The knowledge-based software assistant

Where the Knowledge Based Software Assistant (KBSA) is now, four years after the initial report, is discussed. Also described is what the Rome Air Development Center expects at the end of the first contract iteration. What the second and third contract iterations will look like are characterized

Strategies to Improve Care Transitions between Nursing Homes and Emergency Departments

OBJECTIVE To identify testable solutions that may improve the quality and safety of care transitions between nursing homes (NHs) and emergency departments (EDs). DESIGN Structured focus group interviews. SETTING Group interviews took place in Indianapolis, Indiana. PARTICIPANTS NH administrators, nurses, and physicians; emergency medical services (EMS) directors, paramedics, and emergency medicine technicians (EMTs); ED nurses and physicians; and a representative from the Indiana State Department of Health. MEASUREMENTS Opinions, perceptions, and insights of participants. RESULTS 18 participants were included. The central theme was the need for additional structure to support care transitions between NHs and EDs. Participants agreed that the structure afforded by hospital-to-hospital transfers would benefit patients and providers during transitions between NHs and EDs. Because transfer forms currently vary from NH to NH, participants recommended that the entire state use the same form. They recommended that the transfer form be useful in both directions by including a section for the ED provider to complete to support the ED-to-NH transition. Participants suggested that systems use a transfer checklist to help ensure that all processes occur as expected. They strongly recommended verbal communication across care settings to complement written communication and to improve on deficiencies that occur with transfer form-only strategies. Notably, participants suggested that the different care sites engage in relationship-building efforts to improve compliance with recommendations (e.g., form completion) and collaborative problem solving. CONCLUSION Participants advised additional structure to NH-ED care transitions, similar to hospital-to-hospital transfers, that includes a 2-way, statewide transfer form; a checklist; and verbal communication

Computational translation of genomic responses from experimental model systems to humans

The high failure rate of therapeutics showing promise in mouse models to translate to patients is a pressing challenge in biomedical science. Though retrospective studies have examined the fidelity of mouse models to their respective human conditions, approaches for prospective translation of insights from mouse models to patients remain relatively unexplored. Here, we develop a semi-supervised learning approach for inference of disease-associated human differentially expressed genes and pathways from mouse model experiments. We examined 36 transcriptomic case studies where comparable phenotypes were available for mouse and human inflammatory diseases and assessed multiple computational approaches for inferring human biology from mouse datasets. We found that semi-supervised training of a neural network identified significantly more true human biological associations than interpreting mouse experiments directly. Evaluating the experimental design of mouse experiments where our model was most successful revealed principles of experimental design that may improve translational performance. Our study shows that when prospectively evaluating biological associations in mouse studies, semi-supervised learning approaches, combining mouse and human data for biological inference, provide the most accurate assessment of human in vivo disease processes. Finally, we proffer a delineation of four categories of model system-to-human "Translation Problems" defined by the resolution and coverage of the datasets available for molecular insight translation and suggest that the task of translating insights from model systems to human disease contexts may be better accomplished by a combination of translation-minded experimental design and computational approaches.Boehringer Ingelheim PharmaceuticalsInstitute for Collaborative Biotechnologies (Grant W911NF-09-0001

Investigation of Seal-to-Floor Effects on Semi-Span Transonic Models

In an effort to achieve the maximum possible Reynolds number (Re) when conducting production testing for flight loads aerodynamic databases, it has been the preferred practice of The Boeing Company / Commercial Airplanes (BCA) -- Loads and Dynamics Group since the early 1990's to test large scale semi-span models in the 11- By 11-Foot Transonic Wind Tunnel (TWT) leg of the Unitary Plan Wind Tunnel (UPWT) at the NASA Ames Research Center (ARC). There are many problems related to testing large scale semi-span models of high aspect ratio flexible transport wings, such as; floor boundary layer effects, wing spanwise wall effects, solid blockage buoyancy effects, floor mechanical interference effects, airflow under the model effects, or tunnel flow gradient effects. For most of these issues, BCA has developed and implemented either standard testing methods or numerical correction schemes and these will not be discussed in this document. Other researchers have reported on semi-span transonic testing correction issues, however most of the reported research has been for low Mach testing. Some of the reports for low Mach testing address the difficult problem of preventing undesirable airflow under a semi-span model while ensuring unrestricted main balance functionality, however, for transonic models this issue has gone unresolved. BCA has been cognizant for sometime that there are marked differences in wing pressure distributions from semi-span transonic model testing than from full model or flight testing. It has been suspected that these differences are at least in part due to airflow under the model. Previous efforts by BCA to address this issue have proven to be ineffective or inconclusive and in one situation resulted in broken hardware. This paper reports on a Boeing-NASA collaborative investigation based on a series of small tests conducted between June 2006 and November 2007 in the 11 by 11 foot Transonic Wind Tunnel at NASA Ames on three large commercial jet transport configurations to assess the effects of sealing a semi-span model to the floor and to investigate efficient sealing and testing techniques. This document will show how sealing the model to the floor has a small but remarkably far reaching spanwise effect on wing pressures, wing local section forces and wing force summations

Ubiquitination and proteasomal degradation of ATG12 regulates its proapoptotic activity

During macroautophagy, conjugation of ATG12 to ATG5 is essential for LC3 lipidation and autophagosome formation. Additionally, ATG12 has ATG5-independent functions in diverse processes including mitochondrial fusion and mitochondrial-dependent apoptosis. In this study, we investigated the regulation of free ATG12. In stark contrast to the stable ATG12–ATG5 conjugate, we find that free ATG12 is highly unstable and rapidly degraded in a proteasome-dependent manner. Surprisingly, ATG12, itself a ubiquitin-like protein, is directly ubiquitinated and this promotes its proteasomal degradation. As a functional consequence of its turnover, accumulation of free ATG12 contributes to proteasome inhibitor-mediated apoptosis, a finding that may be clinically important given the use of proteasome inhibitors as anticancer agents. Collectively, our results reveal a novel interconnection between autophagy, proteasome activity, and cell death mediated by the ubiquitin-like properties of ATG12

A Comparison of the Strengths and Weaknesses of Small-Format Aerial Photography Platforms

The demand for small-format aerial photography continues to grow in large part due to the rapid adoption of unmanned aerial vehicles (UAVs). Prior to the explosion of UAV use, this kind of photography was collected using older technologies such as tethered kites and blimps. Due to the increased demand for aerial imagery, this article looks at four platforms commonly used to collect small-format aerial imagery: multi-rotor UAVs, fixed-wing UAVs, kites, and blimps. Practical use considerations are explored, including characteristics of flight and operation, atmospheric and site factors, imaging sensors and costs, and regulatory limitations. Each of the four categories of lifting platform have their strengths and limitations, and they often complement one another. UAVs tends to be more maneuverable and able to cover more ground, but they have limited flight times due to battery technology limitations. They also have clearly defined regulatory requirements for use, whereas the tethered platforms have very few legal restrictions on use. In some cases, a tethered platform may be the only legal option for gathering small-format aerial imagery at a location. There is no one perfect option that will fill all needs, but rather multiple solutions that are better suited to some situations than others. The ways in which some of these strengths and limitations may change in the future in regards to technology and regulations is also discussed

The structure of HI in galactic disks: Simulations vs observations

We generate synthetic HI Galactic plane surveys from spiral galaxy simulations which include stellar feedback processes. Compared to a model without feedback we find an increased scale height of HI emission (in better agreement with observations) and more realistic spatial structure (including supernova blown bubbles). The synthetic data show HI self-absorption with a morphology similar to that seen in observations. The density and temperature of the material responsible for HI self-absorption is consistent with observationally determined values, and is found to be only weakly dependent on absorption strength and star formation efficiency.Comment: 12 pages, 7 figures. Accepted for publication in MNRA

Microcanonical treatment of black hole decay at the Large Hadron Collider

This study of corrections to the canonical picture of black hole decay in large extra dimensions examines the effects of back-reaction corrected and microcanonical emission at the LHC. We provide statistical interpretations of the different multiparticle number densities in terms of black hole decay to standard model particles. Provided new heavy particles of mass near the fundamental Planck scale are not discovered, differences between these corrections and thermal decay will be insignificant at the LHC.Comment: small additions and clarifications, format for J. Phys.