Collection of edible wild fruits in Eastern Region of Ghana

Edible wild fruits were collected in the Eastern Region of Ghana. Interviews and group discussions were the methods used to know the locations and subsequent collecting of the fruits. Twelve accessions of fruits were collected of which most were from trees. Cash crop (cocoa) farms were the habitats for most fruit trees in the region. Chrysophyllum albidum and some trees were deliberately planted in farms for income and sale. Some fruit trees were being domesticated.La collection des fruits sauvages comestibles était entreprise dans la région de l'Est du Ghana. Les entrevues et les discussions en groupe étaient les méthodes adoptées pour connaître les emplacements et par la suite, la collecte des fruits. Douze accessions des fruits étaient ramassées dont la plupart étaient cueillies des arbres. Les champs de culture commerciale (cacao) étaient les habitats pour la plus grandes parties des arbres fruitiers dans la région. Chrysophyllum albidum et quelques arbres étaient délibérément plantés aux champs pour le revenu et le commerce. Certains des arbres fruitiers étaient en train d'être domestiqués. Ghana Journal of Agricultural Science Vol. 40 (2) 2008: pp. 165-16

Numerical simulation of an air-core vortex at a hydraulic intake using OpenFOAM

A vortex is a ubiquitous everyday phenomenon that is observed in nature and it is formed due to the rotational motion of fluid around an axis perpendicular to the free surface. Free surface vortices are a common unwanted occurrence at hydraulic intakes which can cause serious detrimental impacts on mechanical devices such as turbines and pumps. In this paper, an experimentally observed air-core vortex is numerically simulated using the OpenFOAM LTSInterFoam solver. The LTSInterFoam solver has hitherto been mainly used for hydrodynamic studies relating to ship manoeuvrability by researchers. This solver uses a local time stepping approach to speed up convergence towards steady state conditions thus overcoming some of the challenges associated with the use of the conventional interFoam solver for the simulation of free surface vortices. The Shear Stress Transport (SST) k−ω Model was used for the simulation. There was generally good agreement when results from the study were compared with other vortex-related analytical models and experimental data. Overall, the study concludes that the OpenFOAM LTSInterFoam solver is capable of simulating free surface vortices at hydraulic intakes. However, being a steady state solver, the solver cannot account for the transient process involved in the evolution of free surface vortices

Free surface vortices at hydropower intakes: – A state-of-the-art review

This is the final version. Available on open access from Elsevier via the DOI in this recordFor years, the study of free surface vortices at hydropower plant intakes has been a topical and intriguing subject among engineers and researchers. This subject will continue to attract attention especially as the world strives to meet the ever-increasing demand for energy. Despite the numerous benefits associated with hydropower, the sustainability of some hydropower plants is being threatened due to low inflows often associated with climate change. Free surface vortices associated with low water levels or submergence at plant intakes can have very detrimental consequences on the operation of hydropower plants if not addressed. Notwithstanding this, free surface vortex flows have also been found to be very relevant in emerging technologies such as the water vortex hydropower plant system. This paper, therefore, presents a state-of-the-art review of the subject including summarised historical findings, but with an emphasis on current developments, findings and research gaps to guide practitioners and researchers. In response to the research gaps identified, the authors make a number of recommendations for further studies which include establishing relationships between free surface vortices formation and turbine efficiency, development of more accurate models for critical submergence and free surface vortices, assessment of free surface vortices at multiple and multi-level intakes, establishing the relationship between free surface vortices and sediment transport at intakes, application of Computational Fluid Dynamics (CFD) shape optimization tools for intake and anti-vortex device optimisation, as well as the continuing development of CFD tools to simulate air-entrained vortices at hydropower intakes

Wound dressings for a proteolytic-rich environment

Wound dressings have experienced continuous and significant changes over the years based on the knowledge of the biochemical events associated with chronic wounds. The development goes from natural materials used to just cover and conceal the wound to interactive materials that can facilitate the healing process, addressing specific issues in non-healing wounds. These new types of dressings often relate with the proteolytic wound environment and the bacteria load to enhance the healing. Recently, the wound dressing research is focusing on the replacement of synthetic polymers by natural protein materials to delivery bioactive agents to the wounds. This article provides an overview on the novel protein-based wound dressings such as silk fibroin keratin and elastin. The improved properties of these dressings, like the release of antibiotics and growth factors, are discussed. The different types of wounds and the effective parameters of healing process will be reviewed

Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy

Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe

Global variation in anastomosis and end colostomy formation following left-sided colorectal resection

Background End colostomy rates following colorectal resection vary across institutions in high-income settings, being influenced by patient, disease, surgeon and system factors. This study aimed to assess global variation in end colostomy rates after left-sided colorectal resection. Methods This study comprised an analysis of GlobalSurg-1 and -2 international, prospective, observational cohort studies (2014, 2016), including consecutive adult patients undergoing elective or emergency left-sided colorectal resection within discrete 2-week windows. Countries were grouped into high-, middle- and low-income tertiles according to the United Nations Human Development Index (HDI). Factors associated with colostomy formation versus primary anastomosis were explored using a multilevel, multivariable logistic regression model. Results In total, 1635 patients from 242 hospitals in 57 countries undergoing left-sided colorectal resection were included: 113 (6·9 per cent) from low-HDI, 254 (15·5 per cent) from middle-HDI and 1268 (77·6 per cent) from high-HDI countries. There was a higher proportion of patients with perforated disease (57·5, 40·9 and 35·4 per cent; P < 0·001) and subsequent use of end colostomy (52·2, 24·8 and 18·9 per cent; P < 0·001) in low- compared with middle- and high-HDI settings. The association with colostomy use in low-HDI settings persisted (odds ratio (OR) 3·20, 95 per cent c.i. 1·35 to 7·57; P = 0·008) after risk adjustment for malignant disease (OR 2·34, 1·65 to 3·32; P < 0·001), emergency surgery (OR 4·08, 2·73 to 6·10; P < 0·001), time to operation at least 48 h (OR 1·99, 1·28 to 3·09; P = 0·002) and disease perforation (OR 4·00, 2·81 to 5·69; P < 0·001). Conclusion Global differences existed in the proportion of patients receiving end stomas after left-sided colorectal resection based on income, which went beyond case mix alone

Evaluation of appendicitis risk prediction models in adults with suspected appendicitis

Background Appendicitis is the most common general surgical emergency worldwide, but its diagnosis remains challenging. The aim of this study was to determine whether existing risk prediction models can reliably identify patients presenting to hospital in the UK with acute right iliac fossa (RIF) pain who are at low risk of appendicitis. Methods A systematic search was completed to identify all existing appendicitis risk prediction models. Models were validated using UK data from an international prospective cohort study that captured consecutive patients aged 16–45 years presenting to hospital with acute RIF in March to June 2017. The main outcome was best achievable model specificity (proportion of patients who did not have appendicitis correctly classified as low risk) whilst maintaining a failure rate below 5 per cent (proportion of patients identified as low risk who actually had appendicitis). Results Some 5345 patients across 154 UK hospitals were identified, of which two‐thirds (3613 of 5345, 67·6 per cent) were women. Women were more than twice as likely to undergo surgery with removal of a histologically normal appendix (272 of 964, 28·2 per cent) than men (120 of 993, 12·1 per cent) (relative risk 2·33, 95 per cent c.i. 1·92 to 2·84; P < 0·001). Of 15 validated risk prediction models, the Adult Appendicitis Score performed best (cut‐off score 8 or less, specificity 63·1 per cent, failure rate 3·7 per cent). The Appendicitis Inflammatory Response Score performed best for men (cut‐off score 2 or less, specificity 24·7 per cent, failure rate 2·4 per cent). Conclusion Women in the UK had a disproportionate risk of admission without surgical intervention and had high rates of normal appendicectomy. Risk prediction models to support shared decision‐making by identifying adults in the UK at low risk of appendicitis were identified

Evaluation of alternative in vivo drug screening methodology: A single mouse analysis

Traditional approaches to evaluating antitumor agents using human tumor xenograft models have generally used cohorts of 8 to 10 mice against a limited panel of tumor models. An alternative approach is to use fewer animals per tumor line, allowing a greater number of models that capture greater molecular/genetic heterogeneity of the cancer type. We retrospectively analyzed 67 agents evaluated by the Pediatric Preclinical Testing Program to determine whether a single mouse, chosen randomly from each group of a study, predicted the median response for groups of mice using 83 xenograft models. The individual tumor response from a randomly chosen mouse was compared with the group median response using established response criteria. A total of 2,134 comparisons were made. The single tumor response accurately predicted the group median response in 1,604 comparisons (75.16%). The mean tumor response correct prediction rate for 1,000 single mouse random samples was 78.09%. Models had a range for correct prediction (60%-87.5%). Allowing for misprediction of ± one response category, the overall mean correct single mouse prediction rate was 95.28%, and predicted overall objective response rates for group data in 66 of 67 drug studies. For molecularly targeted agents, occasional exceptional responder models were identified and the activity of that agent confirmed in additional models with the same genotype. Assuming that large treatment effects are targeted, this alternate experimental design has similar predictive value as traditional approaches, allowing for far greater numbers of models to be used that more fully encompass the heterogeneity of disease types