28 research outputs found
âA good little tool to get to know yourself a bit betterâ: a qualitative study on usersâ experiences of app-supported menstrual tracking in Europe
Background: Menstrual apps facilitate observation and analysis of menstrual cycles and associated factors through
the collection and interpretation of data entered by users. As a subgroup of health-related apps, menstrual apps
form part of one of the most dynamic and rapidly growing developments in biomedicine and health care.
However, despite their popularity, qualitative research on how people engaging in period-tracking use and
experience these apps remains scarce. Results: An inductive content analysis was performed and eight characteristics of app-supported menstrual
tracking were identified: 1) tracking menstrual cycle dates and regularities, 2) preparing for upcoming periods, 3)
getting to know menstrual cycles and bodies, 4) verifying menstrual experiences and sensations, 5) informing
healthcare professionals, 6) tracking health, 7) contraception and seeking pregnancy, and 8) changes in tracking.
Our study finds that period-tracking via apps has the potential to be an empowering practice as it helps users to be
more aware of their menstrual cycles and health and to gain new knowledge. However, we also show that
menstrual tracking can have negative consequences as it leads to distress in some cases, to privacy issues, and the
work it requires can result in cessation. Finally, we present practical implications for healthcare providers and app
developers.
Conclusions: This qualitative study gives insight into usersâ practices and experiences of app-supported menstrual
tracking. The results provide information for researchers, health care providers and app designers about the
implications of app-supported period-tracking and describe opportunities for patient-doctor interactions as well as
for further development of menstrual apps.This research has received funding from the European Unionâs Horizon 2020
research and innovation program under the Marie SkĆodowska-Curie grant
agreement No 675378
HIV Aspartyl Peptidase Inhibitors Interfere with Cellular Proliferation, Ultrastructure and Macrophage Infection of Leishmania amazonensis
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Previous issue date: 2009Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. LaboratĂłrio de Biologia Molecular e Doenças EndĂȘmicas. Rio de Janeiro, RJ. Brasil.Universidade Federal do Rio de Janeiro. Centro de CiĂȘncias da SaĂșde. Instituto de Microbiologia Prof. Paulo de GĂłes. Departamento de Microbiologia Geral,. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. LaboratĂłrio de Biologia Molecular e Doenças EndĂȘmicas. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. LaboratĂłrio de Biologia Molecular e Doenças EndĂȘmicas. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. LaboratĂłrio de Biologia Molecular e Doenças EndĂȘmicas. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. LaboratĂłrio de Biologia Molecular e Doenças EndĂȘmicas. Rio de Janeiro, RJ. Brasil.Universidade Federal do Rio de Janeiro. Centro de CiĂȘncias da SaĂșde. Instituto de BiofĂsica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Centro de CiĂȘncias da SaĂșde. Instituto de Microbiologia Prof. Paulo de GĂłes. Departamento de Microbiologia Geral,. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Centro de CiĂȘncias da SaĂșde. Instituto de Microbiologia Prof. Paulo de GĂłes. Departamento de Microbiologia Geral,. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. LaboratĂłrio de Biologia Molecular e Doenças EndĂȘmicas. Rio de Janeiro, RJ. Brasil.Leishmania is the etiologic agent of leishmanisais, a protozoan disease whose pathogenic events are not well understood. Current therapy is suboptimal due to toxicity of the available therapeutic agents and the emergence of drug resistance. Compounding these problems is the increase in the number of cases of Leishmania-HIV coinfection, due to the overlap between the AIDS epidemic and leishmaniasis
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Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease.
International audienceRecently, several genome wide association studies (GWAS) have led to the discovery of 9 new loci of genetic susceptibility in Alzheimer's disease (AD). However, the landscape of the AD genetic susceptibility is far away to be complete and in addition to single-SNP analyses as performed in conventional GWAS, complementary strategies need to be applied to overcome limitations inherent to this type of approaches.. We performed a genome wide haplotype association (GWHA) study in the EADI1 study (n=2,025 AD cases and 5,328 controls) by applying a sliding-windows approach. After exclusion of loci already known to be involved in AD (APOE, BIN1 and CR1), 91 regions with suggestive haplotype effects were identified. In a second step, we attempted to replicate the best suggestive haplotype associations in the GERAD1 consortium (2,820 AD cases and 6,356 controls) and observed that 9 of them showed nominal association. In a third step, we tested relevant haplotype associations in a combined analysis of five additional case-control studies (5,093 AD cases and 4,061 controls). We consistently replicated the association of a haplotype within FRMD4A on Chr.10p13 in all the data set analysed (OR=1.68, 95% CI 1.43- 1.96; p=1.1x10-10). We finally searched for association between SNPs within the FRMD4A locus and Ab plasma concentrations in three independent non demented populations (n=2,579). We reported that polymorphisms were associated with plasma Ab42/Ab40 ratio (best signal, p=5.4x10-7). In conclusion, combining both GWHA study and a conservative three-stage replication approach, we characterised FRMD4A as a new genetic risk factor of AD
Understanding 'non-genetic' inheritance : insights from molecular-evolutionary crosstalk
The idea for this paper was initially proposed by I.A.-K. and was further developed by all authors in a workshop generously funded by grant No 789240 from the European Research Council (ERC) to F.J.W. S.E.S. acknowledges support from Wesleyan University and The John Templeton Foundation.Understanding the evolutionary and ecological roles of 'non-genetic' inheritance (NGI) is daunting due to the complexity and diversity of epigenetic mechanisms. We draw on insights from molecular and evolutionary biology perspectives to identify three general features of 'non-genetic' inheritance systems: (i) they are functionally interdependent with, rather than separate from, DNA sequence; (ii) precise mechanisms vary phylogenetically and operationally; and (iii) epigenetic elements are probabilistic, interactive regulatory factors and not deterministic 'epialleles' with defined genomic locations and effects. We discuss each of these features and offer recommendations for future empirical and theoretical research that implements a unifying inherited gene regulation (IGR) approach to studies of 'non-genetic' inheritance.Publisher PDFPeer reviewe
Pyrite depression by dextrin in flotation with xanthates. Adsorption and floatability studies
Depression of pyrite by dextrin in flotation with xanthates has been studied. The adsorption of dextrin and xanthates at the pyrite/aqueous solution interface has been investigated through electrokinetics, Raman spectroscopy and batch adsorption studies using oxidized pyrite. Microflotation studies were undertaken to evaluate the pyrite depression with dextrin using ethyl and propyl xanthates as the collector. The surface density of ferric hydroxide on pyrite depended on pH and was highest about the iep (pH 7.5) of the oxidized pyrite. Dextrin adsorption was directly related to the surface density of ferric hydroxide and took place through two steps suggesting two adsorption mechanisms on ferric hydroxide. Xanthate adsorption as dixanthogen occurred along with ferric hydroxide dissolution causing partial dextrin desorption from the pyrite surface; consequently, co-adsorption of xanthate and dextrin occurred on the surface. Depression of pyrite flotation with xanthate was determined by the oxidation level of the pyrite surface. Floatability of pyrite with xanthate was highly impaired by dextrin at pH 8 only when the surface density of ferric hydroxide on the pyrite surface was very high
Results of a survey on peri-operative nutritional support in pancreatic and biliary surgery in Spain
Disruption of Interleukin-1ÎČ Autocrine Signaling Rescues Complex I Activity and Improves ROS Levels in Immortalized Epithelial Cells with Impaired Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Function
TOCILIZUMAB IN LARGE-VESSEL GIANT CELL ARTERITIS AND TAKAYASU ARTERITIS: MULTICENTRIC OBSERVATIONAL COMPARATIVE STUDY
The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: A meta-analysis study
The only established genetic determinant of non-Mendelian forms of Alzheimer's disease (AD) is the Δ4 allele of the apolipoprotein E gene (APOE). Recently, it has been reported that the P86L polymorphism of the calcium homeostasis modulator 1 gene (CALHM1) is associated with the risk of developing AD. In order to independently assess this association, we performed a meta-analysis of 7,873 AD cases and 13,274 controls of Caucasian origin (from a total of 24 centers in Belgium, Finland, France, Italy, Spain, Sweden, the UK, and the USA). Our results indicate that the CALHM1 P86L polymorphism is likely not a genetic determinant of AD but may modulate age of onset by interacting with the effect of the Δ4 allele of the APOE gene