Sanctuaire de source, sanctuaire des eaux ou simple sanctuaire en milieu humide? Découverte d'un complexe cultuel antique à Magny-Cours (Nièvre)

In advance of the future extension of the "technopole" and the construction of a service station in the district of Magny-Cours, the undertaking of two evaluations covering 15 hectares and 4 hectares, respectively, has revealed dense occupation of the site from the Neolithic period to the Middle Ages. The most important remains are associated with the Roman period and belong to a complex endowed with public buildings including several temples in an organised arrangement. This paper, preliminary to a larger study that will report on the whole of the site, is concerned specifically with the results obtained in a waterlogged area comprised within a zone that was excluded from the rescue excavations. Located near the cult buildings, this area was found to contain a deposit of ex-votos belonging to the beginning of the Roman era.À l'occasion de la future extension du " technopole " sur la commune de Magny-Cours et la création d'une aire de service, la réalisation de deux diagnostics sur 15 ha et 4 ha a permis la mise en évidence d'une occupation dense du Néolithique au Moyen Âge. La période antique rassemble l'essentiel des vestiges, appartenant à un complexe doté de monuments publics dont plusieurs temples à plan centré. Cet article, préambule à une étude globale qui concernera l'ensemble du site, se limite à la présentation des résultats acquis dans une zone humide exclue de la fouille préventive. Située à proximité d'édifices cultuels, elle a livré un dépôt d'ex-voto remontant au début de la période romaine

Molecular Characterization of the Gastrula in the Turtle Emys orbicularis: An Evolutionary Perspective on Gastrulation

Due to the presence of a blastopore as in amphibians, the turtle has been suggested to exemplify a transition form from an amphibian- to an avian-type gastrulation pattern. In order to test this hypothesis and gain insight into the emergence of the unique characteristics of amniotes during gastrulation, we have performed the first molecular characterization of the gastrula in a reptile, the turtle Emys orbicularis. The study of Brachyury, Lim1, Otx2 and Otx5 expression patterns points to a highly conserved dynamic of expression with amniote model organisms and makes it possible to identify the site of mesoderm internalization, which is a long-standing issue in reptiles. Analysis of Brachyury expression also highlights the presence of two distinct phases, less easily recognizable in model organisms and respectively characterized by an early ring-shaped and a later bilateral symmetrical territory. Systematic comparisons with tetrapod model organisms lead to new insights into the relationships of the blastopore/blastoporal plate system shared by all reptiles, with the blastopore of amphibians and the primitive streak of birds and mammals. The biphasic Brachyury expression pattern is also consistent with recent models of emergence of bilateral symmetry, which raises the question of its evolutionary significance

Meta-analysis of SHANK Mutations in Autism Spectrum Disorders: A Gradient of Severity in Cognitive Impairments.

International audienceSHANK genes code for scaffold proteins located at the post-synaptic density of glutamatergic synapses. In neurons, SHANK2 and SHANK3 have a positive effect on the induction and maturation of dendritic spines, whereas SHANK1 induces the enlargement of spine heads. Mutations in SHANK genes have been associated with autism spectrum disorders (ASD), but their prevalence and clinical relevance remain to be determined. Here, we performed a new screen and a meta-analysis of SHANK copy-number and coding-sequence variants in ASD. Copy-number variants were analyzed in 5,657 patients and 19,163 controls, coding-sequence variants were ascertained in 760 to 2,147 patients and 492 to 1,090 controls (depending on the gene), and, individuals carrying de novo or truncating SHANK mutations underwent an extensive clinical investigation. Copy-number variants and truncating mutations in SHANK genes were present in ∼1% of patients with ASD: mutations in SHANK1 were rare (0.04%) and present in males with normal IQ and autism; mutations in SHANK2 were present in 0.17% of patients with ASD and mild intellectual disability; mutations in SHANK3 were present in 0.69% of patients with ASD and up to 2.12% of the cases with moderate to profound intellectual disability. In summary, mutations of the SHANK genes were detected in the whole spectrum of autism with a gradient of severity in cognitive impairment. Given the rare frequency of SHANK1 and SHANK2 deleterious mutations, the clinical relevance of these genes remains to be ascertained. In contrast, the frequency and the penetrance of SHANK3 mutations in individuals with ASD and intellectual disability-more than 1 in 50-warrant its consideration for mutation screening in clinical practice

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure

Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome associated with COVID-19: An Emulated Target Trial Analysis.

RATIONALE: Whether COVID patients may benefit from extracorporeal membrane oxygenation (ECMO) compared with conventional invasive mechanical ventilation (IMV) remains unknown. OBJECTIVES: To estimate the effect of ECMO on 90-Day mortality vs IMV only Methods: Among 4,244 critically ill adult patients with COVID-19 included in a multicenter cohort study, we emulated a target trial comparing the treatment strategies of initiating ECMO vs. no ECMO within 7 days of IMV in patients with severe acute respiratory distress syndrome (PaO2/FiO2 <80 or PaCO2 ≥60 mmHg). We controlled for confounding using a multivariable Cox model based on predefined variables. MAIN RESULTS: 1,235 patients met the full eligibility criteria for the emulated trial, among whom 164 patients initiated ECMO. The ECMO strategy had a higher survival probability at Day-7 from the onset of eligibility criteria (87% vs 83%, risk difference: 4%, 95% CI 0;9%) which decreased during follow-up (survival at Day-90: 63% vs 65%, risk difference: -2%, 95% CI -10;5%). However, ECMO was associated with higher survival when performed in high-volume ECMO centers or in regions where a specific ECMO network organization was set up to handle high demand, and when initiated within the first 4 days of MV and in profoundly hypoxemic patients. CONCLUSIONS: In an emulated trial based on a nationwide COVID-19 cohort, we found differential survival over time of an ECMO compared with a no-ECMO strategy. However, ECMO was consistently associated with better outcomes when performed in high-volume centers and in regions with ECMO capacities specifically organized to handle high demand. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/)

Consumer behavior and cultural effects on taboo products

The economy starts rising up since human beings live in societies and exchange different kinds of goods in order to maintain their daily life. This economy has known several steps from the creation of barter to what is known today, with financial and international markets. In our modern and actual societies, this economy is surrounding every single citizen. They grow up with it, they work into it and thanks to that they are able to buy what they need and what they want. A lot of different companies of several sizes, national or international propose and sell items that is needed to survive (food, clothes and so on) or wishes according to people’s tastes (holidays at the beach, video games and so on). Every single day, consumers are tending to buy those goods or services. The consumer behavior is affected by a lot of different factors. The aim of companies, whatever their products or services are, is to sell as many items as they can and in order to do so they will try to affect their actual and potential consumers to make them want to buy what they produce. In the past, this action was much easier that what have to be done today because before the 20th companies were above all concentrated on their national market. In our actual environment companies tend to internationalize themselves a lot to earn more power, and the impact they wish to create on consumption might become more difficult because of the different cultures earn by each different geographic region. In this work, the consumer behavior will be at the heart of the study. This analysis will try to point out what kind of different factors can affect their final purchase decisions. In order to understand perfectly this field, the study will be reduced to three international companies which sell some products that can be seen as a taboo in several countries. The way those companies sell their products in different cultures will be analyzed as well as the way consumers see the communication campaigns of those companies. It has been found that communication policies and advertisement campaigns cannot be always the same according to the culture and the country of the consumers. Most of the times, in order to succed companies and marketers have to study very deeply the behavior of their potential foreign consumers to understand how they will react to their communication ways. In this work, the consumer approach will be valorized. What they think about companies and their strategies will be deeply studied in order to find out if companies in this specific taboo market use the good methods to attract consumption

Das Lebertal in den Vogesen: ein Bergbaurevier an der Grenze zum germanischen Kulturraum

International audienc

Séquençage des zones codantes du gène de l'érythropoïétine humaine (à propos d'un cas d'anémie avec un taux d'érythropoïétine sérique effondré)

CHATENAY M.-PARIS 11-BU Pharma. (920192101) / SudocSudocFranceF