1,121 research outputs found
embCAB Sequence Variation Among Ethambutol-Resistant Mycobacterium Tuberculosis Isolates Without embB306 Mutation
Mechanisms of resistance to ethambutol in Mycobacterium tuberculosis remain inadequately described. Although there is mounting evidence that mutations of codon 306 in embB play a key role, a significant number of phenotypically ethambutol-resistant strains do not carry mutations in this codon. Here, other mutations in the embCAB operon are suggested to be involved in resistance development
Scalability of Non-intrusive Load Monitoring for Shipboard Applications
The non-intrusive load monitor has been demonstrated as an effective tool for evaluating and monitoring shipboard electro-mechanical systems through analysis of electrical power data. A key advantage of the non-intrusive approach is the ability to reduce sensor count by monitoring collections of loads. This paper reviews trade-offs that affect the likely performance of the NILM in a real world environment.Massachusetts Institute of Technology. Sea Grant College Program; Grainger Foundation; National Science Foundation (U.S.); United States. National Aeronautics and Space Administration; United States. Coast Guard; United States. Office of Naval Research. Electric Ship Research and Development Consortium; NAVSEA; University of North Carolin
C^2/Z_n Fractional branes and Monodromy
We construct geometric representatives for the C^2/Z_n fractional branes in
terms of branes wrapping certain exceptional cycles of the resolution. In the
process we use large radius and conifold-type monodromies, and also check some
of the orbifold quantum symmetries. We find the explicit Seiberg-duality which
connects our fractional branes to the ones given by the McKay correspondence.
We also comment on the Harvey-Moore BPS algebras.Comment: 34 pages, v1 identical to v2, v3: typos fixed, discussion of
Harvey-Moore BPS algebras update
A self-controlled case series to assess the effectiveness of beta blockers for heart failure in reducing hospitalisations in the elderly
Background: To determine the suitability of using the self-controlled case series design to assess improvements in health outcomes using the effectiveness of beta blockers for heart failure in reducing hospitalisations as the example. Methods: The Australian Government Department of Veterans' Affairs administrative claims database was used to undertake a self-controlled case-series in elderly patients aged 65 years or over to compare the risk of a heart failure hospitalisation during periods of being exposed and unexposed to a beta blocker. Two studies, the first using a one year period and the second using a four year period were undertaken to determine if the estimates varied due to changes in severity of heart failure over time. Results: In the one year period, 3,450 patients and in the four year period, 12, 682 patients had at least one hospitalisation for heart failure. The one year period showed a non-significant decrease in hospitalisations for heart failure 4-8 months after starting beta-blockers, (RR, 0.76; 95% CI (0.57-1.02)) and a significant decrease in the 8-12 months post-initiation of a beta blocker for heart failure (RR, 0.62; 95% CI (0.39, 0.99)). For the four year study there was an increased risk of hospitalisation less than eight months post-initiation and significant but smaller decrease in the 8-12 month window (RR, 0.90; 95% CI (0.82, 0.98)). Conclusions: The results of the one year observation period are similar to those observed in randomised clinical trials indicating that the self-controlled case-series method can be successfully applied to assess health outcomes. However, the result appears sensitive to the study periods used and further research to understand the appropriate applications of this method in pharmacoepidemiology is still required. The results also illustrate the benefits of extending beta blocker utilisation to the older age group of heart failure patients in which their use is common but the evidence is sparse.Emmae N Ramsay, Elizabeth E Roughead, Ben Ewald, Nicole L Pratt and Philip Rya
A search for diffuse bands in the circumstellar envelopes of post-AGB stars
In this work we present the results of a systematic search for diffuse bands
(DBs, hereafter) in the circumstellar envelopes of a carefully selected sample
of post-AGB stars. We concentrated on the analysis of 9 of the DBs most
commonly found in the interstellar medium. The strength of these features is
determined using high resolution optical spectroscopy and the results obtained
are compared with literature data on field stars affected only by interstellar
reddening. Based on the weak features observed in the subsample of post-AGB
stars dominated by circumstellar reddening we conclude that the carrier(s) of
these DBs must not be present in the circumstellar environment of these
sources, or at least not under the excitation conditions in which DBs are
formed. The conclusion is applicable to all the post-AGB stars studied,
irrespective of the dominant chemistry or the spectral type of the star
considered. A detailed radial velocity analysis of the features observed in
individual sources confirms this result, as the Doppler shifts measured are
found to be consistent with an interstellar origin.Comment: Accepted for A&
Kinematic properties of early-type galaxy haloes using planetary nebulae
We present new planetary nebulae (PNe) positions, radial velocities, and
magnitudes for 6 early-type galaxies obtained with the Planetary Nebulae
Spectrograph, their two-dimensional velocity and velocity dispersion fields. We
extend this study to include an additional 10 early-type galaxies with PNe
radial velocity measurements available from the literature, to obtain a broader
description of the outer-halo kinematics in early-type galaxies. These data
extend the information derived from stellar kinematics to typically up to ~8
Re. The combination of photometry, stellar and PNe kinematics shows: i) good
agreement between the PNe number density and the stellar surface brightness in
the region where the two data sets overlap; ii) good agreement between PNe and
stellar kinematics; iii) that the mean rms velocity profiles fall into two
groups: with of the galaxies characterized by slowly decreasing profiles and
the remainder having steeply falling profiles; iv) a larger variety of velocity
dispersion profiles; v) that twists and misalignments in the velocity fields
are more frequent at large radii, including some fast rotators; vi) that outer
haloes are characterised by more complex radial profiles of the specific
angular momentum-related lambda_R parameter than observed within 1Re; vii) that
many objects are more rotationally dominated at large radii than in their
central parts; and viii) that the halo kinematics are correlated with other
galaxy properties, such as total luminosity, isophotal shape, total stellar
mass, V/sigma, and alpha parameter, with a clear separation between fast and
slow rotators.Comment: 36 pages, 21 figures, revised version for MNRA
Modeling the Dust Properties of z ~ 6 Quasars with ART^2 -- All-wavelength Radiative Transfer with Adaptive Refinement Tree
The detection of large quantities of dust in z ~ 6 quasars by infrared and
radio surveys presents puzzles for the formation and evolution of dust in these
early systems. Previously (Li et al. 2007), we showed that luminous quasars at
z > 6 can form through hierarchical mergers of gas-rich galaxies. Here, we
calculate the dust properties of simulated quasars and their progenitors using
a three-dimensional Monte Carlo radiative transfer code, ART^2 --
All-wavelength Radiative Transfer with Adaptive Refinement Tree. ART^2
incorporates a radiative equilibrium algorithm for dust emission, an adaptive
grid for inhomogeneous density, a multiphase model for the ISM, and a
supernova-origin dust model. We reproduce the SED and dust properties of SDSS
J1148+5251, and find that the infrared emission are closely associated with the
formation and evolution of the quasar host. The system evolves from a cold to a
warm ULIRG owing to heating and feedback from stars and AGN. Furthermore, the
AGN has significant implications for the interpretation of observation of the
hosts. Our results suggest that vigorous star formation in merging progenitors
is necessary to reproduce the observed dust properties of z~6 quasars,
supporting a merger-driven origin for luminous quasars at high redshifts and
the starburst-to-quasar evolutionary hypothesis. (Abridged)Comment: 26 pages, 22 figures, accepted by ApJ. Version with full resolution
images is available at
http://www.cfa.harvard.edu/~yxli/ARTDUST/astroph0706.3706.pd
The Golden Rule:Interfaith Peacemaking and the Charter for Compassion
The Charter for Compassion has been signed by over two million people from around the world and partnered with hundreds of interfaith organizations and cities seeking to put into practice the Golden Rule, common to the main faith traditions, of doing unto others as you would be done by. This article sets the Charter within the context of a post secular international society and faith-based diplomacy, in which religious interreligious initiatives emerge as serious, rather than peripheral, actors in developing sustainable peace making through bottom-up approaches. The article critically engages with the Charter's claim that ‘any interpretation of scripture that breeds violence, hatred or disdain is illegitimate’ while accepting that peaceful interpretations of scriptures are helpful to peace processes where religious actors are involved. The article explores the claims of the Charter for Compassion International as they seek to make peace through compassion, before concluding that the Charter for Compassion is a long-term project aimed at changing hearts and minds but has had limited substantive impact to date
A population of z> 2 far-infrared Herschel-spire-selected starbursts
We present spectroscopic observations for a sample of 36 Herschel-SPIRE
250-500um selected galaxies (HSGs) at 2<z<5 from the Herschel Multi-tiered
Extragalactic Survey (HerMES). Redshifts are confirmed as part of a large
redshift survey of Herschel-SPIRE-selected sources covering ~0.93deg^2 in six
extragalactic legacy fields. Observations were taken with the Keck I Low
Resolution Imaging Spectrometer (LRIS) and the Keck II DEep Imaging
Multi-Object Spectrograph (DEIMOS). Precise astrometry, needed for
spectroscopic follow-up, is determined by identification of counterparts at
24um or 1.4GHz using a cross-identification likelihood matching method.
Individual source luminosities range from log(L_IR/Lsun)=12.5-13.6
(corresponding to star formation rates 500-9000Msun/yr, assuming a Salpeter
IMF), constituting some of the most intrinsically luminous, distant infrared
galaxies yet discovered. We present both individual and composite rest-frame
ultraviolet spectra and infrared spectral energy distributions (SEDs). The
selection of these HSGs is reproducible and well characterized across large
areas of sky in contrast to most z>2 HyLIRGs in the literature which are
detected serendipitously or via tailored surveys searching only for high-z
HyLIRGs; therefore, we can place lower limits on the contribution of HSGs to
the cosmic star formation rate density at (7+-2)x10^(-3)Msun/yr h^3Mpc^(-3) at
z~2.5, which is >10% of the estimated total star formation rate density (SFRD)
of the Universe from optical surveys. The contribution at z~4 has a lower limit
of 3x10^(-3)Msun/yr h^3 Mpc^(-3), ~>20% of the estimated total SFRD. This
highlights the importance of extremely infrared-luminous galaxies with high
star formation rates to the build-up of stellar mass, even at the earliest
epochs.Comment: 25 pages, 10 figures; ApJ accepte
Rare Copy Number Variants in \u3cem\u3eNRXN1\u3c/em\u3e and \u3cem\u3eCNTN6\u3c/em\u3e Increase Risk for Tourette Syndrome
Tourette syndrome (TS) is a model neuropsychiatric disorder thought to arise from abnormal development and/or maintenance of cortico-striato-thalamo-cortical circuits. TS is highly heritable, but its underlying genetic causes are still elusive, and no genome-wide significant loci have been discovered to date. We analyzed a European ancestry sample of 2,434 TS cases and 4,093 ancestry-matched controls for rare (\u3c 1% frequency) copy-number variants (CNVs) using SNP microarray data. We observed an enrichment of global CNV burden that was prominent for large (\u3e 1 Mb), singleton events (OR = 2.28, 95% CI [1.39–3.79], p = 1.2 × 10−3) and known, pathogenic CNVs (OR = 3.03 [1.85–5.07], p = 1.5 × 10−5). We also identified two individual, genome-wide significant loci, each conferring a substantial increase in TS risk (NRXN1 deletions, OR = 20.3, 95% CI [2.6–156.2]; CNTN6 duplications, OR = 10.1, 95% CI [2.3–45.4]). Approximately 1% of TS cases carry one of these CNVs, indicating that rare structural variation contributes significantly to the genetic architecture of TS
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