It is also very intuitive and easy to understand, even by non-technical people (Lucherini & Rapaccini, 2017). The VSM version that we have chosen is usually applied via standardized symbols (Lucherini & Rapaccini, 2017; Vidal-Carreras et al., 2015) following a 4-stage procedure (Rother & Shook, 1998; Shou et al., 2017): 1) select a product family (each VSM represents a family of sufficiently homogeneous products to represent the process); 2) draw the current VSM; 3) model the improved process by drawing the desirable future VSM; 4) implement actions to obtain a similar process to the future VSM. These four stages can be split into eight in other implementation versions (Tapping, 2007; Tapping et al., 2002; Tapping & Shuker, 2003). The above procedure allows value-added (VA) and nonvalueadded (NVA) activities and initiating actions to be identified to improve the proportion of VA versus NVA (Bevilacqua et al., 2014; Shou et al., 2017; Vidal-Carreras et al., 2015). Our goal is to include any healthcare level (primary care, secondary care - medical specialists, hospitals, referral centers for rare diseases, and geriatric or disability care). We wish to explore the use in organizations of any country worldwide whose ownership is public, private or a nonprofit foundation. We will focus on patient health services. We will not include the pharmaceutical industry or the operation of governmental or nongovernmental public health structures (e.g. ministries, the Red Cross or similar). Different literature reviews on the VSM have been published. Some focus on analyzing several sectors, predominantly manufacturing. Previous research seems to indicate that the VSM allows the transparency of the process to improve by making it much more understandable for the agents involved in it (Shou et al., 2017; Vidal-Carreras et al., 2015); reduce process times (lead times) (Shou et al., 2017) and inventories (Shou et al., 2017). However, these results come mostly from repetitive manufacturing contexts (linked to the automotive or consumer electronics sectors, or their auxiliary industries), and normally from Anglo-Saxon countries. There do not seem to be enough publications in order to generalize these results to all kinds of contexts. Some publications reveal that the barriers from using such tools can overcome facilitators in public service contexts (MarinGarcia et al., 2018b). Very few reviews have focused specifically on the VSM and the health services sector (Nowak et al., 2017; Vidal-Carreras et al., 2015). Both conclude that there is not enough material to provide evidence for and a conclusive answer to our research questions. The systematic review that we propose in this protocol intends to answer (in a future publication) the following questions: 1) what is the VSM research gap that applies to the health services sector that currently exists?; 2) is the VSM being used in hospitals or other health centers?; 3) what VSM version is common in health sector publications?; 4) collect examples of the VSM in hospitals/heath centers; 5) how was the VSM used in the hospitals/health centers that have applied it?; 6) what problems and/or difficulties have arisen while drawing the VSM or after drawing it? Different programs will be used for the bibliometric analysis (see details in Marin-Garcia and Alfalla-Luque (2019)). First, the R Bibliometrix package (Aria & Cuccurullo, 2017; Garfield, 2004; Wulff Barreiro, 2007) and also the suitability of SciMAT (Cobo et al., 2012; Santana & Lopez-Cabrales, 2019) to visualize thematic maps and strategic maps will be tested.Marín García, JA.; Vidal Carreras, PI.; García Sabater, JJ.; Escribano-Martinez, J. (2019). Protocol: Value Stream Maping in Healthcare. A systematic literature review. WPOM-Working Papers on Operations Management. 10(2):36-54. https://doi.org/10.4995/wpom.v10i2.12297OJS3654102Ahluwalia, S. C., Damberg, C. L., Silverman, M., Motala, A., & Shekelle, P. G. (2017). What defines a high-performing health care delivery system: A systematic review. The Joint Commission Journal on Quality and Patient Safety, 43(9), 450-459. https://doi.org/10.1016/j.jcjq.2017.03.010Aloini, D., Cannavacciuolo, L., Gitto, S., Lettieri, E., Malighetti, P., & Visintin, F. (2018). Evidence-based management for performance improvement in healthcare. Management Decision, 56(10), 2063-2068. https://doi.org/10.1108/MD-10-2018-004Andreu Andres, M. A., Garcia-Carbonell, A., González-Ladrón-de-Guevara, F., & Watts, F. (2018). Contrasting innovation competence fincoda model in software engineering: Narrative review. Journal of Industrial Engineering and Management, 11(4), 715-734. https://doi.org/10.3926/jiem.2656Aria, M., & Cuccurullo, C. (2017). Bibliometrix: An r-tool for comprehensive science mapping analysis. Journal of Informetrics, 11(4), 959-975. https://doi.org/10.1016/j.joi.2017.08.007Bevilacqua, M., Ciarapica, F. E., Germani, M., Mazzuto, G., & Paciarotti, C. (2014). Relation of project managers' personality and project performance: An approach based on value stream mapping. Journal of Industrial Engineering and Management, 7(4), 34. https://doi.org/10.3926/jiem.1005Borenstein, M., Hedges, L. V., Higgins, J. P. T., & Rothstein, H. R. (2009). Introduction to meta-analysis. UK: John Wiley & Sons. https://doi.org/10.1002/9780470743386Cobo, M. J., López-Herrera, A. G., Herrera-Viedma, E., & Herrera, F. (2012). Scimat: A new science mapping analysis software tool. Journal of the American Society for Information Science and Technology, 63(8), 1609-1630. https://doi.org/10.1002/asi.22688Coetzee, R., van der Merwe, K., & van Dyk, L. (2016). Lean implementation strategies: How are the toyota way principles addressed? South African Journal of Industrial Engineering, 27(3), 79-91. https://doi.org/10.7166/27-3-1641Cringles, M. C. (2002). Developing an integrated care pathway to manage cancer pain across primary, secondary and tertiary care. International Journal of Palliative Nursing, 8(5), 247-255. https://doi.org/10.12968/ijpn.2002.8.5.10372De Steur, H., Wesana, J., Dora, M. K., Pearce, D., & Gellynck, X. (2016). Applying value stream mapping to reduce food losses and wastes in supply chains: A systematic review. Waste Management, 58, 359-368. https://doi.org/10.1016/j.wasman.2016.08.025Dinis-Carvalho, J., Guimaraes, L., Sousa, R. M., & Leao, C. P. (2018). Waste identification diagram and value stream mapping: A comparative analysis. International Journal of Lean Six Sigma. https://doi.org/10.1108/IJLSS-04-2017-0030Dogan, N. O., & Unutulmaz, O. (2016). Lean production in healthcare: A simulation-based value stream mapping in the physical therapy and rehabilitation department of a public hospital. Total Quality Management & Business Excellence, 27(1-2), 64-80. https://doi.org/10.1080/14783363.2014.945312Fadahunsi, K. P., Akinlua, J. T., O'Connor, S., Wark, P. A., Gallagher, J., Carroll, C., . . . O'Donoghue, J. (2019). Protocol for a systematic review and qualitative synthesis of information quality frameworks in ehealth. Bmj Open, 9(3). https://doi.org/10.1136/bmjopen-2018-024722Garfield, E. (2004). Historiographic mapping of knowledge domains literature. Journal of Information Science, 30(2), 119-145. https://doi.org/10.1177/0165551504042802Gitlow, H., Zuo, Q., Ullmann, S. G., Zambrana, D., Campo, R. E., Lubarsky, D., & Birnbach, D. J. (2013). The causes of never events in hospitals. International Journal of Lean Six Sigma, 4(3), 338-344. https://doi.org/10.1108/IJLSS-03-2013-0016Gonzalez-Aleu, F., Van Aken, E. M., Cross, J., & Glover, W. J. (2018). Continuous improvement project within kaizen: Critical success factors in hospitals. The TQM Journal, 30(4), 335-355. https://doi.org/10.1108/TQM-12-2017-0175Grumbach, K., & Bodenheimer, T. (1995). The organization of health care. JAMA, 273(2), 160-167. https://doi.org/10.1001/jama.1995.03520260082038Heinzen, M., Mettler, S., Coradi, A., & Boutellier, R. (2015). A new application of value-stream mapping in new drug development: A case study within novartis. Drug Discovery Today, 20(3), 301-305. https://doi.org/10.1016/j.drudis.2014.10.009Hines, P., & Rich, N. (1997). The seven value stream mapping tools. International Journal of Operations and Production Management, 17(1), 46-64. https://doi.org/10.1108/01443579710157989Knight, C., Patterson, M., & Dawson, J. (2019). Work engagement interventions can be effective: A systematic review. European Journal of Work and Organizational Psychology, 28(3), 348-372. https://doi.org/10.1080/1359432X.2019.1588887Losilla, J.-M., Oliveras, I., Marin-Garcia, J. A., & Vives, J. (2018). Three risk of bias tools lead to opposite conclusions in observational research synthesis. Journal of Clinical Epidemiology(101), 61-72. https://doi.org/10.1016/j.jclinepi.2018.05.021Lucherini, F., & Rapaccini, M. (2017). Exploring the impact of lean manufacturing on flexibility in smes. Journal of Industrial Engineering and Management, 10(5), 27. https://doi.org/10.3926/jiem.2119Lummus, R. R., Vokurka, R. J., & Rodeghiero, B. (2006). Improving quality through value stream mapping: A case study of a physician's clinic. Total Quality Management and Business Excellence, 17(8), 1063-1075. https://doi.org/10.1080/14783360600748091Makwana, A. D., & Patange, G. S. (2019). A methodical literature review on application of lean & six sigma in various industries. Australian Journal of Mechanical Engineering. https://doi.org/10.1080/14484846.2019.1585225Marin-Garcia, J. A. (2015). Publishing in two phases for focused research by means of "research collaborations". WPOM-Working Papers on Operations Management, 6(2), 76-80. https://doi.org/10.4995/wpom.v6i2.4459Marin-Garcia, J. A. (2016). Upvx-mooc course: Research methodologies-systematic literature review https://www.upvx.es/courses/course-v1:ManagementEducation+researchmethodologies+2016-01/about: UPVx Formación Online. Universitat Politécnica de ValenciaMarin-Garcia, J. A. (2019). Publishing in three stages to support evidence based practice in om, hrm and teaching&learning innovation. WPOM-Working Papers on Operations Management, 10(2), in press.Marin-Garcia, J. A., & Alfalla-Luque, R. (2019). Protocol: How to deal with partial least squares (pls) research in operations management. A guide for sending papers to academic journals. WPOM-Working Papers on Operations Management, 10(1), 29-69. https://doi.org/10.4995/wpom.v10i1.10802Marin-Garcia, J. A., Betancour, E., & Giraldo-OMeara, M. (2018a). Protocol: Literature review on the psychometric properties of the short versions of the scales of social desirability in the answers to competency self-assessment questionnaires. WPOM-Working Papers on Operations Management, 9(1), 14-29. https://doi.org/10.4995/wpom.v9i1.9172Marin-Garcia, J. A., & Bonavia, T. (2011). Strategic priorities and lean manufacturing practices in automotive suppliers. Ten years after. In M. Chiaberge (Ed.), New trends and developments in automotive engineering: InTechMarin-Garcia, J. A., & Carneiro, P. (2010). Desarrollo y validación de un modelo multidimensional de la producción ajustada. Intangible Capital, 6(1), 78-127. https://doi.org/10.3926/ic.2010.v6n1.p78-127Marin-Garcia, J. A., Carneiro, P., & Miralles, C. (2012). Effect of lean manufacturing practices on non-financial performance results: Empirical study in spanish sheltered work centers. In G. Mejia & N. Velasco (Eds.), Production systems and supply chain management in emerging countries: Best practices (pp. 3-24): Springer. https://doi.org/10.1007/978-3-642-26004-9_1Marin-Garcia, J. A., Garcia-Sabater, J. J., & Maheut, J. (2018b). Protocol: Action planning for action research about kaizen in public organizations. The case of higher education. WPOM-Working Papers on Operations Management, 9(1), 13. https://doi.org/10.4995/wpom.v9i1.8990Marin-Garcia, J. A., & Martinez Tomas, J. (2016). Deconstructing amo framework: A systematic review. Intangible Capital, 12(4), 1040-1087. https://doi.org/10.3926/ic.838Marin-Garcia, J. A., & Mateo Martínez, R. (2013). Barreras y facilitadores de la implantación del tpm. Intangible Capital, 9(3), 823-853. https://doi.org/10.3926/ic.360Martinez-Tomas, J., & Marin-Garcia, J. A. (2019). Protocol: What does the wage structure depend on? Evidence from the ine salary national survey (pilot study with 2006 data). WPOM-Working Papers on Operations Management, 10(1), 70-103. https://doi.org/10.4995/wpom.v10i1.11753Martínez Jurado, P. J., & Moyano Fuentes, J. (2017). Aprendiendo a enseñar lean management mediante juegos: Revisión sistemática de la literatura learning to teach lean management through games: Systematic literature review. WPOM-Working Papers on Operations Management, 8, 164-170. https://doi.org/10.4995/wpom.v8i0.7199Medina-López, C., Marin-Garcia, J. A., & Alfalla-Luque, R. (2010). Una propuesta metodológica para la realización de búsquedas sistemáticas de bibliografía (a methodological proposal for the systematic literature review). WPOM-Working Papers on Operations Management, 1(2), 13-30. https://doi.org/10.4995/wpom.v1i2.786Nowak, M., Pfaff, H., & Karbach, U. (2017). Does value stream mapping affect the structure, process, and outcome quality in care facilities? A systematic review. Systematic Reviews, 6, 11. https://doi.org/10.1186/s13643-017-0563-yPatterson, M., Rick, J., Wood, S., Carroll, C., Balain, S., & Booth, A. (2010). Systematic review of the links between human resource management practices and performance: Health Technology Assessment, 14 (51). https://doi.org/10.3310/hta14510Poksinska, B. (2010). The current state of lean implementation in health care: Literature review. Quality Management in Health Care, 19(4), 319-329. https://doi.org/10.1097/QMH.0b013e3181fa07bbPrajogo, D. I., & McDermott, C. M. (2008). The relationships between operations strategies and operations activities in service context. International Journal of Service Industry Management, 19(4), 506-520. https://doi.org/10.1108/09564230810891932Rafique, M. Z., Ab Rahman, M. N., Saibani, N., & Arsad, N. (2019). A systematic review of lean implementation approaches: A proposed technology combined lean implementation framework. Total Quality Management & Business Excellence, 30(3-4), 386-421. https://doi.org/10.1080/14783363.2017.1308818Reijula, J., Nevala, N., Lahtinen, M., Ruohom Aki, V., & Reijula, K. (2014). Lean design improves both health-care facilities and processes: A literature review. Intelligent Buildings International, 6(3), 170-185. https://doi.org/10.1080/17508975.2014.901904Romero, L. F., & Arce, A. (2017). Applying value stream mapping in manufacturing: A systematic literature review. IFAC-PapersOnLine, 50(1), 1075-1086. https://doi.org/10.1016/j.ifacol.2017.08.385Rother, M., & Shook, J. (1998). Learning to see. Value stream mapping to create value and eliminate muda. Massachusetts: Lean Enterprise Institute.Sanchez-Ruiz, L., Marin-Garcia, J. A., & Blanco, B. (2018). Protocol: A meta-review on continuous improvement to know the state of this research field. WPOM-Working Papers on Operations Management, 9(2). https://doi.org/10.4995/wpom.v9i2.10752Sanchez, L., & Blanco, B. (2014). Three decades of continuous improvement. Total Quality Management & Business Excellence, 25(9-10), 986-1001. https://doi.org/10.1080/14783363.2013.856547Santana, M., & Lopez-Cabrales, A. (2019). Sustainable development and human resource management: A science mapping approach. Corporate Social Responsibility and Environmental Management, in press(0). https://doi.org/10.1002/csr.1765Saunders, M., Lewis, P., & Thornhill, A. (2016). Research methods for business students, 7/e. Essex: Pearson Education.Scott, G. (2001). Customer satisfaction: Six strategies for continuous improvement. Journal of Healthcare Management, 46(2), 82. https://doi.org/10.1097/00115514-200103000-00004Shou, W., Wang, J., Wu, P., Wang, X., & Chong, H.-Y. (2017). A cross-sector review on the use of value stream mapping. International Journal of Production Research, 55(13), 3906-3928. https://doi.org/10.1080/00207543.2017.1311031Singh, B., Garg, S. K., & Sharma, S. K. (2011). Value stream mapping: Literature review and implications for indian industry. International Journal of Advanced Manufacturing Technology, 53(5-8), 799-809. https://doi.org/10.1007/s00170-010-2860-7Syltevik, S., Karamperidis, S., Antony, J., & Taheri, B. (2018). Lean for airport services: A systematic literature review and agenda for future research. International Journal of Quality and Reliability Management, 35(1), 34-49. https://doi.org/10.1108/IJQRM-08-2016-0135Tapping, D. (2007). La nueva guia lean de bolsillo (produccion lean). Herramientas para eliminar el desperdicio. United States of America: MCS Media, Inc.Tapping, D., Luyster, T., & Shuker, T. (2002). Value stream management eight steps to planning, mapping, and sustaining lean improvements (1 ed.). New York: Productivity Press. https://doi.org/10.4324/9781482278163Tapping, D., & Shuker, T. (2003). Value stream management for the lean office. New York: Productivity Press. https://doi.org/10.1201/b16934Vandborg, M. P., Edwards, K., Kragstrup, J., Vedsted, P., Hansen, D. G., & Mogensen, O. (2012). A new method for analyzing diagnostic delay in gynecological cancer. International Journal of Gynecological Cancer, 22(5), 712-717. https://doi.org/10.1097/IGC.0b013e31824c6d0eVidal-Carreras, P. I., Garcia-Sabater, J. J., Marin-Garcia, J. A., & Garcia-Sabater, J. P. (2015, 2015). Value stream mapping on healthcare. Paper presented at the 2015 International Conference On Industrial Engineering And Systems Management (Iesm). https://doi.org/10.1109/IESM.2015.7380170Wulff Barreiro, E. (2007). El uso del software histcite para identificar artículos significativos en búsquedas por materias en la web of science. Documentación de las Ciencias de la Información, 30, 45-64

Clinical Heterogeneity of Pulmonary Arterial Hypertension Associated With Variants in TBX4

Background: The knowledge of hereditary predisposition has changed our understanding of Pulmonary Arterial Hypertension. Genetic testing has been widely extended and the application of Pulmonary Arterial Hypertension specific gene panels has allowed its inclusion in the diagnostic workup and increase the diagnostic ratio compared to the traditional sequencing techniques. This is particularly important in the differential diagnosis between Pulmonary Arterial Hypertension and Pulmonary Venoocclusive Disease. Methods: Since November 2011, genetic testing is offered to all patients with idiopathic, hereditable and associated forms of Pulmonary Arterial Hypertension or Pulmonary Venoocclusive Disease included in the Spanish Registry of Pulmonary Arterial Hypertension. Herein, we present the clinical phenotype and prognosis of all Pulmonary Arterial Hypertension patients with disease-associated variants in TBX4. Results: Out of 579 adults and 45 children, we found in eight patients from seven families, disease-causing associated variants in TBX4. All adult patients had a moderate-severe reduction in diffusion capacity. However, we observed a wide spectrum of clinical presentations, including Pulmonary Venoocclusive Disease suspicion, interstitial lung disease, pulmonary vascular abnormalities and congenital heart disease. Conclusions: Genetic testing is now essential for a correct diagnosis work-up in Pulmonary Arterial Hypertension. TBX4-associated Pulmonary Arterial Hypertension has marked clinical heterogeneity. In this regard, a genetic study is extremely useful to obtain an accurate diagnosis and provide appropriate management.This project was founded by Project "Bases Gene´tico Moleculares de la Medicina de Precisio´n en la Hipertensio´n Arterial Pulmonar". Funder: Instituto Carlos III. Ministerio de Economı´a y Competitividad. https://www.isciii.es/Paginas/Inicio.aspx Award number: PI 18/01233 Grant Recipient: P E-

A genome-wide association study follow-up suggests a possible role for PPARG in systemic sclerosis susceptibility

Introduction: A recent genome-wide association study (GWAS) comprising a French cohort of systemic sclerosis (SSc) reported several non-HLA single-nucleotide polymorphisms (SNPs) showing a nominal association in the discovery phase. We aimed to identify previously overlooked susceptibility variants by using a follow-up strategy.<p></p> Methods: Sixty-six non-HLA SNPs showing a P value <10-4 in the discovery phase of the French SSc GWAS were analyzed in the first step of this study, performing a meta-analysis that combined data from the two published SSc GWASs. A total of 2,921 SSc patients and 6,963 healthy controls were included in this first phase. Two SNPs, PPARG rs310746 and CHRNA9 rs6832151, were selected for genotyping in the replication cohort (1,068 SSc patients and 6,762 healthy controls) based on the results of the first step. Genotyping was performed by using TaqMan SNP genotyping assays. Results: We observed nominal associations for both PPARG rs310746 (PMH = 1.90 × 10-6, OR, 1.28) and CHRNA9 rs6832151 (PMH = 4.30 × 10-6, OR, 1.17) genetic variants with SSc in the first step of our study. In the replication phase, we observed a trend of association for PPARG rs310746 (P value = 0.066; OR, 1.17). The combined overall Mantel-Haenszel meta-analysis of all the cohorts included in the present study revealed that PPARG rs310746 remained associated with SSc with a nominal non-genome-wide significant P value (PMH = 5.00 × 10-7; OR, 1.25). No evidence of association was observed for CHRNA9 rs6832151 either in the replication phase or in the overall pooled analysis.<p></p> Conclusion: Our results suggest a role of PPARG gene in the development of SSc

SuperCam Calibration Targets: Design and Development

SuperCam is a highly integrated remote-sensing instrumental suite for NASA’s Mars 2020 mission. It consists of a co-aligned combination of Laser-Induced Breakdown Spectroscopy (LIBS), Time-Resolved Raman and Luminescence (TRR/L), Visible and Infrared Spectroscopy (VISIR), together with sound recording (MIC) and high-magnification imaging techniques (RMI). They provide information on the mineralogy, geochemistry and mineral context around the Perseverance Rover. The calibration of this complex suite is a major challenge. Not only does each technique require its own standards or references, their combination also introduces new requirements to obtain optimal scientific output. Elemental composition, molecular vibrational features, fluorescence, morphology and texture provide a full picture of the sample with spectral information that needs to be co-aligned, correlated, and individually calibrated. The resulting hardware includes different kinds of targets, each one covering different needs of the instrument. Standards for imaging calibration, geological samples for mineral identification and chemometric calculations or spectral references to calibrate and evaluate the health of the instrument, are all included in the SuperCam Calibration Target (SCCT). The system also includes a specifically designed assembly in which the samples are mounted. This hardware allows the targets to survive the harsh environmental conditions of the launch, cruise, landing and operation on Mars during the whole mission. Here we summarize the design, development, integration, verification and functional testing of the SCCT. This work includes some key results obtained to verify the scientific outcome of the SuperCam system

Recomendaciones para la valoración nutricional y el soporte nutricional especializado de los pacientes críticos Recommendations for nutritional assessment and specialized nutritional support of critically ill patients

Debido a las características de los pacientes críticos, la elaboración de recomendaciones sobre el soporte nutricional en estos pacientes es difícil. En muchas ocasiones no está claramente establecido el momento de inicio del soporte nutricional ni las características del mismo, por lo que su aplicación está basada en opiniones de expertos. En el presente documento se presentan las recomendaciones elaboradas por el Grupo de Trabajo de Metabolismo y Nutrición de la sociedad Española de Medicina Intensiva, Crítica y Unidades Coronarias (SEMICYUC). Las recomendaciones están basadas en el análisis de la literatura y en la posterior discusión entre los miembros del grupo de trabajo para definir, mediante consenso, los aspectos más relevantes del soporte metabólico y nutricional de los pacientes en situación crítica. Se han considerado diferentes situaciones clínicas, que se desarrollan en los artículos siguientes de esta publicación. Las presentes recomendaciones pretenden servir de guía para los clínicos con menor experiencia en la consideración de los aspectos metabólicos y nutricionales de los pacientes críticos.Due to the characteristics of critically ill patients, elaborating recommendations on nutritional support for these patients is difficult. Usually the time of onset of nutritional support or its features are not well established, so that its application is based on experts' opinion. In the present document, recommendations formulated by the Metabolism and Nutrition Working Group of the Spanish Society of Intensive and Critical Medicine and Coronary Units (SEMICYUC) are presented. Recommendations are based on the literature analysis and further discussion by the working group members in order to define, consensually, the more relevant issues of metabolic and nutritional support of patients in a critical condition. Several clinical situations have been considered which are developed in the following articles of this publication. The present recommendations aim at providing a guideline for the less experienced clinicians when considering the metabolic and nutritional issues of critically ill patients