The mixed component of the non-commutative parameter \theta_{\mu M}, where
\mu = 0,1,2,3 and M is an extra dimensional index may violate four-dimensional
CPT invariance. We calculate one and two-loop induced couplings of \theta_{\mu
5} with the four-dimensional axial vector current and with the CPT odd dim=6
operators starting from five-dimensional Yukawa and U(1) theories. The
resulting bounds from clock comparison experiments place a stringent constraint
on \theta_{\mu 5}, |\theta_{\mu 5}|^{-1/2} > 5\times 10^{11} GeV. The orbifold
projection and/or localization of fermions on a 3-brane lead to CPT-conserving
physics, in which case the constraints on \theta{\mu 5} are softened.Comment: 4 pages, latex, 1 figur