The Ursinus Weekly, April 22, 1940

Speakers urge more humor, courtesy and Christian living at all-Ursinus conference • Governor names Mr. Helfferich to Pa. educ. council • Next forum to present Dr. Everett R. Clinchy • Women to hold hobby conference, Wednesday • F.D.R. wins straw vote at Harrisburg conclave • Daniel Reed to do monologues on Spoon River Anthology • Ursinus is represented by three at TKA convention • Barnard upholds Amer. govt. for basic pol. science class • Historical encyclopedia contains articles by Carter • Pres. McClure will address Girard College student body • Fireside chats analyze Christianity in college • Co-eds rush preparation for medieval May pageant: The King\u27s daughters • Registrar Sheeder addresses Pennsburg School assembly • I.R.C. will sponsor mock trial of Hitler • Club hears talk in French • German Club holds quiz • Physician talks to pre-meds. on causes of eye diseases • Team eyes weather as busy program appears • Jingmen down Lehigh in season opener, 2-0 • Seven girl courtsters to be honored Wed. • Callow thinks job is to form impressions • Jayvees hopeful for beginner with Perkiomen on Wednesday • Twelve aspirants report for tennis; to meet Mules Wed. • Cricket season to start with game at Princeton, Saturday • Cliff Calvert to coach baseball and football for Merchantville • Jing Johnson\u27s career includes coaching at Bucknell and Lehigh • Preceptresses addressed by ex-dean of women at Whittier • Alspach names John Wise head of class day committee • Seven from Ursinus attend collegiate chemistry meeting • Meistersingers close season; group attends opera Aida • Pre-meds arrange for trip to visit centers of medicine • Dr. White injured • Allen to speak at English Clubhttps://digitalcommons.ursinus.edu/weekly/1841/thumbnail.jp

Wet, wild and convivial : past, present and future contributions of Australia’s ocean pools to surf, beach, pool and body cultures and recreational coasts

I investigated the past, present and possible futures of Australia’s ocean pools, over a hundred public seawater pools sited on rocky surfcoasts, so that waves wash over their walls. My interdisciplinary analysis informed by actor-­‐network theory explored their contributions to surf, beach, pool and body cultures and recreational coasts. Ocean pools have since the nineteenth century been far more significant in the surf, beach, pool and body cultures of Australia and South Africa, than in those of Britain and the United States. Most of Australia’s ocean pools lie within state of New South Wales, and my work strengthens the case for recognising Australian and NSW ocean pools as having distinct collective identities and affinities with their South African counterparts. Ocean pools are sites of social and environmental learning that challenge efforts to establish human mastery over wild natures and depictions of coastal environments as mere stages for enacting human activities unconstrained by non-­‐human nature. They also challenge the notion that people prefer to swim and bathe at patrolled beaches or in private or public pools far less wild than an ocean pool. They are evidence that supervision by suitably trained and equipped lifeguards or lifesavers is not the only or the most satisfactory way to adequately safeguard bathers and swimmers from the dangers of the sea. Australia’s ocean pools demonstrate that regardless of race, class, gender, age or ability, people can and do make themselves at home in pools shared convivially with wild nature and well-­‐suited for sustained, unsupervised recreation and sport on rocky surfcoast. Ocean pools serve as places of refuge, therapeutic and restorative environments, adventure playgrounds, convivial public spaces, visually appealing cultural landscapes, brands, icons and symbols. Australia’s ocean pools are unified by their sites, their affordances and core actor-­‐ networks linked to their fundamental and enduring identity as ‘wild but safe enough surfside pools’. Rocky shores and coastal waters characterised by surf, sharks and rips are among the most persistent macro-­‐actors in these networks that include bathers, swimmers, tourism and transport networks, news media, local councils and progress associations. Australian ocean pools that gained a further identity as ‘public pools for competition and carnivals’ acquired additional actor-­‐networks strongly linked since the late nineteenth century to amateur swimming clubs and schools, and since the twentieth century to surf lifesaving clubs and winter swimming clubs. Those ocean pools nevertheless, remained predominately recreational facilities. As other types of public pools became more affordable, Australia’s ocean pools remained popular despite gaining new identities as an ‘unusually hazardous type of public pool’ and ‘a type of facility no longer created’. The growing threats to ocean pools and their actor-­‐networks are a further unifying factor. As sport and recreation venues cultivating healthy, convivial relationships with wild nature and possessing unrealised potential as centres for community engagement, learning and research, ocean pools are worth emulating on other rocky shores and in other public places. My work strengthens efforts to sustain and create ocean pools and supports further studies on seawater pools and their actor-­‐networks

Gender differences in effectiveness of the Complete Health Improvement Program (CHIP) lifestyle intervention: an Australasian study

Issue addressed: Complete Health Improvement Program (CHIP) is a lifestyle modification program that promotes healthy diet, physical activity and stress management techniques. Among US CHIP participants, differences in gender responsiveness to improvements in chronic disease risk factors were demonstrated. This study examined gender differences in outcomes to the CHIP intervention in Australasia. Methods: Changes in body weight, blood pressure (BP), blood lipid profile and fasting plasma glucose (FPG) were assessed in 925 participants (34.3% men, mean age = 56.0 ± 12.5 years; 65.7% women, mean age = 54.4 ± 13.5 years) 30 days after program commencement. Results: Significant reductions (P \u3c 0.001) in all biometrics measured were found for men and women but were greater among men for total (TC) and low-density lipoprotein cholesterol (LDL), triglycerides (TG), FPG, body mass index (BMI) and TC/high-density lipoprotein cholesterol (HDL) ratio. Participants with highest baseline classifications of BMI, systolic BP, blood lipids and FPG showed greatest reductions in 30 days. Conclusions: CHIP more effectively reduced chronic disease risk factors among men than women. All participants, but particularly men, entering the program with the greatest risk achieved the largest reductions. Possible physiological or behavioural factors include food preferences, making commitments and differential support modes. So what?: Developers of lifestyle intervention programs should consider gender differences in physiological and behavioural factors when planning interventions. In particular, developers should manage expectations of people entering lifestyle interventions to increase awareness that men tend to respond better than women. In addition, this is a call for further research to identify the underlying mechanisms responsible for the disproportionate responsiveness of males

Garment Quality and Sustainability : A User-Based Approach

This paper explores the role played by female perceptions of garment quality in relation to how long clothing is kept and how it is used. It considers perceptions of quality in relation to implications for sustainability in fashion. The research involves two phases of empirical data collection conducted in the UK. The first phase draws on a subset of findings from a 12-month laundry study that surveyed the use and laundering of 32 different garments across a group of 16 women. The second phase comprises a semi-structured interview study with 13 women and focuses on exploring factors that influence garment lifetimes. The central contributions of this paper are the distinctions it makes between the immediate concepts of clothing quality that are understood as “pre-use” to those more gradually developed experiences of quality learnt “during use.” In use, garments are tied into user practices and as such become woven into the actions and experiences of everyday life. The length of time garments are worn and kept is more closely connected to how quality is experienced subjectively by the user than understood within objective industry-based definitions of quality. In relation to sustainability, this suggests new directions for understanding quality with emphasis on user behavior

BHPR research: qualitative1. Complex reasoning determines patients' perception of outcome following foot surgery in rheumatoid arhtritis

Background: Foot surgery is common in patients with RA but research into surgical outcomes is limited and conceptually flawed as current outcome measures lack face validity: to date no one has asked patients what is important to them. This study aimed to determine which factors are important to patients when evaluating the success of foot surgery in RA Methods: Semi structured interviews of RA patients who had undergone foot surgery were conducted and transcribed verbatim. Thematic analysis of interviews was conducted to explore issues that were important to patients. Results: 11 RA patients (9 ♂, mean age 59, dis dur = 22yrs, mean of 3 yrs post op) with mixed experiences of foot surgery were interviewed. Patients interpreted outcome in respect to a multitude of factors, frequently positive change in one aspect contrasted with negative opinions about another. Overall, four major themes emerged. Function: Functional ability & participation in valued activities were very important to patients. Walking ability was a key concern but patients interpreted levels of activity in light of other aspects of their disease, reflecting on change in functional ability more than overall level. Positive feelings of improved mobility were often moderated by negative self perception ("I mean, I still walk like a waddling duck”). Appearance: Appearance was important to almost all patients but perhaps the most complex theme of all. Physical appearance, foot shape, and footwear were closely interlinked, yet patients saw these as distinct separate concepts. Patients need to legitimize these feelings was clear and they frequently entered into a defensive repertoire ("it's not cosmetic surgery; it's something that's more important than that, you know?”). Clinician opinion: Surgeons' post operative evaluation of the procedure was very influential. The impact of this appraisal continued to affect patients' lasting impression irrespective of how the outcome compared to their initial goals ("when he'd done it ... he said that hasn't worked as good as he'd wanted to ... but the pain has gone”). Pain: Whilst pain was important to almost all patients, it appeared to be less important than the other themes. Pain was predominately raised when it influenced other themes, such as function; many still felt the need to legitimize their foot pain in order for health professionals to take it seriously ("in the end I went to my GP because it had happened a few times and I went to an orthopaedic surgeon who was quite dismissive of it, it was like what are you complaining about”). Conclusions: Patients interpret the outcome of foot surgery using a multitude of interrelated factors, particularly functional ability, appearance and surgeons' appraisal of the procedure. While pain was often noted, this appeared less important than other factors in the overall outcome of the surgery. Future research into foot surgery should incorporate the complexity of how patients determine their outcome Disclosure statement: All authors have declared no conflicts of interes

The impact of viral mutations on recognition by SARS-CoV-2 specific T cells.

We identify amino acid variants within dominant SARS-CoV-2 T cell epitopes by interrogating global sequence data. Several variants within nucleocapsid and ORF3a epitopes have arisen independently in multiple lineages and result in loss of recognition by epitope-specific T cells assessed by IFN-γ and cytotoxic killing assays. Complete loss of T cell responsiveness was seen due to Q213K in the A∗01:01-restricted CD8+ ORF3a epitope FTSDYYQLY207-215; due to P13L, P13S, and P13T in the B∗27:05-restricted CD8+ nucleocapsid epitope QRNAPRITF9-17; and due to T362I and P365S in the A∗03:01/A∗11:01-restricted CD8+ nucleocapsid epitope KTFPPTEPK361-369. CD8+ T cell lines unable to recognize variant epitopes have diverse T cell receptor repertoires. These data demonstrate the potential for T cell evasion and highlight the need for ongoing surveillance for variants capable of escaping T cell as well as humoral immunity.This work is supported by the UK Medical Research Council (MRC); Chinese Academy of Medical Sciences(CAMS) Innovation Fund for Medical Sciences (CIFMS), China; National Institute for Health Research (NIHR)Oxford Biomedical Research Centre, and UK Researchand Innovation (UKRI)/NIHR through the UK Coro-navirus Immunology Consortium (UK-CIC). Sequencing of SARS-CoV-2 samples and collation of data wasundertaken by the COG-UK CONSORTIUM. COG-UK is supported by funding from the Medical ResearchCouncil (MRC) part of UK Research & Innovation (UKRI),the National Institute of Health Research (NIHR),and Genome Research Limited, operating as the Wellcome Sanger Institute. T.I.d.S. is supported by a Well-come Trust Intermediate Clinical Fellowship (110058/Z/15/Z). L.T. is supported by the Wellcome Trust(grant number 205228/Z/16/Z) and by theUniversity of Liverpool Centre for Excellence in Infectious DiseaseResearch (CEIDR). S.D. is funded by an NIHR GlobalResearch Professorship (NIHR300791). L.T. and S.C.M.are also supported by the U.S. Food and Drug Administration Medical Countermeasures Initiative contract75F40120C00085 and the National Institute for Health Research Health Protection Research Unit (HPRU) inEmerging and Zoonotic Infections (NIHR200907) at University of Liverpool inpartnership with Public HealthEngland (PHE), in collaboration with Liverpool School of Tropical Medicine and the University of Oxford.L.T. is based at the University of Liverpool. M.D.P. is funded by the NIHR Sheffield Biomedical ResearchCentre (BRC – IS-BRC-1215-20017). ISARIC4C is supported by the MRC (grant no MC_PC_19059). J.C.K.is a Wellcome Investigator (WT204969/Z/16/Z) and supported by NIHR Oxford Biomedical Research Centreand CIFMS. The views expressed are those of the authors and not necessarily those of the NIHR or MRC

Spatial growth rate of emerging SARS-CoV-2 lineages in England, September 2020-December 2021

This paper uses a robust method of spatial epidemiological analysis to assess the spatial growth rate of multiple lineages of SARS-CoV-2 in the local authority areas of England, September 2020–December 2021. Using the genomic surveillance records of the COVID-19 Genomics UK (COG-UK) Consortium, the analysis identifies a substantial (7.6-fold) difference in the average rate of spatial growth of 37 sample lineages, from the slowest (Delta AY.4.3) to the fastest (Omicron BA.1). Spatial growth of the Omicron (B.1.1.529 and BA) variant was found to be 2.81× faster than the Delta (B.1.617.2 and AY) variant and 3.76× faster than the Alpha (B.1.1.7 and Q) variant. In addition to AY.4.2 (a designated variant under investigation, VUI-21OCT-01), three Delta sublineages (AY.43, AY.98 and AY.120) were found to display a statistically faster rate of spatial growth than the parent lineage and would seem to merit further investigation. We suggest that the monitoring of spatial growth rates is a potentially valuable adjunct to outbreak response procedures for emerging SARS-CoV-2 variants in a defined population

Investigation of hospital discharge cases and SARS-CoV-2 introduction into Lothian care homes

Summary Background The first epidemic wave of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in Scotland resulted in high case numbers and mortality in care homes. In Lothian, over one-third of care homes reported an outbreak, while there was limited testing of hospital patients discharged to care homes. Aim To investigate patients discharged from hospitals as a source of SARS-CoV-2 introduction into care homes during the first epidemic wave. Methods A clinical review was performed for all patients discharges from hospitals to care homes from 1st March 2020 to 31st May 2020. Episodes were ruled out based on coronavirus disease 2019 (COVID-19) test history, clinical assessment at discharge, whole-genome sequencing (WGS) data and an infectious period of 14 days. Clinical samples were processed for WGS, and consensus genomes generated were used for analysis using Cluster Investigation and Virus Epidemiological Tool software. Patient timelines were obtained using electronic hospital records. Findings In total, 787 patients discharged from hospitals to care homes were identified. Of these, 776 (99%) were ruled out for subsequent introduction of SARS-CoV-2 into care homes. However, for 10 episodes, the results were inconclusive as there was low genomic diversity in consensus genomes or no sequencing data were available. Only one discharge episode had a genomic, time and location link to positive cases during hospital admission, leading to 10 positive cases in their care home. Conclusion The majority of patients discharged from hospitals were ruled out for introduction of SARS-CoV-2 into care homes, highlighting the importance of screening all new admissions when faced with a novel emerging virus and no available vaccine

SARS-CoV-2 lineage dynamics in England from September to November 2021: high diversity of Delta sub-lineages and increased transmissibility of AY.4.2

Background: Since the emergence of SARS-CoV-2, evolutionary pressure has driven large increases in the transmissibility of the virus. However, with increasing levels of immunity through vaccination and natural infection the evolutionary pressure will switch towards immune escape. Genomic surveillance in regions of high immunity is crucial in detecting emerging variants that can more successfully navigate the immune landscape. Methods: We present phylogenetic relationships and lineage dynamics within England (a country with high levels of immunity), as inferred from a random community sample of individuals who provided a self-administered throat and nose swab for rt-PCR testing as part of the REal-time Assessment of Community Transmission-1 (REACT-1) study. During round 14 (9 September–27 September 2021) and 15 (19 October–5 November 2021) lineages were determined for 1322 positive individuals, with 27.1% of those which reported their symptom status reporting no symptoms in the previous month. Results: We identified 44 unique lineages, all of which were Delta or Delta sub-lineages, and found a reduction in their mutation rate over the study period. The proportion of the Delta sub-lineage AY.4.2 was increasing, with a reproduction number 15% (95% CI 8–23%) greater than the most prevalent lineage, AY.4. Further, AY.4.2 was less associated with the most predictive COVID-19 symptoms (p = 0.029) and had a reduced mutation rate (p = 0.050). Both AY.4.2 and AY.4 were found to be geographically clustered in September but this was no longer the case by late October/early November, with only the lineage AY.6 exhibiting clustering towards the South of England. Conclusions: As SARS-CoV-2 moves towards endemicity and new variants emerge, genomic data obtained from random community samples can augment routine surveillance data without the potential biases introduced due to higher sampling rates of symptomatic individuals. © 2022, The Author(s)