Distributed Ledger Technology for the systematic Investigation and Reduction of Information Asymmetry in Collaborative Networks

Costs, risks and inefficiencies in Collaborative Networks (CNs) resulting from information asymmetries have been discussed in the scientific community for years. In this work, supply chain networks, as common representative of CNs, are used as object of investigation. Therein, problems and requirements of interorganizational information exchange are elaborated as well as the potential role Distributed Ledger Technology (DLT) could play to address them. As major challenge, convincing all relevant network partners to resolve asymmetric information by sharing sensitive data is identified. To face this issue, the value of shared information is prioritized as a motivational aspect. Finally, we propose a search process to systematically assess the benefits of information sharing in collaborative networks. To coordinate and implement this process regarding the derived requirements of CNs we propose system components based on DLT design patterns

Data Sovereignty in Data Donation Cycles - Requirements and Enabling Technologies for the Data-driven Development of Health Applications

Personalized healthcare is expected to increase the efficiency and the effectiveness of health services using different kinds of algorithms on existing data. This approach is currently confronted with the lack of digital data and the desire for self-determined personal data handling. However, the issue of health data donation is on the political agenda of some governments. Within this work, a knowledge base will be created by reviewing existing approaches and technologies regarding this topic with the focus on chronic diseases. A list of requirements will be derived from which we conceptualize a data donation cycle to demonstrate the challenges and opportunities of health data sovereignty and its future possibilities concerning data-driven health application development. By linking the requirements to technological approaches, the baseline for future open ecosystems will be presented

Decision model to design a blockchain-based system for storing sensitive health data

The storage and sharing of sensitive health data in Blockchain-based systems implicates data protection issues that must be addressed when designing such systems. Those issues can be traced back to the properties of decentralized systems. A blessing but also a curse in the context of health data is the transparency of the Blockchain, because it allows the stored data to be viewed by all participants of the network. In addition, the property of immutability is in contrast to the possibility to delete the personal data upon request according to the European General Data Protection Regulation (GDPR). Accordingly, approaches to tackle these issues have recently been discussed in research and industry, e.g. by storing sensitive data encrypted On-Chain or Off-Chain on own servers connected to a Blockchain. These approaches deal with how the confidentiality and integrity of stored data can be guaranteed and how data can be deleted. By reviewing the proposed approaches, we develop a taxonomy to summarize their specific technical characteristics and create a decision model that will allow the selection of a suitable approach for the design of future Blockchain-based systems for the storage of sensitive health data. Afterwards, we demonstrate the utility of the decision model based on a use case for storing test results from a digital dementia screening application. The paper concludes with a discussion of the results and suggestions for future research

Delphi-Analyse: Szenarien und Geschäftsmodelle

Aufbauend auf im Rahmen eines Delphi-Verfahrens erhobenen Daten und Erkenntnissen werden ökonomische Verwertungs- und Geschäftsmodelloptionen für ein Blockchain-basiertes Gesundheitsdatenmanagement- und Zugriff-/Rechteverwaltungssystem zur Einbettung in den ersten deutschen Gesundheitsmarkt diskutiert und reflektiert. Im Fokus steht hierbei die im Rahmen eines BMBF-geförderten Verbundprojekts entwickelte und im Entlassmanagement für onkologische Patientinnen prototypisch umgesetzte BloG³-Lösung. Eine reibungslose sektorenübergreifende, interdisziplinäre Versorgung im Behandlungsprozess von Onkologie-Patientinnen ist als Anwendungsfall von besonderer Relevanz, da hier zahlreiche sowohl stationäre als auch ambulante Versorgungsanbieter eingebunden sind und es hier bei der Überleitung oft noch zu Versorgungs-, Medien- und Informationsbrüchen kommt. In dem Diskussionsbeitrag beschreiben und analysieren wir sowohl den aktuellen und zukünftig zu erwartenden Stand der digitalen Transformation des Gesundheitswesens, als auch die Besonderheiten des deutschen Gesundheitswesens mit Fokus auf die Möglichkeiten für digitale Innovationen profitabel in den regulierten ersten Gesundheitsmarkt in Form von erstattungsfähigen Gesundheitsleistungen zu gelangen. Unter Berücksichtigung der aktuellen und absehbaren zukünftigen Rahmenbedingungen werden mithilfe der Expertinnenmeinungen aus dem Delphi-Verfahren mögliche Szenarien für die Verwertung der BloG³-Lösung für verschiedene Zeithorizonte (kurz-, mittel-, langfristig) reflektiert und diskutiert

Digital Health Apps in the Context of Dementia: Questionnaire Study to Assess the Likelihood of Use Among Physicians

Background: Age-related diseases such as dementia are playing an increasingly important role in global population development. Thus, prevention, diagnostics, and interventions require more accessibility, which can be realized through digital health apps. With the app on prescription, Germany made history by being the first country worldwide to offer physicians the possibility to prescribe and reimburse digital health apps as of the end of the year 2020. Objective: Considering the lack of knowledge about correlations with the likelihood of use among physicians, this study aimed to address the question of what makes the use of a digital health app by physicians more likely. Methods: We developed and validated a novel measurement tool—the Digital Health Compliance Questionnaire (DHCQ)—in an interdisciplinary collaboration of experts to assess the role of proposed factors in the likelihood of using a health app. Therefore, a web-based survey was conducted to evaluate the likelihood of using a digital app called DemPredict to screen for Alzheimer dementia. Within this survey, 5 latent dimensions (acceptance, attitude toward technology, technology experience, payment for time of use, and effort of collection), the dependent variable likelihood of use, and answers to exploratory questions were recorded and tested within directed correlations. Following a non–probability-sampling strategy, the study was completed by 331 physicians from Germany in the German language, of whom 301 (90.9%) fulfilled the study criteria (eg, being in regular contact with patients with dementia). These data were analyzed using a range of statistical methods to validate the dimensions of the DHCQ. Results: The DHCQ revealed good test theoretical measures—it showed excellent fit indexes (Tucker-Lewis index=0.98; comparative fit index=0.982; standardized root mean square residual=0.073; root mean square error of approximation=0.037), good internal consistency (Cronbach α=.83), and signs of moderate to large correlations between the DHCQ dimensions and the dependent variable. The correlations between the variables acceptance, attitude toward technology, technology experience, and payment for the time of use and the dependent variable likelihood of use ranged from 0.29 to 0.79, and the correlation between effort of the collection and likelihood of use was −0.80. In addition, we found high levels of skepticism regarding data protection, and the age of the participants was found to be negatively related to their technical experience and attitude toward technology. Conclusions: In the context of the results, increased communication between the medical and technology sectors and significantly more awareness raising are recommended to make the use of digital health apps more attractive to physicians as they can be adjusted to their everyday needs. Further research could explore the connection between areas such as adherence on the patient side and its impact on the likelihood of use by physicians

The genomes of two key bumblebee species with primitive eusocial organization

Background: The shift from solitary to social behavior is one of the major evolutionary transitions. Primitively eusocial bumblebees are uniquely placed to illuminate the evolution of highly eusocial insect societies. Bumblebees are also invaluable natural and agricultural pollinators, and there is widespread concern over recent population declines in some species. High-quality genomic data will inform key aspects of bumblebee biology, including susceptibility to implicated population viability threats. Results: We report the high quality draft genome sequences of Bombus terrestris and Bombus impatiens, two ecologically dominant bumblebees and widely utilized study species. Comparing these new genomes to those of the highly eusocial honeybee Apis mellifera and other Hymenoptera, we identify deeply conserved similarities, as well as novelties key to the biology of these organisms. Some honeybee genome features thought to underpin advanced eusociality are also present in bumblebees, indicating an earlier evolution in the bee lineage. Xenobiotic detoxification and immune genes are similarly depauperate in bumblebees and honeybees, and multiple categories of genes linked to social organization, including development and behavior, show high conservation. Key differences identified include a bias in bumblebee chemoreception towards gustation from olfaction, and striking differences in microRNAs, potentially responsible for gene regulation underlying social and other traits. Conclusions: These two bumblebee genomes provide a foundation for post-genomic research on these key pollinators and insect societies. Overall, gene repertoires suggest that the route to advanced eusociality in bees was mediated by many small changes in many genes and processes, and not by notable expansion or depauperation

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Preliminary Investigation of Species Diversity of Rice Hopper Parasitoids in Southeast Asia

Ongoing intensification of rice production systems in Southeast Asia is causing devastating yield losses each year due to rice hoppers. Their continuing development of immunity to resistant rice varieties and pesticide applications further complicates this problem. Hence, there is a high demand for biological control agents of rice hoppers. Egg parasitoid wasps are among the most important natural enemies of rice hoppers, such as Nilaparvata lugens and Nephotettix spp. However, our knowledge of their diversity is still very limited, due to their small size and the lack of available morphological information. Classifying these parasitoids is the first step to properly understanding their role in the rice agroecosystem. We used traditional morphological identification, as well as DNA sequencing of the 28S rRNA and the COI genes, to investigate the diversity of four important hopper egg parasitoid genera in the Philippines. Parasitoids of the genera Anagrus, Oligosita, Gonatocerus, and Paracentrobia were collected in eight study landscapes located in Luzon. Our findings illustrate that characterization of species diversity using morphological and molecular analyses were concordant only for the genus Paracentrobia. The genera Anagrus and Gonatocerus exhibited more genetic diversity than estimated with the morphological analysis, while the opposite was observed for Oligosita. This is the first study investigating the molecular diversity of rice hopper parasitoids in the Philippines. More research combining morphological, behavioral, and molecular methods, as well as the establishment of a comprehensive DNA database, are urgently needed to assess the performance and suitability of these organisms as biocontrol agents