Technological agglomeration and the emergence of clusters and networks in nanotechnology

Research and development at the nanoscale requires a large degree of integration, from convergence of research disciplines in new fields of enquiry to new linkages between start-ups, regional actors and research facilities. Based on the analysis of two clusters in nanotechnologies (MESA+ (Twente) and other centres in The Netherlands and Minatec in Grenoble in France), the paper discusses the phenomenon of technological agglomeration: co-located scientific and technological fields associated to coordinated technology platforms to some extent actively shaped by institutional entrepreneurs. Such co-location and coordination are probably a prerequisite for the emergence of strong nanocluster

Statistics in the Landscape of Intersecting Brane Models

An approach towards a statistical survey of four dimensional supersymmetric vacua in the string theory landscape is described and illustrated with three examples of ensembles of intersecting D-brane models. The question whether it is conceivable to make predictions based on statistical distributions is discussed. Especially interesting in this context are possible correlations between low energy observables. As an example we look at correlations between properties of the gauge sector of intersecting D-brane models and Gepner model constructions.Comment: Submitted for the SUSY07 proceedings, 4 pages, 2 figure

Breaking CPT by mixed non-commutativity

The mixed component of the non-commutative parameter \theta_{\mu M}, where \mu = 0,1,2,3 and M is an extra dimensional index may violate four-dimensional CPT invariance. We calculate one and two-loop induced couplings of \theta_{\mu 5} with the four-dimensional axial vector current and with the CPT odd dim=6 operators starting from five-dimensional Yukawa and U(1) theories. The resulting bounds from clock comparison experiments place a stringent constraint on \theta_{\mu 5}, |\theta_{\mu 5}|^{-1/2} > 5\times 10^{11} GeV. The orbifold projection and/or localization of fermions on a 3-brane lead to CPT-conserving physics, in which case the constraints on \theta{\mu 5} are softened.Comment: 4 pages, latex, 1 figur

Characterizing the emergence of a technological field:Expectations, agendas and networks in Lab-on-a-chip technologies

this paper we develop and use mapping tools to investigate emerging technological fields by studying the dynamics of expectations, agenda building and early networks. In our approach, expectations describe shared beliefs with regard to prospective entities and positions. Agendas are sets of priorities present to guide the actors in their work. The structure that arises as a result of the actions and interactions of actors is the emerging network. For emerging technologies these processes are susceptible to change and the technological paths that may arise are still easy to influence. We propose that not only looking at expectation dynamics, but also including agenda setting and networks dynamics is essential in order to successfully capture the complexities of the emergence of technological paths. A major challenge for this work lies in unveiling the socio-technical dynamics leading to path emergence. For this purpose we investigate the phenomena of irreversibilities that emerge during the ongoing interactions of researchers, institutes, policy makers and firms. With these aspects in mind, we will use a broadened view of expectation dynamics in order to arrive at an improved understanding of the building blocks of path emergence. We illustrate our approach with a case study of Lab-on-a-chip technology for medical and pharmaceutical applications

Freedom and constraints in the K3 landscape

We consider ``magnetized brane'' compactifications of the type I/heterotic string on K3 with U(1) background fluxes. The gauge group and matter content of the resulting six-dimensional vacua are parameterized by a matrix encoding a lattice contained within the even, self-dual lattice Γ[superscript 3,19]. Mathematical results of Nikulin on lattice embeddings make possible a simple classification of all such solutions. We find that every six-dimensional theory parameterized in this way by a negative semi-definite matrix whose trace satisfies a simple tadpole constraint can be realized as a K3 compactification. This approach makes it possible to explicitly and efficiently construct all models in this class with any particular allowed gauge group and matter content, so that one can immediately ``dial-a-model'' with desired properties

The embedding of universities in innovation ecosystems: The case of marine research at the University of Bergen

While historically the core missions of universities have been research and teaching, it has become increasingly recognised that universities have become significant sources of knowledge and capabilities. This third mission is cementing the role of universities as suppliers of qualified labour and generators of knowledge and technologies that promote innovation in a variety of innovation ecosystems. The main goal of the paper is to illustrate an approach that captures the various contributions of universities to their innovation ecosystems. Often territorially bounded, such links provide insights into the characteristics and geography of the various linkage for a university. With the case of the University of Bergen and its role within the marine innovation ecosystem of Western Norway, this ‘ecosystem fingerprint’, can be seen as a useful means to clarify the third mission of universities through the linkages and interdependencies with various actors. The authors demonstrate that a university can act both as a global pipeline provider and take active part in the local buzz, providing this concept with new empirical insight. The authors conclude that the university is highly embedded in both the marine innovation ecosystem and the knowledge ecosystem, but with linkages extended to interconnected business ecosystems.publishedVersio

No evidence that protein truncating variants in BRIP1 are associated with breast cancer risk: implications for gene panel testing.

BACKGROUND: BRCA1 interacting protein C-terminal helicase 1 (BRIP1) is one of the Fanconi Anaemia Complementation (FANC) group family of DNA repair proteins. Biallelic mutations in BRIP1 are responsible for FANC group J, and previous studies have also suggested that rare protein truncating variants in BRIP1 are associated with an increased risk of breast cancer. These studies have led to inclusion of BRIP1 on targeted sequencing panels for breast cancer risk prediction. METHODS: We evaluated a truncating variant, p.Arg798Ter (rs137852986), and 10 missense variants of BRIP1, in 48 144 cases and 43 607 controls of European origin, drawn from 41 studies participating in the Breast Cancer Association Consortium (BCAC). Additionally, we sequenced the coding regions of BRIP1 in 13 213 cases and 5242 controls from the UK, 1313 cases and 1123 controls from three population-based studies as part of the Breast Cancer Family Registry, and 1853 familial cases and 2001 controls from Australia. RESULTS: The rare truncating allele of rs137852986 was observed in 23 cases and 18 controls in Europeans in BCAC (OR 1.09, 95% CI 0.58 to 2.03, p=0.79). Truncating variants were found in the sequencing studies in 34 cases (0.21%) and 19 controls (0.23%) (combined OR 0.90, 95% CI 0.48 to 1.70, p=0.75). CONCLUSIONS: These results suggest that truncating variants in BRIP1, and in particular p.Arg798Ter, are not associated with a substantial increase in breast cancer risk. Such observations have important implications for the reporting of results from breast cancer screening panels.The COGS project is funded through a European Commission's Seventh Framework Programme grant (agreement number 223175 - HEALTH-F2-2009-223175). BCAC is funded by Cancer Research UK [C1287/A10118, C1287/A12014] and by the European Community´s Seventh Framework Programme under grant agreement number 223175 (grant number HEALTH-F2-2009-223175) (COGS). Funding for the iCOGS infrastructure came from: the European Community's Seventh Framework Programme under grant agreement n° 223175 (HEALTH-F2-2009-223175) (COGS), Cancer Research UK (C1287/A10118, C1287/A 10710, C12292/A11174, C1281/A12014, C5047/A8384, C5047/A15007, C5047/A10692, C8197/A16565), the National Institutes of Health (CA128978) and Post-Cancer GWAS initiative (1U19 CA148537, 1U19 16 CA148065 and 1U19 CA148112 - the GAME-ON initiative), the Department of Defense (W81XWH-10-1- 0341), the Canadian Institutes of Health Research (CIHR) for the CIHR Team in Familial Risks of Breast Cancer, Komen Foundation for the Cure, the Breast Cancer Research Foundation, and the Ovarian Cancer Research Fund. This study made use of data generated by the Wellcome Trust Case Control consortium. Funding for the project was provided by the Wellcome Trust under award 076113. The results published here are in part based upon data generated by The Cancer Genome Atlas Project established by the National Cancer Institute and National Human Genome Research Institute.This is the author accepted manuscript. The final version is available from BMJ Group at http://dx.doi.org/10.1136/jmedgenet-2015-103529

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus

A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P=9.2 × 10-20), ER-negative BC (P=1.1 × 10-13), BRCA1-associated BC (P=7.7 × 10-16) and triple negative BC (P-diff=2 × 10-5). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (P=2 × 10-3) and ABHD8 (P<2 × 10-3). Chromosome conformation capture identifies interactions between four candidate SNPs and ABHD8, and luciferase assays indicate six risk alleles increased transactivation of the ADHD8 promoter. Targeted deletion of a region containing risk SNP rs56069439 in a putative enhancer induces ANKLE1 downregulation; and mRNA stability assays indicate functional effects for an ANKLE1 3′-UTR SNP. Altogether, these data suggest that multiple SNPs at 19p13 regulate ABHD8 and perhaps ANKLE1 expression, and indicate common mechanisms underlying breast and ovarian cancer risk

Novel genetic loci associated with hippocampal volume

The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (rg =-0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness