Exercising for the Pleasure and for the Pain of It: The Implications of Different Forms of Hedonistic Thinking in Theories of Physical Activity Behavior

Exercising for the pleasure and for the pain of it: the implications of different forms of hedonistic thinking in theories of physical activity behavio

Precis of Vaulting Ambition: Sociobiology and the Quest for Human Nature

The debate about the credentials of sociobiology has persisted because scholars have failed to distinguish the varieties of sociobiology and because too little attention has been paid to the details of the arguments that are supposed to support the provocative claims about human social behavior. I seek to remedy both dcfieieneies. After analysis of the relationships among different kinds of sociobiology and contemporary evolutionary theory, I attempt to show how some of the studies of the behavior of nonhuman animals meet the methodological standards appropriate to evolutionary research. I contend that the efforts of E. O. Wilson, Richard Alexander, Charles Lumsden, and others to generate conclusions about human nature are flawed, both because they apply evolutionary ideas in an unrigorous fashion and because they use dubious assumptions to connect their evolutionary analyses with their conclusions. This contention rests on analyses of many of the major sociobiological proposals about human social behavior, including: differences in sex roles, racial hostility, homosexuality, conflict between parents and adolescent offspring, incest avoidance, the avunculate, alliances in combat, female infanticide, and gene-culture coevolution. Vaulting Ambition thus seeks to identify what is good in sociobiology, to expose the errors of premature speculations about human nature, and to prepare the way for serious study of the evolution of human social behavior

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.

Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm Hg systolic blood pressure or  ≥90 mm Hg diastolic blood pressure). Even small increments in blood pressure are associated with an increased risk of cardiovascular events. This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention

El egoísmo psicológico

Not available<br><br>El egoísmo psicológico es una teoría sobre la motivación que afirma que nuestros deseos últimos son autoccntrados. Las crío ticas contra el egoísmo psicológico se pueden dividir en tres categorías: <i>a)</i> se dice que no es una auténtica teoría; <i>b)</i> que es una teoría refutada por la observación de la conducta; <i>c)</i> que se debería rechazar en favor de una teoría alternativa según la cual los seres humanos tienen deseos últimos tanto egoístas como altruistas. Se analizan estos tres tipos de crítica y se concluye que la situación del debate entre egoísmo y pluralismo motivacional es de tablas. Situación que puede encontrar alguna salida a partir de consideraciones evolucionistas. El egoísmo no merece ser considerado como hipótesis por defecto. Aunque sea en un grado pequeño, el peso de la evidencia favorece al pluralismo

The Two Faces of Fitness

the product pe, which is itself a mathematical expectation. Thus, a trait that enhances an organism's viability, but renders it sterile, has an overall fitness of zero. And a trait that slightly reduces viability, while dramatically augmenting fertility, may be very fit overall. The expansion of the concept of fitness to encompass both viability and fertility resulted from the interaction of two roles that the concept of fitness plays in evolutionary theory. It describes the relationship of an organism to its environment. It also has a mathematical representation that allows predictions and explanations to be formulated. Fitness is both an ecological descriptor and a mathematical predictor. The descriptive ecological content of the concept was widened to bring it into correspondence with the role that fitness increasingly played as a mathematical parameter in the theory of natural selection. In this paper I want to discuss several challenges that have arisen in connection with the id

Prediction Versus Accommodation and the Risk of Overfitting

When a scientist uses an observation to formulate a theory, it is no surprise that the resulting theory accurately captures that observation. However, when the theory makes a novel prediction—when it predicts an observation that was not used in its formulation—this seems to provide more substantial confirmation of the theory. This paper presents a new approach to the vexed problem of understanding the epistemic difference between prediction and accommodation. In fact, there are several problems that need to be disentangled; in all of them, the key is the concept of overfitting. We float the hypothesis that accommodation is a defective methodology only when the methods used to accommodate the data fail to guard against the risk of overfitting. We connect our analysis with the proposals that other philosophers have made. We also discuss its bearing on the conflict between instrumentalism and scientific realism