Misura della raccolta di luce in una striscia di scintillatore plastico letta con fotomoltiplicatori al silicio

In questo lavoro è stata studiata la risposta a particelle al minimo di ionizzazione di un rivelatore, che sarà utilizzato per l'identificazione di muoni in SHIP (Search for HIdden Particles), esperimento proposto al CERN e ancora in fase di approvazione. Il rivelatore è basato su una striscia di scintillatore lunga tre metri accoppiata ad una fibra ottica Wave Lenght Shifter (WLS) e letta da due fotomoltiplicatori al Silicio (SiPM), posti ad entrambi i capi. Lo scopo principale del lavoro è la misura della raccolta di luce del rivelatore e la valutazione della lunghezza di attenuazione della striscia. I risultati mostrano che, nonostante l'attenuazione, la configurazione scelta per il rivelatore è tale da garantire una buona raccolta di luce lungo tutta la striscia

A Derivative of the Thiopeptide GE2270A Highly Selective against Propionibacterium acnes

A chemical derivative of the thiopeptide GE2270A, designated NAI003, was found to possess a substantially reduced antibacterial spectrum in comparison to the parent compound, being active against just a few Gram-positive bacteria. In particular, NAI003 retained low MICs against all tested isolates of Propionibacterium acnes and, to a lesser extent, against Enterococcus faecalis. Furthermore, NAI003 showed a time- and dose-dependent killing of both a clindamycin-resistant and a clindamycinsensitive P. acnes isolate. Gel shift experiments indicated that, like the parent compound, NAI003 retained the ability to bind to elongation factors Tu (EF-Tus) derived from Escherichia coli, E. faecalis, or P. acnes, albeit with reduced efficiency. In contrast, EF-Tus derived from the NAI003-insensitive Staphylococcus aureus or Streptococcus pyogenes did not bind this compound. These results were confirmed by in vitro studies using a hybrid translation system, which indicated that NAI003 can inhibit most efficiently protein synthesis driven by the P. acnes EF-Tu. P. acnes mutants resistant to NAI003 were isolated by direct plating. With one exception, all analyzed strains carried mutations in the tuf gene, encoding EF-Tu. Because of its selective effect on P. acnes in comparison to resident skin flora, NAI003 represents a promising candidate for the topical treatment of acne, which has already completed a phase 1 clinical study

Dynamics of charge transfer from plasmonic nanoparticles to cerium oxide

The combination of semiconducting oxide-based materials with plasmonic nanoparticles (NPs) aims to efficiently convert solar light into chemical or electric energy, exploiting the excitation of localized surface plasmon resonance (LSPR) in the NPs that leads to a significant energy/charge transfer to the oxide. By performing UV-Visible spectrophotometry measurements on systems composed of Cu/Au NPs embedded in a matrix of CeO2, we observed a wide absorption band in the visible range, ascribed to the LSPR excitation in the NPs. Femtosecond transient absorption spectroscopy at different pump energies across the LSPR band of the NPs unveiled a persistent charge transfer from the NPs to CeO2. Efficiency up to 35% for systems with Au NPs has been estimated

Lifetime of Photogenerated Positive Charges in Hybrid Cerium Oxide-Based Materials from Space and Mirror Charge Effects in Time-Resolved Photoemission Spectroscopy

Space and mirror charge effects in time-resolved photoemission spectroscopy can be modeled to obtain relevant information on the recombination dynamics of charge carriers. We successfully extracted from these phenomena the reneutralization characteristic time of positive charges generated by photoexcitation in CeO2-based films. For the above-band-gap excitation, a large fraction of positive carriers with a lifetime that exceeds 100 ps are generated. Otherwise, the sub-band-gap excitation induces the formation of a significantly smaller fraction of charges with lifetimes of tens of picoseconds, ascribed to the excitation of defect sites or to multiphoton absorption. When the oxide is combined with Ag nanoparticles, the sub-band-gap excitation of localized surface plasmon resonances leads to reneutralization times longer than 300 ps. This was interpreted by considering the electronic unbalance at the surface of the nanoparticles generated by the injection of electrons, via localized surface plasmon resonance (LSPR) decay, into CeO2. This study represents an example of how to exploit the space charge effect in gaining access to the surface carrier dynamics in CeO2 within the picosecond range of time, which is fundamental to describe the photocatalytic processes

Modified Gravity and Cosmology: An Update by the CANTATA Network

General Relativity and the $\Lambda$CDM framework are currently the standard lore and constitute the concordance paradigm. Nevertheless, long-standing open theoretical issues, as well as possible new observational ones arising from the explosive development of cosmology the last two decades, offer the motivation and lead a large amount of research to be devoted in constructing various extensions and modifications. All extended theories and scenarios are first examined under the light of theoretical consistency, and then are applied to various geometrical backgrounds, such as the cosmological and the spherical symmetric ones. Their predictions at both the background and perturbation levels, and concerning cosmology at early, intermediate and late times, are then confronted with the huge amount of observational data that astrophysics and cosmology are able to offer recently. Theories, scenarios and models that successfully and efficiently pass the above steps are classified as viable and are candidates for the description of Nature. We list the recent developments in the fields of gravity and cosmology, presenting the state of the art, high-lighting the open problems, and outlining the directions of future research. Its realization is performed in the framework of the COST European Action "Cosmology and Astrophysics Network for Theoretical Advances and Training Actions"

Deep-Sea Bioluminescence Blooms after Dense Water Formation at the Ocean Surface

The deep ocean is the largest and least known ecosystem on Earth. It hosts numerous pelagic organisms, most of which are able to emit light. Here we present a unique data set consisting of a 2.5-year long record of light emission by deep-sea pelagic organisms, measured from December 2007 to June 2010 at the ANTARES underwater neutrino telescope in the deep NW Mediterranean Sea, jointly with synchronous hydrological records. This is the longest continuous time-series of deep-sea bioluminescence ever recorded. Our record reveals several weeks long, seasonal bioluminescence blooms with light intensity up to two orders of magnitude higher than background values, which correlate to changes in the properties of deep waters. Such changes are triggered by the winter cooling and evaporation experienced by the upper ocean layer in the Gulf of Lion that leads to the formation and subsequent sinking of dense water through a process known as “open-sea convection”. It episodically renews the deep water of the study area and conveys fresh organic matter that fuels the deep ecosystems. Luminous bacteria most likely are the main contributors to the observed deep-sea bioluminescence blooms. Our observations demonstrate a consistent and rapid connection between deep open-sea convection and bathypelagic biological activity, as expressed by bioluminescence. In a setting where dense water formation events are likely to decline under global warming scenarios enhancing ocean stratification, in situ observatories become essential as environmental sentinels for the monitoring and understanding of deep-sea ecosystem shifts

Deep-Sea Bioluminescence Blooms after Dense Water Formation at the Ocean Surface

<p>The deep ocean is the largest and least known ecosystem on Earth. It hosts numerous pelagic organisms, most of which are able to emit light. Here we present a unique data set consisting of a 2.5-year long record of light emission by deep-sea pelagic organisms, measured from December 2007 to June 2010 at the ANTARES underwater neutrino telescope in the deep NW Mediterranean Sea, jointly with synchronous hydrological records. This is the longest continuous time-series of deep-sea bioluminescence ever recorded. Our record reveals several weeks long, seasonal bioluminescence blooms with light intensity up to two orders of magnitude higher than background values, which correlate to changes in the properties of deep waters. Such changes are triggered by the winter cooling and evaporation experienced by the upper ocean layer in the Gulf of Lion that leads to the formation and subsequent sinking of dense water through a process known as "open-sea convection". It episodically renews the deep water of the study area and conveys fresh organic matter that fuels the deep ecosystems. Luminous bacteria most likely are the main contributors to the observed deep-sea bioluminescence blooms. Our observations demonstrate a consistent and rapid connection between deep open-sea convection and bathypelagic biological activity, as expressed by bioluminescence. In a setting where dense water formation events are likely to decline under global warming scenarios enhancing ocean stratification, in situ observatories become essential as environmental sentinels for the monitoring and understanding of deep-sea ecosystem shifts.</p>

Dark Energy and Modified Gravity

Despite two decades of tremendous experimental and theoretical progress, the riddle of the accelerated expansion of the Universe remains to be solved. On the experimental side, our understanding of the possibilities and limitations of the major dark energy probes has evolved; here we summarize the major probes and their crucial challenges. On the theoretical side, the taxonomy of explanations for the accelerated expansion rate is better understood, providing clear guidance to the relevant observables. We argue that: i) improving statistical precision and systematic control by taking more data, supporting research efforts to address crucial challenges for each probe, using complementary methods, and relying on cross-correlations is well motivated; ii) blinding of analyses is difficult but ever more important; iii) studies of dark energy and modified gravity are related; and iv) it is crucial that R&D for a vibrant dark energy program in the 2030s be started now by supporting studies and technical R&D that will allow embryonic proposals to mature. Understanding dark energy, arguably the biggest unsolved mystery in both fundamental particle physics and cosmology, will remain one of the focal points of cosmology in the forthcoming decade