HST Imaging of the Globular Clusters in the Fornax Cluster: NGC 1399 and NGC 1404

The Fornax cluster galaxies NGC 1399 and NGC 1404 are ideal for studying the effects of a cluster environment on globular cluster systems. Here we present new optical imaging of these two galaxies from both the Hubble Space Telescope's Wide Field and Planetary Camera 2 and the Cerro Tololo Inter-American Observatory's 1.5m telescope. The combination of both data sets provides unique insight on the spatial and colour distribution of globular clusters. From B-I colours, we find that both galaxies have a broad globular cluster metallicity distribution that is inconsistent with a single population. Two Gaussians provide a reasonable representation of the metallicity distribution in each galaxy. The metal-rich subpopulation is more centrally concentrated than the metal-poor one. We show that the radial metallicity gradient can be explained by the changing relative mix of the two globular cluster subpopulations. We derive globular cluster surface density profiles, and find that they are flatter (i.e. more extended) than the underlying starlight. The total number of globular clusters and specific frequency are calculated to be N = 5700 +/- 500, S_N = 11.5 +/- 1.0 for NGC 1399 and N = 725 +/- 145, S_N = 2.0 +/- 0.5 for NGC 1404. Our results are compared to the expectations of globular cluster formation scenarios.Comment: 21 pages, Latex, 13 figures, submitted to MNRA

clc is co-expressed with clf or cntfr in developing mouse muscles

BACKGROUND: The ciliary neurotrophic factor (CNTF) receptor is composed of two signalling receptor chains, gp130 and the leukaemia inhibitory factor receptor, associated with a non-signalling CNTF binding receptor α component (CNTFR). This tripartite receptor has been shown to play important roles in the development of motor neurons, but the identity of the relevant ligand(s) is still not clearly established. Recently, we have identified two new ligands for the CNTF receptor complex. These are heterodimeric cytokines composed of cardiotrophin-like cytokine (CLC) associated either with the soluble receptor subunit cytokine-like factor-1 (CLF) or the soluble form of the binding receptor itself (sCNTFR). RESULTS: Here we show that, during development, clc is expressed in lung, kidney, vibrissae, tooth, epithelia and muscles during the period of development corresponding to when motoneuron loss is observed in mice lacking a functional CNTF receptor. In addition, we demonstrate that it is co-expressed at the single cell level with clf and cntfr, supporting the idea that CLC might be co-secreted with either CLF or sCNTFR. CONCLUSION: This expression pattern is in favor of CLC, associated either with CLF or sCNTFR, being an important player in the signal triggered by the CNTF receptor being required for motoneuron development

Metallicity Gradients at Large Galactocentric Radii Using the Near-infrared Calcium Triplet

We describe a new spectroscopic technique for measuring radial metallicity gradients out to large galactocentric radii. We use the DEIMOS multi-object spectrograph on the Keck telescope and the galaxy spectrum extraction technique of Proctor et al. (2009). We also make use of the metallicity sensitive near-infrared (NIR) Calcium triplet (CaT) features together with single stellar population models to obtain metallicities. Our technique is applied as a pilot study to a sample of three relatively nearby (<30 Mpc) intermediate-mass to massive early-type galaxies. Results are compared with previous literature inner region values and generally show good agreement. We also include a comparison with profiles from dissipational disk-disk major merger simulations. Based on our new extended metallicity gradients combined with other observational evidence and theoretical predictions, we discuss possible formation scenarios for the galaxies in our sample. The limitations of our new technique are also discussed.Comment: 13 Pages, 9 Figures, 7 Tables, Accepted for publication in MNRA

Feminist Reflections on the Scope of Labour Law: Domestic Work, Social Reproduction and Jurisdiction

Drawing on feminist labour law and political economy literature, I argue that it is crucial to interrogate the personal and territorial scope of labour. After discussing the “commodification” of care, global care chains, and body work, I claim that the territorial scope of labour law must be expanded beyond that nation state to include transnational processes. I use the idea of social reproduction both to illustrate and to examine some of the recurring regulatory dilemmas that plague labour markets. I argue that unpaid care and domestic work performed in the household, typically by women, troubles the personal scope of labour law. I use the example of this specific type of personal service relation to illustrate my claim that the jurisdiction of labour law is historical and contingent, rather than conceptual and universal. I conclude by identifying some of the implications of redrawing the territorial and personal scope of labour law in light of feminist understandings of social reproduction

Contribuição ao ensino da nomenclatura de compostos de orgânicos utilizando jogo de tabuleiro de baixo custo / Contribution to teaching the nomenclature of organic compounds using a low-cost board game

O presente projeto desenvolveu um jogo de tabuleiro de baixo custo visando o ensino da nomenclatura e identificação dos grupos funcionais de compostos orgânicos. As concepções dos estudantes sobre as atividades realizadas foram avaliadas através dos resultados gerados pela aplicação dos questionários diagnóstico (aplicada antes do jogo) e formativo (aplicado depois do jogo) e um protocolo de entrevista semiestruturada. Com isso, observou-se que a utilização de jogos didáticos é uma importante ferramenta facilitadora da aprendizagem e uma excelente alternativa no que se refere a despertar o interesse no aluno e suprir de forma dinâmica as dificuldades dos alunos. 

Red Clump Morphology as Evidence Against a New Intervening Stellar Population as the Primary Source of Microlensing Toward the LMC

We examine the morphology of the color-magnitude diagram (CMD) for core helium-burning (red clump) stars to test the recent suggestion by Zaritsky & Lin (1997) that an extension of the red clump in the Large Magellanic Cloud (LMC) toward brighter magnitudes is due to an intervening population of stars that is responsible for a significant fraction of the observed microlensing toward the LMC. Using our own CCD photometry of several fields across the LMC, we confirm the presence of this additional red clump feature, but conclude that it is caused by stellar evolution rather than a foreground population. We do this by demonstrating that the feature (1) is present in all our LMC fields, (2) is in precise agreement with the location of the blue loops in the isochrones of intermediate age red clump stars with the metallicity and age of the LMC, (3) has a relative density consistent with stellar evolution and LMC star formation history, and (4) is present in the Hipparcos CMD for the solar neighborhood where an intervening population cannot be invoked. Assuming there is no systematic shift in the model isochrones, which fit the Hipparcos data in detail, a distance modulus of $\mu_{LMC} = 18.3$ provides the best fit to our dereddened CMD.Comment: 21 pages LaTex (aaspp4.sty), including three tables and 9 figures (1 is .ps, 8 are .gif). Accepted for publication by Astronomical Journal on March 16, 1998. One error corrected and major revisions now lead to an even stronger argument for the stellar evolutionary origin of features in the LMC color magnitude diagram, claimed by others to be an intervening stellar population and major source of microlensing optical depth toward the LM

Recent Applications of Fluorescence Recovery after Photobleaching (FRAP) to Membrane Bio-Macromolecules

This review examines some recent applications of fluorescence recovery after photobleaching (FRAP) to biopolymers, while mainly focusing on membrane protein studies. Initially, we discuss the lateral diffusion of membrane proteins, as measured by FRAP. Then, we talk about the use of FRAP to probe interactions between membrane proteins by obtaining fundamental information such as geometry and stoichiometry of the interacting complex. Afterwards, we discuss some applications of FRAP at the cellular level as well as the level of organisms. We conclude by comparing diffusion coefficients obtained by FRAP and several other alternative methods

Impact of safety-related dose reductions or discontinuations on sustained virologic response in HCV-infected patients: Results from the GUARD-C Cohort

BACKGROUND: Despite the introduction of direct-acting antiviral agents for chronic hepatitis C virus (HCV) infection, peginterferon alfa/ribavirin remains relevant in many resource-constrained settings. The non-randomized GUARD-C cohort investigated baseline predictors of safety-related dose reductions or discontinuations (sr-RD) and their impact on sustained virologic response (SVR) in patients receiving peginterferon alfa/ribavirin in routine practice. METHODS: A total of 3181 HCV-mono-infected treatment-naive patients were assigned to 24 or 48 weeks of peginterferon alfa/ribavirin by their physician. Patients were categorized by time-to-first sr-RD (Week 4/12). Detailed analyses of the impact of sr-RD on SVR24 (HCV RNA <50 IU/mL) were conducted in 951 Caucasian, noncirrhotic genotype (G)1 patients assigned to peginterferon alfa-2a/ribavirin for 48 weeks. The probability of SVR24 was identified by a baseline scoring system (range: 0-9 points) on which scores of 5 to 9 and <5 represent high and low probability of SVR24, respectively. RESULTS: SVR24 rates were 46.1% (754/1634), 77.1% (279/362), 68.0% (514/756), and 51.3% (203/396), respectively, in G1, 2, 3, and 4 patients. Overall, 16.9% and 21.8% patients experienced 651 sr-RD for peginterferon alfa and ribavirin, respectively. Among Caucasian noncirrhotic G1 patients: female sex, lower body mass index, pre-existing cardiovascular/pulmonary disease, and low hematological indices were prognostic factors of sr-RD; SVR24 was lower in patients with 651 vs. no sr-RD by Week 4 (37.9% vs. 54.4%; P = 0.0046) and Week 12 (41.7% vs. 55.3%; P = 0.0016); sr-RD by Week 4/12 significantly reduced SVR24 in patients with scores <5 but not 655. CONCLUSIONS: In conclusion, sr-RD to peginterferon alfa-2a/ribavirin significantly impacts on SVR24 rates in treatment-naive G1 noncirrhotic Caucasian patients. Baseline characteristics can help select patients with a high probability of SVR24 and a low probability of sr-RD with peginterferon alfa-2a/ribavirin

Serum procalcitonin elevation in critically ill patients at the onset of bacteremia caused by either gram negative or gram positive bacteria

<p>Abstract</p> <p>Background</p> <p>In the ICU, bacteremia is a life-threatening infection whose prognosis is highly dependent on early recognition and treatment with appropriate antibiotics. Procalcitonin levels have been shown to distinguish between bacteremia and noninfectious inflammatory states accurately and quickly in critically ill patients. However, we still do not know to what extent the magnitude of PCT elevation at the onset of bacteremia varies according to the Gram stain result.</p> <p>Methods</p> <p>Review of the medical records of every patient treated between May, 2004 and December, 2006 who had bacteremia caused by either Gram positive (GP) or Gram negative (GN) bacteria, and whose PCT dosage at the onset of infection was available.</p> <p>Results</p> <p>97 episodes of either GN bacteremia (<it>n </it>= 52) or GP bacteremia (<it>n </it>= 45) were included. Procalcitonin levels were found to be markedly higher in patients with GN bacteremia than in those with GP bacteremia, whereas the SOFA score value in the two groups was similar. Moreover, in the study population, a high PCT value was found to be independently associated with GN bacteremia. A PCT level of 16.0 ng/mL yielded an 83.0% positive predictive value and a 74.0% negative predictive value for GN-related bacteremia in the study cohort (AUROCC = 0.79; 95% CI, 0.71–0.88).</p> <p>Conclusion</p> <p>In a critically ill patient with clinical sepsis, GN bacteremia could be associated with higher PCT values than those found in GP bacteremia, regardless of the severity of the disease.</p