6 research outputs found
Antimicrobial Activity, Acute Toxicity and Cytoprotective Effect of Crassocephalum Vitellinum (Benth.) S. Moore Extract in a Rat Ethanol-HCl Gastric Ulcer Model.
- Author
- A Ramesh
- Abdul W Kidukuli
- AHF Kayonga
- BN Meyer
- C Nasuti
- DCNO Ramathal
- Emmanuel E Haule
- EW Ngari
- H Shay
- J Ellof
- J Nsanzimana
- JB Harbone
- JT Litchfield
- LC Klein-Júnior
- M-J Mukazayire
- M-J Mukazayire
- M-J Mukazayire
- Mainen J Moshi
- MJ Moshi
- MJ Mukazayire
- O Polterait
- OO Owonubi
- Ramadhani SO Nondo
- Rogasian LA Mahunnah
- S Dasetour
- T Mizui
- T Yamada
- X Jian-Hui
- Publication venue
- Biomed Central
- Publication date
- 01/01/2014
- Field of study
A decoction of Crassocephallum vitellinum (Benth.) S. Moore (Asteraceae) is used in Kagera Region to treat peptic ulcers. This study seeks to evaluate an aqueous ethanol extract of aerial parts of the plant for safety and efficacy. An 80% ethanolic extract of C. vitellinum at doses of 100, 200, 400 and 800 mg/kg body wt was evaluated for ability to protect Sprague Dawley rats from acidified ethanol gastric ulceration in comparison with 40 mg/kg body wt pantoprazole. The extract and its dichloromethane, ethyl acetate, and aqueous fractions were also evaluated for acute toxicity in mice, brine shrimp toxicity, and antibacterial activity against four Gram negative bacteria; Escherichia coli (ATCC 25922), Salmonella typhi (NCTC 8385), Vibrio cholera (clinical isolate), and Streptococcus faecalis (clinical isolate). The groups of phytochemicals present in the extract were also determined. The ethanolic extract of C. vitellinum dose-dependently protected rat gastric mucosa against ethanol/HCl insult to a maximum of 88.3% at 800 mg/kg body wt, affording the same level of protection as by 40 mg/kg body wt pantoprazole. The extract also exhibited weak antibacterial activity against S. typhi and E. coli, while its ethyl acetate, dichloromethane and aqueous fractions showed weak activity against K. pneumonia, S.typhi, E. coli and V. cholera. The extract was non-toxic to mice up to 5000 mg/kg body wt, and the total extract (LC50 = 37.49 μg/ml) and the aqueous (LC50 = 87.92 μg/ml), ethyl acetate (LC50 = 119.45 μg/ml) and dichloromethane fractions (88.79 μg/ml) showed low toxicity against brine shrimps. Phytochemical screening showed that the extract contains tannins, saponins, flavonoids, and terpenoids. The results support the claims by traditional healers that a decoction of C.vitellinum has antiulcer activity. The mechanism of cytoprotection is yet to be determined but the phenolic compounds present in the extract may contribute to its protective actions. However, the dose conferring gastro-protection in the rat is too big to be translated to clinical application; thus bioassay guided fractionation to identify active compound/s or fractions is needed, and use of more peptic ulcer models to determine the mechanism for the protective action
Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019
- Author
- Abbafati C
- Abbas KM
- Abbasi M
- Abbasi-Kangevari M
- Abbasifard M
- Abbastabar H
- Abd El Razek HM
- Abd El Razek MM
- Abd-Allah F
- Abdelalim A
- Abdollahi M
- Abdollahpour I
- Abdulkader RS
- Abdullah KH
- Abedi A
- Abedi P
- Abegaz KH
- Abolhassani H
- Abosetugn AE
- Aboyans V
- Abrams EM
- Abreu LG
- Abrigo MRM
- Abu Haimed AK
- Abu-Gharbieh E
- Abu-Raddad LJ
- Abualhasan A
- Abushouk AI
- Acebedo A
- Ackerman IN
- Adabi M
- Adair T
- Adamu AA
- Adebayo OM
- Adedeji IA
- Adekanmbi V
- Adelson JD
- Adeoye AM
- Adetokunboh OO
- Adham D
- Advani SM
- Afarideh M
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- Agesa KM
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- Nguyen CT
- Nguyen DN
- Nguyen HLT
- Nguyen J
- Nguyen M
- Nguyen M
- Nguyen TH
- Nichols E
- Nigatu D
- Nigatu YT
- Nikbakhsh R
- Nikpoor AR
- Nixon MR
- Nnaji CA
- Nomura S
- Norheim OF
- Norrving B
- Noubiap JJ
- Nowak C
- Nsoesie EO
- Nunez-Samudio V
- Oancea B
- Odell CM
- Ogbo FA
- Oghenetega OB
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- Okunga EW
- Oladnabi M
- Olagunju AT
- Olusanya BO
- Olusanya JO
- Oluwasanu MM
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- Ortiz A
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- Skou ST
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- Troeger CE
- Truelsen TC
- Tsai AC
- Tsatsakis A
- Tyrovolas S
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- Ullah I
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- Umeokonkwo CD
- Undurraga EA
- Unnikrishnan B
- Upadhyay E
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- Valdez PR
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- Wunrow HY
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- Yaminfirooz M
- Yano Y
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- Yeheyis TY
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- Yilgwan CS
- Yilma MT
- Yip P
- Yonemoto N
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- Younis MZ
- Younker TP
- Yousefi B
- Yousefi Z
- Yousefifard M
- Yousefinezhadi T
- Yousuf AY
- Yu C
- Yu Y
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- Yuce D
- Yusefzadeh H
- Zadey S
- Zahabi SS
- Zaidi SS
- Zaki L
- Zaki MES
- Zakzuk J
- Zamani M
- Zamanian M
- Zandian H
- Zangeneh A
- Zarafshan H
- Zastrozhin MS
- Zewdie KA
- Zhang J
- Zhang Y
- Zhang Z-J
- Zhao JT
- Zhao X-JG
- Zhao Y
- Zheleva B
- Zheng P
- Zhou M
- Zhu C
- Ziapour A
- Zimsen SRM
- Zlavog BS
- Zodpey S
- Publication venue
- 'Elsevier BV'
- Publication date
- 17/10/2020
- Field of study
Five insights from the Global Burden of Disease Study 2019
- Author
- Abbafati C
- Abbas KM
- Abbasi M
- Abbasi-Kangevari M
- Abbasifard M
- Abbastabar H
- Abd El Razek HM
- Abd El Razek MM
- Abd-Allah F
- Abdelalim A
- Abdollahi M
- Abdollahpour I
- Abdulkader RS
- Abdullah KH
- Abedi A
- Abedi P
- Abegaz KH
- Abolhassani H
- Abosetugn AE
- Aboyans V
- Abrams EM
- Abreu LG
- Abrigo MRM
- Abu Haimed AK
- Abu-Gharbieh E
- Abu-Raddad LJ
- Abualhasan A
- Abushouk AI
- Acebedo A
- Ackerman IN
- Adabi M
- Adair T
- Adamu AA
- Adebayo OM
- Adedeji IA
- Adekanmbi V
- Adelson JD
- Adeoye AM
- Adetokunboh OO
- Adham D
- Advani SM
- Afarideh M
- Afshari M
- Afshin A
- Agardh EE
- Agarwal G
- Agasthi P
- Agesa KM
- Aghaali M
- Aghamir SMK
- Agrawal A
- Ahmad T
- Ahmadi A
- Ahmadi K
- Ahmadi M
- Ahmadieh H
- Ahmadpour E
- Ahmed MB
- Aji B
- Akalu TY
- Akinyemi RO
- Akinyemiju T
- Akombi B
- Akunna CJ
- Al-Aly Z
- Al-Mekhlafi HM
- Al-Raddadi RM
- Alahdab F
- Alam K
- Alam N
- Alam S
- Alam T
- Alanezi FM
- Alanzi TM
- Albertson SB
- Alcalde-Rabanal JE
- Alema NM
- Alemu BW
- Alemu YM
- Alhabib KF
- Alhassan RK
- Ali M
- Ali S
- Alicandro G
- Alijanzadeh M
- Alinia C
- Alipour V
- Alizade H
- Aljunid SM
- Alla F
- Allebeck P
- Almadi MAH
- Almasi A
- Almasi-Hashiani A
- Almasri NA
- Almulhim AM
- Alonso J
- Altirkawi KA
- Alumran AK
- Alvis-Guzman N
- Alvis-Zakzuk NJ
- Amare AT
- Amare B
- Amini S
- Amini-Rarani M
- Aminorroaya A
- Amiri F
- Amit AML
- Amugsi DA
- Amul GGH
- Anbesu EW
- Ancuceanu R
- Anderlini D
- Anderson JA
- Andrei CL
- Andrei T
- Androudi S
- Angus C
- Anjomshoa M
- Ansari F
- Ansari I
- Ansari-Moghaddam A
- Antonazzo IC
- Antonio CAT
- Antony CM
- Antriyandarti E
- Anvari D
- Anwer R
- Appiah SCY
- Arab-Zozani M
- Arabloo J
- Aravkin AY
- Arba AAK
- Aremu O
- Ariani F
- Aripov T
- Armoon B
- Arnlov J
- Arowosegbe OO
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- Arzani A
- Asaad M
- Asadi-Aliabadi M
- Asadi-Pooya AA
- Asgari S
- Asghari B
- Ashbaugh C
- Assmus M
- Atafar Z
- Athari SS
- Atnafu DD
- Atout MMW
- Atre SR
- Atteraya MS
- Ausloos F
- Ausloos M
- Avila-Burgos L
- Avokpaho EFGA
- Ayano G
- Ayanore MA
- Aynalem GL
- Aynalem YA
- Ayza MA
- Azari S
- Azarian G
- Azene ZN
- Azhar G
- Azzopardi PS
- Babaee E
- Badawi A
- Badiye AD
- Bagherzadeh M
- Bagli E
- Bahrami MA
- Baig AA
- Bairwa M
- Bakhshaei MH
- Bakhtiari A
- Bakkannavar SM
- Balachandran A
- Balakrishnan S
- Balalla S
- Balassyano S
- Baldasseroni A
- Bali AO
- Ball K
- Ballew SH
- Balzi D
- Banach M
- Bandpei MAM
- Banerjee SK
- Banik PC
- Bannick MS
- Bante AB
- Bante SA
- Baraki AG
- Barboza MA
- Barker-Collo SL
- Barnighausen TW
- Barrero LH
- Barthelemy CM
- Barua L
- Barzegar A
- Basaleem H
- Bassat Q
- Basu S
- Baune BT
- Bayati M
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- Becker JS
- Bedi N
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- Benziger CP
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- Bhutta ZA
- Bibi S
- Bicer BK
- Biehl MH
- Bijani A
- Bikbov B
- Bilano V
- Bin Sayeed MS
- Bin Zaman S
- Biondi A
- Birihane BM
- Bisanzio D
- Bisignano C
- Biswas RK
- Bitew H
- Bjorge T
- Bockarie MJ
- Bohlouli S
- Bohluli M
- Bojia HA
- Bolla SR
- Boloor A
- Boon-Dooley AS
- Borges G
- Borzi AM
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- Bose D
- Bosetti C
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- Boufous S
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- Brady OJ
- Braithwaite D
- Brauer M
- Brayne C
- Breitborde NJK
- Breitner S
- Brenner H
- Breusov AV
- Briant PS
- Briggs AM
- Briko AN
- Briko NI
- Britton GB
- Brugha T
- Bryazka D
- Buchbinder R
- Bumgarner BR
- Burkart K
- Burnett RT
- Busse R
- Butt ZA
- Caetano dos Santos FL
- Cahill LE
- Cahuana-Hurtado L
- Cai T
- Callender CSKH
- Camera LA
- Campos-Nonato IR
- Cao J
- Car J
- Car LT
- Cardenas R
- Carreras G
- Carrero JJ
- Carvalho F
- Castaldelli-Maia JM
- Castaneda-Orjuela CA
- Castelpietra G
- Castle CD
- Castro E
- Castro F
- Catala-Lopez F
- Causey K
- Cederroth CR
- Cercy KM
- Cerin E
- Chalek J
- Chandan JS
- Chang AR
- Chang AY
- Chang J-C
- Chang K-L
- Charan J
- Charlson FJ
- Chattu VK
- Chaturvedi S
- Cherbuin N
- Chimed-Ochir O
- Chin KL
- Chirinos-Caceres JL
- Cho DY
- Choi J-YJ
- Christensen H
- Chu D-T
- Chung MT
- Chung S-C
- Cicuttini FM
- Ciobanu LG
- Cirillo M
- Cislaghi B
- Classen TKD
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- Collins EL
- Comfort H
- Compton K
- Conti S
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- Cortesi PA
- Costa VM
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- Cowie BC
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- Cunningham M
- D'Amico E
- da Silva DD
- Dahlawi SMA
- Dai H
- Dai H
- Damasceno AAM
- Damiani G
- Dandona L
- Dandona R
- Daneshpajouhnejad P
- Dangel WJ
- Danielsson A-K
- Dargan PI
- Darshan BB
- Darwesh AM
- Daryani A
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- Das Neves J
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- Dash AP
- Davey G
- Davila-Cervantes CA
- Davis AC
- Davitoiu DV
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- De Leo D
- De Neve J-W
- Dean FE
- DeCleene NK
- Deen A
- Defo BK
- Degenhardt L
- DeLang M
- Dellavalle RP
- Demeke FM
- Demoz GT
- Demsie DG
- Denova-Gutierrez E
- Dereje ND
- Deribe K
- Dervenis N
- Desai R
- Desalew A
- Dessie GA
- Deuba K
- Dharmaratne SD
- Dhungana GP
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- Diaz D
- Dichgans M
- Didarloo A
- Dingels ZV
- Dippenaar IN
- Dirac MA
- Djalalinia S
- Do HT
- Dokova K
- Doku DT
- Dolecek C
- Dolgert AJ
- Dorostkar F
- Doshi CP
- Doshi PP
- Doshmangir L
- Douiri A
- Doxey MC
- Doyle KE
- Driscoll TR
- Dubljanin E
- Dunachie SJ
- Duncan BB
- Duraes AR
- Eagan AW
- Ebrahimi H
- Edvardsson D
- Effiong A
- Ehrlich JR
- El Nahas N
- El Sayed I
- El Tantawi M
- El-Jaafary SI
- Elbarazi I
- Elgendy IY
- Elhabashy HR
- Elsharkawy A
- Elyazar IRF
- Emamian MH
- Emmons-Bell S
- Erskine HE
- Eshrati B
- Eskandari K
- Eskandarieh S
- Esmaeilnejad S
- Esmaeilzadeh F
- Esteghamati A
- Esteghamati S
- Estep K
- Etemadi A
- Etisso AE
- Ezekannagha O
- Fanzo J
- Farag T
- Farahmand M
- Faraj A
- Faraon EJA
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- Faridnia R
- Farinha CSES
- Farioli A
- Faris PS
- Faro A
- Faruque M
- Farzadfar F
- Fattahi N
- Fazaeli AA
- Fazlzadeh M
- Feigin VL
- Feldman R
- Fereshtehnejad S-M
- Fernandes E
- Ferrara G
- Ferrara P
- Ferrari AJ
- Ferreira ML
- Feyissa GT
- Filip I
- Fischer F
- Fisher JL
- Fitzgerald R
- Flohr C
- Flor LS
- Foigt NA
- Folayan MO
- Fomenkov AA
- Force LM
- Fornari C
- Forooshani ZSD
- Foroutan M
- Fox JT
- Francis JM
- Frank TD
- Franklin RC
- Freitas M
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- Fukumoto T
- Fukutaki K
- Fuller JE
- Fullman N
- Furtado JM
- Gad MM
- Gaidhane AM
- Gakidou E
- Galles NC
- Gallus S
- Gamkrelidze A
- Garcia-Basteiro AL
- Gardner WM
- Geberemariyam BS
- Gebrehiwot AM
- Gebremedhin KB
- Gebremeskel GG
- Gebremeskel LG
- Gebresillassie BM
- Gebreslassie AAAA
- Gela JD
- Geramo YCD
- Geremew A
- Gesesew HA
- Gething PW
- Gezae KE
- Ghadimi M
- Ghadiri K
- Ghaffarifar F
- Ghafourifard M
- Ghajar A
- Ghamari F
- Ghashghaee A
- Ghiasvand H
- Ghith N
- Gholamian A
- Ghosh R
- Giampaoli S
- Gilani SA
- Gill PS
- Gill TK
- Gillum RF
- Ginawi IA
- Ginindza TG
- Gitimoghaddam M
- Giussani G
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- Glushkova EV
- Gnedovskaya EV
- Godinho MA
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- Golechha M
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- Gopalani SV
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- Gorini G
- Gorman TM
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- Goudarzi H
- Goudarzian AH
- Goulart AC
- Goulart BNG
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- Grosso G
- Gubari MIM
- Gudi N
- Gugnani HC
- Guimaraes ALS
- Guimaraes RA
- Guled RA
- Gultie T
- Guo G
- Guo Y
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- Hachinski V
- Haddock B
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- Hafiz A
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- Haile LM
- Haile TG
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- Haj-Mirzaian A
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- Halvaei I
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- Hameed S
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- Hamilton EB
- Hammer MS
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- Han H
- Handiso DW
- Hanif A
- Hankey GJ
- Hanson SW
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- Harvey JD
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- Hassanipour S
- Hassankhani H
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- Publication venue
- Publication date
- 01/01/2020
- Field of study
The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a rules-based synthesis of the available evidence on levels and trends in health outcomes, a diverse set of risk factors, and health system responses. GBD 2019 covered 204 countries and territories, as well as first administrative level disaggregations for 22 countries, from 1990 to 2019. Because GBD is highly standardised and comprehensive, spanning both fatal and non-fatal outcomes, and uses a mutually exclusive and collectively exhaustive list of hierarchical disease and injury causes, the study provides a powerful basis for detailed and broad insights on global health trends and emerging challenges. GBD 2019 incorporates data from 281 586 sources and provides more than 3.5 billion estimates of health outcome and health system measures of interest for global, national, and subnational policy dialogue. All GBD estimates are publicly available and adhere to the Guidelines on Accurate and Transparent Health Estimate Reporting. From this vast amount of information, five key insights that are important for health, social, and economic development strategies have been distilled. These insights are subject to the many limitations outlined in each of the component GBD capstone papers.Peer reviewe
Measuring universal health coverage based on an index of effective coverage of health services in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019
- Author
- Abbafati C
- Abbastabar H
- Abd-Allah F
- Abdollahi M
- Abedi A
- Abolhassani H
- Abosetugn AE
- Abreu LG
- Abrigo MRM
- Abu Haimed AK
- Abushouk AI
- Adabi M
- Adebayo OM
- Adekanmbi V
- Adelson JD
- Adetokunboh OO
- Adham D
- Advani SM
- Afshin A
- Agarwal G
- Agasthi P
- Aghamir SMK
- Agrawal A
- Ahmad T
- Akinyemi RO
- Al-Aly Z
- Al-Mekhlafi HM
- Al-Raddadi RM
- Alahdab F
- Alam K
- Albertson SB
- Alemu YM
- Alhassan RK
- Ali M
- Ali S
- Alipour V
- Aljunid SM
- Alla F
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- Alonso J
- Altirkawi KA
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- Alvis-Zakzuk NJ
- Amini S
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2020
- Field of study
Background Achieving universal health coverage (UHC) involves all people receiving the health services they need, of high quality, without experiencing financial hardship. Making progress towards UHC is a policy priority for both countries and global institutions, as highlighted by the agenda of the UN Sustainable Development Goals (SDGs) and WHO's Thirteenth General Programme of Work (GPW13). Measuring effective coverage at the health-system level is important for understanding whether health services are aligned with countries' health profiles and are of sufficient quality to produce health gains for populations of all ages. Methods Based on the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, we assessed UHC effective coverage for 204 countries and territories from 1990 to 2019. Drawing from a measurement framework developed through WHO's GPW13 consultation, we mapped 23 effective coverage indicators to a matrix representing health service types (eg, promotion, prevention, and treatment) and five population-age groups spanning from reproductive and newborn to older adults (≥65 years). Effective coverage indicators were based on intervention coverage or outcome-based measures such as mortality-to-incidence ratios to approximate access to quality care; outcome-based measures were transformed to values on a scale of 0–100 based on the 2·5th and 97·5th percentile of location-year values. We constructed the UHC effective coverage index by weighting each effective coverage indicator relative to its associated potential health gains, as measured by disability-adjusted life-years for each location-year and population-age group. For three tests of validity (content, known-groups, and convergent), UHC effective coverage index performance was generally better than that of other UHC service coverage indices from WHO (ie, the current metric for SDG indicator 3.8.1 on UHC service coverage), the World Bank, and GBD 2017. We quantified frontiers of UHC effective coverage performance on the basis of pooled health spending per capita, representing UHC effective coverage index levels achieved in 2019 relative to country-level government health spending, prepaid private expenditures, and development assistance for health. To assess current trajectories towards the GPW13 UHC billion target—1 billion more people benefiting from UHC by 2023—we estimated additional population equivalents with UHC effective coverage from 2018 to 2023. Findings Globally, performance on the UHC effective coverage index improved from 45·8 (95% uncertainty interval 44·2–47·5) in 1990 to 60·3 (58·7–61·9) in 2019, yet country-level UHC effective coverage in 2019 still spanned from 95 or higher in Japan and Iceland to lower than 25 in Somalia and the Central African Republic. Since 2010, sub-Saharan Africa showed accelerated gains on the UHC effective coverage index (at an average increase of 2·6% [1·9–3·3] per year up to 2019); by contrast, most other GBD super-regions had slowed rates of progress in 2010–2019 relative to 1990–2010. Many countries showed lagging performance on effective coverage indicators for non-communicable diseases relative to those for communicable diseases and maternal and child health, despite non-communicable diseases accounting for a greater proportion of potential health gains in 2019, suggesting that many health systems are not keeping pace with the rising non-communicable disease burden and associated population health needs. In 2019, the UHC effective coverage index was associated with pooled health spending per capita (r=0·79), although countries across the development spectrum had much lower UHC effective coverage than is potentially achievable relative to their health spending. Under maximum efficiency of translating health spending into UHC effective coverage performance, countries would need to reach 1398pooledhealthspendingpercapita(US adjusted for purchasing power parity) in order to achieve 80 on the UHC effective coverage index. From 2018 to 2023, an estimated 388·9 million (358·6–421·3) more population equivalents would have UHC effective coverage, falling well short of the GPW13 target of 1 billion more people benefiting from UHC during this time. Current projections point to an estimated 3·1 billion (3·0–3·2) population equivalents still lacking UHC effective coverage in 2023, with nearly a third (968·1 million [903·5–1040·3]) residing in south Asia. Interpretation The present study demonstrates the utility of measuring effective coverage and its role in supporting improved health outcomes for all people—the ultimate goal of UHC and its achievement. Global ambitions to accelerate progress on UHC service coverage are increasingly unlikely unless concerted action on non-communicable diseases occurs and countries can better translate health spending into improved performance. Focusing on effective coverage and accounting for the world's evolving health needs lays the groundwork for better understanding how close—or how far—all populations are in benefiting from UHC. Funding Bill & Melinda Gates Foundation
Five insights from the Global Burden of Disease Study 2019
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- Zangeneh A
- Zarafshan H
- Zastrozhin MS
- Zewdie KA
- Zhang J
- Zhang Y
- Zhang Z-J
- Zhao JT
- Zhao X-JG
- Zhao Y
- Zheleva B
- Zheng P
- Zhou M
- Zhu C
- Ziapour A
- Zimsen SRM
- Zlavog BS
- Zodpey S
- Publication venue
- ELSEVIER SCIENCE INC
- Publication date
- 17/10/2020
- Field of study
The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a rules-based synthesis of the available evidence on levels and trends in health outcomes, a diverse set of risk factors, and health system responses. GBD 2019 covered 204 countries and territories, as well as first administrative level disaggregations for 22 countries, from 1990 to 2019. Because GBD is highly standardised and comprehensive, spanning both fatal and non-fatal outcomes, and uses a mutually exclusive and collectively exhaustive list of hierarchical disease and injury causes, the study provides a powerful basis for detailed and broad insights on global health trends and emerging challenges. GBD 2019 incorporates data from 281 586 sources and provides more than 3·5 billion estimates of health outcome and health system measures of interest for global, national, and subnational policy dialogue. All GBD estimates are publicly available and adhere to the Guidelines on Accurate and Transparent Health Estimate Reporting. From this vast amount of information, five key insights that are important for health, social, and economic development strategies have been distilled. These insights are subject to the many limitations outlined in each of the component GBD capstone papers
Five insights from the Global Burden of Disease Study 2019
- Author
- Abbafati C
- Abbas KM
- Abbasi M
- Abbasi-Kangevari M
- Abbasifard M
- Abbastabar H
- Abd El Razek HM
- Abd El Razek MM
- Abd-Allah F
- Abdelalim A
- Abdollahi M
- Abdollahpour I
- Abdulkader RS
- Abdullah KH
- Abedi A
- Abedi P
- Abegaz KH
- Abolhassani H
- Abosetugn AE
- Aboyans V
- Abrams EM
- Abreu LG
- Abrigo MRM
- Abu Haimed AK
- Abu-Gharbieh E
- Abu-Raddad LJ
- Abualhasan A
- Abushouk AI
- Acebedo A
- Ackerman IN
- Adabi M
- Adair T
- Adamu AA
- Adebayo OM
- Adedeji IA
- Adekanmbi V
- Adelson JD
- Adeoye AM
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- Adham D
- Advani SM
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- Afshari M
- Afshin A
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- Agesa KM
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- Ahmad T
- Ahmadi A
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- Akalu TY
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- Paternina-Caicedo AJ
- Pathak A
- Pathak M
- Patten SB
- Patton GC
- Paudel D
- Paudel S
- Paulson KR
- Pease SA
- Peden AE
- Pennini A
- Pepito VCF
- Peprah EK
- Pereira A
- Pereira DM
- Pereira J
- Perico N
- Pescarini JM
- Pesudovs K
- Pham HQ
- Phillips MR
- Piccinelli C
- Pierce M
- Pigott DM
- Pilgrim T
- Pilz TM
- Pinheiro M
- Piradov MA
- Pirsaheb M
- Pishgar F
- Plana-Ripoll O
- Plass D
- Pletcher M
- Pokhrel KN
- Polibin RV
- Polinder S
- Polkinghorne KR
- Pond CD
- Postma MJ
- Pottoo FH
- Pourjafar H
- Pourmalek F
- Pourshams A
- Poznanska A
- Prada SI
- Prakash S
- Prakash V
- Prasad N
- Preotescu L
- Pribadi DRA
- Pupillo E
- Quazi Syed Z
- Quintanilla BPA
- Rabiee M
- Rabiee N
- Radfar A
- Rafiee A
- Rafiei A
- Raggi A
- Rahim F
- Rahimi-Movaghar A
- Rahman MA
- Rahman MHU
- Rajabpour-Sanati A
- Rajati F
- Rakovac I
- Ram P
- Ramezanzadeh K
- Rana SM
- Ranabhat CL
- Ranta A
- Rao PC
- Rao SJ
- Rasella D
- Rashedi V
- Rastogi P
- Rath GK
- Rathi P
- Rawaf DL
- Rawaf S
- Rawal L
- Rawassizadeh R
- Rawat R
- Razo C
- Regassa LD
- Reiner RCJ
- Reinig N
- Reitsma MB
- Remuzzi G
- Renjith V
- Renzaho AMN
- Resnikoff S
- Rezaei N
- Rezaei N
- Rezai MS
- Rezapour A
- Rhinehart P-A
- Riahi SM
- Ribeiro ALP
- Ribeiro D
- Ribeiro DC
- Rickard J
- Rincon JCC
- Rivera JA
- Robalik T
- Roberts NLS
- Roberts S
- Robinson SR
- Rodriguez-Ramirez S
- Roever L
- Rolfe S
- Romoli M
- Ronfani L
- Room R
- Roshandel G
- Rostamian M
- Roth GA
- Rothenbacher D
- Rubagotti E
- Rumisha SF
- Rwegerera GM
- Saadatagah S
- Sabour S
- Sachdev PS
- Saddik B
- Sadeghi E
- Sadeghi M
- Saeedi R
- Saeidi S
- Safari Y
- Safi S
- Safiri S
- Sagar R
- Sahebkar A
- Sahraian MA
- Sajadi SM
- Salahshoor MR
- Salam N
- Salama JS
- Salamati P
- Salem H
- Salem MR
- Salimi Y
- Salimzadeh H
- Salman OM
- Salomon JA
- Salz I
- Samad Z
- Sambala EZ
- Samy AM
- Sanabria J
- Sanchez-Pimienta TG
- Santomauro DF
- Santos IS
- Santos JV
- Santric-Milicevic MM
- Saraswathy SYI
- Sarmiento-Suarez R
- Sarrafzadegan N
- Sartorius B
- Sarveazad A
- Sathian B
- Sathish T
- Sattin D
- Savic M
- Sawyer SM
- Saxena D
- Saxena S
- Saylan M
- Sbarra AN
- Schaeffer LE
- Schiavolin S
- Schlaich MP
- Schmidt MI
- Schutte AE
- Schwebel DC
- Schwendicke F
- Section MPA
- Seedat S
- Sekerija M
- Senbeta AM
- Senthilkumaran S
- Sepanlou SG
- Serdar B
- Serre ML
- Servan-Mori E
- Sha F
- Shabani M
- Shackelford KA
- Shadid J
- Shafaat O
- Shahabi S
- Shahbaz M
- Shaheen AA
- Shaikh MA
- Shaji KS
- Shalash AS
- Shams-Beyranvand M
- Shamsi M
- Shamsizadeh M
- Shannawaz M
- Sharafi K
- Sharafi Z
- Sharan S
- Sharara F
- Sharifi H
- Sharma R
- Shaw DH
- Sheena BS
- Sheikh A
- Sheikhtaheri A
- Shetty BSK
- Shetty RS
- Shibuya K
- Shield KD
- Shiferaw WS
- Shigematsu M
- Shin JI
- Shin M-J
- Shiri R
- Shirkoohi R
- Shivakumar KM
- Shrime MG
- Shuval K
- Siabani S
- Sierpinski R
- Sigfusdottir ID
- Sigurvinsdottir R
- Silva DAS
- Silva JP
- Simonetti B
- Simpson KE
- Singh A
- Singh JA
- Singh P
- Sinha DN
- Skiadaresi E
- Skou ST
- Skryabin VY
- Sliwa K
- Smith A
- Smith EUR
- Sobngwi E
- Soheili A
- Sokhan A
- Soltani S
- Somefun OD
- Soofi M
- Sorensen RJD
- Soriano JB
- Sorrie MB
- Soshnikov S
- Soyiri IN
- Spencer CN
- Spotin A
- Spurlock EE
- Sreeramareddy CT
- Srinivasan V
- Sripada K
- Stanaway JD
- Stark BA
- Steel N
- Stefan SC
- Stein C
- Stein DJ
- Steiner C
- Steiner TJ
- Steuben KM
- Stockfelt L
- Stokes MA
- Stovner LJ
- Straif K
- Stranges S
- Stubbs JL
- Suchdev PS
- Sudaryanto A
- Sufiyan MB
- Suleria HAR
- Sulo G
- Sultan I
- Swope CB
- Sykes BL
- Sylte DO
- Szocska M
- Szumowski L
- Tabares-Seisdedos R
- Tabb KM
- Tabuchi T
- Tadakamadla SK
- Taddele BW
- Tadesse DB
- Taherkhani A
- Tahir Z
- Tajdini M
- Takahashi K
- Takala JS
- Tamiru AT
- Tang M
- Tanser FC
- Tareque MI
- Tarigan IU
- Taveira N
- Taylor HJ
- Teagle WL
- Teame H
- Tediosi F
- Tefera YG
- Tehrani-Banihashemi A
- Teklehaimanot BF
- Tela FG
- Temsah M-H
- Terrason S
- Tesema GA
- Tessema ZT
- Thakur B
- Thankappan KR
- Thapar R
- Thomas N
- Thomson AM
- Thrift AG
- Thurston GD
- Titova MV
- Tlou B
- Tohidinik HR
- Tonelli M
- Topor-Madry R
- Topouzis F
- Toroudi HP
- Torre AE
- Touvier M
- Tovani-Palone MR
- Traini E
- Tran BX
- Travillian R
- Trias-Llimos S
- Troeger CE
- Truelsen TC
- Tsai AC
- Tsatsakis A
- Tyrovolas S
- Uddin R
- Ullah I
- Ullah S
- Umeokonkwo CD
- Undurraga EA
- Unnikrishnan B
- Upadhyay E
- Uthman OA
- Vacante M
- Vaicekonyte R
- Vakilian A
- Valdez PR
- Valli A
- Van Donkelaar A
- Vardavas C
- Varughese S
- Vasankari TJ
- Vasconcelos AMN
- Vasseghian Y
- Veisani Y
- Velasquez IM
- Venketasubramanian N
- Vidale S
- Violante FS
- Vlassov V
- Vollset SE
- Vongpradith A
- Vos T
- Vu GT
- Vujcic IS
- Vukovic A
- Vukovic R
- Waheed Y
- Wallin MT
- Walters MK
- Wamai RG
- Wang F
- Wang H
- Wang H
- Wang J
- Wang Y
- Wang Y
- Wang Y-P
- Ward JL
- Watson A
- Watson S
- Wei J
- Wei MYW
- Weintraub RG
- Weiss DJ
- Weiss J
- Welay FT
- Weldesamuel GT
- Werdecker A
- West JJ
- Westerman R
- Whisnant JL
- Whiteford HA
- Wiangkham T
- Wickramasinghe ND
- Wiens KE
- Wijeratne T
- Wilner LB
- Wilson S
- Wiysonge CS
- Wojtyniak B
- Woldu G
- Wolfe CDA
- Wondmeneh TG
- Wondmieneh AB
- Wool EE
- Wozniak SS
- Wu A-M
- Wu C
- Wu J
- Wunrow HY
- Xie Y
- Xu G
- Xu R
- Yadgir S
- Yamada T
- Yamagishi K
- Yaminfirooz M
- Yano Y
- Yaya S
- Yazdi-Feyzabadi V
- Yearwood JA
- Yeheyis TY
- Yeshitila YG
- Yilgwan CS
- Yilma MT
- Yip P
- Yonemoto N
- Yoon S-J
- York HW
- Younis MZ
- Younker TP
- Yousefi B
- Yousefi Z
- Yousefifard M
- Yousefinezhadi T
- Yousuf AY
- Yu C
- Yu Y
- Yuan C-W
- Yuce D
- Yusefzadeh H
- Zadey S
- Zahabi SS
- Zaidi SS
- Zaki L
- Zaki MES
- Zakzuk J
- Zamani M
- Zamanian M
- Zandian H
- Zangeneh A
- Zarafshan H
- Zastrozhin MS
- Zewdie KA
- Zhang J
- Zhang Y
- Zhang Z-J
- Zhao JT
- Zhao X-JG
- Zhao Y
- Zheleva B
- Zheng P
- Zhou M
- Zhu C
- Ziapour A
- Zimsen SRM
- Zlavog BS
- Zodpey S
- Publication venue
- Publication date
- 01/01/2020
- Field of study