388 research outputs found

    Die historische Entwicklung der Sterblichkeit in Mecklenburg-Schwerin im 19. Jahrhundert

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    "Embedded in the Rostock research group of historical demography 'A History of Aging Societies', the authors examined the demographic transition of Mecklenburg in the 19th century. On the basis of statistical population data from the Tate 18th up to the early 20th century, which survived in the form of statistics manuals and census listings, the increase of life expectancy and mortality decline was analysed for the Grand Duchy of Mecklenburg-Schwerin. In an optimization procedure the mortality conditions were calculated with the 'Generalised Inverse Projection' (GIP), a mathematic and statistic method using the historical birth, death and population totals. The results gained from the study allowed an integration of this north German province into the European context and was used for the comparison with its Scandinavian neighbours Denmark and Sweden, which were the forerunner countries of historical mortality decline. The study showed that 19th century Mecklenburg rather followed the Scandinavian scheme of low mortality, in contrast to other German regions. Little correlation exists between the favourable historical development of mortality in Mecklenburg-Schwerin and the relatively high mortality rates in today's Mecklenburg-Western Pomerania." (author's abstract

    Onecut-dependent Nkx6.2 transcription factor expression is required for proper formation and activity of spinal locomotor circuits.

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    In the developing spinal cord, Onecut transcription factors control the diversification of motor neurons into distinct neuronal subsets by ensuring the maintenance of Isl1 expression during differentiation. However, other genes downstream of the Onecut proteins and involved in motor neuron diversification have remained unidentified. In the present study, we generated conditional mutant embryos carrying specific inactivation of Onecut genes in the developing motor neurons, performed RNA-sequencing to identify factors downstream of Onecut proteins in this neuron population, and employed additional transgenic mouse models to assess the role of one specific Onecut-downstream target, the transcription factor Nkx6.2. Nkx6.2 expression was up-regulated in Onecut-deficient motor neurons, but strongly downregulated in Onecut-deficient V2a interneurons, indicating an opposite regulation of Nkx6.2 by Onecut factors in distinct spinal neuron populations. Nkx6.2-null embryos, neonates and adult mice exhibited alterations of locomotor pattern and spinal locomotor network activity, likely resulting from defective survival of a subset of limb-innervating motor neurons and abnormal migration of V2a interneurons. Taken together, our results indicate that Nkx6.2 regulates the development of spinal neuronal populations and the formation of the spinal locomotor circuits downstream of the Onecut transcription factors

    Indoor location based services challenges, requirements and usability of current solutions

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    Indoor Location Based Services (LBS), such as indoor navigation and tracking, still have to deal with both technical and non-technical challenges. For this reason, they have not yet found a prominent position in people’s everyday lives. Reliability and availability of indoor positioning technologies, the availability of up-to-date indoor maps, and privacy concerns associated with location data are some of the biggest challenges to their development. If these challenges were solved, or at least minimized, there would be more penetration into the user market. This paper studies the requirements of LBS applications, through a survey conducted by the authors, identifies the current challenges of indoor LBS, and reviews the available solutions that address the most important challenge, that of providing seamless indoor/outdoor positioning. The paper also looks at the potential of emerging solutions and the technologies that may help to handle this challenge

    Violence today

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    Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45468/1/11089_2005_Article_BF01768523.pd

    Singing the same tune? International continuities and discontinuities in how police talk about using force

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    This article focuses on a research project conducted in six jurisdictions: England, The Netherlands, Germany, Australia, Venezuela, and Brazil. These societies are very different ethnically, socially, politically, economically, historically and have wildly different levels of crime. Their policing arrangements also differ significantly: how they are organised; how their officers are equipped and trained; what routine operating procedures they employ; whether they are armed; and much else besides. Most relevant for this research, they represent policing systems with wildly different levels of police shootings, Police in the two Latin American countries represented here have a justified reputation for the frequency with which they shoot people, whereas at the other extreme the police in England do not routinely carry firearms and rarely shoot anyone. To probe whether these differences are reflected in the way that officers talk about the use of force, police officers in these different jurisdictions were invited to discuss in focus groups a scenario in which police are thwarted in their attempt to arrest two youths (one of whom is a known local criminal) by the youths driving off with the police in pursuit, and concludes with the youths crashing their car and escaping in apparent possession of a gun, It might be expected that focus groups would prove starkly different, and indeed they were, but not in the way that might be expected. There was little difference in affirmation of normative and legal standards regarding the use of force. It was in how officers in different jurisdictions envisaged the circumstances in which the scenario took place that led Latin American officers to anticipate that they would shoot the suspects, whereas officers in the other jurisdictions had little expectation that they would open fire in the conditions as they imagined them to be

    A Literature Survey and Classifications on Data Deanonymisation

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    The problem of disclosing private anonymous data has become increasingly serious particularly with the possibility of carrying out deanonymisation attacks on publishing data. The related work available in the literature is inadequate in terms of the number of techniques analysed, and is limited to certain contexts such as Online Social Networks. We survey a large number of state-of-the-art techniques of deanonymisation achieved in various methods and on different types of data. Our aim is to build a comprehensive understanding about the problem. For this survey, we propose a framework to guide a thorough analysis and classifications. We are interested in classifying deanonymisation approaches based on type and source of auxiliary information and on the structure of target datasets. Moreover, potential attacks, threats and some suggested assistive techniques are identified. This can inform the research in gaining an understanding of the deanonymisation problem and assist in the advancement of privacy protection
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