Governing land: reflections from IFPRI research

"Land is still among the most important assets of the rural population in the developing world. Land resources are governed by a variety of tenure systems based on statutory, customary, or religious law. At the same time, many national, subnational, and local institutions administer the application and enforcement of these laws, relying on a wide variety of policies, rules, and regulations that promote different practices for using and managing land and land-based resources. IFPRI contributes to land policy debates by demonstrating the importance of land policy and its impact on rural people. This occurs across multiple dimensions, including people's livelihoods, the sustainability of the resource base, and the effectiveness of the institutions that govern land. This brief summarizes findings of relevant IFPRI research on land management and governance to promote strategies and policies targeted toward the achievement of gender equity, poverty reduction, and sustainable resource management." Author's SummaryGovernance, Poverty reduction, Sustainability, Gender equality, Gender, Environmental management, Devolution,

Biting the bullet: how to secure access to drylands resources for multiple users

"Close to one billion people worldwide depend directly upon the drylands for their livelihoods. Because of their climatic conditions and political and economic marginalization drylands also have some of the highest incidents of poverty. Pastoral and sedentary production systems coexist in these areas and both very often use common property arrangements to manage access and use of natural resources. Despite their history of complementary interactions, pastoralists and sedentary farmers are increasingly faced with conflicting claims over land and other natural resources. Past policy interventions and existing regulatory frameworks have not been able to offer lasting solutions to the problems related to land tenure and resource access; problems between the multiple and differentiated drylands resource users, as part of broader concerns over resource degradation and the political and economic marginalization of the drylands. This paper discusses enduring tension in efforts to secure rights in drylands. On the one hand are researchers and practitioners who advocate for statutory law as the most effective guarantor of rights, especially of group rights. On the other side are those who underscore the complexity of customary rights and the need to account for dynamism and flexibility in drylands environments in particular. It explores innovative examples of dealing with secure access to resources and comes to the conclusion that process, rather than content, should be the focus of policy makers. Any attempt to secure access for multiple users in variable drylands environments should identify frameworks for conflict resolution, in a negotiated manner, crafting rules from the ground upwards, in addition to a more generalized or generic identification of rights. Elite capture and exclusion of women and young people continue to pose significant challenges in such decentralized processes. For rights to be meaningfully secured there is need to identify the nature and sources of threats that create insecurities " Author's AbstractProperty rights, Natural resources, Land tenure, Customary rights, Secure access, Environmental management, Devolution, Gender,

Gender and collective action: A conceptual framework for analysis

"This paper presents a framework for investigating the intersection of collective action and gender; i.e. how gender-oriented analysis can foster more effective collective action in the context of agriculture and natural resource management and how collective action can be used as a vehicle for gender equity. We begin with definitions of the key concepts and then present three entry points for a gendered analysis of collective action-motivations, effectiveness, and impact on gender equity- vis-à-vis the Institutional Analysis and Development (IAD) framework(Oakerson 1992; Ostrom 1991). At the heart of this framework is the action arena, which is shaped by a host of initial conditions, including asset endowments, vulnerabilities, and legal and governance systems that influence a range of outcomes. Applying a gender lens to this framework, we present an analysis of how women and men experience the initial set of conditions differently and thus, have different motivations and capacities for engaging in collective action. Next, we look at how the gender composition of groups affects theeffectiveness of collective action, and finally, at the impact of collective action on gender equity and women's empowerment. We conclude with a discussion of how this framework can improve our understanding of gender and collective action in order to facilitate more effective collective action while fostering gender equity." Author's AbstractGender, Collective action,

Decentralization, pro-poor land policies, and democratic governance:

"Decentralized approaches to development are gaining increasing prominence. Land tenure reform policy has been affected by many different types of decentralization. However, the literature on land tenure reform rarely explicitly addressed the implications of decentralization, and vice versa. This paper provides a review of how the issues of decentralization are linked to land tenure reform, in theory and practice. Both decentralization and land tenure reform each encompass a number of different, but related concepts and approaches. We begin with clarifying some key terms related to these different approaches, then look in more detail at contending perspectives on decentralization, and how these relate to the United Nations Development Programme's (UNDP) pillars of democratic governance. We then review the different types of land tenure reform in terms of the role of centralized and decentralized institutions, illustrating the strengths and weaknesses, gaps and challenges with experience from a range of developing countries. The final section turns to conclusions and policy recommendations, considering how decentralized approaches to land tenure reform can contribute to goals such as gender equity, social cohesion, human rights, and the identity of indigenous peoples." authors' abstractDecentralization, Land, Tenure reform, Democratic governance, Rights, Registration, Redistribution, Restitution, Recognition, Devolution,

Mutations in alpha-B-crystallin cause autosomal dominant axonal Charcot–Marie–Tooth disease with congenital cataracts

Background and purpose: Mutations in the alpha-B-crystallin (CRYAB) gene have initially been associated with myofibrillar myopathy, dilated cardiomyopathy and cataracts. For the first time, peripheral neuropathy is reported here as a novel phenotype associated with CRYAB. // Methods: Whole-exome sequencing was performed in two unrelated families with genetically unsolved axonal Charcot–Marie–Tooth disease (CMT2), assessing clinical, neurophysiological and radiological features. // Results: The pathogenic CRYAB variant c.358A>G;p.Arg120Gly was segregated in all affected patients from two unrelated families. The disease presented as late onset CMT2 (onset over 40 years) with distal sensory and motor impairment and congenital cataracts. Muscle involvement was probably associated in cases showing mild axial and diaphragmatic weakness. In all cases, nerve conduction studies demonstrated the presence of an axonal sensorimotor neuropathy along with chronic neurogenic changes on needle examination. // Discussion: In cases with late onset autosomal dominant CMT2 and congenital cataracts, it is recommended that CRYAB is considered for genetic testing. The identification of CRYAB mutations causing CMT2 further supports a continuous spectrum of expressivity, from myopathic to neuropathic and mixed forms, of a growing number of genes involved in protein degradation and chaperone-assisted autophagy

How cancer cells hijack DNA double-strand break repair pathways to gain genomic instability

DNA double-strand breaks (DSBs) are a significant threat to the viability of a normal cell, since they can result in loss of genetic material if mitosis or replication is attempted in their presence. Consequently, evolutionary pressure has resulted in multiple pathways and responses to enable DSBs to be repaired efficiently and faithfully. Cancer cells, which are under pressure to gain genomic instability, have a striking ability to avoid the elegant mechanisms by which normal cells maintain genomic stability. Current models suggest that in normal cells DSB repair occurs in a hierarchical manner that promotes rapid and efficient rejoining first, with the utilisation of additional steps or pathways of diminished accuracy if rejoining is unsuccessful or delayed. We evaluate the fidelity of DSB repair pathways and discuss how cancer cells promote the utilisation of less accurate processes. Homologous recombination serves to promote accuracy and stability during replication, providing a battlefield for cancer to gain instability. Non-homologous end-joining, a major DSB repair pathway in mammalian cells, usually operates with high fidelity and only switches to less faithful modes if timely repair fails. The transition step is finely tuned and provides another point of attack during tumour progression. In addition to DSB repair, a DSB signalling response activates processes such as cell cycle checkpoint arrest, which enhance the possibility of accurate DSB repair. We will consider the ways by which cancers modify and accost these processes to gain genomic instabilit

Genetic landscape of congenital insensitivity to pain and hereditary sensory and autonomic neuropathies

Congenital insensitivity to pain (CIP) and hereditary sensory and autonomic neuropathies (HSAN) are clinically and genetically heterogeneous disorders exclusively or predominantly affecting the sensory and autonomic neurons. Due to the rarity of the diseases and findings based mainly on single case reports or small case series, knowledge about these disorders is limited. Here, we describe the molecular workup of a large international cohort of CIP/HSAN patients including patients from normally under-represented countries. We identify 80 previously unreported pathogenic or likely pathogenic variants in a total of 73 families in the >20 known CIP/HSAN-associated genes. The data expand the spectrum of disease-relevant alterations in CIP/HSAN, including novel variants in previously rarely recognized entities such as ATL3-, FLVCR1- and NGF-associated neuropathies and previously under-recognized mutation types such as larger deletions. In silico predictions, heterologous expression studies, segregation analyses and metabolic tests helped to overcome limitations of current variant classification schemes that often fail to categorize a variant as disease-related or benign. The study sheds light on the genetic causes and disease-relevant changes within individual genes in CIP/HSAN. This is becoming increasingly important with emerging clinical trials investigating subtype or gene-specific treatment strategies

Governing land: reflections from IFPRI research

"Land is still among the most important assets of the rural population in the developing world. Land resources are governed by a variety of tenure systems based on statutory, customary, or religious law. At the same time, many national, subnational, and local institutions administer the application and enforcement of these laws, relying on a wide variety of policies, rules, and regulations that promote different practices for using and managing land and land-based resources. IFPRI contributes to land policy debates by demonstrating the importance of land policy and its impact on rural people. This occurs across multiple dimensions, including people’s livelihoods, the sustainability of the resource base, and the effectiveness of the institutions that govern land. This brief summarizes findings of relevant IFPRI research on land management and governance to promote strategies and policies targeted toward the achievement of gender equity, poverty reduction, and sustainable resource management." -- Author's SummaryNon-PRIFPRI1; Governance; CAPRiEPT

Information Asymmetries and Distribution of Preferences in Comitology: Can the member states of the European Union limit the discretionary space of the Commission?

This study assesses the impact of the Comitology procedures on the European Commission s discretionary space in the implementation process. The different institutional rules of the procedures influence decisively to what degree the member states can limit the discretion of their agent, the Commission. Within a Committee the configuration of the member states preferences and the information asymmetry in favor of the Commission have an impact on the discretionary space of the actors.The empirical test is based on two cases: the management committee implementing the action programme to combat discrimination and the regulatory committee regarding the revision of the eco-label award scheme . The analysis of the two cases shows that the actors preferences depending on the decision rules of the respective procedure define indeed the Commission s discretionary space, while the influence of the actor s level of information remains uncertain