The temporal signature of self: Temporal measures of restingâ state EEG predict selfâ consciousness

The self is the core of our mental life. Previous investigations have demonstrated a strong neural overlap between selfâ related activity and resting state activity. This suggests that information about selfâ relatedness is encoded in our brain’s spontaneous activity. The exact neuronal mechanisms of such â restâ self containment,â however, remain unclear. The present EEG study investigated temporal measures of resting state EEG to relate them to selfâ consciousness. This was obtained with the selfâ consciousness scale (SCS) which measures Private, Public, and Social dimensions of self. We demonstrate positive correlations between Private selfâ consciousness and three temporal measures of resting state activity: scaleâ free activity as indexed by the powerâ law exponent (PLE), the autoâ correlation window (ACW), and modulation index (MI). Specifically, higher PLE, longer ACW, and stronger MI were related to higher degrees of Private selfâ consciousness. Finally, conducting eLORETA for spatial tomography, we found significant correlation of Private selfâ consciousness with activity in cortical midline structures such as the perigenual anterior cingulate cortex and posterior cingulate cortex. These results were reinforced with a dataâ driven analysis; a machine learning algorithm accurately predicted an individual as having a â highâ or â lowâ Private selfâ consciousness score based on these measures of the brain’s spatiotemporal structure. In conclusion, our results demonstrate that Private selfâ consciousness is related to the temporal structure of resting state activity as featured by temporal nestedness (PLE), temporal continuity (ACW), and temporal integration (MI). Our results support the hypothesis that selfâ related information is temporally contained in the brain’s resting state. â Restâ self containmentâ can thus be featured by a temporal signature.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/147871/1/hbm24412.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/147871/2/hbm24412_am.pd

Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice.

To gain insight into how mutant huntingtin (mHtt) CAG repeat length modifies Huntington's disease (HD) pathogenesis, we profiled mRNA in over 600 brain and peripheral tissue samples from HD knock-in mice with increasing CAG repeat lengths. We found repeat length-dependent transcriptional signatures to be prominent in the striatum, less so in cortex, and minimal in the liver. Coexpression network analyses revealed 13 striatal and 5 cortical modules that correlated highly with CAG length and age, and that were preserved in HD models and sometimes in patients. Top striatal modules implicated mHtt CAG length and age in graded impairment in the expression of identity genes for striatal medium spiny neurons and in dysregulation of cyclic AMP signaling, cell death and protocadherin genes. We used proteomics to confirm 790 genes and 5 striatal modules with CAG length-dependent dysregulation at the protein level, and validated 22 striatal module genes as modifiers of mHtt toxicities in vivo

π+\pi^+ photoproduction on the proton for photon energies from 0.725 to 2.875 GeV

Differential cross sections for the reaction $\gamma p \to n \pi^+$ have been measured with the CEBAF Large Acceptance Spectrometer (CLAS) and a tagged photon beam with energies from 0.725 to 2.875 GeV. Where available, the results obtained here compare well with previously published results for the reaction. Agreement with the SAID and MAID analyses is found below 1 GeV. The present set of cross sections has been incorporated into the SAID database, and exploratory fits have been made up to 2.7 GeV. Resonance couplings have been extracted and compared to previous determinations. With the addition of these cross sections to the world data set, significant changes have occurred in the high-energy behavior of the SAID cross-section predictions and amplitudes.Comment: 18 pages, 10 figure

Dermoscopic evaluation of nodular melanoma

Importance: Nodular melanoma (NM) is a rapidly progressing potentially lethal skin tumor for which early diagnosis is critical

Commodity risk assessment of Juglans regia plants from Turkey

The European Commission requested the EFSA Panel on Plant Health to prepare and deliver risk assessments for commodities listed in Commission Implementing Regulation (EU) 2018/2019 as ‘High risk plants, plant products and other objects’. This Scientific Opinion covers the plant health risks posed by 2‐year‐old grafted bare rooted plants for planting of Juglans regia imported from Turkey, taking into account the available scientific information, including the technical information provided by Turkey. The relevance of any pest for this Opinion was based on evidence following defined criteria. Two EU quarantine pests, Anoplophora chinensis and Lopholeucaspis japonica, and three pests not regulated in the EU, two insects (Garella musculana, Euzophera semifuneralis) and one fungus (Lasiodiplodia pseudotheobromae), fulfilled all relevant criteria and were selected for further evaluation. For these pests, the risk mitigation measures proposed in the technical dossier from Turkey were evaluated by considering the possible limiting factors. For these pests, an expert judgement was given on the likelihood of pest freedom taking into consideration the risk mitigation measures acting on the pests, including uncertainties associated with the assessment. While the estimated degree of pest freedom varied among pests, Lasiodiplodia pseudotheobromae was the pest most frequently expected on the commodity. The expert knowledge elicitation indicated, with 95% certainty, that 9,554 or more grafted bare rooted plants per 10,000 will be free from Lasiodiplodia pseudotheobromae

Search for supersymmetry in events with b-quark jets and missing transverse energy in pp collisions at 7 TeV

Results are presented from a search for physics beyond the standard model based on events with large missing transverse energy, at least three jets, and at least one, two, or three b-quark jets. The study is performed using a sample of proton-proton collision data collected at sqrt(s) = 7 TeV with the CMS detector at the LHC in 2011. The integrated luminosity of the sample is 4.98 inverse femtobarns. The observed number of events is found to be consistent with the standard model expectation, which is evaluated using control samples in the data. The results are used to constrain cross sections for the production of supersymmetric particles decaying to b-quark-enriched final states in the context of simplified model spectra.Comment: Submitted to Physical Review