Relativistic Landau damping of longitudinal waves in isotropic pair plasmas

Landau damping is described in relativistic electron-positron plasmas. Relativistic electron-positron plasma theory contains important new effects when compared with classical plasmas. For example, there are undamped superluminal wave modes arising from both a continuous and discrete mode structure, the former even in the classical limit. We present here a comprehensive analytical treatment of the general case resulting in a compact and useful form for the dispersion relation. The classical pair-plasma case is addressed, for completeness, in an appendix

Gas-plasma compressional wave coupling by momentum transfer

Pressure disturbances in a gas-plasma mixed fluid will result in a hybrid response, with magnetosonic plasma waves coupled to acoustic waves in the neutral gas. In the analytical and numerical treatment presented here, we demonstrate the evolution of the total fluid medium response under a variety of conditions, with the gas-plasma linkage achieved by additional coupling terms in the momentum equations of each species. The significance of this treatment lies in the consideration of density perturbations in such fluids: there is no 'pure' mode response, only a collective one in which elements of the characteristics of each component are present. For example, an initially isotropic gas sound wave can trigger an anisotropic magnetic response in the plasma, with the character of each being blended in the global evolution. Hence sound waves do not remain wholly isotropic, and magnetic responses are less constrained by pure magnetoplasma dynamics

Unplugging the Universe: the neglected electromagnetic consequence of decoupling

This letter concentrates on the non-equilibrium evolution of magnetic field structures at the onset of recombination, when the charged particle current densities decay as neutrals are formed. We consider the effect that a decaying magnetic flux has on the acceleration of particles via the transient induced electric field. Since the residual charged-particle number density is small as a result of decoupling, we shall consider the magnetic and electric fields essentially to be imposed, neglecting the feedback from any minority accelerated population. We find that the electromagnetic treatment of this phase transition can produce energetic electrons scattered throughout the Universe. Such particles could have a significant effect on cosmic evolution in several ways: (i) their presence could delay the effective end of the recombination era; (ii) they could give rise to plasma concentrations that could enhance early gravitational collapse of matter by opposing cosmic expansion to a greater degree than neutral matter could; (iii) they could continue to be accelerated, and become the seed for reionisation at the later epoch $z \approx 10$.Comment: 4 pages, no figure

Early childhood epilepsies:epidemiology, classification, aetiology, and socio-economic determinants

Epilepsies of early childhood are frequently resistant to therapy and often associated with cognitive and behavioural comorbidity. Aetiology focused precision medicine, notably gene-based therapies, may prevent seizures and comorbidities. Epidemiological data utilizing modern diagnostic techniques including whole genome sequencing and neuroimaging can inform diagnostic strategies and therapeutic trials. We present a 3-year, multicentre prospective cohort study, involving all children under 3 years of age in Scotland presenting with epilepsies. We used two independent sources for case identification: clinical reporting and EEG record review. Capture-recapture methodology was then used to improve the accuracy of incidence estimates. Socio-demographic and clinical details were obtained at presentation, and 24 months later. Children were extensively investigated for aetiology. Whole genome sequencing was offered for all patients with drug-resistant epilepsy for whom no aetiology could yet be identified. Multivariate logistic regression modelling was used to determine associations between clinical features, aetiology, and outcome. Three hundred and ninety children were recruited over 3 years. The adjusted incidence of epilepsies presenting in the first 3 years of life was 239 per 100 000 live births [95% confidence interval (CI) 216–263]. There was a socio-economic gradient to incidence, with a significantly higher incidence in the most deprived quintile (301 per 100 000 live births, 95% CI 251–357) compared with the least deprived quintile (182 per 100 000 live births, 95% CI 139–233), χ2 odds ratio = 1.7 (95% CI 1.3–2.2). The relationship between deprivation and incidence was only observed in the group without identified aetiology, suggesting that populations living in higher deprivation areas have greater multifactorial risk for epilepsy. Aetiology was determined in 54% of children, and epilepsy syndrome was classified in 54%. Thirty-one per cent had an identified genetic cause for their epilepsy. We present novel data on the aetiological spectrum of the most commonly presenting epilepsies of early childhood. Twenty-four months after presentation, 36% of children had drug-resistant epilepsy (DRE), and 49% had global developmental delay (GDD). Identification of an aetiology was the strongest determinant of both DRE and GDD. Aetiology was determined in 82% of those with DRE, and 75% of those with GDD. In young children with epilepsy, genetic testing should be prioritized as it has the highest yield of any investigation and is most likely to inform precision therapy and prognosis. Epilepsies in early childhood are 30% more common than previously reported. Epilepsies of undetermined aetiology present more frequently in deprived communities. This likely reflects increased multifactorial risk within these populations

A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.

We conducted a multi-stage, genome-wide association study of bladder cancer with a primary scan of 591,637 SNPs in 3,532 affected individuals (cases) and 5,120 controls of European descent from five studies followed by a replication strategy, which included 8,382 cases and 48,275 controls from 16 studies. In a combined analysis, we identified three new regions associated with bladder cancer on chromosomes 22q13.1, 19q12 and 2q37.1: rs1014971, (P = 8 × 10⁻¹²) maps to a non-genic region of chromosome 22q13.1, rs8102137 (P = 2 × 10⁻¹¹) on 19q12 maps to CCNE1 and rs11892031 (P = 1 × 10⁻⁷) maps to the UGT1A cluster on 2q37.1. We confirmed four previously identified genome-wide associations on chromosomes 3q28, 4p16.3, 8q24.21 and 8q24.3, validated previous candidate associations for the GSTM1 deletion (P = 4 × 10⁻¹¹) and a tag SNP for NAT2 acetylation status (P = 4 × 10⁻¹¹), and found interactions with smoking in both regions. Our findings on common variants associated with bladder cancer risk should provide new insights into the mechanisms of carcinogenesis

Physiology of Escherichia coli at high osmolarity and its use in industrial ethanol production

Biofuels are becoming increasingly important in the light of climate change, increasing energy demands and higher fuel prices. Their production must be carefully balanced against the production of foods and use of fresh water, both of which are consumed by crop based biofuels such as corn ethanol. One proposed solution is to instead use waste materials such as plant matter including wood offcuts and plant trimmings. This waste can be turned into syngas (a mix of CO and H₂) and converted to ethanol using microorganisms. Production of ethanol using microorganisms however, is complicated as the ethanol produced by the cells becomes toxic at higher concentrations, inhibiting their growth and further production. The usual method of keeping the toxicity down to allow further production is to continuously distil ethanol off at low concentrations and consequently, a high cost. Since the mechanisms of ethanol damage to microbes are similar to those that occur during osmotic challenge: damage to the membrane, cytoplasmic dehydration, and protein unfolding, I hypothesized that we can use knowledge of osmoregulatory mechanisms to increase the resistance of cells to ethanol damage and decrease distillation costs. While working under this hypothesis I had to address some of the challenges one faces when understanding the physiology and growth of microbes, and for the purpose I have developed a number of useful techniques; a method for calibrating optical densities to cell number, a neural network for identifying cells and determining their concentrations via microscope imaging and a simple particle diffusion simulation for correcting errors due to confinement of particles within cells. In addition, I have produced a simplified model of industrial production to help evaluate economic impacts that changes to the growth of microbes and the plant process may have. To study any useful links between osmolarity and ethanol resistance, I chose to use Escherichia coli as the model organism due to the large amount of data available on its osmoregulatory mechanisms. It has been long known that when bacteria do grow at high but not lethal osmolarity, they grow at a reduced rate which, even if it increases the ethanol resistance, may have a detrimental effect on the desired production rates. So therefore, in addition to testing the ethanol tolerance of the bacteria under different osmotic conditions, and as a second focus of this project, I have tried to understand why the reduction in growth rates occurs, with the hope of mitigating this effect. This will offer a better understanding of osmotic growth and provide useful insights for industrial bio-production. To this end, I have tried to discern some of the possible reasons for this slower growth by measuring various cell physiological parameters such as batch-culture yield, cytoplasmic diffusion and proteome allocation using my newly developed techniques. I have found a reduction in the cell yield with increasing osmolarity of 50% with an increase of 1Osm of osmotic agent, a slight decrease in cytoplasmic diffusion and a slight decrease in RNA content at high osmolarity. I have also proposed a coarse-grained model of proteome partitioning to help integrate these results and explain growth at high osmolarity. It is still to be determined if, as a whole, the changes observed explain fully the reduction in growth. When it comes to ethanol resistance, and contrary to my hypothesis, I found that increasing the osmolarity of the medium with sucrose or NaCl reduced the ethanol resistance. However, I found that the proW gene provides significant ethanol resistance, indicating glycine betaine, or another substrate for this transporter, is highly useful as a protectant. And this transporter is a potential candidate for overexpression. A reduction in growth temperature also provides significant solvent tolerance at the expense of a reduction in growth rate and hence production.Restricted Acces

HLA class I and II diversity contributes to the etiologic heterogeneity of non-Hodgkin lymphoma subtypes

A growing number of loci within the human leukocyte antigen (HLA) region have been implicated in non-Hodgkin lymphoma (NHL) etiology. Here, we test a complementary hypothesis of "heterozygote advantage" regarding the role of HLA and NHL, whereby HLA diversity is beneficial and homozygous HLA loci are associated with increased disease risk. HLA alleles at class I and II loci were imputed from genome-wide association studies (GWAS) using SNP2HLA for 3,617 diffuse large B-cell lymphomas (DLBCL), 2,686 follicular lymphomas (FL), 2,878 chronic lymphocytic leukemia/small lymphocytic lymphomas (CLL/SLL), 741 marginal zone lymphomas (MZL), and 8,753 controls of European descent. Both DLBCL and MZL risk were elevated with homozygosity at class I HLA-B and -C loci (OR DLBCL = 1.31, 95% CI = 1.06–1.60; OR MZL = 1.45, 95% CI = 1.12–1.89) and class II HLA-DRB1 locus (OR DLBCL = 2.10, 95% CI = 1.24–3.55; OR MZL = 2.10, 95% CI = 0.99–4.45). Increased FL risk was observed with the overall increase in number of homozygous HLA class II loci (P trend < 0.0001, FDR = 0.0005). These results support a role for HLA zygosity in NHL etiology and suggests that distinct immune pathways may underly the etiology of the different NHL subtypes. Significance: HLA gene diversity reduces risk for non-Hodgkin lymphoma