2,098 research outputs found
Freezing and large time scales induced by geometrical frustration
We investigate the properties of an effective Hamiltonian with competing
interactions involving spin and chirality variables, relevant for the
description of the {\it trimerized} version of the spin-1/2 {\it kagome}
antiferromagnet. Using classical Monte Carlo simulations, we show that
remarkable behaviors develop at very low temperatures. Through an {\it order by
disorder} mechanism, the low-energy states are characterized by a dynamical
freezing of the chiralities, which decouples the lattice into ``dimers'' and
``triangles'' of antiferromagnetically coupled spins. Under the presence of an
external magnetic field, the particular topology of the chiralities induces a
very slow spin dynamics, reminiscent of what happens in ordinary spin glasses.Comment: 12 pages, 13 figure
In silico ischaemia-induced reentry at the Purkinjeventricle interface
This computational modelling work illustrates the influence of hyperkalaemia and electrical uncoupling induced by defined ischaemia on action potential (AP) propagation and the incidence of reentry at the Purkinjeventricle interface in mammalian hearts.
Unidimensional and bidimensional models of the Purkinjeventricle subsystem, including ischaemic conditions (defined as phase 1B) in the ventricle and an ischaemic border zone, were developed by altering several important electrophysiological parameters of the LuoRudy AP model of the ventricular myocyte. Purkinje electrical activity was modelled using the equations of DiFrancesco and Noble. Our study suggests that an extracellular potassium concentration [K](o) 14 mM and a slight decrease in intercellular coupling induced by ischaemia in ventricle can cause conduction block from Purkinje to ventricle. Under these conditions, propagation from ventricle to Purkinje is possible. Thus, unidirectional block (UDB) and reentry can result. When conditions of UDB are met, retrograde propagation with a long delay (320 ms) may re-excite Purkinje cells, and give rise to a reentrant pathway. This induced reentry may be the origin of arrhythmias observed in phase 1B ischaemia.
In a defined setting of ischaemia (phase 1B), a small amount of uncoupling between ventricular cells, as well as between Purkinje and ventricular tissue, may induce UDBs and reentry. Hyperkalaemia is also confirmed to be an important factor in the genesis of reentrant rhythms, since it regulates the range of coupling in which UDBs may be induced.This work was supported: (i) by the European Commission preDiCT grant (DG-INFSO-224381), (ii) by the 'VI Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica' from the Ministerio de Economia y Competitividad of Spain (grant number TIN2012-37546-C03-01) and the European Commission (European Regional Development Funds - ERDF - FEDER), and (iii) by the Programa de Apoyo a la Investigacioon y Desarrollo (PAID-06-11-2002) de la Universidad Politecnica de Valencia, Programa Prometeo (PROMETEO/2012/030) de la Conselleria d'Educacio Formacio I Ocupacio, Generalitat Valenciana, and (iv) Direccion General de Politica Cientifica de la Generalitat Valenciana (GV/2013/119).Esteban Ramírez, J.; Saiz Rodríguez, FJ.; Romero Pérez, L.; Ferrero De Loma-Osorio, JM.; Trénor Gomis, BA. (2014). In silico ischaemia-induced reentry at the Purkinjeventricle interface. EP-Europace. 16(3):444-451. https://doi.org/10.1093/europace/eut386S44445116
On the consistency of the peculiar GRBs 060218 and 060614 with the Ep,i - Eiso correlation
We analyze and discuss the position of GRB 060218 and GRB 060614 in the Ep,i
- Eiso plane. GRB 060218 is important because of its similarity with GRB
980425, the proto-type event of the GRB-SN connection. While GRB 980425 is an
outlier of the Ep,i - Eiso correlation, we find that GRB 060218 is fully
consistent with it. This evidence, combined with the `chromatic' behavior of
the afterglow light curves, is at odds with the hypothesis that GRB 060218 was
a `standard' GRB seen off-axis and supports the existence of a class of truly
sub--energetic GRBs. GRB 060614 is a peculiar event not accompanied by a bright
Supernova. Based on published spectral information, we find that also this
event is consistent with the Ep,i - Eiso correlation. We discuss the
implications of our results for the rate of sub--energetic GRBs, the GRB/SN
connection and the properties of the newly discovered sub-class of long GRBs
not associated with bright Supernovae. We have included in our analysis other
recent GRBs with clear evidence (or clear no evidence) of associated SNe.Comment: 9 pages, 4 figures, FINAL REVISED VERSION (added Figure 4 and short
GRBs in Figure 1; minor changes and style corrections applied; references
updated), submitted to A&A on November 25, 200
The Optical SN 2012bz Associated with the Long GRB 120422A
The association of Type Ic SNe with long-duration GRBs is well established.
We endeavor, through accurate ground-based observational campaigns, to
characterize these SNe at increasingly high redshifts. We obtained a series of
optical photometric and spectroscopic observations of the Type Ic SN2012bz
associated with the Swift long-duration GRB120422A (z=0.283) using the 3.6-m
TNG and the 8.2-m VLT telescopes. The peak times of the light curves of
SN2012bz in various optical filters differ, with the B-band and i'-band light
curves reaching maximum at ~9 and ~23 rest-frame days, respectively. The
bolometric light curve has been derived from individual bands photometric
measurements, but no correction for the unknown contribution in the
near-infrared (probably around 10-15%) has been applied. Therefore, the present
light curve should be considered as a lower limit to the actual UV-optical-IR
bolometric light curve. This pseudo-bolometric curve reaches its maximum (Mbol
= -18.56 +/- 0.06) at 13 +/- 1 rest-frame days; it is similar in shape and
luminosity to the bolometric light curves of the SNe associated with z<0.2 GRBs
and more luminous than those of SNe associated with XRFs. A comparison with the
model generated for the bolometric light curve of SN2003dh suggests that
SN2012bz produced only about 15% less 56Ni than SN2003dh, about 0.35 Msol.
Similarly the VLT spectra of SN2012bz, after correction for Galactic extinction
and for the contribution of the host galaxy, suggest comparable explosion
parameters with those observed in SN2003dh (EK~3.5 x 10^52 erg, Mej~7 Msol) and
a similar progenitor mass (~25-40 Msol). GRB120422A is consistent with the
Epeak-Eiso and the EX,iso-Egamma,iso-E_peak relations. GRB120422A/SN2012bz
shows the GRB-SN connection at the highest redshift so far accurately monitored
both photometrically and spectroscopically.Comment: 7 pages, 6 figures, 2 tables, accepted for publication in Astronomy &
Astrophysic
Transition from Fireball to Poynting-flux-dominated Outflow in Three-Episode GRB 160625B
The ejecta composition is an open question in gamma-ray bursts (GRB) physics.
Some GRBs possess a quasi-thermal spectral component in the time-resolved
spectral analysis, suggesting a hot fireball origin. Others show a featureless
non-thermal spectrum known as the "Band" function, consistent with a
synchrotron radiation origin and suggesting that the jet is
Poynting-flux-dominated at the central engine and likely in the emission region
as well. There are also bursts showing a sub-dominant thermal component and a
dominant synchrotron component suggesting a likely hybrid jet composition. Here
we report an extraordinarily bright GRB 160625B, simultaneously observed in
gamma-rays and optical wavelengths, whose prompt emission consists of three
isolated episodes separated by long quiescent intervals, with the durations of
each "sub-burst" being 0.8 s, 35 s, and 212 s, respectively. Its high
brightness (with isotropic peak luminosity L
erg/s) allows us to conduct detailed time-resolved spectral analysis in each
episode, from precursor to main burst and to extended emission. The spectral
properties of the first two sub-bursts are distinctly different, allowing us to
observe the transition from thermal to non-thermal radiation between
well-separated emission episodes within a single GRB. Such a transition is a
clear indication of the change of jet composition from a fireball to a
Poynting-flux-dominated jet.Comment: Revised version reflecting the referees' comments. 27 pages, 11
figures, 5 tables. The final edited version will appear in Nature Astronom
An optical supernova associated with the X-ray flash XRF 060218
Long-duration gamma-ray bursts (GRBs) are associated with type Ic supernovae
that are more luminous than average and that eject material at very high
velocities. Less-luminous supernovae were not hitherto known to be associated
with GRBs, and therefore GRB-supernovae were thought to be rare events. Whether
X-ray flashes - analogues of GRBs, but with lower luminosities and fewer
gamma-rays - can also be associated with supernovae, and whether they are
intrinsically 'weak' events or typical GRBs viewed off the axis of the burst,
is unclear. Here we report the optical discovery and follow-up observations of
the type Ic supernova SN 2006aj associated with X-ray flash XRF 060218.
Supernova 2006aj is intrinsically less luminous than the GRB-supernovae, but
more luminous than many supernovae not accompanied by a GRB. The ejecta
velocities derived from our spectra are intermediate between these two groups,
which is consistent with the weakness of both the GRB output and the supernova
radio flux. Our data, combined with radio and X-ray observations, suggest that
XRF 060218 is an intrinsically weak and soft event, rather than a classical GRB
observed off-axis. This extends the GRB-supernova connection to X-ray flashes
and fainter supernovae, implying a common origin. Events such as XRF 060218 are
probably more numerous than GRB-supernovae.Comment: Final published versio
Challenging GRB models through the broadband dataset of GRB060908
Context: Multiwavelength observations of gamma-ray burst prompt and afterglow
emission are a key tool to disentangle the various possible emission processes
and scenarios proposed to interpret the complex gamma-ray burst phenomenology.
Aims: We collected a large dataset on GRB060908 in order to carry out a
comprehensive analysis of the prompt emission as well as the early and late
afterglow. Methods: Data from Swift-BAT, -XRT and -UVOT together with data from
a number of different ground-based optical/NIR and millimeter telescopes
allowed us to follow the afterglow evolution from about a minute from the
high-energy event down to the host galaxy limit. We discuss the physical
parameters required to model these emissions. Results: The prompt emission of
GRB060908 was characterized by two main periods of activity, spaced by a few
seconds of low intensity, with a tight correlation between activity and
spectral hardness. Observations of the afterglow began less than one minute
after the high-energy event, when it was already in a decaying phase, and it
was characterized by a rather flat optical/NIR spectrum which can be
interpreted as due to a hard energy-distribution of the emitting electrons. On
the other hand, the X-ray spectrum of the afterglow could be fit by a rather
soft electron distribution. Conclusions: GRB060908 is a good example of a
gamma-ray burst with a rich multi-wavelength set of observations. The
availability of this dataset, built thanks to the joint efforts of many
different teams, allowed us to carry out stringent tests for various
interpretative scenarios showing that a satisfactorily modeling of this event
is challenging. In the future, similar efforts will enable us to obtain
optical/NIR coverage comparable in quality and quantity to the X-ray data for
more events, therefore opening new avenues to progress gamma-ray burst
research.Comment: A&A, in press. 11 pages, 5 figure
Provider attitudes about childbearing and knowledge of safer conception at two HIV clinics in Malawi
The NORMAN Suspect List Exchange (NORMAN-SLE): facilitating European and worldwide collaboration on suspect screening in high resolution mass spectrometry
Background: The NORMAN Association (https://www.norman-.network.com/) initiated the NORMAN Suspect List Exchange (NORMAN-SLE; https://www.norman-.network.com/nds/SLE/) in 2015, following the NORMAN collaborative trial on non-target screening of environmental water samples by mass spectrometry. Since then, this exchange of information on chemicals that are expected to occur in the environment, along with the accompanying expert knowledge and references, has become a valuable knowledge base for "suspect screening" lists. The NORMAN-SLE now serves as a FAIR (Findable, Accessible, Interoperable, Reusable) chemical information resource worldwide.Results: The NORMAN-SLE contains 99 separate suspect list collections (as of May 2022) from over 70 contributors around the world, totalling over 100,000 unique substances. The substance classes include per- and polyfluoroalkyl substances (PFAS), pharmaceuticals, pesticides, natural toxins, high production volume substances covered under the European REACH regulation (EC: 1272/2008), priority contaminants of emerging concern (CECs) and regulatory lists from NORMAN partners. Several lists focus on transformation products (TPs) and complex features detected in the environment with various levels of provenance and structural information. Each list is available for separate download. The merged, curated collection is also available as the NORMAN Substance Database (NORMAN SusDat). Both the NORMAN-SLE and NORMAN SusDat are integrated within the NORMAN Database System (NDS). The individual NORMAN-SLE lists receive digital object identifiers (DOIs) and traceable versioning via a Zenodo community (https:// zenodo.org/communities/norman-.sle), with a total of > 40,000 unique views, > 50,000 unique downloads and 40 citations (May 2022). NORMAN-SLE content is progressively integrated into large open chemical databases such as PubChem (https://pubchem.ncbi.nlm.nih.gov/) and the US EPA's CompTox Chemicals Dashboard (https://comptox. epa.gov/dashboard/), enabling further access to these lists, along with the additional functionality and calculated properties these resources offer. PubChem has also integrated significant annotation content from the NORMAN-SLE, including a classification browser (https://pubchem.ncbi.nlm.nih.gov/classification/#hid=101).Conclusions: The NORMAN-SLE offers a specialized service for hosting suspect screening lists of relevance for the environmental community in an open, FAIR manner that allows integration with other major chemical resources. These efforts foster the exchange of information between scientists and regulators, supporting the paradigm shift to the "one substance, one assessment" approach. New submissions are welcome via the contacts provided on the NORMAN-SLE website (https://www.norman-.network.com/nds/SLE/)
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
Meeting abstrac
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