Wissens- und Technologietransfer in nationalen Innovationssystemen

Die Arbeit untersucht die Rolle des Wissens- und Technologietransfers in nationalen Innovationssystemen und insbesondere im Innovationsprozess. Bisher vorliegende Arbeiten zu diesem Thema behandeln entweder den Wissens- und Technologietransfer als einen eigenständigen Prozeß oder den Aufbau nationaler Innovationssysteme. Die Verbindung beider Konzepte ist Gegenstand der Arbeit

Robust Modeling of Volumes for Dynamic Simulations of Thermo-Fluid Stream Networks

Modeling of complex thermo-fluid systems often leads to either many states or large non-linear systems of equations, which are both undesirable especially for real-time applications. Both of these issues can be solved by our algebraic stream-dominated approach to build hard real-time capable simulations. In this approach volume elements play a central role as boundaries and loop-breakers for fluid streams. In this paper, we first derive a lumped state standard volume model from first principle and then several specialized volumes for different applications. We regularize the models to perform robustly, even in degenerated operating conditions that might appear in dynamic simulations. While doing so, we show all approximations and assumptions used to arrive at the final models. Finally, we present some application examples showcasing the use of the different volumes for dynamic simulations. Alongside the models developed in this paper these examples are part of our open-source Modelica library and their implementation is therefore available

Molecular simulation of thermosetting polymer hardening: reactive events enabled by controlled topology transfer

We present a quantum mechanical / molecular mechanics (QM/MM) to tackle chemical reactions with substantial molecular reorganization. For this, molecular dynamics simulations with smoothly switched interaction models are used to suggest suitable product states, whilst a Monte Carlo algorithm is employed to assess the reaction likeliness subject to energetic feasibility. As a demonstrator, we study the cross-linking of bisphenol F diglycidyl ether (BFDGE) and 4,6-diethyl-2-methylbenzene-1,3-diamine (DETDA). The modeling of epoxy curing was supplemented by Differential Scanning Calorimetry (DSC) measurements, which confirms the degrees of cross-linking as a function of curing temperature. Likewise, the heat of formation and the mechanical properties of the resulting thermosetting polymer are found to be in good agreement with previous experiments.Comment: To be published in ACS Macromolecule

The DLR ThermoFluid Stream Library

This paper introduces the DLR Thermofluid Stream Library: a free open-source library for the robust modeling of complex thermofluid architectures. Designed to be easy to use, easy to adapt, and enriched by a number of examples, this library contains the fundamental components for many different applications, such as thermal management of electric cars, power plants, or building physics. Different from many previous software implementations, the library exploits a new computational concept on the basis of the fluid inertance that derives the mass flow balance in such a manner that large non-linear equations systems in implicit form can be avoided. Hence, there is a reliable and efficient computational scheme for simulation and initialization. Although this scheme is explained in detail in previous publications, this paper focuses on the implementational aspects of the library, explaining its structure, the underlying equations of key components and providing basic examples. In addition to the practical value of the library, we also aim to display the underlying thought driving the design of the software

Generation of subdivision : hierarchies for efficient occlusion culling of large polygonal models

Veröffentlichung des Wilhelm-Schickard-Institut für Informatik Universität Tübinge

OpenGL-assisted Visibility Queries of Large Polygonal Models

Veröffentlichung des Wilhelm-Schickard-Institut für Informatik Universität Tübinge

Growth factors in multiple myeloma: a comprehensive analysis of their expression in tumor cells and bone marrow environment using Affymetrix microarrays

<p>Abstract</p> <p>Background</p> <p>Multiple myeloma (MM) is characterized by a strong dependence of the tumor cells on their microenvironment, which produces growth factors supporting survival and proliferation of myeloma cells (MMC). In the past few years, many myeloma growth factors (MGF) have been described in the literature. However, their relative importance and the nature of the cells producing MGF remain unidentified for many of them.</p> <p>Methods</p> <p>We have analysed the expression of 51 MGF and 36 MGF receptors (MGFR) using Affymetrix microarrays throughout normal plasma cell differentiation, in MMC and in cells from the bone marrow (BM) microenvironment (CD14, CD3, polymorphonuclear neutrophils, stromal cells and osteoclasts).</p> <p>Results</p> <p>4/51 MGF and 9/36 MGF-receptors genes were significantly overexpressed in plasmablasts (PPC) and BM plasma cell (BMPC) compared to B cells whereas 11 MGF and 11 MGFR genes were overexpressed in BMPC compared to PPC. 3 MGF genes (AREG, NRG3, Wnt5A) and none of the receptors were significantly overexpressed in MMC versus BMPC. Furthermore, 3/51 MGF genes were overexpressed in MMC compared to the the BM microenvironment whereas 22/51 MGF genes were overexpressed in one environment subpopulation compared to MMC.</p> <p>Conclusions</p> <p>Two major messages arise from this analysis 1) The majority of MGF genes is expressed by the bone marrow environment. 2) Several MGF and their receptors are overexpressed throughout normal plasma cell differentiation. This study provides an extensive and comparative analysis of MGF expression in plasma cell differentiation and in MM and gives new insights in the understanding of intercellular communication signals in MM.</p

Photography-based taxonomy is inadequate, unnecessary, and potentially harmful for biological sciences

The question whether taxonomic descriptions naming new animal species without type specimen(s) deposited in collections should be accepted for publication by scientific journals and allowed by the Code has already been discussed in Zootaxa (Dubois & Nemésio 2007; Donegan 2008, 2009; Nemésio 2009a–b; Dubois 2009; Gentile & Snell 2009; Minelli 2009; Cianferoni & Bartolozzi 2016; Amorim et al. 2016). This question was again raised in a letter supported by 35 signatories published in the journal Nature (Pape et al. 2016) on 15 September 2016. On 25 September 2016, the following rebuttal (strictly limited to 300 words as per the editorial rules of Nature) was submitted to Nature, which on 18 October 2016 refused to publish it. As we think this problem is a very important one for zoological taxonomy, this text is published here exactly as submitted to Nature, followed by the list of the 493 taxonomists and collection-based researchers who signed it in the short time span from 20 September to 6 October 2016

Wissens- und Technologietransfer in nationalen Innovationssystemen

Die Arbeit untersucht die Rolle des Wissens- und Technologietransfers in nationalen Innovationssystemen und insbesondere im Innovationsprozess. Bisher vorliegende Arbeiten zu diesem Thema behandeln entweder den Wissens- und Technologietransfer als einen eigenständigen Prozeß oder den Aufbau nationaler Innovationssysteme. Die Verbindung beider Konzepte ist Gegenstand der Arbeit