Anemia asociado a mortalidad en pacientes con Covid-19 en el Hospital Regional Eleazar Guzmán Barrón de Nuevo Chimbote 2021

El presente estudio de investigación tuvo como objetivo principal determinar la asociación entre la anemia y mortalidad por COVID-19 en el Hospital Regional Eleazar Guzmán Barrón Chimbote 2021, por lo tanto se realizó una investigación observacional, de corte transversal, retrospectivo de casos y controles, la población estuvo constituida por 4 747 pacientes hospitalizados con COVID-19 en el servicio diferenciado de COVID 19 Hospital Regional Eleazar Guzmán Barón, Chimbote durante el periodo Enero – Agosto del 2021, en donde el tamaño Muestral realizado con Epidat V. 4.2 corresponde a 349 pares emparejados según la edad, además se realizó una ficha de recolección de datos para recolectar información de las historias clínicas de los pacientes con COVID 19. En cuanto a los resultados se obtuvo que; no existe una asociación entre la anemia y mortalidad por COVID 19 (OR 1: 1.92 IC: 95% (0,91 – 4.16) y (p = 0,080; p > 0,05), la frecuencia de anemia es del 30% en los pacientes con COVID, 19, siendo el grado leve más frecuente en un 30%, el sexo masculino tuvo una mayor predominancia en un 75% a diferencia del sexo femenino en un 25%, la edad más prevalente fue el rango entre 30 a 59 años con un 60%, no se halló una asociación significativa con la mortalidad (p= 0,289 p < 0,05)Tesi

Safety Of Switching From Natalizumab Straight Into Fingolimod In A Group Of Jcv-positive Patients With Multiple Sclerosis

To assess safety of the switch between natalizumab and fingolimod without a washout period. Methods: Prospective data on 25 JCV positive patients who underwent this medication switch were collected and analyzed. Results: After a median period of nine months from the medication switch, there were no safety issues to report. The patients had good disease control and no adverse events were reported. Conclusion: Washout may not be necessary in daily practice when switching from natalizumab to fingolimod. Expertise on multiple sclerosis management, however, is essential for drug switching.74865065

Um estudo dos problemas de projeto de matrizes de portas com tecnologia CMOS

This work discusses the aspects related to the basic cell features, and the problems f general array structure. The basic array sizing and spacing parameters, and eletrical and eletrical design problems are evaluated. An analysis of some peripheral circuits, with simulation results, is done. Finally, the results of a greate array reversal engineering are also shown.Este trabalho abrange desde aspectos ligados às características da célula básica, até os problemas da estrutura geral da matriz. São avaliados os parâmetros para dimensionamento e espaçamento dos dispositivos da matriz básica, além dos problemas elétricos de projeto. É feita uma análise dos principais tipos de circuitos de periferia, com apresentação dos resultados de simulação. Finalmente, os resultados obtidos na engenharia reversa de uma matriz de portas são também apresentados

Agricultura 4.0: uma abordagem a partir dos princípios FAIR e tecnologia blockchain para gestão de dados de levantamentos pedológicos

A vasta quantidade de dados que é gerada diariamente, em todas as áreas do conhecimento, necessita de formas inovadoras de curadoria e extração de conhecimento para que seja usada de modo inteligente, mostrando de onde são extraídas as descobertas com habilidade para transformar a realidade do agronegócio. Atualmente, a agricultura 4.0 está sendo transformada pela big data, em especial, dados de qualidade e metadados, são usados pelos agricultores, pesquisadores e formuladores de políticas para auxiliar os processos de decisão. Neste trabalho foi feita uma análise de como os princípios FAIR, os metadados de proveniência e a tecnologia blockchain podem auxiliar na proteção de dados. Apresentamos uma proposta de melhoria da plataforma OpenSoils que já conta com um aporte para a proveniência de dados e um grande potencial para se tornar um modelo seguro de base para coleta de dados de solo. Este estudo mostra que a adoção da tecnologia blockchain nesta plataforma pode contribuir para tornar, tanto estudos pedológicos quanto suas aplicações mais confiáveis, seguras e dinâmicas.Sociedad Argentina de Informática e Investigación Operativ

The ARAUCARIA project: Grid-Based Quantitative Spectroscopic Study of Massive Blue Stars in NGC55

The quantitative study of the physical properties and chemical abundances of large samples of massive blue stars at different metallicities is a powerful tool to understand the nature and evolution of these objects. Their analysis beyond the Milky Way is challenging, nonetheless it is doable and the best way to investigate their behavior in different environments. Fulfilling this task in an objective way requires the implementation of automatic analysis techniques that can perform the analyses systematically, minimizing at the same time any possible bias. As part of the ARAUCARIA project we carry out the first quantitative spectroscopic analysis of a sample of 12 B-type supergiants in the galaxy NGC55 at 1.94 Mpc away. By applying the methodology developed in this work, we derive their stellar parameters, chemical abundances and provide a characterization of the present-day metallicity of their host galaxy. Based on the characteristics of the stellar atmosphere/line formation code FASTWIND, we designed and created a grid of models for the analysis of massive blue supergiant stars. Along with this new grid, we implemented a spectral analysis algorithm. Both tools were specially developed to perform fully consistent quantitative spectroscopic analyses of low spectral resolution of B-type supergiants in a fast and objective way. We present the main characteristics of our FASTWIND model grid and perform a number of tests to investigate the reliability of our methodology. The automatic tool is applied afterward to a sample of 12 B-type supergiant stars in NGC55, deriving the stellar parameters and abundances. The results indicate that our stars are part of a young population evolving towards a red supergiant phase. The derived chemical composition hints to an average metallicity similar to the one of the Large Magellanic Cloud, with no indication of a spatial trend across the galaxy.Comment: 19 pages, 12 figures and 9 tables. Accpeted for publication in A&

Segurança na mudança direta de natalizumabe para fingolimode em um grupo de pacientes com esclerose múltipla e positivos para JCV

To assess safety of the switch between natalizumab and fingolimod without a washout period. Methods Prospective data on 25 JCV positive patients who underwent this medication switch were collected and analyzed. Results After a median period of nine months from the medication switch, there were no safety issues to report. The patients had good disease control and no adverse events were reported. Conclusion Washout may not be necessary in daily practice when switching from natalizumab to fingolimod. Expertise on multiple sclerosis management, however, is essential for drug switching748650652Avaliar a segurança na mudança entre natalizumabe e fingolimode sem período de washout. Métodos Dados prospectivos de 25 pacientes positivos para vírus JC que tiveram sua medicação modificada foram coletados e analisados. Resultados Após uma mediana de nove meses da troca de medicação, não havia aspectos de segurança a relatar. Os pacientes estavam com bom controle da doença e não foram relatados eventos adversos. Conclusão Washout pode não ser necessário na prática diária para a mudança entre natalizumabe e fingolimode. No entanto, expertise no manejo de esclerose múltipla é essencial para esta troca entre medicaçõe

Non-perturbative Euler-Heisenberg Lagrangian and Paraelectricity in Magnetized Massless QED

In this paper we calculate the non-perturbative Euler-Heisenberg Lagrangian for massless QED in a strong magnetic field $H$, where the breaking of the chiral symmetry is dynamically catalyzed by the external magnetic field via the formation of an electro-positron condensate. This chiral condensate leads to the generation of dynamical parameters that have to be found as solutions of non-perturbative Schwinger-Dyson equations. Since the electron-positron pairing mechanism leading to the breaking of the chiral symmetry is mainly dominated by the contributions from the infrared region of momenta much smaller than $\sqrt{eH}$, the magnetic field introduces a dynamical ultraviolet cutoff in the theory that also enters in the non-perturbative Euler-Heisenberg action. Using this action, we show that the system exhibits a significant paraelectricity in the direction parallel to the magnetic field. The nonperturbative nature of this effect is reflected in the non-analytic dependence of the obtained electric susceptibility on the fine-structure constant. The strong paraelectricity in the field direction is linked to the orientation of the electric dipole moments of the pairs that form the chiral condensate. The large electric susceptibility can be used to detect the realization of the magnetic catalysis of chiral symmetry breaking in physical systems.Comment: 18 pages, to be published in NP

Classification methods to identify lesions in skin starting from spectra of diffuse reflectance

Con el objetivo de discriminar lesiones benignas y malignas en la piel humana a partir de espectros de reflexión difusa, se han analizado diferentes algoritmos de clasificación usando el software de aprendizaje automático y reconocimiento de patrones WEKA. Además, dada la alta dimensionalidad de la señal espectral, fue empleada una técnica selección de atributos para determinar las variables que aporten la mayor cantidad de información. Se probó la clasificación de la señal usando los algoritmos de máquinas de vectores de soporte, redes neuronales y bosques aleatorios, el desempeño fue evaluado usando el promedio de la k-fold cross-validation tomando en cuenta los porcentajes de instancias clasificadas correctamente, el índice kappa, el área bajo la curva ROC, la sensibilidad, y la especifidad. Finalmente se demuestra que el algoritmo de redes neuronales con los parámetros momentum y learning rate en 0,6 y 0,3 respectivamente, es el que mejor se adapta al problema de reconocimiento de patrones ya que clasifica correctamente al 89,89% de los casos.In order to differentiate between benign and malignant lesions in the human skin using diffuse reflection spectra, different classification algorithms were tested using the WEKA data mining software. In addition, due to the high dimensionality of the spectral signal, an attribute selection technique was applied to determine the variables that contribute with more information. The spectral signal classification was tested using support vector machines, neural networks and random forests, their performance was measured using the k-fold cross-validation percentages of the Kappa statistic, area under the ROC curve, specificity and sensitivity. Finally it is shown that the one layer neural network with 6 neurons and the parameters momentum and learning rate in 0.6 and 0.3 respectively, is best suited to the problem of pattern recognition, achieving correctly classify 89.89% of the cases

Perfil sorológico do vírus John Cunningham (JCV) em pacientes com esclerose múltipla

Treatment options for multiple sclerosis (MS) have changed over the last few years, bringing about a new category of drugs with more efficient profiles. However, these drugs have come with a whole new profile of potential adverse events that neurologists have to learn well and quickly. One of the most feared complications of these MS treatments is progressive multifocal leukoencephalopathy caused by the reactivation of the John Cunningham virus (JCV). Objective: To identify the serologic profile of JCV in patients with MS. Methods: Data on serum antibodies for JCV were obtained using the enzyme-linked immunosorbent assay provided by the STRATIFY-JCV program. Results: A total of 1,501 blood tests were obtained from 1,102 patients with MS. There were 633 patients (57.1%) who were positive for antibodies for JCV and 469 patients who were negative (42.9%). Twenty-three patients became positive after initially having negative JCV antibody status. The rate of seroconversion was 18.5% over 22 months. Conclusion: The JCV serologic profile and seroconversion in Brazilian patients were similar to those described in other countries.As opções terapêuticas para esclerose múltipla (EM) modificaram-se ao longo dos últimos anos, trazendo uma nova categoria de drogas com melhor perfil de eficácia. No entanto, estas drogas vieram com um novo perfil de potenciais eventos adversos que exigem que o neurologista os reconheça bem e rapidamente. Uma das complicações mais temidas destes tratamentos para a EM é a leucoencefalopatia multifocal progressiva (LEMP), causada pela reativação do vírus John Cunningham (JCV). Objetivo: Identificar o perfil sorológico de JCV em pacientes com EM. Métodos: Dados sorológicos de JCV foram obtidos através do ensaio por enzimas imuno-adsorvidas (ELISA) fornecido pelo programa STRATIFY-JCV. Resultados: Um total de 1.501 testes sanguíneos foram obtidos de 1.102 pacientes com EM. O grupo teve 633 pacientes (57,1%) soropositivos para anticorpos anti-JCV e 469 pacientes negativos (42,9%). Vinte e três pacientes se tornaram posivitos após resultados iniciais negativos para anticorpos anti-JCV. A taxa de soroconversão foi 18,5% em 22 meses. Conclusão: O perfil sorológico do JCV e a soroconversão nos pacientes brasileiros foi semelhante àquela descrita em outros países