Brief for Respondent. Oxford Health Plans LLC v. Sutter, 569 U.S. 564 (2013) (No. 12-135), 2013 U.S. S. Ct. Briefs LEXIS 946

QUESTION PRESENTED Did the arbitrator exceed[] [his] powers, within the meaning of section 10(a)(4) of the Federal Arbitration Act, when he concluded that the arbitration paragraph agreed to by the parties authorized class arbitration

Survival of verapamil-poisoned rats treated with triiodothyronine.

Life-threatening toxicity due to calcium channel blocker ingestion is commonly encountered by emergency medicine physicians and toxicologists. Despite a vast array of research on its treatment, results have proven inconsistent. The goal of this study is to evaluate potential vasopressor effects of triiodothyronine (T3) in rats poisoned with verapamil. Following anesthesia and intubation, ten Sprague-Dawley rats were given intravenous verapamil infusion of 10 mg/kg/h. This dose was titrated until a mean arterial pressure (MAP) of 50-55 mmHg was achieved and maintained for a period of at least 5 min. The verapamil infusion was then maintained at that rate. Five rats were randomized to receive a T3 bolus of 0.4 mcg/kg preceding an infusion of 1.5 mcg/kg/day which was doubled every 2 min until any of the following endpoints: systolic blood pressure of 100 mmHg, an elapsed time of 60 min, or death. The other five received an equal volume of normal saline solution. The primary outcome measure was survival with secondary outcomes of MAP and heart rate. The T3 group did have a slightly longer, yet not statistically significant, average time to cessation of electrical activity-30.0 +/- 14.4 min versus 23.8 +/- 9.5 min in the placebo group. Average MAP decreased nearly identically in the two groups. Heart rates were not reliable indicators of toxicity in this rat model as there was little decrease until immediately prior to death in most animals. Despite significant variability in toxicity among individual animals, no statistically significant difference in survival time, heart rate, or MAP was found between groups treated with T3 and those receiving saline

A First Estimate of the Baryonic Mass Function of Galaxies

We estimate the baryonic (stellar+cold gas) mass function of galaxies in the local Universe by assigning a complete sample of Two Micron All Sky Survey and Sloan Digital Sky Survey galaxies a gas fraction based on a statistical sample of the entire population, under the assumption of a universally-applicable stellar initial mass function. The baryonic mass function is similar to the stellar mass function at the high mass end, and has a reasonably steep faint-end slope owing to the typically high cold gas fractions and low stellar mass-to-light ratios characteristic of low-mass galaxies. The Schechter Function fit parameters are phi* = 0.0108(6) per cubic Mpc per dex of mass, M* = 5.3(3)x10^10 solar masses, and alpha = -1.21(5), with formal error estimates given in parentheses (for a Hubble constant of 100 km/s per Mpc). We show that the neutral and molecular hydrogen mass functions derived using this indirect route are in agreement with direct estimates, validating our indirect method. Integrating under the baryonic mass function and incorporating all sources of uncertainty, we find that the baryonic (stellar+cold gas) mass density implied by this estimate is Omega_cold baryon = 0.0024+0.0007-0.0014, or 8% +4% -5% of the Big Bang nucleosynthesis expectation.Comment: ApJ Letters, accepted. 4 pages, 2 embedded figure

Systematic Review of Multidisciplinary Chronic Pain Treatment Facilities

This study reviewed the published literature evaluating multidisciplinary chronic pain treatment facilities to provide an overview of their availability, caseload, wait times, and facility characteristics. A systematic literature review was conducted using PRISMA guidelines following a search of MEDLINE, PsycINFO, and CINAHL databases. Inclusion criteria stipulated that studies be original research, survey more than one pain treatment facility directly, and describe a range of available treatments. Fourteen articles satisfied inclusion criteria. Results showed little consistency in the research design used to describe pain treatment facilities. Availability of pain treatment facilities was scarce and the reported caseloads and wait times were generally high. A wide range of medical, physical, and psychological pain treatments were available. Most studies reported findings on the percentage of practitioners in different health care professions employed. Future studies should consider using more comprehensive search strategies to survey facilities, improving clarity on what is considered to be a pain treatment facility, and reporting on a consistent set of variables to provide a clear summary of the status of pain treatment facilities. This review highlights important information for policymakers on the scope, demand, and accessibility of pain treatment facilities.Samantha Fashler is supported by an Ontario Graduate Scholarship and a Canadian Institutes of Health Research (CIHR) Vanier Canada Graduate Scholarship. Lindsay Burns is supported by a Frederick Banting and Charles Best CIHR Doctoral Scholarship. Joel Katz is supported by a CIHR Canada Research Chair in Health Psychology. This project was conducted in collaboration with the Canadian Pain Coalition (CPC) as a part of the Report Card on Pain

Understanding the shape of the halo-mass and galaxy-mass cross-correlation functions

We use the Millennium Simulation to measure the cross-correlation between halo centres and mass (or equivalently the average density profiles of dark haloes) in a LCDM cosmology. We present results for radii in the range 10 kpc/h < r < 30 Mpc/h for halo masses in the range 4e10 Msol/h < M200 < 4e14 Msol/h. Both at z=0 and at z=0.76 these cross-correlations are surprisingly well fit by approximating the inner region by a density profile of NFW or Einasto form, the outer region by a biased version of the linear mass autocorrelation function, and by adopting the maximum of the two where they are comparable. We use a simulation of the formation of galaxies within the Millennium Simulation to explore how these results are reflected in cross-correlations between galaxies and mass. These are directly observable through galaxy-galaxy lensing. Here also we find that simple models can represent the simulation results remarkably well, typically to < 10%. Such models can be used to extend our results to other redshifts, to cosmologies with other parameters, and to other assumptions about how galaxies populate dark haloes. The characteristic features predicted in the galaxy-galaxy lensing signal should provide a strong test of the LCDM cosmology as well as a route to understanding how galaxies form within it.Comment: 14 pages, 15 figures submitted to MNRAS, replaced incorrect figure fil

Case Series of Synthetic Cannabinoid Intoxication from One Toxicology Center.

Synthetic cannabinoid use has risen at alarming rates. This case series describes 11 patients exposed to the synthetic cannabinoid, MAB-CHMINACA who presented to an emergency department with life-threatening toxicity including obtundation, severe agitation, seizures and death. All patients required sedatives for agitation, nine required endotracheal intubation, three experienced seizures, and one developed hyperthermia. One developed anoxic brain injury, rhabdomyolysis and died. A significant number were pediatric patients. The mainstay of treatment was aggressive sedation and respiratory support. Synthetic cannabinoids pose a major public health risk. Emergency physicians must be aware of their clinical presentation, diagnosis and treatment

Rigidly Supersymmetric Gauge Theories on Curved Superspace

In this note we construct rigidly supersymmetric gauged sigma models and gauge theories on certain Einstein four-manifolds, and discuss constraints on these theories. In work elsewhere, it was recently shown that on some nontrivial Einstein four-manifolds such as AdS$_4$, N=1 rigidly supersymmetric sigma models are constrained to have target spaces with exact K\"ahler forms. Similarly, in gauged sigma models and gauge theories, we find that supersymmetry imposes constraints on Fayet-Iliopoulos parameters, which have the effect of enforcing that K\"ahler forms on quotient spaces be exact. We also discuss general aspects of universality classes of gauged sigma models, as encoded by stacks, and also discuss affine bundle structures implicit in these constructions.Comment: 23 pages; references added; more discussion added; v4: typos fixe

Propulsion in a viscoelastic fluid

Flagella beating in complex fluids are significantly influenced by viscoelastic stresses. Relevant examples include the ciliary transport of respiratory airway mucus and the motion of spermatozoa in the mucus-filled female reproductive tract. We consider the simplest model of such propulsion and transport in a complex fluid, a waving sheet of small amplitude free to move in a polymeric fluid with a single relaxation time. We show that, compared to self-propulsion in a Newtonian fluid occurring at a velocity U_N, the sheet swims (or transports fluid) with velocity U / U_N = [1+De^2 (eta_s)/(eta) ]/[1+De^2], where eta_s is the viscosity of the Newtonian solvent, eta is the zero-shear-rate viscosity of the polymeric fluid, and De is the Deborah number for the wave motion, product of the wave frequency by the fluid relaxation time. Similar expressions are derived for the rate of work of the sheet and the mechanical efficiency of the motion. These results are shown to be independent of the particular nonlinear constitutive equations chosen for the fluid, and are valid for both waves of tangential and normal motion. The generalization to more than one relaxation time is also provided. In stark contrast with the Newtonian case, these calculations suggest that transport and locomotion in a non-Newtonian fluid can be conveniently tuned without having to modify the waving gait of the sheet but instead by passively modulating the material properties of the liquid.Comment: 21 pages, 1 figur

Numerical study of one-dimensional and interacting Bose-Einstein condensates in a random potential

We present a detailed numerical study of the effect of a disordered potential on a confined one-dimensional Bose-Einstein condensate, in the framework of a mean-field description. For repulsive interactions, we consider the Thomas-Fermi and Gaussian limits and for attractive interactions the behavior of soliton solutions. We find that the disorder average spatial extension of the stationary density profile decreases with an increasing strength of the disordered potential both for repulsive and attractive interactions among bosons. In the Thomas Fermi limit, the suppression of transport is accompanied by a strong localization of the bosons around the state k=0 in momentum space. The time dependent density profiles differ considerably in the cases we have considered. For attractive Bose-Einstein condensates, a bright soliton exists with an overall unchanged shape, but a disorder dependent width. For weak disorder, the soliton moves on and for a stronger disorder, it bounces back and forth between high potential barriers.Comment: 13 pages, 13 figures, few typos correcte