Coherence-factor-based rough surface clutter suppression for forward-looking GPR imaging

We present an enhanced imaging procedure for suppression of the rough surface clutter arising in forward-looking ground-penetrating radar (FL-GPR) applications. The procedure is based on a matched filtering formulation of microwave tomographic imaging, and employs coherence factor (CF) for clutter suppression. After tomographic reconstruction, the CF is first applied to generate a "coherence map" of the region in front of the FL-GPR system illuminated by the transmitting antennas. A pixel-by-pixel multiplication of the tomographic image with the coherence map is then performed to generate the clutter-suppressed image. The effectiveness of the CF approach is demonstrated both qualitatively and quantitatively using electromagnetic modeled data of metallic and plastic shallow-buried targets

DIVERSITY OF FUNGI IN THE ALLIUM URSINUM L COVERED SOIL FOREST

In the soil,ecosystem there are differences in the diversity and spatial distribution of the fungal community. Forest soil samples were harvested in the spring season from the area of influence of plants of Allium ursinum L., in the western part of the country.The study of fungal diversity was carried out on the "soil grain method" on the sifted and ungrounded soil samples. The composition of fungal species is diverse, but there are also repetions (rehearsals) where the number of species is limited. The species present in both forest soil samples is Circinellaspp, followed by Penicillium spp and Aspergillus spp, the latter being isolated only from the sifted soil sample.The low-frequency species are: Torulaherbarum (species isolated from both soil samples), Chaetomium spirale (highlighted only in sampled (sifted) soil), Fusarium spp, Helminthosporiumspp and Mortierellamonospora, the last species isolated from the unsifted soil sample.Â

A simple asthma prediction tool for preschool children with wheeze or cough

BACKGROUND Many preschool children have wheeze or cough, but only some have asthma later. Existing prediction tools are difficult to apply in clinical practice or exhibit methodological weaknesses. OBJECTIVE We sought to develop a simple and robust tool for predicting asthma at school age in preschool children with wheeze or cough. METHODS From a population-based cohort in Leicestershire, United Kingdom, we included 1- to 3-year-old subjects seeing a doctor for wheeze or cough and assessed the prevalence of asthma 5 years later. We considered only noninvasive predictors that are easy to assess in primary care: demographic and perinatal data, eczema, upper and lower respiratory tract symptoms, and family history of atopy. We developed a model using logistic regression, avoided overfitting with the least absolute shrinkage and selection operator penalty, and then simplified it to a practical tool. We performed internal validation and assessed its predictive performance using the scaled Brier score and the area under the receiver operating characteristic curve. RESULTS Of 1226 symptomatic children with follow-up information, 345 (28%) had asthma 5 years later. The tool consists of 10 predictors yielding a total score between 0 and 15: sex, age, wheeze without colds, wheeze frequency, activity disturbance, shortness of breath, exercise-related and aeroallergen-related wheeze/cough, eczema, and parental history of asthma/bronchitis. The scaled Brier scores for the internally validated model and tool were 0.20 and 0.16, and the areas under the receiver operating characteristic curves were 0.76 and 0.74, respectively. CONCLUSION This tool represents a simple, low-cost, and noninvasive method to predict the risk of later asthma in symptomatic preschool children, which is ready to be tested in other populations

Riscul limfedemului după tratamentul cancerului mamar

Spital Universitar Clinic de Urgențe “Sf. Spiridon”, Iași, Al XI-lea Congres al Asociației Chirurgilor „Nicolae Anestiadi” din Republica Moldova și cea de-a XXXIII-a Reuniune a Chirurgilor din Moldova „Iacomi-Răzeșu” 27-30 septembrie 2011Introducere: Importanța problemei este legată de incidența crescută (între 3 și 87%), consecințele limfedemului fiind asupra integrării profesionale, riscului de erizipel, calității vieții și relației cu membrii familiei. Scopul lucrării: De a sublinia importanța profilaxiei precoce, luând în calcul factori ce țin de boală, chirurg și pacientă. Material și metodă: S-au luat în studiu 1104 paciente tratate pentru neoplasm mamar între 2000 și 2010. La 228 cazuri s-a efectuat intervenție conservatoare (cadranectomie și evidare limfo-gangionara), la 876-operația Madden. S-au evaluat factorii favorizanți ai limfedemului preexistenti terapiei pentru neoplasmul de sân, factorii favorizanți în postoperator și terapia asociată. Rezultate: Cu o dispensarizare la fiecare 3 luni în primul an și la 6 luni ulterior, s-au decelat 42 observații cu limfedem al membrului superior mediu și sever, precoce (până la 21 zile postoperator) - 8 observații, între 21 zile și 12 luni - 4 observații și după 12 luni - 30 observații. Limfedemul sever a apărut în 13 cazuri la paciente de peste 60 ani, ținând cont de factorii favorizanți, 8 paciente au beneficiat de măsuri terapeutice (administrarea de flavonoide micronizate, heparina fractionata, masaj, banda elastică, gimnastica membrului superior, scădere ponderală) cu rezultate bune, iar la 5 paciente nu s-au obținut beneficii evidente. Pacientele cu limfedem moderat (29cazuri) au avut o evoluție favorabilă în urma aplicării acelorași măsuri terapeutice în 25 cazuri, 4 paciente rămânând cu limfedem moderat permanent. Concluzii: Limfedemul mederat și sever au apărut (pe cazuistica analizata) numai după operația Madden. Femeia vârstnică ar fi mai predispusă la limfedem. Ablația minuțioasă a grăsimii din jurul venei axilare ar predispune la limfedem prin interceptarea celor 2 colectoare principale axilare. Greutatea corporală mare, efortul fizic important postoperator constituie factori favorizanti ai limfedemului. Există măsuri terapeutice adjuvante pentru limfedem, cu rezultate favorabile

Copy number variation of the beta-defensin genes in Europeans: no supporting evidence for association with lung function, chronic obstructive pulmonary disease or asthma

Lung function measures are heritable, predict mortality and are relevant in diagnosis of chronic obstructive pulmonary disease (COPD). COPD and asthma are diseases of the airways with major public health impacts and each have a heritable component. Genome-wide association studies of SNPs have revealed novel genetic associations with both diseases but only account for a small proportion of the heritability. Complex copy number variation may account for some of the missing heritability. A well-characterised genomic region of complex copy number variation contains beta-defensin genes (DEFB103, DEFB104 and DEFB4), which have a role in the innate immune response. Previous studies have implicated these and related genes as being associated with asthma or COPD. We hypothesised that copy number variation of these genes may play a role in lung function in the general population and in COPD and asthma risk. We undertook copy number typing of this locus in 1149 adult and 689 children using a paralogue ratio test and investigated association with COPD, asthma and lung function. Replication of findings was assessed in a larger independent sample of COPD cases and smoking controls. We found evidence for an association of beta-defensin copy number with COPD in the adult cohort (OR = 1.4, 95%CI:1.02–1.92, P = 0.039) but this finding, and findings from a previous study, were not replicated in a larger follow-up sample(OR = 0.89, 95%CI:0.72–1.07, P = 0.217). No robust evidence of association with asthma in children was observed. We found no evidence for association between beta-defensin copy number and lung function in the general populations. Our findings suggest that previous reports of association of beta-defensin copy number with COPD should be viewed with caution. Suboptimal measurement of copy number can lead to spurious associations. Further beta-defensin copy number measurement in larger sample sizes of COPD cases and children with asthma are needed

Breastfeeding, lung volumes and alveolar size at school-age

Background: Previous studies found larger lung volumes at school-age in formerly breastfed children, with some studies suggesting an effect modification by maternal asthma. We wanted to explore this further in children who had undergone extensive lung function testing. The current study aimed to assess whether breastfeeding was associated with larger lung volumes and, if so, whether all compartments were affected. We also assessed association of breastfeeding with apparent diffusion coefficient (ADC), which measures freedom of gas diffusion in alveolar-acinar compartments and is a surrogate of alveolar dimensions. Additionally, we assessed whether these effects were modified by maternal asthma.Methods: We analysed data from 111 children and young adults aged 11–21 years, who had participated in detailed lung function testing, including spirometry, plethysmography and measurement of ADC of 3Helium (3He) by MR. Information on breastfeeding came from questionnaires applied in early childhood (age 1–4 years). We determined the association between breastfeeding and these measurements using linear regression, controlling for potential confounders.Results: We did not find significant evidence for an association between duration of breastfeeding and lung volumes or alveolar dimensions in the entire sample. In breastfed children of mothers with asthma, we observed larger lung volumes and larger average alveolar size than in non-breastfed children, but the differences did not reach significance levels.Conclusions: Confirmation of effects of breastfeeding on lung volumes would have important implications for public health. Further investigations with larger sample sizes are warranted

Measurement of the CKM angle γ from a combination of B±→Dh± analyses

A combination of three LHCb measurements of the CKM angle γ is presented. The decays B±→D K± and B±→Dπ± are used, where D denotes an admixture of D0 and D0 mesons, decaying into K+K−, π+π−, K±π∓, K±π∓π±π∓, K0Sπ+π−, or K0S K+K− final states. All measurements use a dataset corresponding to 1.0 fb−1 of integrated luminosity. Combining results from B±→D K± decays alone a best-fit value of γ =72.0◦ is found, and confidence intervals are set γ ∈ [56.4,86.7]◦ at 68% CL, γ ∈ [42.6,99.6]◦ at 95% CL. The best-fit value of γ found from a combination of results from B±→Dπ± decays alone, is γ =18.9◦, and the confidence intervals γ ∈ [7.4,99.2]◦ ∪ [167.9,176.4]◦ at 68% CL are set, without constraint at 95% CL. The combination of results from B± → D K± and B± → Dπ± decays gives a best-fit value of γ =72.6◦ and the confidence intervals γ ∈ [55.4,82.3]◦ at 68% CL, γ ∈ [40.2,92.7]◦ at 95% CL are set. All values are expressed modulo 180◦, and are obtained taking into account the effect of D0–D0 mixing

Differential branching fraction and angular analysis of the decay B0→K∗0μ+μ−

The angular distribution and differential branching fraction of the decay B 0→ K ∗0 μ + μ − are studied using a data sample, collected by the LHCb experiment in pp collisions at s√=7 TeV, corresponding to an integrated luminosity of 1.0 fb−1. Several angular observables are measured in bins of the dimuon invariant mass squared, q 2. A first measurement of the zero-crossing point of the forward-backward asymmetry of the dimuon system is also presented. The zero-crossing point is measured to be q20=4.9±0.9GeV2/c4 , where the uncertainty is the sum of statistical and systematic uncertainties. The results are consistent with the Standard Model predictions

Measurement of the relative rate of prompt χc0, χc1 and χc2 production at √s=7TeV

Prompt production of charmonium χc0, χc1 and χc2 mesons is studied using proton-proton collisions at the LHC at a centre-of-mass energy of √s=7TeV. The χc mesons are identified through their decay to J/ψγ, with J/ψ→μ+mu− using photons that converted in the detector. A data sample, corresponding to an integrated luminosity of 1.0fb−1 collected by the LHCb detector, is used to measure the relative prompt production rate of χc1 and χc2 in the rapidity range 2.0<y<4.5 as a function of the J/ψ transverse momentum from 3 to 20 GeV/c. First evidence for χc0 meson production at a hadron collider is also presented