Étude du processus de socialisation organisationnelle des nouvelles recrues dans le secteur hôtelier

In a context of shortage of certain profiles or qualifications, companies are faced with the challenge of integrating and retaining new recruits, and must imagine and implement new solutions in terms of organizational socialization. Hotel establishments - in Morocco - do not escape this economic imperative which questions the place of team management, management of organizations and leadership of superiors. This observation is more striking in the luxury hotel industry in Marrakech, which faces a fairly demanding clientele in relation to the quality of service and the quality of the profiles. Executive profiles are increasingly in demand, although they are rare at the base, in addition to the Covid'19 crisis has pushed many of them to leave the hotel sector. To do this, hotel establishments are required to implement organizational socialization strategies to better retain and keep them. The objective of this article is to study the process of organizational socialization of new recruits. The field survey covered a sample of 17 new recruits from different hotels in the city of Marrakech to trace their integration journey, and explain in sufficient detail how organizational socialization practices contribute to successful integration. The method used for data collection is the semi-structured interview, the interviews have been transcribed in full. The data was analyzed through thematic content analysis assisted by the NVivo software. This survey has the particularity of identifying organizational socialization strategies in hotel establishments, the course of the organizational socialization process, and the factors that influence it. Keywords: Integration - Hotel establishment - Morocco - Marrakech - organizational socialization. JEL Classification: M12 Paper type: Empirical researchDans un contexte de pénurie de certains profils et qualification, les entreprises sont confrontées au défi d’intégration et de rétention des nouvelles recrues, et se doivent d’imaginer puis de mettre en place de nouvelles solutions en matière de socialisation organisationnelle. Les établissements hôteliers - au Maroc - n’échappent pas à cet impératif économique qui vient questionner la place du management d’équipe, du management des organisations et du leadership des supérieurs. Ce constat est plus marquant dans l’hôtellerie de luxe à Marrakech qui fait face à une clientèle assez exigeante par rapport à la qualité de service et à la qualité des profils. Les profils de cadres sont de plus en plus demandés, bien qu’ils soient rares à la base, en plus la crise du Covid’19 a poussé un grand nombre d’entre eux à quitter le secteur hôtelier. Pour y remédier, les établissements hôteliers sont tenus de mettre en place des stratégies de socialisation organisationnelle pour mieux les fidéliser et mieux les garder. L’objectif de cet article est d’étudier le processus de socialisation organisationnelle des nouvelles recrues. L’enquête terrain a couvert un échantillon de 17 nouvelles recrues de différents hôtels de la ville de Marrakech pour retracer leur parcours d’intégration, et expliquer avec suffisamment de détails comment les pratiques de socialisation organisationnelle contribuent à la réussite de l’intégration. La méthode utilisée pour la collecte des données est l’entretien semi-directif, les entretiens ont été retranscrits intégralement. Les données ont été analysées à travers l’analyse thématique du contenu assistée par le logiciel NVivo. Cette enquête présente la particularité de cerner les stratégies de socialisation organisationnelle dans les établissements hôteliers, le déroulement du processus de socialisation organisationnelle, et les facteurs qui l’influencent. Mots-clés : Intégration - établissements hôteliers - Maroc - Marrakech – socialisation organisationnelle. Classification JEL : M12 Type de l’article : Recherche appliqué

Etude De La Pertinence Des IG Comme Outil De Différenciation Des Produits De Terroir: CAS DE l’IGP Argane Dans La Ville d’Agadir Et Regions

The differentiation of local products is considered as a necessity nowadays given the standardization flows are increasing. This differentiation can be established especially through the Distinctive Signs of Origin and Quality (DSOQ). Our work has shown through the example of the PGI (Protected Geographical Indication) Argane, that GIs are a relevant tool for the differentiation of local products if they (GIs) are placed in a favorable context to their application. Our paper answers the following question: "To what extent geographical indications are meant as an effective tool for differentiation of local products: case of the PGI Argane in the city of Agadir and regions? To do so, we used an exploratory qualitative study through semi-structured interviews with a sample of people representing different stakeholders of Agadir and its regions, preceded of course by a literature review on the different key concepts

L’ATTEINTE RENALE CHEZ LES PATIENTS DREPANOCYTAIRES

Purpose: to estimate the frequency of renal abnormalities in patients with sickle cell disease and to assess the role of blood transfusion and treatment with hydroxyurea in sickle cell nephropathy prevention. Patients and methods: It’s a descriptive and cross-sectional study conducted hematology laboratory at Ibn Rochd University Hospital of Casablanca. The study was conducted during a period of one year (1 January to 31 December 2008). We included in this study patients with sickle cell disease all ages and gender confused. All patients underwent renal laboratory tests. Results: During the study period, 30 patients were collected. The average age of patients was 26 years. Eighteen patients (60%) had homozygous sickle cell disease SS and 12 had a heterozygous form (8 patients with SA (27%), 2 patients SC and 2 patients Sb). Abnormal renal laboratory tests were found in 14 patients (46,7%). Of the 14 patients with renal impairment, 7 have received blood transfusions (OR = 0.23 IC95% [0.03 to 1.50]). Eight of our patients were on hydroxyurea, 2 had abnormal renal function. (OR= 1  IC95% [0.10 to 8.90]) Conclusion: Sickle cell disease is associated with significant abnormalities of renal function. These abnormalities are more frequent in the SS genotype. We have not been able to prove the beneficial effect of the use of hydroxyurea or blood transfusion in the prevention of renal dysfunctions, perhaps due to the relatively small number of patients included in this study.But : Estimer la fréquence des anomalies biologiques rénales chez les patients atteints de drépanocytose et évaluer  le rôle de la transfusion sanguine et du traitement par hydroxyurée dans la prévention de la néphropathie drépanocytaire. Patients et méthodes : étude transversale de type descriptive réalisée au laboratoire d’hématologie du centre hospitalier universitaire Ibn Rochd de Casablanca. L’étude a été menée durant une période d’une année (du 1er Janvier au 31 Décembre 2008). Nous avons inclus dans cette étude tout patient drépanocytaire tout âge et tout sexe confondu. Tous les patients ont bénéficié d’un bilan biologique rénal. Résultats : Durant la période de l’étude, 30 patients ont été colligés. L’âge moyen des patients était 26 ans. Dix huit patients (60%) présentaient une drépanocytose homozygote SS et 12 avaient une drépanocytose hétérozygote (8 patients SA (27%), 2 patients SC et  2 patients Sbêta. Des anomalies du bilan biologique rénal ont été retrouvés chez 14 patients soit 46,7%. Sur ces 14 patients ayant une atteinte rénale, 7  seulement avaient déjà reçu des transfusions sanguines (OR=0,23 IC95%[0,03-1,50]). Huit de nos patients étaient sous hydroxyurée dont 2 avaient une anomalie de la fonction rénale. (OR=1 IC95%[0,10-8,90] ) Conclusion : La drépanocytose est associée à d'importantes anomalies de la fonction rénale.  Ces anomalies sont plus fréquentes dans le génotype SS. Nous n’avons pas pu prouver l’effet bénéfique de l'utilisation de l'hydroxyurée ou de la transfusion sanguine dans la prévention de l’atteinte rénale, peut-être en raison du nombre relativement faible des patients inclus dans ce travail

Use of stable CHO pools and CHO TGE to accelerate SARS-CoV-2 vaccine development

Please click Additional Files below to see the full abstract

Using a genetically encoded sensor to identify inhibitors of Toxoplasma gondii Ca2+ Signalling

This work was supported in part by National Institutes of Health Grants AI-110027 and AI-096836 (to S. N. J. M.) and 1DP5OD017892 (to S. L.).The life cycles of apicomplexan parasites progress in accordance with fluxes in cytosolic Ca2+. Such fluxes are necessary for events like motility and egress from host cells. We used genetically encoded Ca2+ indicators (GCaMPs) to develop a cell-based phenotypic screen for compounds that modulate Ca2+ signaling in the model apicomplexan Toxoplasma gondii. In doing so, we took advantage of the phosphodiesterase inhibitor zaprinast, which we show acts in part through cGMP-dependent protein kinase (protein kinase G; PKG) to raise levels of cytosolic Ca2+. We define the pool of Ca2+ regulated by PKG to be a neutral store distinct from the endoplasmic reticulum. Screening a library of 823 ATP mimetics, we identify both inhibitors and enhancers of Ca2+ signaling. Two such compounds constitute novel PKG inhibitors and prevent zaprinast from increasing cytosolic Ca2+. The enhancers identified are capable of releasing intracellular Ca2+ stores independently of zaprinast or PKG. One of these enhancers blocks parasite egress and invasion and shows strong antiparasitic activity against T. gondii. The same compound inhibits invasion of the most lethal malaria parasite, Plasmodium falciparum. Inhibition of Ca2+-related phenotypes in these two apicomplexan parasites suggests that depletion of intracellular Ca2+ stores by the enhancer may be an effective antiparasitic strategy. These results establish a powerful new strategy for identifying compounds that modulate the essential parasite signaling pathways regulated by Ca2+, underscoring the importance of these pathways and the therapeutic potential of their inhibition.Publisher PDFPeer reviewe

Using a Genetically Encoded Sensor to Identify Inhibitors of Toxoplasma gondii Ca 2+ Signaling

The life cycles of apicomplexan parasites progress in accordance with fluxes in cytosolic Ca2+. Such fluxes are necessary for events like motility and egress from host cells. We used genetically encoded Ca2+ indicators (GCaMPs) to develop a cell-based phenotypic screen for compounds that modulate Ca2+ signaling in the model apicomplexan Toxoplasma gondii. In doing so, we took advantage of the phosphodiesterase inhibitor zaprinast, which we show acts in part through cGMP-dependent protein kinase (protein kinase G; PKG) to raise levels of cytosolic Ca2+. We define the pool of Ca2+ regulated by PKG to be a neutral store distinct from the endoplasmic reticulum. Screening a library of 823 ATP mimetics, we identify both inhibitors and enhancers of Ca2+ signaling. Two such compounds constitute novel PKG inhibitors and prevent zaprinast from increasing cytosolic Ca2+. The enhancers identified are capable of releasing intracellular Ca2+ stores independently of zaprinast or PKG. One of these enhancers blocks parasite egress and invasion and shows strong antiparasitic activity against T. gondii. The same compound inhibits invasion of the most lethal malaria parasite, Plasmodium falciparum. Inhibition of Ca2+-related phenotypes in these two apicomplexan parasites suggests that depletion of intracellular Ca2+ stores by the enhancer may be an effective antiparasitic strategy. These results establish a powerful new strategy for identifying compounds that modulate the essential parasite signaling pathways regulated by Ca2+, underscoring the importance of these pathways and the therapeutic potential of their inhibition

Polyubiquitin binding to ABIN1 is required to prevent autoimmunity

The protein ABIN1 possesses a polyubiquitin-binding domain homologous to that present in nuclear factor kappa B (NF-kappa B) essential modulator (NEMO), a component of the inhibitor of NF-kappa B (I kappa B) kinase (IKK) complex. To address the physiological significance of polyubiquitin binding, we generated knockin mice expressing the ABIN1[D485N] mutant instead of the wild-type (WT) protein. These mice developed all the hallmarks of autoimmunity, including spontaneous formation of germinal centers, isotype switching, and production of autoreactive antibodies. Autoimmunity was suppressed by crossing to MyD88(-/-) mice, demonstrating that toll-like receptor (TLR)-MyD88 signaling pathways are needed for the phenotype to develop. The B cells and myeloid cells of the ABIN1[D485N] mice showed enhanced activation of the protein kinases TAK, IKK-alpha/beta, c-Jun N-terminal kinases, and p38 alpha mitogen-activated protein kinase and produced more IL-6 and IL-12 than WT. The mutant B cells also proliferated more rapidly in response to TLR ligands. Our results indicate that the interaction of ABIN1 with polyubiquitin is required to limit the activation of TLR-MyD88 pathways and prevent autoimmunity

RPRD1A and RPRD1B Are Human RNA Polymerase II C-Terminal Domain Scaffolds for Ser5 Dephosphorylation

The RNA polymerase II (RNAPII) carboxyl-terminal domain (CTD) heptapeptide repeats (Y1-S2-P3-T4-S5-P6-S7) undergo dynamic phosphorylation and dephosphorylation during the transcription cycle to recruit factors that regulate transcription, RNA processing and chromatin modification. We show here that RPRD1A and RPRD1B form homodimers and heterodimers through their coiled-coil domains and interact preferentially via CTD interaction domains (CIDs) with CTD repeats phosphorylated at S2 and S7. Our high resolution crystal structures of the RPRD1A, RPRD1B and RPRD2 CIDs, alone and in complex with CTD phosphoisoforms, elucidate the molecular basis of CTD recognition. In an interesting example of cross-talk between different CTD modifications, our data also indicate that RPRD1A and RPRD1B associate directly with RPAP2 phosphatase and, by interacting with CTD repeats where phospho-S2 and/or phospho-S7 bracket a phospho-S5 residue, serve as CTD scaffolds to coordinate the dephosphorylation of phospho-S5 by RPAP2