7 research outputs found
Free practising medicine society
- Publication venue
- Endoscopica, Nancy, France
- Publication date
- 01/01/2001
- Field of study
COVID-19 outcomes in patients with inflammatory rheumatic and musculoskeletal diseases treated with rituximab: a cohort study
- Author
- Aeschlimann Florence
- Agard Christian
- Ait-Abdallah Nassim
- Albert Jean-David
- Alcais Didier
- Allain Jean-SĂ©bastien
- Allanore Yannick
- Amador-Borreiro Blanca
- Amoura Zahir
- Andre Emma
- Arbault AnaĂŻs
- Arlet Jean-BenoĂźt
- Arnaud Laurent
- Arniaud Denis
- Arty-Hue Herliette
- Atlan Lucie
- Audemard-Verger Alexandra
- Audoin-Pajot Christine
- Audren Victor
- Avouac JĂ©rĂŽme
- Bach-Bunner Maxime
- Bacquet-Deschryver HĂ©lĂšne
- Bader-Meunier Brigitte
- Balandraud Nathalie
- Balblanc Jean-Charles
- Bally Stéphane
- Banal Frédéric
- Banneville BĂ©atrice
- Barbery Pierre
- Barnetche Thomas
- Barrelet Audre
- Barrois-Delattre Emilie
- Basch André
- Baumier Vincent
- Bayer Guillaume
- Bayle Sophie
- Beauvais Catherine
- Beinat Rudie
- Belin VĂ©ronique
- Belkhir Rakiba
- Belot Alexandre
- Benainous Ruben
- Benammar Mohammed
- Benhamou Mathilde
- Benhamou Ygal
- Benmansour Ahmed
- Bennet Pascal
- Bernoux-Manat Brigitte
- Berthet Elise
- Berthoux Emilie
- Bertolini Ewa
- Bigot Adrien
- Bisson-Vaivre Aurélia
- Blaison Gilles
- Bolla Gilles
- Bonidan Olivier
- Bonnet Christine
- Borie Raphaël
- Bossert Marie
- Boudou Laurence
- Bouhour Françoise
- Bouiller KĂ©vin
- Bouldoires Bastien
- Boussoualim Karima
- Bouvard Eric
- Brondino Regine
- Buchlin Pierre
- Cabantous Laurence
- Cacoub Patrice
- Cadiou Simon
- Carbasse Aurélia
- Carteni Maurizio
- Castel Brice
- Cathebras Pascal
- Caumont Hervé
- Celant Annalisa
- Chaigne Benjamin
- Chaillous BenoĂźt
- Champy Romuald
- Charcot AgnĂšs
- Charles Pierre
- Charlot-Lambrecht Isabelle
- Charpin Caroline
- Chatelus Emmanuel
- Chaudier Bernard
- Chazerain Pascal
- Chertok Pascale
- Chevalier Xavier
- Chevreau Maxime
- Chotard Emilie
- Chu Miow Lin Delphine
- Claudepierre Pascal
- Clavel Gaëlle
- Clavel-Osorio Cyril
- Cohen Fleur
- Cohen Gregory
- Colette-Cedoz Marie-Eve
- Collercandy Nived
- Colombey Antoine
- Comarmond Chloé
- Combe Bernard
- Comparon CĂ©line
- Constant Elodie
- Coquerelle Pascal
- Corli Justine
- Corre Clémence
- Costedoat-Chalumeau Nathalie
- Couret Marie
- Courvoisier Natacha
- Coury-Lucas Fabienne
- Coutarel CĂ©cile
- Coutier Fabrice
- Damade Richard
- Daver-Malaterre Laurence
- Dehimat Sarahe
- Delahousse Michel
- Denarie Delphine
- Deprouw Camille
- Dernis Emanuelle
- Deroux Alban
- Desbarbieux Renaud
- Descamps Elise
- Deslandre Chantal
- Desmurs Marie
- Despaux Jacques
- Desplats Marie
- Detree Frédérick
- Devauchelle-Pensec Valérie
- Devaux Mathilde
- Dhote Robin
- Dieude Philippe
- Dieudonne Yannick
- Diot Elisabeth
- Direz Guillaume
- Djeddi Djamal-Dine
- Domont Fanny
- Douvier Sarah
- Drouet BĂ©atrice
- Drumez Elodie
- Duc Catherine
- Ducornet Angélique
- Dufauret-Lombard Carine
- Duhamel Alain
- Dumaine CĂ©cile
- Dumel Anne-Elisabeth
- Dumoulin-Richez Chantal
- Duquesne AgnĂšs
- Durand GĂ©raldine
- Durandin-Truffinet Mariane
- Duret Pierre-Marie
- Duval MaĂŻka
- Ebbo Mikaël
- Ebstein Esther
- Economu-Dubosc Andra
- El Mahou Soumaya
- Emilie Stéphanie
- Euvrard Romain
- Evon Philippe
- Fabre Sylvie
- Fagedet Dorothée
- Farhat Meryem
- Fauconier Marion
- Fautrel Bruno
- Fechtenbaum Jacques
- Felten Renaud
- Fernandes Fanny
- Ferreira-Maldent Nicole
- Feurer Elodie
- Fichet Amandine
- Flaisler Françoise
- Flipo René-Marc
- Florens Nans
- Foltz Violaine
- Fontanges Elisabeth
- Foret Jennifer
- Fougerousse Anne-Claire
- Fouque-Aubert Anne
- Foutrier-Morello Catherine
- Francois-Pradier HĂ©lĂšne
- Frantzen LĂ©a
- Fritz Pierre
- Froissart Antoine
- Fulpin Jean
- Fuzibet Piera
- Gaches Francis
- Gagneux-Lemoussu Laurence
- Galland Joris
- Gandjbakhch Frédérique
- Garnier Nicole
- Garraud Thomas
- Garrot Jean-François
- Gastaldi Romain
- Gaud-Listrat VĂ©ronique
- Gauthier-Prieur Maud
- Georgescu Dana
- Georgin-Lavialle Sophie
- Gerard Nathalie
- Gervais Elisabeth
- Gibert Christelle
- Gibert Eric
- Gill Ghislaine
- Gillard JĂ©rĂŽme
- Gilson MĂ©lanie
- Gimonnet Pauline
- Giraud-Morelet Aude
- Giraudet-Le Quintrec Jeanine-Sophie
- Glace Baptiste
- Glanowski Camille
- Godeau Bertrand
- Gombert Bruno
- Gonnet-Gracia Camille
- Goulenok Tiphaine
- Goupille Philippe
- Gourmelen Olivier
- Govindaraju-Audouard Sophie
- Grados Franck
- Grall-Lerosey Martine
- Grardel Bruno
- Grasland Anne
- Grateau Gilles
- Groza Monica
- Guillaud Constance
- Guillaume SĂ©verine
- Guillibert Caroline
- Guillot Xavier
- Guilpain Philippe
- Gury Aline
- Guyot Marie-HĂ©lĂšne
- Hachulla Eric
- Hacquard-Bouder CĂ©cile
- Havard Marie-Noelle
- Hellier Jean-Pierre
- Hennequin Pascal
- Henriot Basile
- HENRY Julien
- Hentgen VĂ©ronique
- Herasse Muriel
- Hermet Marion
- Hernandez Julie
- Hie Miguel
- Hilliquin Pascal
- Hinschberger Olivier
- Hittinger-Roux Ambre
- Holubar Jan
- Hudry Christophe
- Huguenel Serge
- Jaccard Clara
- Jacquemier Jean-Michel,
- Jamard Bénédicte
- Jan Catherine
- Jean Sylvie
- Jouvray Mathieu
- Juge Pierre-Antoine
- Juillard Laurent
- Jullien Denis
- Kabala Anna
- Kabchou Abdelkrim
- Karkowski Ludovic
- Karman Françoise
- Kemiche Farid
- Keraen Jérémy
- Kieffer Pierre
- Kone-Paut Isabelle
- Koreichi Abdeldajallil
- Kostine Marie
- La Batide Alanore Sylvain
- Lafforgue Pierre
- Lahalle Sophie
- Lambert Marc
- Lambrecht Isabelle
- Langlois Vincent
- Lanot Sylvain
- Lanteri Aurélia
- Larbre Jean-Paul
- Latourte Augustin
- Lavigne Christian
- Le Guen Guegan Sophie
- Le Guenno Guillaume,
- Lebrun AgnĂšs
- Ledoult Emmanuel
- Legoupil Nathalie
- Legrand Erick
- Leguy Diane
- Lejeune Charlotte
- Leloire Olivier
- Leroux Christophe
- Leroy RĂ©mi
- Leroy-Gouix Marie
- Leturcq Tifenn
- Leurs Amélie
- Leveque-Michaud CĂ©line
- Limbach François-Xavier
- Liote Frédéric
- Lohse Anne
- Lozac'h Pierre
- Lucas Virginie
- Madelon Aurélie
- Magy-Bertrand Nadine
- Mahevas Matthieu
- Maillard HĂ©lĂšne
- Maillet Thibault
- Malochet-Guinamand Sandrine
- Mangon Quentin
- Marchou-Lopez Sylvie
- Margarit Nathalie
- Marhadour Thierry
- Maria Alexandre Thibault Jacques
- Mariette Xavier
- Marotte Hubert
- Martin Claire
- Mathian Alexis
- Maurier François
- Maury Frédéric
- Mazet-Guillaume Betty
- Mazouyez Arnaud
- Mazyad Hassan
- Mehsen-Cetre Nadia
- Meinzer Ulrich
- Mekinian ArsĂšne
- Melki Isabelle
- Messer Laurent
- Miceli Corinne
- Michaud Martin
- Michel Catherine
- Michel Matthias
- Michon Mathilde
- Milesi-Lecat Anne-Marie
- Molto Anna
- Moly Marie
- Moranne Olivier
- Morel Gautier
- Morel Hugo
- Morel Jacques
- Morin Franck
- Moulinier Laurence
- Moulis Guillaume
- Moura Bertrand
- Nguyen Minh
- Nicolas-Vullierme Sabine
- Nielly Hubert
- Nocturne Gaétane
- Nottez Aurore
- Ollagnon Henri-Olivier
- Pacaud-Vitoux Isabelle
- Pagnier Anne
- Paris Caroline
- Parrot Antoine
- Pascart Tristan
- Pascaud-Mansour Yasmina
- Paulin LĂŠtitia
- Pavy Stephan
- Penhoat-Gahier MĂ©lanie
- Perard Laurent
- Pers Yves-Marie
- Pertuiset Edouard
- Pha Micheline
- Pham Thao
- Pichon Maud
- Pierreisnard Audrey
- Pizana Gabrielle
- Plassard Samira
- Poignant Sylvaine
- Poix Elsa
- Portier AgnĂšs
- Pouchot Jacques
- Poulet Antoine
- Pugnet Grégory
- Puyraimond-Zemmour DĂ©borah
- Quartier-Dit-Maire Pierre
- Quenet Marion
- Queyrel Viviane
- Raffray LoĂŻc
- Remy Philippe
- Renard Myriam
- Rene Jessica
- Revuz Sabine
- Rey Bénédicte
- Richard-Colmant Gaëlle
- Richez Christophe
- Riviere Etienne
- Riviere SĂ©bastien
- Robin Sophie
- Rohmer Julien
- Roitg Isabelle
- Rolland Michel
- Romier MĂ©lanie
- Roriz MĂ©lanie
- Rosenberg Carole
- Rossi Linda
- Roth Olivier
- Rouidi Sid-Ahmed
- Roumier Mathilde
- Rousiere Mickaël
- Rousselin Clémentine
- Rouviere Bénédicte
- Roux Christian
- Roux Fabienne
- Roux Marielle
- Roux Nicolas
- Rouzaud Diane
- Rozenberg Sylvie
- Sacco Isabelle
- Sadji Fatiha
- Sailler Laurent
- Salliot Carine
- Salmon Jean-Hugues
- Saraux Alain
- Schmidt Jean
- Seguier Julie
- Sellam Jérémie
- Senbel Eric
- Sene Thomas
- Senet Patricia
- Seror RaphaĂšle
- Servettaz Amélie
- Seve Pascal
- Sicaud Aurélie
- Simoens Justine
- Smets Perrine
- Sobanski Vincent
- Sordet Christelle
- Sornay-Rendu Elisabeth
- Souchaud-Debouverie Odile
- Sparsa LĂŠtitia
- Spielmann Lionel
- Stavris Chloé
- Steib Sarah
- Straus Catherine
- Strotz Victor
- Szafors Paulina
- Taffignon-Clave SĂ©verine
- Tenenbaum Nora
- Theillac Claire
- Thomachot BenoĂźt
- Thomas Thierry
- Tieulie Nathalie
- Tiriau Soizic
- Tison Alice
- Toussirot Eric
- Trefond Ludovic
- Trijau Sophie
- Trouillier SĂ©bastien
- Trouvin Anne-Priscille
- Truchetet Marie-Elise
- Ulrich Marc
- Vaquier Jacques
- Veillard Eric
- Veillon Laurent
- Vial Guillaume
- Viallard Jean-François
- Victor Judith
- Vidon Claire
- Vidon Mathias
- Vigne Camille
- Virone Alexandre
- Warzocha Ursula
- Wendling Daniel
- Werle Claude
- Wibaux CĂ©cile
- Willems Alexandra
- Wisniewski Michel
- Woessner Juliette
- Xerri-Campano Bernadette
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/06/2021
- Field of study
International audienceBackground: Various observations have suggested that the course of COVID-19 might be less favourable in patients with inflammatory rheumatic and musculoskeletal diseases receiving rituximab compared with those not receiving rituximab. We aimed to investigate whether treatment with rituximab is associated with severe COVID-19 outcomes in patients with inflammatory rheumatic and musculoskeletal diseases.Methods: In this cohort study, we analysed data from the French RMD COVID-19 cohort, which included patients aged 18 years or older with inflammatory rheumatic and musculoskeletal diseases and highly suspected or confirmed COVID-19. The primary endpoint was the severity of COVID-19 in patients treated with rituximab (rituximab group) compared with patients who did not receive rituximab (no rituximab group). Severe disease was defined as that requiring admission to an intensive care unit or leading to death. Secondary objectives were to analyse deaths and duration of hospital stay. The inverse probability of treatment weighting propensity score method was used to adjust for potential confounding factors (age, sex, arterial hypertension, diabetes, smoking status, body-mass index, interstitial lung disease, cardiovascular diseases, cancer, corticosteroid use, chronic renal failure, and the underlying disease [rheumatoid arthritis vs others]). Odds ratios and hazard ratios and their 95% CIs were calculated as effect size, by dividing the two population mean differences by their SD. This study is registered with ClinicalTrials.gov, NCT04353609.Findings: Between April 15, 2020, and Nov 20, 2020, data were collected for 1090 patients (mean age 55·2 years [SD 16·4]); 734 (67%) were female and 356 (33%) were male. Of the 1090 patients, 137 (13%) developed severe COVID-19 and 89 (8%) died. After adjusting for potential confounding factors, severe disease was observed more frequently (effect size 3·26, 95% CI 1·66-6·40, p=0·0006) and the duration of hospital stay was markedly longer (0·62, 0·46-0·85, p=0·0024) in the 63 patients in the rituximab group than in the 1027 patients in the no rituximab group. 13 (21%) of 63 patients in the rituximab group died compared with 76 (7%) of 1027 patients in the no rituximab group, but the adjusted risk of death was not significantly increased in the rituximab group (effect size 1·32, 95% CI 0·55-3·19, p=0·53).Interpretation: Rituximab therapy is associated with more severe COVID-19. Rituximab will have to be prescribed with particular caution in patients with inflammatory rheumatic and musculoskeletal diseases
Severity of COVID-19 and survival in patients with rheumatic and inflammatory diseases: data from the French RMD COVID-19 cohort of 694 patients
- Author
- Abdeldajallil Koreichi
- Abdelkrim Kabchou
- AgnĂšs Charcot
- AgnĂšs Lebrun
- AgnĂšs Portier
- Ahmed Benmansour
- Alain Duhamel
- Alexandra Willems
- Alexandre Belot
- Alexandre Maria
- Alexandre Virone
- Alexis Mathian
- Alice Tison
- Aline Gury
- Amandine Fichet
- Ambre Hittinger-Roux
- Amélie Servettaz
- Andra Economu-Dubosc
- André Basch
- Angers Mazouyez Arnaud
- Angélique Ducornet
- Anna Kabala
- Anna Molto
- Annalisa Celant
- Anne Fouque-Aubert
- Anne Grasland
- Anne Lohse
- Anne-Claire Fougerousse
- Anne-Elisabeth Dumel
- Anne-Marie Milesi-Lecat
- Antoine Colombey
- Antoine Froissart
- Antoine Parrot
- Antoine Poulet
- ArsĂšne Mekinian
- Aude Giraud-Morelet
- Audre Barrelet
- Augustin Latourte
- Aurélia Bisson-Vaivre
- Aurélia Carbasse
- Aurélia Lanteri
- Aurélie Madelon
- Aurélie Sicaud
- Baptiste Glace
- Basile Henriot
- Bastien Bouldoires
- Benjamin Chaigne
- BenoĂźt Chaillous
- BenoĂźt Thomachot
- Bernadette Xerri-Campano
- Bernard Chaudier
- Bernard Combe
- Bertrand Godeau
- Bertrand Moura
- Betty Mazet-Guillaume
- Blanca Amador-Borreiro
- Brice Castel
- Brigitte Bader-Meunier
- Brigitte Bernoux-Manat
- Bruno Fautrel
- Bruno Gombert
- Bruno Grardel
- BĂ©atrice Banneville
- BĂ©atrice Drouet
- Bénédicte Jamard
- Camille Glanowski
- Camille Gonnet-Gracia
- Camille Vigne
- Carine Dufauret-Lombard
- Carine Salliot
- Caroline Charpin
- Catherine Duc
- Catherine Foutrier-Morello
- Catherine Jan
- Chantal Deslandre
- Charlotte Lejeune
- Chloé Comarmond
- Christelle Gibert
- Christelle Sordet
- Christian Roux
- Christine Audoin-Pajot
- Christine Bonnet
- Christophe Hudry
- Christophe Leroux
- Christophe Richez
- Claire Vidon
- Clara Jaccard
- Claude Werle
- Clémence Corre
- Clémentine Rousselin
- Constance Guillaud
- Cyril Clavel-Osorio
- CĂ©cile Coutarel
- CĂ©cile Dumaine
- CĂ©cile Hacquard-Bouder
- CĂ©line Comparon
- Dana Georgescu
- Daniel Wendling
- Denis Arniaud
- Denis Jullien
- Diane Rouzaud
- Didier Alcais
- Djamal-Dine Djeddi
- DĂ©borah Puyraimond-Zemmour
- Edouard Pertuiset
- Elisabeth Diot
- Elisabeth Fontanges
- Elisabeth Gervais
- Elisabeth Sornay-Rendu
- Elise Descamps
- Elodie Constant
- Elodie Drumez
- Elodie Feurer
- Elsa Poix
- Emilie Berthoux
- Emilie Chotard
- Emma Andre
- Emmanuel Chatelus
- Emmanuel Ledoult
- Eric Bouvard
- Eric Gibert
- Eric Hachulla
- Eric Senbel
- Eric Toussirot
- Eric Veillard
- Erick Legrand
- Esther Ebstein
- Etienne Riviere
- Ewa Bertolini
- Fabienne Coury-Lucas
- Fabienne Roux
- Fabrice Coutier
- Fanny Domont
- Fanny Fernandes
- Farid Kemiche
- Fatiha Sadji
- Fleur Cohen
- Florence Aeschlimann
- Francis Gaches
- Franck Grados
- Franck Morin
- François Maurier
- Françoise Bouhour
- Françoise Flaisler
- Françoise Karman
- Frédéric Banal
- Frédéric Liote
- Frédéric Maury
- Frédérick Detree
- Frédérique Gandjbakhch
- Gabrielle Argenteuil Pizana
- Gautier Morel
- Gaétane Nocturne
- Gaëlle Clavel
- Gaëlle Richard-Colmant
- Ghislaine Gill
- Gilles Blaison
- Gilles Bolla
- Gilles Grateau
- Gregory Cohen
- Grégory Pugnet
- Guillaume Bayer
- Guillaume Direz
- Guillaume Le Guenno
- Guillaume Moulis
- Guillaume Vial
- GĂ©raldine Durand
- Hassan Contamine-Sur-Arve Mazyad
- Henri-Olivier Ollagnon
- Herliette Arty-Hue
- Hervé Caumont
- Hubert Marotte
- Hubert Nielly
- Hugo Morel
- HĂ©lĂšne Bacquet-Deschryver
- HĂ©lĂšne Francois-Pradier
- HĂ©lĂšne Maillard
- Isabelle Charlot-Lambrecht
- Isabelle Kone-Paut
- Isabelle Melki
- Isabelle Pacaud-Vitoux
- Isabelle Roitg
- Isabelle Sacco
- Jacques Despaux
- Jacques Fechtenbaum
- Jacques Morel
- Jacques Pouchot
- Jean Fulpin
- Jean Schmidt
- Jean-BenoĂźt Arlet
- Jean-Charles Balblanc
- Jean-David Albert
- Jean-François Garrot
- Jean-François Viallard
- Jean-Hugues Salmon
- Jean-Michel Jacquemier
- Jean-Paul Larbre
- Jean-Pierre Hellier
- Jeanine-Sophie Giraudet-Le Quintrec
- Jennifer Foret
- Jessica Rene
- Joris Galland
- Judith Victor
- Julie Seguier
- Julien Henry
- Julien Rohmer
- Juliette Woessner
- Justine Simoens
- Jérémie Sellam
- Jérémy Keraen
- JĂ©rĂŽme Avouac
- JĂ©rĂŽme Gillard
- Karima Boussoualim
- KĂ©vin Bouiller
- Laurence Boudou
- Laurence Daver-Malaterre
- Laurence Gagneux-Lemoussu
- Laurence Moulinier
- Laurent Arnaud
- Laurent Juillard
- Laurent Messer
- Laurent Perard
- Laurent Sailler
- Laurent Veillon
- Lin Chu Miow
- Linda Rossi
- Lucie Atlan
- Ludovic Karkowski
- Ludovic Trefond
- LĂŠtitia Paulin
- LĂŠtitia Sparsa
- LĂ©a Frantzen
- Marie Couret
- Marie Desmurs
- Marie Desplats
- Marie Moly
- Marie-EliseEric Veillard EricVeillard
- Marie-Eve Colette-Cedoz
- Marie-HĂ©lĂšne Guyot
- Marie-Noelle Havard
- Marielle Roux
- Marion Fauconier
- Marion Hermet
- Marion Quenet
- Martin Michaud
- Mathias Vidon
- Mathieu Jouvray
- Mathilde Benhamou
- Mathilde Devaux
- Mathilde Michon
- Mathilde Roumier
- Matthieu Mahevas
- Maud Gauthier-Prieur
- Maud Pichon
- Maurizio Carteni
- Maxime Bach-Bunner
- Maxime Chevreau
- Michel Delahousse
- Michel Rolland
- Michel Wisniewski
- Micheline Pha
- Mickaël Rousiere
- Miguel Hie
- Mikaël Ebbo
- Minh Nguyen
- Mohammed Benammar
- Monica Groza
- Muriel Herasse
- Myriam Renard
- MĂ©lanie Gahier Penhoat
- MĂ©lanie Gilson
- MĂ©lanie Romier
- MĂ©lanie Roriz
- Nadia Mehsen-Cetre
- Nans Florens
- Nassim Ait-Abdallah
- Natacha Courvoisier
- Nathalie Balandraud
- Nathalie Costedoat-Chalumeau
- Nathalie Gerard
- Nathalie Legoupil
- Nathalie Margarit
- Nathalie Tieulie
- Nicolas Roux
- Nicole Ferreira-Maldent
- Nicole Garnier
- Nived Collercandy
- Nora Tenenbaum
- Odile Souchaud-Debouverie
- Olivier Bonidan
- Olivier Gourmelen
- Olivier Leloire
- Olivier Moranne
- Olivier Roth
- Pascal Bennet
- Pascal Cathebras
- Pascal Chazerain
- Pascal Claudepierre
- Pascal Hennequin
- Pascal Seve
- Pascale Chertok
- Patrice Cacoub
- Patricia Senet
- Paulina Szafors
- Pauline Grenoble Gimonnet
- Perrine Smets
- Philippe Dieude
- Philippe Evon
- Philippe Goupille
- Philippe Guilpain
- Philippe Remy
- Piera Fuzibet
- Pierre Buchlin
- Pierre Charles
- Pierre Fritz
- Pierre Lafforgue
- Pierre Quartier-Dit-Maire
- Pierre-Antoine Juge
- Pierre-Marie Duret
- Quentin Mangon
- Rakiba Belkhir
- Raphaël Borie
- Raphaële Seror
- Regine Brondino
- Renaud Felten
- René-Marc Flipo
- Richard Damade
- Robin Dhote
- Romain Euvrard
- Romain Gastaldi
- Romuald Champy
- Ruben Benainous
- RĂ©mi Leroy
- Sabine Nicolas-Vullierme
- Sabine Revuz
- Samira Plassard
- Sandrine Malochet-Guinamand
- Sarah Steib
- Sarahe Dehimat
- Serge Huguenel
- Sid-Ahmed Rouidi
- Sophie Bayle
- Sophie Georgin-Lavialle
- Sophie Govindaraju-Audouard
- Sophie Lahalle
- Sophie Le Guen Guegan
- Sophie Robin
- Sophie Trijau
- Soumaya El Mahou
- Stephan Pavy
- Stéphane Bally
- Sylvain La Batide Alanore
- Sylvain Lanot
- Sylvie Fabre
- Sylvie Jean
- Sylvie Marchou-Lopez
- Sylvie Rozenberg
- SĂ©bastien Riviere
- SĂ©bastien Trouillier
- SĂ©verine Guillaume
- SĂ©verine Taffignon-Clave
- Thao Pham
- Thibault Maillet
- Thierry Marhadour
- Thierry Thomas
- Thomas Barnetche
- Thomas Garraud
- Thomas Sene
- Tifenn Leturcq
- Tiphaine Goulenok
- Tristan Pascart
- Ulrich Meinzer
- Ursula Warzocha
- Valérie Devauchelle-Pensec
- Victor Audren
- Victor Strotz
- Vincent Baumier
- Vincent Langlois
- Vincent Sobanski
- Violaine Foltz
- Virginie Lucas
- VĂ©ronique Belin
- VĂ©ronique Gaud-Listrat
- VĂ©ronique Hentgen
- Xavier Chevalier
- Xavier Guillot
- Xavier Mariette
- Yannick Allanore
- Yannick Dieudonne
- Yasmina Pascaud-Mansour
- Ygal Benhamou
- Yves-Marie Pers
- Zahir Amoura
- Publication venue
- 'BMJ'
- Publication date
- 02/12/2020
- Field of study
International audienceObjectives: There is little known about the impact of SARS-CoV-2 on patients with inflammatory rheumatic and musculoskeletal diseases (iRMD). We examined epidemiological characteristics associated with severe disease, then with death. We also compared mortality between patients hospitalised for COVID-19 with and without iRMD.Methods: Individuals with suspected iRMD-COVID-19 were included in this French cohort. Logistic regression models adjusted for age and sex were used to estimate adjusted ORs and 95% CIs of severe COVID-19. The most significant clinically relevant factors were analysed by multivariable penalised logistic regression models, using a forward selection method. The death rate of hospitalised patients with iRMD-COVID-19 (moderate-severe) was compared with a subset of patients with non-iRMD-COVID-19 from a French hospital matched for age, sex, and comorbidities.Results: Of 694 adults, 438 (63%) developed mild (not hospitalised), 169 (24%) moderate (hospitalised out of the intensive care unit (ICU) and 87 (13%) severe (patients in ICU/deceased) disease. In multivariable imputed analyses, the variables associated with severe infection were age (OR=1.08, 95% CI: 1.05-1.10), female gender (OR=0.45, 95% CI: 0.25-0.80), body mass index (OR=1.07, 95% CI: 1.02-1.12), hypertension (OR=1.86, 95% CI: 1.01-3.42), and use of corticosteroids (OR=1.97, 95% CI: 1.09-3.54), mycophenolate mofetil (OR=6.6, 95% CI: 1.47-29.62) and rituximab (OR=4.21, 95% CI: 1.61-10.98). Fifty-eight patients died (8% (total) and 23% (hospitalised)). Compared with 175 matched hospitalised patients with non-iRMD-COVID-19, the OR of mortality associated with hospitalised patients with iRMD-COVID-19 was 1.45 (95% CI: 0.87-2.42) (n=175 each group).Conclusions: In the French RMD COVID-19 cohort, as already identified in the general population, older age, male gender, obesity, and hypertension were found to be associated with severe COVID-19. Patients with iRMD on corticosteroids, but not methotrexate, or tumour necrosis factor alpha and interleukin-6 inhibitors, should be considered as more likely to develop severe COVID-19. Unlike common comorbidities such as obesity, and cardiovascular or lung diseases, the risk of death is not significantly increased in patients with iRMD
Severity of COVID-19 and survival in patients with rheumatic and inflammatory diseases: data from the French RMD COVID-19 cohort of 694 patients
- Author
- Aeschlimann Florence
- Ait-Abdallah Nassim
- Albert Jean-David
- Alcais Didier
- Allanore yannick
- Amador-Borreiro Blanca
- Amoura Zahir
- Andre Emma
- Argenteuil Pizana Gabrielle
- Arlet Jean-BenoĂźt
- Arnaud Laurent
- Arniaud Denis
- Arty-Hue Herliette
- Atlan Lucie
- Audoin-Pajot Christine
- Audren Victor
- Avouac JĂ©rĂŽme
- Bach-Bunner Maxime
- Bacquet-Deschryver HĂ©lĂšne
- Bader-Meunier Brigitte
- Balandraud Nathalie Idhal : Nathalie-Balandraud
- Balblanc Jean-Charles
- Bally Stéphane
- Banal Frédéric
- Banneville BĂ©atrice
- Barnetche Thomas
- Barrelet Audre
- Basch André
- Baumier Vincent
- Bayer Guillaume
- Bayle Sophie
- Belin VĂ©ronique
- Belkhir Rakiba
- Belot Alexandre
- Benainous Ruben
- Benammar Mohammed
- Benhamou Mathilde
- Benhamou ygal
- Benmansour Ahmed
- Bennet Pascal
- Bernoux-Manat Brigitte
- Berthoux Emilie
- Bertolini Ewa
- Bisson-Vaivre Aurélia
- Blaison Gilles
- Bolla Gilles
- Bonidan Olivier
- Bonnet Christine
- Borie Raphaël
- Boudou Laurence
- Bouhour Françoise
- Bouiller KĂ©vin
- Bouldoires Bastien
- Boussoualim Karima
- Bouvard Eric
- Brondino Regine
- Buchlin Pierre
- Cacoub Patrice
- Carbasse Aurélia
- Carteni Maurizio
- Castel Brice
- Cathebras Pascal
- Caumont Hervé
- Celant Annalisa
- Chaigne Benjamin
- Chaillous BenoĂźt
- Champy Romuald
- Charcot AgnĂšs
- Charles Pierre
- Charlot-Lambrecht Isabelle
- Charpin Caroline
- Chatelus Emmanuel
- Chaudier Bernard
- Chazerain Pascal
- Chertok Pascale
- Chevalier Xavier
- Chevreau Maxime
- Chotard Emilie
- Chu Miow Lin
- Claudepierre Pascal
- Clavel Gaëlle
- Clavel-Osorio Cyril
- Cohen Fleur
- Cohen Gregory
- Colette-Cedoz Marie-Eve
- Collercandy Nived
- Colombey Antoine
- Comarmond Chloé
- Combe Bernard
- Comparon CĂ©line
- Constant Elodie
- Contamine-Sur-Arve Mazyad Hassan
- Corre Clémence
- Costedoat-Chalumeau Nathalie
- Couret Marie
- Courvoisier Natacha
- Coury-Lucas Fabienne
- Coutarel CĂ©cile
- Coutier Fabrice
- Damade Richard
- Daver-Malaterre Laurence
- Dehimat Sarahe
- Delahousse Michel
- Descamps Elise
- Deslandre Chantal
- Desmurs Marie
- Despaux Jacques
- Desplats Marie
- Detree Frédérick
- Devauchelle-Pensec Valérie
- Devaux Mathilde
- Dhote Robin
- Dieude Philippe
- Dieudonne yannick
- Diot Elisabeth
- Direz Guillaume
- Djeddi Djamal-Dine
- Domont Fanny
- Drouet BĂ©atrice
- Drumez Elodie
- Duc Catherine
- Ducornet Angélique
- Dufauret-Lombard Carine
- Duhamel Alain
- Dumaine CĂ©cile
- Dumel Anne-Elisabeth
- Durand GĂ©raldine
- Duret Pierre-Marie
- Ebbo Mikaël
- Ebstein Esther
- Economu-Dubosc Andra
- El Mahou Soumaya
- Euvrard Romain
- Evon Philippe
- Fabre Sylvie
- Fauconier Marion
- Fautrel Bruno
- Fechtenbaum Jacques
- Felten Renaud
- Fernandes Fanny
- Ferreira-Maldent Nicole
- Feurer Elodie
- Fichet Amandine
- Flaisler Françoise
- Flipo René-Marc
- Florens Nans
- Foltz Violaine
- Fontanges Elisabeth
- Foret Jennifer
- Fougerousse Anne-Claire
- Fouque-Aubert Anne
- Foutrier-Morello Catherine
- Francois-Pradier HĂ©lĂšne
- Frantzen LĂ©a
- Fritz Pierre
- Froissart Antoine
- Fulpin Jean
- Fuzibet Piera
- Gaches Francis
- Gagneux-Lemoussu Laurence
- Gahier Penhoat MĂ©lanie
- Galland Joris
- Gandjbakhch Frédérique
- Garnier Nicole
- Garraud Thomas
- Garrot Jean-François
- Gastaldi Romain
- Gaud-Listrat VĂ©ronique
- Gauthier-Prieur Maud
- Georgescu Dana
- Georgin-Lavialle Sophie
- Gerard Nathalie
- Gervais Elisabeth
- Gibert Christelle
- Gibert Eric
- Gill Ghislaine
- Gillard JĂ©rĂŽme
- Gilson MĂ©lanie
- Giraud-Morelet Aude
- Giraudet-Le Quintrec Jeanine-Sophie
- Glace Baptiste
- Glanowski Camille
- Godeau Bertrand
- Gombert Bruno
- Gonnet-Gracia Camille
- Goulenok Tiphaine
- Goupille Philippe
- Gourmelen Olivier
- Govindaraju-Audouard Sophie
- Grados Franck
- Grardel Bruno
- Grasland Anne
- Grateau Gilles
- Grenoble Gimonnet Pauline
- Groza Monica
- Guillaud Constance
- Guillaume SĂ©verine
- Guillot Xavier
- Guilpain Philippe
- Gury Aline
- Guyot Marie-HĂ©lĂšne
- Hachulla Eric
- Hacquard-Bouder CĂ©cile
- Havard Marie-Noelle
- Hellier Jean-Pierre
- Hennequin Pascal
- Henriot Basile
- Henry Julien
- Hentgen VĂ©ronique
- Herasse Muriel
- Hermet Marion
- Hie Miguel
- Hittinger-Roux Ambre
- Hudry Christophe
- Huguenel Serge
- Jaccard Clara
- Jacquemier Jean-Michel
- Jamard Bénédicte
- Jan Catherine
- Jean Sylvie
- Jouvray Mathieu
- Juge Pierre-Antoine
- Juillard Laurent
- Jullien Denis
- Kabala Anna
- Kabchou Abdelkrim
- Karkowski Ludovic
- Karman Françoise
- Kemiche Farid
- Keraen Jérémy
- Kone-Paut Isabelle
- Koreichi Abdeldajallil
- La Batide Alanore Sylvain
- Lafforgue Pierre
- Lahalle Sophie
- Langlois Vincent
- Lanot Sylvain
- Lanteri Aurélia
- Larbre Jean-Paul
- Latourte Augustin
- Le Guen Guegan Sophie
- Le Guenno Guillaume
- Lebrun AgnĂšs
- Ledoult Emmanuel
- Legoupil Nathalie
- Legrand Erick
- Lejeune Charlotte
- Leloire Olivier
- Leroux Christophe
- Leroy RĂ©mi
- Leturcq Tifenn
- Liote Frédéric
- Lohse Anne
- Lucas Virginie
- Madelon Aurélie
- Mahevas Matthieu
- Maillard HĂ©lĂšne
- Maillet Thibault
- Malochet-Guinamand Sandrine
- Mangon Quentin
- Marchou-Lopez Sylvie
- Margarit Nathalie
- Marhadour Thierry
- Maria Alexandre
- Mariette Xavier
- Marotte Hubert
- Mathian Alexis
- Maurier François
- Maury Frédéric
- Mazet-Guillaume Betty
- Mazouyez Arnaud Angers
- Mehsen-Cetre Nadia
- Meinzer Ulrich
- Mekinian ArsĂšne
- Melki Isabelle
- Messer Laurent
- Michaud Martin
- Michon Mathilde
- Milesi-Lecat Anne-Marie
- Molto Anna
- Moly Marie
- Moranne Olivier
- Morel Gautier
- Morel Hugo
- Morel Jacques
- Morin Franck
- Moulinier Laurence
- Moulis Guillaume
- Moura Bertrand
- Nguyen Minh
- Nicolas-Vullierme Sabine
- Nielly Hubert
- Nocturne Gaétane
- Ollagnon Henri-Olivier
- Pacaud-Vitoux Isabelle
- Parrot Antoine
- Pascart Tristan
- Pascaud-Mansour yasmina
- Paulin LĂŠtitia
- Pavy Stephan
- Perard Laurent
- Pers yves-Marie
- Pertuiset Edouard
- Pha Micheline
- Pham Thao
- Pichon Maud
- Plassard Samira
- Poix Elsa
- Portier AgnĂšs
- Pouchot Jacques
- Poulet Antoine
- Pugnet Grégory
- Puyraimond-Zemmour DĂ©borah
- Quartier-Dit-Maire Pierre
- Quenet Marion
- Remy Philippe
- Renard Myriam
- Rene Jessica
- Revuz Sabine
- Richard-Colmant Gaëlle
- Richez Christophe
- Riviere Etienne
- Riviere SĂ©bastien
- Robin Sophie
- Rohmer Julien
- Roitg Isabelle
- Rolland Michel
- Romier MĂ©lanie
- Roriz MĂ©lanie
- Rossi Linda
- Roth Olivier
- Rouidi Sid-Ahmed
- Roumier Mathilde
- Rousiere Mickaël
- Rousselin Clémentine
- Roux Christian
- Roux Fabienne
- Roux Marielle
- Roux Nicolas
- Rouzaud Diane
- Rozenberg Sylvie
- Sacco Isabelle
- Sadji Fatiha
- Sailler Laurent
- Salliot Carine
- Salmon Jean-Hugues
- Schmidt Jean
- Seguier Julie
- Sellam Jérémie
- Senbel Eric
- Sene Thomas
- Senet Patricia
- Seror Raphaële
- Servettaz Amélie
- Seve Pascal
- Sicaud Aurélie
- Simoens Justine
- Smets Perrine
- Sobanski Vincent
- Sordet Christelle
- Sornay-Rendu Elisabeth
- Souchaud-Debouverie Odile
- Sparsa LĂŠtitia
- Steib Sarah
- Strotz Victor
- Szafors Paulina
- Taffignon-Clave SĂ©verine
- Tenenbaum Nora
- Thomachot BenoĂźt
- Thomas Thierry
- Tieulie Nathalie
- Tison Alice
- Toussirot Eric
- Trefond Ludovic
- Trijau Sophie
- Trouillier SĂ©bastien
- Veillard Ericveillard Marie-Eliseeric
- Veillard Eric
- Veillon Laurent
- Vial Guillaume
- Viallard Jean-François
- Victor Judith
- Vidon Claire
- Vidon Mathias
- Vigne Camille
- Virone Alexandre
- Warzocha Ursula
- Wendling Daniel
- Werle Claude
- Willems Alexandra
- Wisniewski Michel
- Woessner Juliette
- Xerri-Campano Bernadette
- Publication venue
- 'BMJ'
- Publication date
- 02/12/2020
- Field of study
International audienceObjectives: There is little known about the impact of SARS-CoV-2 on patients with inflammatory rheumatic and musculoskeletal diseases (iRMD). We examined epidemiological characteristics associated with severe disease, then with death. We also compared mortality between patients hospitalised for COVID-19 with and without iRMD.Methods: Individuals with suspected iRMD-COVID-19 were included in this French cohort. Logistic regression models adjusted for age and sex were used to estimate adjusted ORs and 95% CIs of severe COVID-19. The most significant clinically relevant factors were analysed by multivariable penalised logistic regression models, using a forward selection method. The death rate of hospitalised patients with iRMD-COVID-19 (moderate-severe) was compared with a subset of patients with non-iRMD-COVID-19 from a French hospital matched for age, sex, and comorbidities.Results: Of 694 adults, 438 (63%) developed mild (not hospitalised), 169 (24%) moderate (hospitalised out of the intensive care unit (ICU) and 87 (13%) severe (patients in ICU/deceased) disease. In multivariable imputed analyses, the variables associated with severe infection were age (OR=1.08, 95% CI: 1.05-1.10), female gender (OR=0.45, 95% CI: 0.25-0.80), body mass index (OR=1.07, 95% CI: 1.02-1.12), hypertension (OR=1.86, 95% CI: 1.01-3.42), and use of corticosteroids (OR=1.97, 95% CI: 1.09-3.54), mycophenolate mofetil (OR=6.6, 95% CI: 1.47-29.62) and rituximab (OR=4.21, 95% CI: 1.61-10.98). Fifty-eight patients died (8% (total) and 23% (hospitalised)). Compared with 175 matched hospitalised patients with non-iRMD-COVID-19, the OR of mortality associated with hospitalised patients with iRMD-COVID-19 was 1.45 (95% CI: 0.87-2.42) (n=175 each group).Conclusions: In the French RMD COVID-19 cohort, as already identified in the general population, older age, male gender, obesity, and hypertension were found to be associated with severe COVID-19. Patients with iRMD on corticosteroids, but not methotrexate, or tumour necrosis factor alpha and interleukin-6 inhibitors, should be considered as more likely to develop severe COVID-19. Unlike common comorbidities such as obesity, and cardiovascular or lung diseases, the risk of death is not significantly increased in patients with iRMD
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies
- Author
- Abad Jorge
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Accordino Giulia
- Achille Cristian
- Acosta-Ampudia Yeny
- Agra Juan José Cåceres
- Aguilera-Albesa Sergio
- AguilĂł-Cucurull Aina
- Aiuti Alessandro
- Aiuti Alessandro
- Aiuti Alessandro
- Akcan Ăzge Metin
- Al-Muhsen Saleh
- Al-Mulla Fahd
- Alavoine Loubna
- Albert Matthew
- Albisures Jonathan Antonio Roblero
- Alcover Andres
- Aldave Juan
- Algera Anne Geke
- Aliberti Anna
- Alkan Gulsum
- Alkhater Suzan
- Alkhater Suzan
- Allardet-Servent Jerome
- Allavena Clotilde
- Allende Luis
- Alonso-Arias Rebeca
- Alshahrani Mohammed
- Alsina Laia
- Alvarez Josep Trenado
- Alyanakian Marie-Alexandra
- Amador-Borrero Blanca
- Amat Karine
- Amoura Zahir
- Anaya Juan-Manuel
- Anderson Mark
- Anderson Mark
- Andreakos Evangelos
- Andreakos Evangelos
- Andrejak Claire
- Andrés Ana De
- Anglicheau Dany
- Angoulvant François
- Annereau Jean-Philippe
- AntolĂ Arnau
- Appelman Brent
- Arias Andrés
- Arias Andrés Augusto
- Arkin Lisa
- Arquero Miguel Fernandez
- Arranz MarĂa JesĂșs
- Arrestier Romain
- Arrestier Romain
- Asano Takaki
- Aschard Hugues
- Aubart MĂ©lodie
- Auguet Teresa
- Avramenko Iryna
- Aytekin Gökhan
- Aytekin Selma Erol
- Azot Axelle
- Azoulay Cecile
- Bachelet Delphine
- Bahram Seiamak
- Bajolle Fanny
- Baldanti Fausto
- Baldolli Aurélie
- Ballester Maite
- Baris-Feldman Hagit
- Barreiros Lucila
- Barrou Benoit
- Bartoli Marie
- Barzaghi Federica
- Basmaci Romain
- Basso Sabrina
- Bastard Paul
- Batten Isabella
- Bauters Fré
- Bax Diane
- Bayhan Gulsum Iclal
- Behillil Sylvie
- Behillill Sylvie
- Bellani Giacomo
- Belot Alexandre
- Belot Alexandre
- Belot Alexandre
- Beluze Marine
- Benech Nicolas
- Benkerrou Dehbia
- Beretta Ilaria
- Bergin Colm
- Bertholon Frédérique
- Bettini Laura Rachele
- Beudel Martijn
- Bezrodnik Liliana
- Bhavsar Krishna
- Biggs Catherine
- Biggs Catherine
- Bilbao Agurtzane
- Bilguvar Kaya
- Biondi Andrea
- Bitker Laurent
- Bizien Lucy
- Blanchard-Rohner Geraldine
- Blanco Ignacio
- BlandiniĂšres Adeline
- Bleibtreu Alexandre
- Bloomfield Marketa
- BlĂĄzquez-Gamero Daniel
- Bogaard Harm Jan
- Bogunovic Dusan
- Boisson Bertrand
- Bolivar-Prados Mireia
- Bolze Alexandre
- Bomers Marije
- Bondarenko Anastasiia
- Bondarenko Anastasiia
- Bondarenko Anastasiia
- Bonfanti Paolo
- Bonneaudeau Brigitte
- Bonta Peter
- Borghesi Alessandro
- Borie Raphael
- Borrero Blanca Amador
- Bos Lieuwe
- Bosteels CĂ©dric
- Botdhlo-Nevers Elisabeth
- Botelho-Nevers Elisabeth
- Botta Michela
- Bouadma Lila
- Bouadma Lila
- Boucherit Soraya
- Boudhabhay Idris
- Bouiller KĂ©vin
- Boulanger CĂ©cile
- Bourgeois Fleur Le
- Bourgeon Marilou
- Bourke Nollaig
- Bourke Nollaig
- Bourke Nollaig
- Bouscambert-Duchamp Maude
- Bousfiha Ahmed
- Bousfiha Ahmed
- Bousfiha Ahmed
- Bousquet Aurore
- Bousso Philippe
- Boutolleau David
- Bouvattier Claire
- Boyarchuk Oksana
- Boyarchuk Oksana
- Bozdemir Ćefika Elmas
- Bravais Juliette
- Briones M. Luisa
- Briseño-Roa Luis
- Brodin Petter
- Brodin Petter
- Brouwer Matthijs
- Bruhns Pierre
- Bruneau LĂ©a
- Brunner Marie-Eve
- Bruno Raffaele
- Bryceson Yenan
- Bueno Maria Rita P.
- Bugiani Marianna
- Buis David
- Bukhari Huda
- Bulle Esther
- Burdet Charles
- Burdet Charles
- Burrel Sonia
- Bustamante Carlos
- Bustamante Jacinta
- Butte Manish
- BĂ©ziat Vivien
- Cannet Dorothée
- Capra Ruggero
- Carapito Raphael
- Carrabba Maria
- Carrillo Jorge
- Casanova Jean-Laurent
- Casanova Jean-Laurent
- Casari Giorgio
- Casari Giorgio
- Casari Giorgio
- Casasnovas Carlos
- Caseris Marion
- Cassaniti Irene
- Castagnoli Riccardo
- Castelle Martin
- Castelli Francesco
- Castro Mateus
- Catherinot Emilie
- Cazzaniga Marina
- Celik Jale Bengi
- Cerf-Bensussan Nadine
- Cervantes-Gonzalez Minerva
- Ceschi Alessandro
- Chahine Abir
- Chair Anissa
- Chakravorty Samya
- Chalumeau Martin
- Charbit Bruno
- Charpentier Charlotte
- Chauvineau-Grenier Angélique
- Chen Jie
- Cheng Matthew
- Chirouze Catherine
- Chirouze Catherine
- Chouchane Osoul
- Chrabieh Maya
- Christodoulou John
- Ciceri Fabio
- Citerio Giuseppe
- Clavé Pere
- Clercq Jozefien De
- Cloherty Alex
- Clotet Bonaventura
- Cobat Aurélie
- Codina Anna
- Coelho Alexandra
- Coeuret-Pellicer Mireille
- Cognasse Fabrice
- Cognasse Fabrice
- Cohen Yves
- Colobran Roger
- Colobran Roger
- Comarmond Cloé
- Combes Alain
- Comoli Patrizia
- Condino-Neto Antonio
- Condino-Neto Antonio
- Conlon Niall
- Connolly Emma
- Constantinescu Stefan
- Conti Francesca
- Contro Ernesto
- Cooper Megan
- Cordel Hugues
- Correales Luisa Paola Duarte
- Corsico Angelo
- Couffignal Camille
- Couffin-Cadiergues Sandrine
- Couffin-Cadiergues Sandrine
- Coulongeat Matthieu
- CoĆkuner Taner
- Cruz InĂ©s MarĂn
- Cuadros Esmeralda Nuñez
- Cumano Ana
- Cvetkovski Aleksandar
- Cyrus Cyril
- Daganou Maria
- Dalgard Clifton
- Dalgard Clifton
- Dalmau David
- Dalmau David
- Danielson Jeffrey
- Danion François
- Darazam Ilad Alavi
- Darley David Ross
- Das Vincent
- Dauby Nicolas
- Dauger Stéphane
- de Brabander Justin
- de Bree Godelieve
- de Bruin Sanne
- de Chambrun Marc Pineton
- de Diego Rebeca Perez
- de Jong Menno
- de la Chapelle Aliénor
- de Lamballerie Xavier
- de Montmollin Etienne
- de Munter Paul
- de Pontual Loic
- de Prost Nicolas
- de Rotte Maurits
- de Vera MartĂn Castillo
- de Vries Heder
- Debard Alexa
- Debette Stéphanie
- Debette Stéphanie
- Debray Marie-Pierre
- Dechanet Aline
- Dehban Amin
- Delmonte Ottavia
- Delplancq Geoffroy
- Demar Magalie
- Demirkol Yasemin Kendir
- Demoule Alexandre
- Deplanque Dominique
- Deplanque Dominique
- Deriano Ludovic
- Desai Murkesh
- Descamps Diane
- Descamps Diane
- Desguerre Isabelle
- Desille-Dugast Mireille
- Desmarets Maxime
- Desvallée Mathilde
- Di Sabatino Antonio
- Di Santo James
- Diallo Alpha
- Diego Rebeca PĂ©rez De
- Diehl Jean-Luc
- Diehl Jean-Luc
- Dijkstra Mirjam
- Dillies Marie-AgnĂšs
- Ding Li
- Dinh Khoa Manh
- Diouf Alphonsine
- Djossou FĂ©lix
- Dobbelaere Stephanie
- Dobbs Kerry
- Dominguez-Garrido Elena
- DomĂnguez-Garrido Elena
- Dongelmans Dave
- Dorgham Karim
- Dorival CĂ©line
- Drolet Beth
- Dromer Françoise
- Dubos François
- Dubost Clément
- Duffy Darragh
- Duffy Darragh
- Dufouil Carole
- Dujardin Romein
- Dunne Jean
- Dupont Annabelle
- Duval Xavier
- Duval Xavier
- Duvlis Sotirija
- Dyer Adam
- Dâangio Mariella
- Dâenfert Christophe
- Dâortenzio Eric
- Eberl GĂ©rard
- Ecobichon Jean-Luc
- Ekwall Olov
- El Baghdadi Jamila
- El Bakkouri Jalila
- Elbers Paul
- Elnagdy Marwa
- Eloy Philippine
- Emiroglu Melike
- Endo Akifumi
- Enninga Jost
- Enouf Vincent
- Enouf Vincent
- Epaulard Olivier
- Erdeniz Emine Hafize
- Erikstrup Christian
- Erikstrup Christian
- Esperou HĂ©lĂšne
- Espinosa-Padilla Sara
- Esposito-Farase Marina
- Espérou HélÚne
- Etienne Manuel
- Eto Shohei
- Euvrard Romain
- Fabio Giovanna
- Faivre Laurence
- Falck Antonin
- Fallon Aoife
- Fartoukh Muriel
- Faure Morgane
- Fekkar Arnaud
- Feldman Hagit Baris
- Feldman Hagit Baris
- Fellay Jacques
- Fellay Jacques
- Fellay Jacques
- Ferrer Ricard
- Ferreres Jose
- Fievet Nathalie
- Flaig Amandine
- Fleuren Lucas
- Flores Carlos
- Flores Carlos
- Florkin Benoit
- Fontes Magnus
- Foti Giuseppe
- Fouchard Julie
- Franco José Luis
- Franco José Luis
- Francois Bruno
- Frezouls Wahiba
- Froidure Antoine
- FumadĂł Victoria
- Fung Kitty
- Fusco Francesca
- Gagneux-Brunon Amandine
- Gagro Alenka
- Gallian Pierre
- Garcia-Prat Marina
- GarcĂa Paula Andrea Gaviria
- Garot Denis
- Garçon Pierre
- Gatineau Audrey Giraud
- Gaudet Alexandre
- Gault Nathalie
- Gaussem Pascale
- Gaymard Alexandre
- Gayretli Zeynep
- Geerlings Suzanne
- Geijtenbeek Theo
- Gentile Stéphanie
- Gervais Adrian
- Ghirardello Stefano
- Ghosn Jade
- Gigante Tristan
- Gil-Herrera Juana
- Gilardin Laurent
- Gilardin Laurent
- Gilg Morgane
- Girbes Armand
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- Stilma Willemke
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- Su Helen
- Su Helen
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- SĂĄnchez-RamĂłn Silvia
- SĂ€rekannu Karita
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- SĂžrensen Erik
- Taccone Fabio
- Talouarn Estelle
- Tanaka Junko
- Tancevski Ivan
- Tancevski Ivan
- Tandjaoui-Lambiotte Yacine
- Tandjaoui-Lambiotte Yacine
- Tangy Frédéric
- Tangye Stuart
- Tangye Stuart
- Tardivon Coralie
- Tardy Bernard
- Taupin Jean-Luc
- Tavernier Simon
- Tayoun Ahmad Abou
- Tellier Marie-Capucine
- Terrier Benjamin
- Terrier Olivier
- Teunissen Charlotte
- Tharaux Pierre-Louis
- Thibault Chloé
- Thiery Guillaume
- Thoral Patrick
- Thorball Christian
- Thorn Karolina
- Thumerelle Caroline
- Thy Michael
- Tiberghien Pierre
- Tiberghien Pierre
- Timsit Jean-François
- Tipu Imran
- Tolstrup Martin
- Tolstrup Martin
- Tomasoni Gabriele
- Toubert Antoine
- Toubiana Julie
- Touvier Mathilde
- Townsend Liam
- Triantafyllia Vasiliki
- Trouillet-Assant Sophie
- Trouillet-Assant Sophie
- Troya JesĂșs
- Troya JesĂșs
- Tsang Owen
- Tserel Liina
- Tso Eugene
- Tsonas Anissa
- Tsumura Miyuki
- Tual Christelle
- Tubiana Sarah
- Tubiana Sarah
- Tucci Alessandra
- Tuinman Pieter
- Turvey Stuart
- Tzourio Christophe
- Téoulé François
- Uddin K.
- Uddin Mohammed
- Ungeheuer Marie-Noëlle
- Ursini Matilde Valeria
- Utsumi Takanori
- Uzunhan Yurdagul
- Vabres Pierre
- Valencia-Ramos Juan
- Valsecchi Maria Grazia
- van Agtmael Michiel
- van Baarle Frank
- van Braeckel Eva
- van de Beek Diederik
- van de Beek Diederik
- van de Beek Diederik
- van den Rym Ana Maria
- van der Poll Tom
- van der Valk Marc
- van der Werf Sylvie
- van der Werf Sylvie
- van Mourik Niels
- van Praet Jens
- van Vugt MichĂšle
- Vanderlinden Dimitri
- Vandernoot Isabelle
- Vanel Noémie
- Vasse Marc
- Veelo Denise
- Veislinger Aurélie
- Velez-Santamaria Valentina
- Veliz Silvia Patricia Zuniga
- Venet Fabienne
- Vergara José Alejandro Daza
- Vidaur Loreto
- Vidaur Loreto
- Vidigal Mateus
- Vidigal Mateus
- Viel SĂ©bastien
- Vignali Valérie
- Vilaire-Meunier Marie
- Villain CĂ©dric
- Villar-GarcĂa Judit
- Vincent Audrey
- Vinh Donald
- Vinh Donald
- Visseaux Benoit
- Visseaux Benoit
- Vlaar Alexander
- Vogt Guillaume
- Voiriot Guillaume
- Volleman Carolien
- Volokha Alla
- von Bernuth Horst
- von Stemann Jakob Hjorth
- Vught Lonneke
- Vuotto Fanny
- VĂ©lez VerĂłnica Posada
- Waucquier Nawal
- Wauters Els
- Wauters Joost
- Wauters Joost
- Wauters Joost
- Wiedemann Aurélie
- Wiersinga W. Joost
- Wouters Dorien
- Wu Alan
- Wu Tak-Chiu
- YahĆi Aysun
- Yang Rui
- Yasar Kadriye Kart
- Yazdanpanah Yazdan
- Yazdanpanah Yazdan
- Yepes Jairo David Torres
- Yesilbas Osman
- Yildiz Mehmet
- Young Barnaby
- YĂŒkselmiĆ Ufuk
- Zatz Mayana
- Zatz Mayana
- Zatz Mayana
- Zawadzki Pawel
- Zhang Peng
- Zhang Qian
- Zhang Shen-Ying
- Zhang Yu
- Zimmer Christophe
- Zins Marie
- Zins Marie
- Zuccaro Valentina
- Zwinderman A.
- Ăñigo-Campos Antonio
- Ăz Ćadiye KĂŒbra TĂŒter
- Ăzkan Esra AkyĂŒz
- Ăzçelik Tayfun
- Publication venue
- 'Proceedings of the National Academy of Sciences'
- Publication date
- 24/05/2022
- Field of study
International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population
The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies
- Author
- Abad Jorge
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Abel Laurent
- Accordino Giulia
- Achille Cristian
- Acosta-Ampudia Yeny
- Agra Juan José Cåceres
- Aguilera-Albesa Sergio
- AguilĂł-Cucurull Aina
- Aiuti Alessandro
- Aiuti Alessandro
- Aiuti Alessandro
- Akcan Ăzge Metin
- Al-Muhsen Saleh
- Al-Mulla Fahd
- Alavoine Loubna
- Albert Matthew
- Albisures Jonathan Antonio Roblero
- Alcover Andres
- Aldave Juan
- Algera Anne Geke
- Aliberti Anna
- Alkan Gulsum
- Alkhater Suzan
- Alkhater Suzan
- Allardet-Servent Jerome
- Allavena Clotilde
- Allende Luis
- Alonso-Arias Rebeca
- Alshahrani Mohammed
- Alsina Laia
- Alvarez Josep Trenado
- Alyanakian Marie-Alexandra
- Amador-Borrero Blanca
- Amat Karine
- Amoura Zahir
- Anaya Juan-Manuel
- Anderson Mark
- Anderson Mark
- Andreakos Evangelos
- Andreakos Evangelos
- Andrejak Claire
- Andrés Ana De
- Anglicheau Dany
- Angoulvant François
- Annereau Jean-Philippe
- AntolĂ Arnau
- Appelman Brent
- Arias Andrés
- Arias Andrés Augusto
- Arkin Lisa
- Arquero Miguel Fernandez
- Arranz MarĂa JesĂșs
- Arrestier Romain
- Arrestier Romain
- Asano Takaki
- Aschard Hugues
- Aubart MĂ©lodie
- Auguet Teresa
- Avramenko Iryna
- Aytekin Gökhan
- Aytekin Selma Erol
- Azot Axelle
- Azoulay Cecile
- Bachelet Delphine
- Bahram Seiamak
- Bajolle Fanny
- Baldanti Fausto
- Baldolli Aurélie
- Ballester Maite
- Baris-Feldman Hagit
- Barreiros Lucila
- Barrou Benoit
- Bartoli Marie
- Barzaghi Federica
- Basmaci Romain
- Basso Sabrina
- Bastard Paul
- Batten Isabella
- Bauters Fré
- Bax Diane
- Bayhan Gulsum Iclal
- Behillil Sylvie
- Behillill Sylvie
- Bellani Giacomo
- Belot Alexandre
- Belot Alexandre
- Belot Alexandre
- Beluze Marine
- Benech Nicolas
- Benkerrou Dehbia
- Beretta Ilaria
- Bergin Colm
- Bertholon Frédérique
- Bettini Laura Rachele
- Beudel Martijn
- Bezrodnik Liliana
- Bhavsar Krishna
- Biggs Catherine
- Biggs Catherine
- Bilbao Agurtzane
- Bilguvar Kaya
- Biondi Andrea
- Bitker Laurent
- Bizien Lucy
- Blanchard-Rohner Geraldine
- Blanco Ignacio
- BlandiniĂšres Adeline
- Bleibtreu Alexandre
- Bloomfield Marketa
- BlĂĄzquez-Gamero Daniel
- Bogaard Harm Jan
- Bogunovic Dusan
- Boisson Bertrand
- Bolivar-Prados Mireia
- Bolze Alexandre
- Bomers Marije
- Bondarenko Anastasiia
- Bondarenko Anastasiia
- Bondarenko Anastasiia
- Bonfanti Paolo
- Bonneaudeau Brigitte
- Bonta Peter
- Borghesi Alessandro
- Borie Raphael
- Borrero Blanca Amador
- Bos Lieuwe
- Bosteels CĂ©dric
- Botdhlo-Nevers Elisabeth
- Botelho-Nevers Elisabeth
- Botta Michela
- Bouadma Lila
- Bouadma Lila
- Boucherit Soraya
- Boudhabhay Idris
- Bouiller KĂ©vin
- Boulanger CĂ©cile
- Bourgeois Fleur Le
- Bourgeon Marilou
- Bourke Nollaig
- Bourke Nollaig
- Bourke Nollaig
- Bouscambert-Duchamp Maude
- Bousfiha Ahmed
- Bousfiha Ahmed
- Bousfiha Ahmed
- Bousquet Aurore
- Bousso Philippe
- Boutolleau David
- Bouvattier Claire
- Boyarchuk Oksana
- Boyarchuk Oksana
- Bozdemir Ćefika Elmas
- Bravais Juliette
- Briones M. Luisa
- Briseño-Roa Luis
- Brodin Petter
- Brodin Petter
- Brouwer Matthijs
- Bruhns Pierre
- Bruneau LĂ©a
- Brunner Marie-Eve
- Bruno Raffaele
- Bryceson Yenan
- Bueno Maria Rita P.
- Bugiani Marianna
- Buis David
- Bukhari Huda
- Bulle Esther
- Burdet Charles
- Burdet Charles
- Burrel Sonia
- Bustamante Carlos
- Bustamante Jacinta
- Butte Manish
- BĂ©ziat Vivien
- Cannet Dorothée
- Capra Ruggero
- Carapito Raphael
- Carrabba Maria
- Carrillo Jorge
- Casanova Jean-Laurent
- Casanova Jean-Laurent
- Casari Giorgio
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- Zatz Mayana
- Zawadzki Pawel
- Zhang Peng
- Zhang Qian
- Zhang Shen-Ying
- Zhang Yu
- Zimmer Christophe
- Zins Marie
- Zins Marie
- Zuccaro Valentina
- Zwinderman A.
- Ăñigo-Campos Antonio
- Ăz Ćadiye KĂŒbra TĂŒter
- Ăzkan Esra AkyĂŒz
- Ăzçelik Tayfun
- Publication venue
- 'Proceedings of the National Academy of Sciences'
- Publication date
- 24/05/2022
- Field of study
International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population