A qualitative exploration of sleep-related sexual interests: Somnophilia and dormaphilia

Somnophilia is an under-researched paraphilia. Consequently, there are discrepancies in its definition and conceptual understanding. Also, literature regarding the sexual interest in being asleep during sexual activity (dormaphilia) is even more limited. As such, there is a need to understand these paraphilias more deeply. This study recruited 232 participants online to discuss the content, origin, sexual appeal, emotional appraisal, and behavioural enactment of their somnophilic and dormaphilic interests and fantasies. A Thematic Analysis led to the identification of four main themes: (1) Relevance of Sleep State; (2) Roles within Sleep Sex; (3) Enactment of Sleep Paraphilia and (4) Lack of Consent and Awareness. These four themes spanned across both those reporting somnophilic and dormaphilic fantasies. The Discussion explores the multi-faceted nature of the interests, and implications for the understanding of somnophilia and dormaphilia. This study provides the first qualitative exploration of sleep-related paraphilias

Endometrial ablation and resection versus hysterectomy for heavy menstrual bleeding: an updated systematic review and meta-analysis of effectiveness and complications

To evaluate the clinical efficacy, safety, and cost-effectiveness of endometrial ablation or resection (E:A/R) compared to hysterectomy for the treatment of heavy menstrual bleeding. Literature search was conducted, and randomized control trials (RCTs) comparing (E:A/R) versus hysterectomy were reviewed. The search was last updated in November 2022. Twelve RCTs with 2,028 women (hysterectomy: n=977 vs. [E:A/R]: n=1,051) were included in the analyzis. The meta-analysis revealed that the hysterectomy group showed improved patient-reported and objective bleeding symptoms more than those of the (E:A/R) group, with risk ratios of (mean difference [MD], 0.75; 95% confidence intervals [CI], 0.71 to 0.79) and (MD, 44.00; 95% CI, 36.09 to 51.91), respectively. Patient satisfaction was higher post-hysterectomy than (E:A/R) at 2 years of follow-up, but this effect was absent with long-term follow-up. (E:A/R) is considered an alternative to hysterectomy as a surgical management for heavy menstrual bleeding. Although both procedures are highly effective, safe, and improve the quality of life, hysterectomy is significantly superior at improving bleeding symptoms and patient satisfaction for up to 2 years. However, it is associated with longer operating and recovery times and a higher rate of postoperative complications. The initial cost of (E:A/R) is less than the cost of hysterectomy, but further surgical requirements are common; therefore, there is no difference in the cost for long-term follow-up

Effects of Extreme Sleep Deprivation on Human Performance

Sleep is a fundamental recuperative process for the nervous system. Disruption of this homeostatic drive can lead to severe impairments of the operator’s ability to perceive, recognize, and respond to emergencies and/or unanticipated events, putting the operator at risk. Therefore, establishing a comprehensive understanding of how sleep deprivation influences human performance is essential in order to counter fatigue or to develop mitigation strategies. The goal of the present study was to examine the psychological effects of prolonged sleep deprivation (approx. 75 hrs) over a four-day span on a general aviation pilot flying a fixed-based flight simulator. During the study, a series of tasks were employed every four hours in order to examine the pilot’s perceptual and higher level cognitive abilities. Overall, results suggest that the majority of cognitive and perceptual degradation occurs between 30-40 hours into the flight. Limitations and future research directions are also discussed

Somnophilia: Examining its various forms and associated constructs

Somnophilia refers to the interest in having sex with a sleeping person. Using an online sample of 437 participants, the present study provides the first empirical examination of somnophilia, its various forms, and theorized correlates. Participants completed the newly developed Somnophilia Interest and Proclivity Scale, which comprises three subscales (Active consensual, Passive consensual, and Active non-consensual somnophilia). In order to test hypotheses about the convergent and divergent validity of different paraphilic interests, participants also completed scales measuring necrophilic, rape-related, and sadistic/masochistic sexual fantasies, rape proclivity, and the need for sexual dominance/submission. Male participants scored higher than females on all scales except the passive subscale. For both males and females, each subscale was associated most strongly with conceptually-congruent variables. These results support existing theoretical assumptions about somnophilia, as well as offering newer insights, such as distinguishing between active and passive somnophilia. Limitations and implications for further research are discussed

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field