The progress of TMT Laser Guide Star Facility

The Laser Guide Star Facility (LGSF) is responsible for generating the artificial laser guide stars required by the TMT Laser Guide Star (LGS) AO systems. The LGSF uses multiple sodium lasers to generate and project several LGS asterisms from a laser launch telescope located behind the TMT secondary mirror. The LGSF includes 3 main subsystems: (1) the laser system, (2) the beam transfer optics (BTO) system, (3) the associated laser safety system. At present, the LGSF is in the preliminary design phase. During this phase, the laser launch telescope trade study, Beam transfer optical path trade study are compared carefully, and some critical components prototypes have been carried out to verify the requirements, such as the polarization status control and test, the Fast Steer Mirror (FSM) prototype test

Overall Survival Analysis and Characterization of an EGFR Mutated Non-Small Cell Lung Cancer (NSCLC) Population

BACKGROUND: Patients with activating somatic mutations in the Epidermal Growth Factor Receptor (EGFR) have better clinical outcomes when treated with Tyrosine Kinase Inhibitors (TKI) over chemotherapy. However, the impact of the use of TKIs on overall survival outside clinical trials is not well established. OBJECTIVE: To characterize and analyze the overall survival of a Caucasian population with NSCLC and EGFR mutations. METHODS: A retrospective cohort analysis of patients with NSCLC screened for EGFR mutations (exons 18-21) between October 2009 and July 2013 was conducted. Clinical and pathological characteristics, mutational EGFR status, treatment and overall survival were evaluated. RESULTS: From the 285 patients which performed screening for EGFR mutations, 54 (18.9%) had mutations, 25 (46.3%) of which in exon 19 and 20 of which (37.0%) in exon 21. The occurrence of mutations was associated with female sex and non-smoking habits (both, P<.001). The median survival of the global population was 12.0 months, with a better overall survival in mutated than non-mutated patients (20.0 vs 11.0 months, respectively; P=.007). CONCLUSION: These data contribute for a better knowledge of our lung cancer population concerning the mutational status and clinical outcomes, confirming a better overall survival for the patients with EGFR TKI sensible mutations.info:eu-repo/semantics/publishedVersio

The progress of TMT Laser Guide Star Facility

The Laser Guide Star Facility (LGSF) is responsible for generating the artificial laser guide stars required by the TMT Laser Guide Star (LGS) AO systems. The LGSF uses multiple sodium lasers to generate and project several LGS asterisms from a laser launch telescope located behind the TMT secondary mirror. The LGSF includes 3 main subsystems: (1) the laser system, (2) the beam transfer optics (BTO) system, (3) the associated laser safety system. At present, the LGSF is in the preliminary design phase. During this phase, the laser launch telescope trade study, Beam transfer optical path trade study are compared carefully, and some critical components prototypes have been carried out to verify the requirements, such as the polarization status control and test, the Fast Steer Mirror (FSM) prototype test

Rac and Rho GTPases in cancer cell motility control

Rho GTPases represent a family of small GTP-binding proteins involved in cell cytoskeleton organization, migration, transcription, and proliferation. A common theme of these processes is a dynamic reorganization of actin cytoskeleton which has now emerged as a major switch control mainly carried out by Rho and Rac GTPase subfamilies, playing an acknowledged role in adaptation of cell motility to the microenvironment. Cells exhibit three distinct modes of migration when invading the 3 D environment. Collective motility leads to movement of cohorts of cells which maintain the adherens junctions and move by photolytic degradation of matrix barriers. Single cell mesenchymal-type movement is characterized by an elongated cellular shape and again requires extracellular proteolysis and integrin engagement. In addition it depends on Rac1-mediated cell polarization and lamellipodia formation. Conversely, in amoeboid movement cells have a rounded morphology, the movement is independent from proteases but requires high Rho GTPase to drive elevated levels of actomyosin contractility. These two modes of cell movement are interconvertible and several moving cells, including tumor cells, show an high degree of plasticity in motility styles shifting ad hoc between mesenchymal or amoeboid movements. This review will focus on the role of Rac and Rho small GTPases in cell motility and in the complex relationship driving the reciprocal control between Rac and Rho granting for the opportunistic motile behaviour of aggressive cancer cells. In addition we analyse the role of these GTPases in cancer progression and metastatic dissemination

Ovarian cancer molecular pathology.

Peer reviewe

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P &lt; 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

Melfa Road Walk N’ Roll Tactical Urbanism Interventions for Improving Road Safety and Nature Connections

The objective of the Melfa Road Project (MRP) is to address inadequacies in street safety in East Acadia neighbourhood while incorporating community ideas for enhancing biodiversity, fostering environmental education, and promoting connections to nature for children. The MRP inventories all classes of land-use, soft landscapes, canopy cover, and above ground-infrastructure features. Metric outputs show that 52% of land-use types is public land, 18% is residential, 2% is institutional, 66% of soft landscapes are lawns, 22% is wild greenery, and11% are planting beds. There are 101 trees in the study site, 64% of which are deciduous, and the rest is coniferous, which encompasses a total canopy cover of 13.5%. Through a site assessment and QGIS analysis, the MRP examines overarching problems associated with Melfa Road, such as lack of street safety signs, unsuitable placement of garbage dumps, and underutilised parking lots. Through an extensive literature review we suggest opportunities for tactical urbanism interventions (TUI) that adhere to UBC land-use plans and initiatives. Melfa Road is heavily depended on by students, children, and families and is trafficked by vehicles, bicyclists, and pedestrians. There is abundant greenspace accessibility for passive or active recreation, for activities such as walking, playing, bicycling, and lounging. These outdoor areas provide a moment for relaxation but missed opportunities in past designs along with the placement of current roads and parking lots creates a barrier to these beneficial activities. Disclaimer: “UBC SEEDS provides students with the opportunity to share the findings of their studies, as well as their opinions, conclusions and recommendations with the UBC community. The reader should bear in mind that this is a student project/report and is not an official document of UBC. Furthermore readers should bear in mind that these reports may not reflect the current status of activities at UBC. We urge you to contact the research persons mentioned in a report or the SEEDS Coordinator about the current status of the subject matter of a project/report.”Forestry, Faculty ofUnreviewedUndergraduat